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Tanzeela Hanif, Kishor Dhaygude, Matti Kankainen, Jutta Renkonen, Pirkko Mattila, Teija Ojala, Sakari Joenvaara, Mika Mäkelä, Anna Pelkonen, Paula Kauppi, Tari Haahtela, Risto Renkonen, Sanna Toppila-Salmi
Nasal epithelial transcriptome is altered by the season. Birch pollen allergen immunotherapy recovers microbial community diversity and alters expression of allergy related genes.
February 12, 2019: Journal of Allergy and Clinical Immunology
N Rafiee Tari, E Arranz, M Corredig
An increasing body of evidence demonstrates that differences in protein composition in the food matrix can significantly affect its biological functionality. The present research hypothesized that a matrix containing the same level of dairy protein, but with different composition, even when showing similar properties during digestion, may have a different biological functionality. To test this hypothesis, three matrices, containing 2.8% protein and similar amounts of fat and solid were prepared, either with 100% whey proteins, or with a ratio of caseins to whey protein of 40 : 60, but differing in β-casein ratio...
February 15, 2019: Food & Function
Jenny J J M Huijs, Irene L D Houtman, Toon W Taris, Roland W B Blonk
BACKGROUND: The present study aimed to investigate the effects of a stepwise, bottom-up participatory program with a tailor-made intervention process addressing the level of mental retirement in a sample of Dutch employees. Mental retirement refers to feelings of being disconnected from your work and your organization. Prevention of mental retirement is important since sustainable employability is becoming more important in today's society due to the ageing of the working population and the changes in skills demands...
February 14, 2019: BMC Public Health
Péter Poór, Gábor Patyi, Zoltán Takács, András Szekeres, Nikolett Bódi, Mária Bagyánszki, Irma Tari
The growth regulator, salicylic acid (SA) plays an important role in the induction of cell death in plants. Production of reactive oxygen species (ROS) by mitochondrial electron transport chain (mtETC), cytochrome c (cyt c) release from mitochondria and loss of mitochondrial integrity can be observed during cell death execution in plant tissues. The aim of this work was to study the putative role of hexokinases (HXKs) in the initiation of cell death using tomato (Solanum lycopersicum L.) leaves and mitochondria isolated from plants exposed to a sublethal, 0...
February 13, 2019: Journal of Plant Research
Giuseppe Roberto, Francesco Barone-Adesi, Francesco Giorgianni, Valeria Pizzimenti, Carmen Ferrajolo, Michele Tari, Claudia Bartolini, Roberto Da Cas, Marina Maggini, Stefania Spila-Alegiani, Paolo Francesconi, Gianluca Trifirò, Elisabetta Poluzzi, Fabio Baccetti, Rosa Gini
BACKGROUND: The incretin-based medicines GLP1 analogues (GLP1a) and dipeptidyl peptidase-4 inhibitors (DPP4i) are hypoglycaemic agents licensed for the treatment of type 2 diabetes mellitus (T2DM). Although these drugs possess comparable efficacy and low risk of hypoglycaemia, differences in terms of route of administration (subcutaneous versus oral), effect on body weight and gastrointestinal tolerabily can impact their actual use in clinical practice. This study aimed to describe the real-world utilization of incretin-based medicines in the Italian clinical practice...
February 7, 2019: BMC Endocrine Disorders
Kristina M Gicas, Alex Cheng, Iris Rawtaer, Taylor S Willi, William J Panenka, Donna J Lang, Geoff N Smith, Fidel Vila-Rodriguez, Olga Leonova, Chantelle J Giesbrecht, Andrea A Jones, Alasdair M Barr, Ric M Procyshyn, Tari Buchanan, G William MacEwan, Wayne Su, Alexandra T Vertinsky, Alexander Rauscher, Norm O'Rourke, Wendy Loken Thornton, Allen E Thornton, William G Honer
OBJECTIVE: We investigated white matter differences associated with distinct neurocognitive profiles derived from a large cohort of marginally housed persons with comorbid physical and mental illnesses. Our prior work identified three profile cluster groups: a high functioning group (Cluster 1), a low functioning group with relative strength in decision-making (Cluster 3), and an intermediary group with a relative decision-making weakness (Cluster 2). This study extends previous findings of cortical gray matter differences between these groups with evidence for putative neurodevelopmental abnormalities in the low cognitive functioning group (i...
February 6, 2019: Brain and Behavior
Anna Weiss, Samantha Grossmith, Danielle Cutts, Sage A Mikami, Johanna A Suskin, Mary Knust Graichen, Negui Arilis Rojas, Lydia E Pace, Eileen Joyce, Esther Rhei, Rochelle Scheib, Brittany Bychkovsky, Judy E Garber, Daniel Morganstern, Tari A King
PURPOSE: Existing high-risk clinic models focus on patients with known risk factors, potentially missing many high-risk patients. Here we describe our experience implementing universal risk assessment in an ambulatory breast center. METHODS: Since May 2017, all breast center patients completed a customized intake survey addressing known breast cancer risk factors and lifestyle choices. Patient characteristics, family history, risk scores, and lifestyle factors were examined; patients with high-risk breast lesions were excluded...
January 21, 2019: Breast Cancer Research and Treatment
Suzanne B Coopey, Kinyas Kartal, Clara Li, Adam Yala, Regina Barzilay, Heather R Faulkner, Tari A King, Francisco Acevedo, Judy E Garber, Anthony J Guidi, Kevin S Hughes
PURPOSE: Atypical ductal hyperplasia (ADH) significantly increases the risk of breast cancer in women. However, little is known about the implications of ADH in men. METHODS: Review of 932 males with breast pathology was performed to identify cases of ADH. Patients were excluded if ADH was upgraded to cancer on excision, or if they had contralateral breast cancer. Cases were reviewed to determine whether any male with ADH developed breast cancer. RESULTS: Nineteen males were diagnosed with ADH from June 2003 to September 2018...
January 21, 2019: Breast Cancer Research and Treatment
Serena Nik-Zainal, Helen Davies, Johan Staaf, Manasa Ramakrishna, Dominik Glodzik, Xueqing Zou, Inigo Martincorena, Ludmil B Alexandrov, Sancha Martin, David C Wedge, Peter Van Loo, Young Seok Ju, Marcel Smid, Arie B Brinkman, Sandro Morganella, Miriam R Aure, Ole Christian Lingjærde, Anita Langerød, Markus Ringnér, Sung-Min Ahn, Sandrine Boyault, Jane E Brock, Annegien Broeks, Adam Butler, Christine Desmedt, Luc Dirix, Serge Dronov, Aquila Fatima, John A Foekens, Moritz Gerstung, Gerrit K J Hooijer, Se Jin Jang, David R Jones, Hyung-Yong Kim, Tari A King, Savitri Krishnamurthy, Hee Jin Lee, Jeong-Yeon Lee, Yilong Li, Stuart McLaren, Andrew Menzies, Ville Mustonen, Sarah O'Meara, Iris Pauporté, Xavier Pivot, Colin A Purdie, Keiran Raine, Kamna Ramakrishnan, F Germán Rodríguez-González, Gilles Romieu, Anieta M Sieuwerts, Peter T Simpson, Rebecca Shepherd, Lucy Stebbings, Olafur A Stefansson, Jon Teague, Stefania Tommasi, Isabelle Treilleux, Gert G Van den Eynden, Peter Vermeulen, Anne Vincent-Salomon, Lucy Yates, Carlos Caldas, Laura Van't Veer, Andrew Tutt, Stian Knappskog, Benita Kiat Tee Tan, Jos Jonkers, Åke Borg, Naoto T Ueno, Christos Sotiriou, Alain Viari, P Andrew Futreal, Peter J Campbell, Paul N Span, Steven Van Laere, Sunil R Lakhani, Jorunn E Eyfjord, Alastair M Thompson, Ewan Birney, Hendrik G Stunnenberg, Marc J van de Vijver, John W M Martens, Anne-Lise Børresen-Dale, Andrea L Richardson, Gu Kong, Gilles Thomas, Michael R Stratton
In the Methods section of this Article, 'greater than' should have been 'less than' in the sentence 'Putative regions of clustered rearrangements were identified as having an average inter-rearrangement distance that was at least 10 times greater than the whole-genome average for the individual sample. '. The Article has not been corrected.
January 18, 2019: Nature
Mansooreh Jamshidian-Tehrani, Amin Nabavi, Abolfazl Kasaee, Narges Hasanpoor, Eahsan Elhami, Shervin Sharif-Kashani, Ahamd Masoumi, M Hossein Nowroozzadeh, Ali Sadeghi-Tari
PURPOSE: To evaluate alterations in orbital color Doppler imaging (CDI) parameters and their correlation to disease activity and severity in patients with thyroid eye disease (TED). METHODS: Seventy-six orbits of 45 TED patients and 40 orbits of 40 normal controls were enrolled in this cross-sectional study. According to clinical activity score (CAS), patients were categorized to active (CAS ≥ 3) or inactive disease (CAS < 3). Patients were also classified as having mild, moderate or severe disease...
January 10, 2019: Orbit
Rinaa S Punglia, Kaitlyn Bifolck, Mehra Golshan, Constance Lehman, Laura Collins, Kornelia Polyak, Elizabeth Mittendorf, Judy Garber, Shelley E Hwang, Stuart J Schnitt, Ann H Partridge, Tari A King
Ductal carcinoma in situ (DCIS) is a highly heterogeneous disease. It presents in a variety of ways and may or may not progress to invasive cancer, which poses challenges for both diagnosis and treatment. On May 15, 2017, the Dana-Farber/Harvard Cancer Center hosted a retreat for over 80 breast specialists including medical oncologists, surgical oncologists, radiation oncologists, radiologists, pathologists, physician assistants, nurses, nurse practitioners, researchers, and patient advocates to discuss the state of the science, treatment challenges, and key questions relating to DCIS...
November 2018: JNCI cancer spectrum
Saeid Atighechi, Niloofar Tari, Mohammadhossein Baradaranfar, Mohammadhossein Dadgarnia, Vahid Zand, Mojtaba Meybodian, Mohammad Mandegari, Sedighe Vaziribozorg
INTRODUCTION: This study aimed to evaluate postsurgical changes of nasal tip and lateral nostril characteristics after semi-tongue-in-groove (TIG) technique in open rhinoplasty surgery. MATERIALS AND METHODS: This prospective observational study was performed in a before-after setting on 22 patients who underwent open rhinoplasty surgery using semi-TIG technique. Postoperative photographs were analyzed for nasal tip and lateral nostril changes at several time points (1, 4, and 12 weeks after surgery) and were compared with preoperative photographs...
December 28, 2018: Journal of Craniofacial Surgery
Adil Allahverdiyev, Gamze Tari, Melahat Bagirova, Emrah Sefik Abamor
Cancer is the leading cause of death worldwide. In developed as well as developing countries, breast cancer is the most common cancer found among women. Currently, treatment of breast cancer consists mainly of surgery, chemotherapy, hormone therapy, and radiotherapy. In recent years, because of increased understanding of the therapeutic potential of immunotherapy in cancer prevention, cancer vaccines have gained importance. Here, we review various immunotherapeutic breast cancer vaccines including peptide-based vaccines, whole tumor cell vaccines, gene-based vaccines, and dendritic cell vaccines...
December 2018: Journal of Breast Cancer
Delia Vîrgă, Wilmar B Schaufeli, Toon W Taris, Ilona van Beek, Coralia Sulea
Researchers are becoming increasingly interested in how early experiences within the family are relevant to an individual's behavior at work. Drawing on Bowlby's attachment theory, the present study addresses this topic by examining the relationship between attachment in adulthood and job performance, and the mediating role of burnout in that relationship. We used data from two samples (201 Dutch employees and 178 Romanian working students) and structural equation modeling to test this mediation model and its possible invariance across both samples...
January 2, 2019: Journal of Psychology
Keiichi Akutagawa, Tsuyoshi Fujita, Kazuhisa Ouhara, Tasuku Takemura, Misako Tari, Mikihito Kajiya, Shinji Matsuda, Shohei Kuramitsu, Noriyoshi Mizuno, Hideki Shiba, Hidemi Kurihara
Diabetic patients are at an increased risk of developing severe and progressive periodontitis. Periodontal disease also increases the severity of diabetes by enhancing insulin resistance. Therefore, the regulation of periodontal inflammation in diabetic patients may contribute to the control of both diseases. Glycyrrhizic acid exerts anti-inflammatory effects by inhibiting high mobility group box 1 (HMGB1). HMGB1, one of the ligands of the receptor for advanced glycation end products (RAGE), is a damage-associated molecular pattern and induces inflammatory cytokine production...
December 29, 2018: International Immunopharmacology
Tari Adrian, Rodiah Rahmawaty Lubis, T Siti Harilza Zubaidah
AIM: To analyze the associations between frequency of prosthesis cleaning with the discharge characteristics and the tear film in subjects with anophthalmic socket post evisceration with dermis fat graft. SUBJECTS AND METHODS: This study is an analytic observational with cross sectional design study with control. The subjects of the study were unilateral acquired anophthalmic socket after evisceration with dermis fat graft at University of Sumatera Utara General Hospital which amounts to 30 subjects or 60 eyes (30 unilateral anophthalmic sockets, 30 contralateral eyes)...
November 25, 2018: Open Access Macedonian Journal of Medical Sciences
Tari Turner, Emily Steele, Chris Mavergames, Julian Elliott
BACKGROUND: The conduct and publication of scientific research are increasingly open and collaborative. There is growing interest in Web-based platforms that can effectively enable global, multidisciplinary scientific teams and foster networks of scientists in areas of shared research interest. Designed to facilitate Web-based collaboration in research evidence synthesis, TaskExchange highlights the potential of these kinds of platforms. OBJECTIVE: This paper describes the development, growth, and future of TaskExchange, a Web-based platform facilitating collaboration in research evidence synthesis...
December 13, 2018: JMIR Research Protocols
Péter Poór, Péter Borbély, Zalán Czékus, Zoltán Takács, Attila Ördög, Boris Popović, Irma Tari
Abscisic acid (ABA) regulates many salt stress-related processes of plants such as water balance, osmotic stress tolerance and photosynthesis. In this study we investigated the responses of wild type (WT) and the ABA-deficient sitiens mutant of tomato (Solanum lycopersicum cv. Rheinlands Ruhm) to sublethal and lethal salt stress elicited by 100 mM and 250 mM NaCl, respectively. Sitiens mutants displayed much higher decrease in water potential, stomatal conductance and net CO2 assimilation rate under high salinity, especially at lethal salt stress, than the WT...
December 8, 2018: Journal of Plant Physiology
Kristin L Schreiber, Nantthasorn Zinboonyahgoon, Xinling Xu, Tara Spivey, Tari King, Laura Dominici, Ann Partridge, Mehra Golshan, Gary Strichartz, Rob R Edwards
The severity and impact of acute pain after breast surgery varies markedly among individuals, underlining the importance of comprehensively identifying specific risk factors, including psychosocial and psychophysical traits. In this prospective observational study, women (n = 234) undergoing breast-conserving surgery, mastectomy, or mastectomy with reconstruction completed a brief bedside quantitative sensory testing battery, along with measures of psychosocial characteristics. Postoperative pain severity, impact, and opioid use at 2 weeks were assessed using Brief Pain Inventory and procedure-specific breast cancer pain questionnaires...
November 23, 2018: Journal of Pain: Official Journal of the American Pain Society
Maurizio Sessa, Annamaria Mascolo, Cristina Scavone, Ilaria Perone, Annalisa Di Giorgio, Michele Tari, Annamaria Fucile, Antonella De Angelis, Daniel Bech Rasmussen, Magnus Thorsten Jensen, Kristian Kragholm, Francesco Rossi, Annalisa Capuano, Liberata Sportiello
Rationale: Long-term clinical implications of beta-blockade in obstructive airway diseases remains controversial. We investigated if within the first 5 years of treatment patients with heart failure and obstructive airway diseases using non β1-adrenoreceptor selective beta-blockers have an increased risk of being hospitalized for all-causes, heart failure, and chronic obstructive pulmonary disease (COPD) when compared to patient using selective beta-blockers. Methods: Carvedilol users were propensity matched 1:1 for co-treatments, age, gender, and year of inclusion in the cohort with metoprolol/bisoprolol/nebivolol users...
2018: Frontiers in Pharmacology
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