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Tetsuya Nojima, Isabelle Chauvel, Benjamin Houot, François Bousquet, Jean-Pierre Farine, Claude Everaerts, Daisuke Yamamoto, Jean-François Ferveur
Desaturase1 (desat1) is one of the few genes known to be involved in the two complementary aspects of sensory communication - signal emission and signal reception - in Drosophila melanogaster. In particular, desat1 is necessary for the biosynthesis of major cuticular pheromones in both males and females. It is also involved in the male ability to discriminate sex pheromones. Each of these two sensory communication aspects depends on distinct desat1 putative regulatory regions. Here, we used (i) mutant alleles resulting from the insertion/excision of a transposable genomic element inserted in a desat1 regulatory region, and (ii) transgenics made with desat1 regulatory regions used to target desat1 RNAi...
February 6, 2019: Journal of Neurogenetics
Marie-Françoise Vecchierini, Valérie Attali, Jean-Marc Collet, Marie-Pia d'Ortho, Frederic Goutorbe, Jean-Baptiste Kerbrat, Damien Leger, Florent Lavergne, Christelle Monaca, Pierre-Jean Monteyrol, Laurent Morin, Eric Mullens, Bernard Pigearias, Francis Martin, Hauria Khemliche, Lionel Lerousseau, Jean-Claude Meurice, Darius Abedipour, Aurélie Allard-Redon, Alexandre Aranda, Valérie Attali, Frédérique Bavozet, Martine Becu, Wally Beruben, Jerome Bessard, Isabelle Bonafe, Mohammed Boukhana, Bruno Chabrol, Gérard Chatte, Chauvel Lebret, Jean-Marc Collet, Olivier Coste, Nathalie Dumont, Sophie Durand-Amat, Marie-Pia D'ortho, Jean Marc Elbaum, Olivier Gallet De Santerre, Frédéric Goutorbes, Thierry Grandjean, Wilma Guyot, Doniphan Hammer, Carmen Havasi, Pascal Huet, Jean Baptiste Kerbrat, Hauria Khemliche, Christian Koltes, Damien Leger, Laurent Lacassagne, Xavier Laur, Lionel Lerousseau, Olivier Liard, Christophe Loisel, Matthieu Longuet, Anne Mallart, Francis Martin, Frédéric Merle Beral, Jean Claude Meurice, Zoubida Mokhtari, Christelle Monaca, Pierre Jean Monteyrol, Jean-François Muir, Eric Mullens, Dominique Muller, Charles Paoli, François Xavier Petit, Bernard Pigearias, Marc Pradines, Arnauld Prigent, Gil Putterman, Marc Rey, Mickael Samama, Renaud Tamisier, Michel Tiberge, Cyrille Tison, Fabienne Tordjman, Bernard Triolet, Christian Vacher, Marie-Françoise Vecchierini, Alain Verain
PURPOSE: Mandibular repositioning devices (MRDs) are an effective treatment option for obstructive sleep apnea syndrome (OSAS), particularly in patients who refuse or cannot tolerate continuous positive airway pressure (CPAP). However, sex differences in the response to therapy and predictors of response are not clearly defined. This analysis of data from the long-term prospective ORCADES trial compared MRD efficacy in men and women with OSAS. METHODS: The ORCADES study included patients with newly diagnosed mild-to-moderate or severe OSAS who refused or were non-compliant with CPAP...
December 22, 2018: Sleep & Breathing, Schlaf & Atmung
Emilija Cvetkovska, William Alves Martins, Jorge Gonzalez-Martinez, Ken Taylor, Jian Li, Olesya Grinenko, John Mosher, Richard Leahy, Patrick Chauvel, Dileep Nair
We describe a patient with unilateral periventricular nodular heterotopia (PNH) and drug-resistant epilepsy, whose SEEG revealed that seizures were arising from the PNH, with the almost simultaneous involvement of heterotopic neurons ("micronodules") scattered within the white matter, and subsequently the overlying cortex. Laser ablation of heterotopic nodules and the adjacent white matter rendered the patient seizure free. This case elucidates that "micronodules" scattered in white matter between heterotopic nodules and overlying cortex might be another contributor in complex epileptogenicity of heterotopia...
2019: Epilepsy & Behavior Case Reports
Amandine Grappe, Sridevi V Sarma, Pierre Sacré, Jorge González-Martínez, Catherine Liégeois-Chauvel, F-Xavier Alario
Language is mediated by pathways connecting distant brain regions that have diverse functional roles. For word production, the network includes a ventral pathway, connecting temporal and inferior frontal regions, and a dorsal pathway, connecting parietal and frontal regions. Despite the importance of word production for scientific and clinical purposes, the functional connectivity underlying this task has received relatively limited attention, and mostly from techniques limited in either spatial or temporal resolution...
October 13, 2018: Journal of Computational Neuroscience
Laure Malric, Sylvie Monferran, Caroline Delmas, Florent Arnauduc, Perrine Dahan, Sabrina Boyrie, Pauline Deshors, Vincent Lubrano, Dina Ferreira Da Mota, Julia Gilhodes, Thomas Filleron, Aurore Siegfried, Solène Evrard, Aline Kowalski-Chauvel, Elizabeth Cohen-Jonathan Moyal, Christine Toulas, Anthony Lemarié
Glioblastomas (GB) are malignant brain tumors with poor prognosis despite treatment with surgery and radio/chemotherapy. These tumors are defined by an important cellular heterogeneity and notably contain a subpopulation of GB-initiating cells (GIC), which contribute to tumor aggressiveness, resistance, and recurrence. Some integrins are specifically expressed by GICs and could be actionable targets to improve GB treatment. Here, integrin β8 (ITGB8) was identified as a potential selective target in this highly tumorigenic GIC subpopulation...
September 28, 2018: Molecular Cancer Research: MCR
Yvan Bédouin, Doina-Margareta Gordin, Pascal Pellen-Mussi, Fabienne Pérez, Sylvie Tricot-Doleux, Cora Vasilescu, Silviu Iulian Drob, Dominique Chauvel-Lebret, Thierry Gloriant
To enhance their longevity, dental implants must be highly biocompatible and must have a low elastic modulus close to that of the bone. They must also possess a high superficial hardness and a high corrosion resistance. For these reasons, a recently developed low-modulus Ti-27Nb alloy with nontoxic elements was treated by gas nitriding at high temperature in this study. A very thin nitrided layer of 0.5 μm in thickness followed by an enriched nitrogen zone was observed. Consequently, a very high hardness evaluated at about 1800 HV was obtained in surface, which represents an increase of 4-5 times the hardness of the non-nitrided alloy...
September 28, 2018: Journal of Biomedical Materials Research. Part B, Applied Biomaterials
Christopher E Gonzalez, Rachel A Mak-McCully, Burke Q Rosen, Sydney S Cash, Patrick Y Chauvel, Hélène Bastuji, Marc Rey, Eric Halgren
Since their discovery, slow oscillations have been observed to group spindles during non-REM sleep. Previous studies assert that the slow-oscillation downstate (DS) is preceded by slow spindles (10-12 Hz) and followed by fast spindles (12-16 Hz). Here, using both direct transcortical recordings in patients with intractable epilepsy ( n = 10, 8 female), as well as scalp EEG recordings from a healthy cohort ( n = 3, 1 female), we find in multiple cortical areas that both slow and fast spindles follow the DS. Although discrete oscillations do precede DSs, they are theta bursts (TBs) centered at 5-8 Hz...
November 14, 2018: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
A Sauret, M-C Andro-Garçon, J Chauvel, A Ligneul, P Dupas, C Fressange-Mazda, P Le Ruyet, A Dabadie
OBJECTIVE: The purpose of this study was to evaluate the dose-dependent effect of human milk fortifier (HMF) on the osmolality of various preterm human milks (PHMs) at different gestational and lactation stages, and with different storage and treatment conditions that are routinely used in neonatal intensive care units (NICUs). STUDY DESIGN: Twenty-four mothers who had given birth to their baby before 28 or between 29 and 31 weeks of pregnancy participated in the study after 1-2 weeks or 3-4 weeks breastfeeding after delivery...
October 2018: Archives de Pédiatrie: Organe Officiel de la Sociéte Française de Pédiatrie
Aline Kowalski-Chauvel, Anouchka Modesto, Valerie Gouaze-Andersson, Laurent Baricault, Julia Gilhodes, Caroline Delmas, Anthony Lemarie, Christine Toulas, Elizabeth Cohen-Jonathan-Moyal, Catherine Seva
Radiotherapy is the cornerstone of glioblastoma (GBM) standard treatment. However, radioresistance of cancer cells leads to an inevitable recurrence. In the present study, we showed that blocking α6-integrin in cells derived from GBM biopsy specimens cultured as neurospheres, sensitized cells to radiation. In cells downregulated for α6-integrin expression, we observed a decrease in cell survival after irradiation and an increase in radio-induced cell death. We also demonstrated that inhibition of α6-integrin expression affects DNA damage checkpoint and repair...
August 29, 2018: Cell Death & Disease
Elia M Pestana Knight, Olesya Grinenko, Juan Bulacio, William Bingaman, Ajay Gupta, Patrick Chauvel
No abstract text is available yet for this article.
August 2018: Neurology. Clinical Practice
Mélanie Legrand, Sophie Bachellier-Bassi, Keunsook K Lee, Yogesh Chaudhari, Hélène Tournu, Laurence Arbogast, Hélène Boyer, Murielle Chauvel, Vitor Cabral, Corinne Maufrais, Audrey Nesseir, Irena Maslanka, Emmanuelle Permal, Tristan Rossignol, Louise A Walker, Ute Zeidler, Sadri Znaidi, Floris Schoeters, Charlotte Majgier, Renaud A Julien, Laurence Ma, Magali Tichit, Christiane Bouchier, Patrick Van Dijck, Carol A Munro, Christophe d'Enfert
No abstract text is available yet for this article.
September 19, 2018: Nucleic Acids Research
Jingqi Li, Jiamin Shen, Shiqin Liu, Maelig Chauvel, Wenwei Yang, Jian Mei, Ling Lei, Li Wu, Jian Gao, Yong Yang
Whether habit stimulation is effective in DOC patient arousal has not been reported. In this paper, we analyzed the responses of DOC patients to habit stimulation. Nineteen DOC patients with alcohol consumption or smoking habits were recruited and 64-channel EEG signals were acquired both at the resting state and at three stimulation states. Wavelet transformation and nonlinear dynamics were used to extract the features of EEG signals and four brain lobes were selected to investigate the degree of EEG response to habit stimulation...
August 2018: Neuroscience Bulletin
Tao Yu, Xueyuan Wang, Yongjie Li, Guojun Zhang, Gregory Worrell, Patrick Chauvel, Duanyu Ni, Liang Qiao, Chang Liu, Liping Li, Liankun Ren, Yuping Wang
Epilepsy has been classically seen as a brain disorder resulting from abnormally enhanced neuronal excitability and synchronization. Although it has been described since antiquity, there are still significant challenges achieving the therapeutic goal of seizure freedom. Deep brain stimulation of the anterior nucleus of the thalamus has emerged as a promising therapy for focal drug-resistant epilepsy; the basic mechanism of action, however, remains unclear. Here, we show that desynchronization is a potential mechanism of deep brain stimulation of the anterior nucleus of the thalamus by studying local field potentials recordings from the cortex during high-frequency stimulation (130 Hz) of the anterior nucleus of the thalamus in nine patients with drug-resistant focal epilepsy...
September 1, 2018: Brain: a Journal of Neurology
Mélanie Legrand, Sophie Bachellier-Bassi, Keunsook K Lee, Yogesh Chaudhari, Hélène Tournu, Laurence Arbogast, Hélène Boyer, Murielle Chauvel, Vitor Cabral, Corinne Maufrais, Audrey Nesseir, Irena Maslanka, Emmanuelle Permal, Tristan Rossignol, Louise A Walker, Ute Zeidler, Sadri Znaidi, Floris Schoeters, Charlotte Majgier, Renaud A Julien, Laurence Ma, Magali Tichit, Christiane Bouchier, Patrick Van Dijck, Carol A Munro, Christophe d'Enfert
The advent of the genomic era has made elucidating gene function on a large scale a pressing challenge. ORFeome collections, whereby almost all ORFs of a given species are cloned and can be subsequently leveraged in multiple functional genomic approaches, represent valuable resources toward this endeavor. Here we provide novel, genome-scale tools for the study of Candida albicans, a commensal yeast that is also responsible for frequent superficial and disseminated infections in humans. We have generated an ORFeome collection composed of 5099 ORFs cloned in a Gateway™ donor vector, representing 83% of the currently annotated coding sequences of C...
August 21, 2018: Nucleic Acids Research
J Chauvel-Picard, J Massardier, A Gleizal
We describe a paramedian cleft of the lower lip that cannot be explained by embryological development in a child with only one predisposing factor, which was fetal reduction for a multiple pregnancy. To the best of our knowledge, there has been no report of a cleft that has been induced by the reduction of a multifetal pregnancy.
July 2018: British Journal of Oral & Maxillofacial Surgery
Héloïse Barailler, Brigitte Milpied, Annick Chauvel, Pauline Claraz, Alain Taïeb, Julien Seneschal, Anne-Sophie Darrigade
No abstract text is available yet for this article.
May 22, 2018: Journal of Allergy and Clinical Immunology in Practice
J Chauvel-Picard, A Gleizal
We described the first case of para-commissural cleft of the lower lip in a 2 year-old child. He is from a trichorionic triamniotic triplet pregnancy after ovarian stimulation. He has no history except a selective fetal reduction of the mother. We correct this cleft of the lower lip with a double plasty of Malek. The functional and aesthetic result is satisfactory. This particular cleft cannot be explained by the embryological theory. We favor two hypothesis to explain this anomaly: a vascular origin with the stapedial artery and the selective fetal reduction...
April 19, 2018: Journal of Stomatology, Oral and Maxillofacial Surgery
Faustine Régnier, Louis Chauvel
BACKGROUND: Digital devices are driving economic and social transformations, but assessing the uses, perceptions, and impact of these new technologies on diet and physical activity remains a major societal challenge. OBJECTIVE: We aimed to determine under which social, economic, and cultural conditions individuals in France were more likely to be actively invested in the use of self-tracking diet and fitness apps for better health behaviors. METHODS: Existing users of 3 diet and fitness self-tracking apps (Weight Watchers, MyFitnessPal, and sport apps) were recruited from 3 regions of France...
April 20, 2018: JMIR MHealth and UHealth
Jack Longman, Daniel Veres, Vasile Ersek, Donald L Phillips, Catherine Chauvel, Calin G Tamas
Lead (Pb) isotopes provide valuable insights into the origin of Pb within a sample, typically allowing for reliable fingerprinting of their source. This is useful for a variety of applications, from tracing sources of pollution-related Pb, to the origins of Pb in archaeological artefacts. However, current approaches investigate source proportions via graphical means, or simple mixing models. As such, an approach, which quantitatively assesses source proportions and fingerprints the signature of analysed Pb, especially for larger numbers of sources, would be valuable...
April 18, 2018: Scientific Reports
Javier Olivera, Francesco Andreoli, Anja K Leist, Louis Chauvel
Although cohort and country differences in average cognitive levels are well established, identifying the degree and determinants of inequalities in old age cognitive functioning could guide public health and policymaking efforts. We use all publicly available and representative old age surveys with comparable information to assess inequalities of cognitive functioning for six distinctive age groups in 29 countries. We document that cognitive inequalities in old age are largely determined by earlier educational inequalities as well as gender differential survival rates...
May 2018: Economics and Human Biology
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