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Eileen Luders, Florian Kurth
Meditating is an active mental process that has been proposed to lead to structural changes in the brain, especially if occurring repeatedly, regularly, and over longer periods of time. Thus, meditators might present with a distinctive brain anatomy detectable via modern imaging technologies. This article summarizes findings as reported in the imaging literature when comparing long-term meditators with controls. The morphometric analyses applied include global, regional, and local measures, such as voxel-wise or point-wise estimates...
December 27, 2018: Current Opinion in Psychology
Shakila Jabeen, Jaime A Espinoza, Lilly Anne Torland, Manuela Zucknick, Surendra Kumar, Vilde D Haakensen, Torben Lüders, Olav Engebraaten, Anne-Lise Børresen-Dale, Jon Amund Kyte, Pavel Gromov, Bjørn Naume, Vessela Kristensen, Irina Gromova, Xavier Tekpli
Cancers elicit an immune response by modifying the microenvironment. The immune system plays a pivotal role in cancer recognition and eradication. While the potential clinical value of infiltrating lymphocytes at the tumor site has been assessed in breast cancer, circulating cytokines - the molecules coordinating and fine-tuning immune response - are still poorly characterized. Using two breast cancer cohorts (MicMa, n = 131, DCTB, n = 28) and the multiplex Luminex platform, we measured the levels of 27 cytokines in the serum of breast cancer patients prior to treatment...
2019: Oncoimmunology
Sandra Barteit, Florian Neuhann, Till Bärnighausen, Sigrid Lüders, Gregory Malunga, Geoffrey Chileshe, Clemence Marimo, Albrecht Jahn
BACKGROUND: Zambia is faced with a severe shortage of health workers and challenges in national health financing. This burdens the medical licentiate practitioner (MLP) program for training nonphysician clinical students in Zambia because of the shortage of qualified medical lecturers and learning resources at training sites. To address this shortage and strengthen the MLP program, a self-directed electronic health (eHealth) platform was introduced, comprising technology-supported learning (e-learning) for medical education and support for health care practice...
January 15, 2019: JMIR MHealth and UHealth
Max-Heinrich Laves, Jens Bicker, Lüder A Kahrs, Tobias Ortmaier
PURPOSE: Automated segmentation of anatomical structures in medical image analysis is a prerequisite for autonomous diagnosis as well as various computer- and robot-aided interventions. Recent methods based on deep convolutional neural networks (CNN) have outperformed former heuristic methods. However, those methods were primarily evaluated on rigid, real-world environments. In this study, existing segmentation methods were evaluated for their use on a new dataset of transoral endoscopic exploration...
January 16, 2019: International Journal of Computer Assisted Radiology and Surgery
Ana Maria de Barros Cazé, Adriana Bender Moreira de Lacerda, Débora Lüders, Juliana De Conto, Jair Marques, Tony Leroux
Introduction  Tobacco farming exposes workers to various health risks due to the high application of pesticides needed to control pests, weeds and fungal diseases that prevent the tobacco plant growth. Objective  To analyze the perception of the quality of life of tobacco growers exposed to pesticides, with emphasis on general health, hearing, and working conditions. Method  This is a descriptive, cross-sectional study using a quantitative approach with farmers from southern Brazil. Data were collected from November of 2012 to November of 2014...
January 2019: International Archives of Otorhinolaryngology
Katja A Lüders, Stefan Nessler, Kathrin Kusch, Julia Patzig, Ramona B Jung, Wiebke Möbius, Klaus-Armin Nave, Hauke B Werner
Proteolipid protein (PLP) is the most abundant integral membrane protein in central nervous system (CNS) myelin. Expression of the Plp-gene in oligodendrocytes is not essential for the biosynthesis of myelin membranes but required to prevent axonal pathology. This raises the question whether the exceptionally high level of PLP in myelin is required later in life, or whether high-level PLP expression becomes dispensable once myelin has been assembled. Both models require a better understanding of the turnover of PLP in myelin in vivo...
January 14, 2019: Glia
Florenza Lüder Ripoli, Manuela Buettner, André Bleich
No abstract text is available yet for this article.
2019: ALTEX
Maria Jung, Jörg Ellinger, Heidrun Gevensleben, Isabella Syring, Christine Lüders, Luka de Vos, Svenja Pützer, Friedrich Bootz, Jennifer Landsberg, Glen Kristiansen, Dimo Dietrich
BACKGROUND: Novel targeted treatments and immunotherapies have substantially changed therapeutic options for advanced and metastatic RCCs (RCCs).5 However, accurate diagnostic tests for the identification of high-risk patients are urgently needed. Here, we analyzed SHOX2 mRNA expression in RCC tissues and SHOX2 6 gene body methylation quantitatively in circulating cell-free DNA (ccfDNA) and RCC tissues with regard to risk stratification. METHODS: The clinical performance of SHOX2 methylation was tested retrospectively and prospectively in a training and testing cohort of RCC tissue samples (n = 760 in total)...
January 9, 2019: Clinical Chemistry
Sandra Barteit, Albrecht Jahn, Sekelani S Banda, Till Bärnighausen, Annel Bowa, Geoffrey Chileshe, Dorota Guzek, Margarida Mendes Jorge, Sigrid Lüders, Gregory Malunga, Florian Neuhann
E-learning has been heralded as a revolutionary force for medical education, especially for low-resource countries still suffering from a dire lack of health care workers. However, despite over two decades of e-learning endeavors and interventions across sub-Saharan Africa and other low- and middle-income countries, e-learning for medical education has not gained momentum and continues to fall short of the anticipated revolution. Many e-learning interventions have been cul-de-sac pilots that have not been scaled up but rather terminated after the pilot phase...
January 9, 2019: Journal of Medical Internet Research
Ayham Alkhachroum, Haifa Al-Abri, Alok Sachdeva, Sarita Maturu, Jennifer Waldron, Han Wang, Macym Rizvi, Guadalupe Fernandez-Baca Vaca, Hans O Lüders
No abstract text is available yet for this article.
December 31, 2018: Journal of Clinical Neurophysiology: Official Publication of the American Electroencephalographic Society
Mathias Luderer, Nurcihan Kaplan-Wickel, Agnes Richter, Iris Reinhard, Falk Kiefer, Tillmann Weber
BACKGROUND: Attention-deficit/hyperactivity disorder (ADHD) is a common comorbid disorder that is frequently overlooked in adults with alcohol use disorder (AUD). Moreover, identifying ADHD in AUD patients is time-consuming and difficult. The aim of this study was to assess the clinical utility of two self-report screening instruments for adult ADHD in AUD patients. METHODS: 404 adults seeking residential treatment for AUD were screened using the Conners' Adult ADHD Rating Scale Screening Self-Rating (CAARS-S-SR) and the Adult ADHD Rating Scale (ASRS)...
December 10, 2018: Drug and Alcohol Dependence
Florian Kurth, Nicolas Cherbuin, Eileen Luders
The amygdala, an anatomical composite of several nuclei that have been grouped anatomically and functionally into three major subareas, has been reported to decrease in size with increasing age and to differ in size between male and female brains. However, findings are rather inconsistent across existing studies, possibly reflecting differences in the cohorts examined or the approaches chosen to define and measure the dimensions of the amygdala. Here, we investigated possible effects of age and sex on the amygdala as well as age-by-sex interactions in 100 healthy subjects (50 men/50 women) aged 18-69 years...
December 13, 2018: Human Brain Mapping
Stephan Lüders, Bastian Schrader, Jörg Bäsecke, Hermann Haller, Albrecht Elsässer, Michael Koziolek, Joachim Schrader
BACKGROUND:  For the prevention of cardiovascular risk factors (RF) there are numerous recommendations of professional societies, which relate to the personal way of life of individuals (for example nutrition/diet, physical activity, stress reduction etc.). The implementation of these recommendations is so far poor. In the ELITE study, data on RF, nutritional behavior, physical activity and quality of life in the Oldenburger Münsterland region are to be collected prospectively and improved by individual information...
December 13, 2018: Deutsche Medizinische Wochenschrift
Eléonore Ostermann, Stefan Loroch, Zhikang Qian, Albert Sickmann, Lüder Wiebusch, Wolfram Brune
Cytomegaloviruses (CMVs) have a highly restricted host range as they replicate only in cells of their own or closely related species. To date, the molecular mechanisms underlying the CMV host restriction remain poorly understood. However, it has been shown that mouse cytomegalovirus (MCMV) can be adapted to human cells and that adaptation goes along with adaptive mutations in several viral genes. In this study, we identify MCMV M117 as a novel host range determinant. Mutations in this gene enable the virus to cross the species barrier and replicate in human RPE-1 cells...
December 10, 2018: PLoS Pathogens
Sandra Barteit, Albrecht Jahn, Annel Bowa, Sigrid Lüders, Gregory Malunga, Clemence Marimo, Sigrid Wolter, Florian Neuhann
BACKGROUND: Zambia faces a severe shortage of health workers, particularly in rural areas. To tackle this shortage, the Medical Licentiate program was initiated at Chainama College of Health Sciences in the capital, Lusaka, in 2002. The objective of the program was to alleviate the shortage of human resources in curative care. On-the-job training is conducted in decentralized teaching hospitals throughout Zambia. However, the program faces significant challenges such as shortages of senior medical instructors and learning materials...
November 27, 2018: JMIR Medical Education
Carolin Lüders, Johannes Thewes, Marc Assmann
We introduce a technique to determine photon correlations of optical light fields in real time. The method is based on ultrafast phase-randomized homodyne detection and allows us to follow the temporal evolution of the second-order correlation function g(2) (0) of a light field. We demonstrate the capabilities of our approach by applying it to a laser diode operated in the threshold region. In particular, we are able to monitor the emission dynamics of the diode switching back and forth between lasing and spontaneous emission with a g(2) (0)-sampling rate of 100 kHz...
September 17, 2018: Optics Express
Sabrina Eggmann, Martin L Verra, Gere Luder, Jukka Takala, Stephan M Jakob
INTRODUCTION: Neuromuscular weakness resulting in severe functional impairment is common in critical care survivors. This study aimed to evaluate effects of an early progressive rehabilitation intervention in mechanically ventilated adults at risk. METHODS: This was a parallel, two-arm, assessor-blinded, randomised controlled trial with 6-months follow-up that was conducted in a mixed ICU of an academic centre in Switzerland. Previously independent, mechanically ventilated, critically ill adults with expected critical care stay ≥72 hours (n = 115) were randomised to a control group receiving standard physiotherapy including early mobilisation or to an experimental group with early endurance and resistance training combined with mobilisation...
2018: PloS One
Shuo Huang, Haifa Al-Abri, Alok Sachdeva, Ayham M Alkhachroum, Stephanie Shatzman, Hans Lüders
We report a case of focal status epilepticus (SE) associated with peri-ictal water drinking (PIWD) behavior in a nine-year-old left-handed boy with epilepsy. We reviewed prior cases of epileptic peri-ictal water drinking. Only one adult patient with status epilepticus and PIWD has been reported previously. This is the first reported case of PIWD SE in a pediatric patient with frontal lobe epilepsy. We found PIWD to have no lateralizing value.
2018: Epilepsy & Behavior Case Reports
Silke Lüder
No abstract text is available yet for this article.
November 2018: MMW Fortschritte der Medizin
Ulrike Luderer, Matthew J Meier, Gregory W Lawson, Marc A Beal, Carole L Yauk, Francesco Marchetti
Polycyclic aromatic hydrocarbons (PAHs) like benzo[a]pyrene (BaP) are ubiquitous environmental contaminants formed during incomplete combustion of organic materials. Our prior work showed that transplacental exposure to BaP depletes ovarian follicles and increases prevalence of epithelial ovarian tumors later in life. We used the MutaMouse transgenic rodent model to address the hypothesis that ovarian mutations play a role in tumorigenesis caused by prenatal exposure to BaP. Pregnant MutaMouse females were treated with 0, 10, 20, or 40 mg/kg/day BaP orally on gestational days 7-16, covering critical windows of ovarian development...
October 24, 2018: Environmental and Molecular Mutagenesis
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