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natriuretic peptide BNP

Na-Wei Liu, Xin Huang, Shuang Liu, Wen-Jian Liu, Hua Wang, Wei-da Wang, Yue Lu
Thrombocytopenia is a condition characterized by abnormally low levels of thrombocytes and often induced by chemotherapy. Recombinant human interleukin-11 (rhIL-11) is a cytokine that can stimulate thrombopoiesis and is commonly used to treat thrombocytopenia. We observed the side effects of rhIL-11 in 24 leukemia patients with chemotherapy-induced thrombocytopenia. To determine the cardiovascular effects of rhIL-11, we detected changes in the patients' serum brain natriuretic peptide (BNP), blood pressure fluctuations, weight change, and whether edema or heart failure occurred in leukemia patients after chemotherapy...
March 15, 2019: Supportive Care in Cancer: Official Journal of the Multinational Association of Supportive Care in Cancer
Halyna Loi, Frederic Boal, Helene Tronchere, Mathieu Cinato, Solomiia Kramar, Oleksandra Oleshchuk, Mykhaylo Korda, Oksana Kunduzova
Cardiovascular complications are the most prevalent cause of morbidity and mortality in diabetic patients. Metformin is currently the first-line blood glucose-lowering agent with potential relevance to cardiovascular diseases. However, the underpinning mechanisms of action remain elusive. Here, we report that metformin represses cardiac apoptosis at least in part through inhibition of Forkhead box O1 (FoxO1) pathway. In a mouse model of ischemia-reperfusion (I/R), treatment with metformin attenuated cardiac and hypertrophic remodeling after 14 days of post-reperfusion...
2019: Frontiers in Pharmacology
Jun Tang, Jian-Zhu Zhao, Kai-Ming Ren, Fu-Shuang Zheng, Xi-Wen Wang, Hai-Jun Liu, Jun-Gang Zhao, Ji-Bin Lu
BACKGROUND: Atrial fibrillation (AF) is a common complication after radical surgery of esophageal cancer. The aim of this study was to explore AF risk factors after radical surgery of esophageal carcinoma. METHOD: The data of 335 patients with esophageal cancer who were admitted in our hospital from January 2014 to August 2016 for the first time were retrospectively analyzed. We retrieved the papers in some data banks using the search terms including English and Chinese search terms, and obtained 13 factors which were mentioned in more than 6 papers...
March 14, 2019: Journal of Cardiothoracic Surgery
Min-Yu Lai, Wei-Chih Kan, Ya-Ting Huang, John Chen, Chih-Chung Shiao
Plasma N-terminal pro-brain natriuretic peptide (NT-proBNP) is an excellent prognostic⁻predictive tool in heart failure (HF) patients, but its plasma level changes following therapy. The comparison of prognosis⁻predictivity of a single measurement of plasma NT-pro BNP in different follow-up periods in acute HF patients has been less studied. This study aimed to evaluate whether the association between initial plasma NT-proBNP levels and all-cause mortality would decrease along with an increased follow-up period in patients with acute HF...
March 13, 2019: Journal of Clinical Medicine
Jose B N Moreira, Martin Wohlwend, Simone Fenk, Ingrid Åmellem, Arnar Flatberg, Jasenka Kraljevic, Jasna Marinovic, Marko Ljubkovic, Geir Bjørkøy, Ulrik Wisløff
The benefits of physical activity in cardiovascular diseases have long been appreciated. However, the molecular mechanisms that trigger and sustain the cardiac benefits of exercise are poorly understood, and it is anticipated that unveiling these mechanisms will identify novel therapeutic targets. In search of these mechanisms we took advantage of unbiased RNA-sequencing (RNA-seq) technology to discover cardiac gene targets whose expression is disrupted in heart failure (HF) and rescued by exercise in a rat model...
March 10, 2019: Progress in Cardiovascular Diseases
Alicia Montaner Ramón, Itziar Serrano Viñuales, Lorenzo Jiménez Montañés, Carmen Ruiz De La Cuesta Martín, María Pilar Samper Villagrasa, Segundo Rite Gracia
Antecedentes y objetivo: el ductus arterioso persistente hemodinámicamente significativo (DAP-HS) se asocia a mayor riesgo de enterocolitis necrotizante (ECN) y peor tolerancia enteral en los recién nacidos prematuros (RNPT). Se ha demostrado asociación entre el propéptido natriurético cerebral (proBNP) y el DAP-HS. Nuestro objetivo fue analizar la relación entre los niveles de proBNP y la tolerancia enteral, el riesgo de ECN y la ganancia ponderal en el RNPT. Material y métodos: estudio retrospectivo observacional, que incluyó a RNPT menores de 32 semanas de gestación y/o 1...
June 29, 2018: Nutrición Hospitalaria: Organo Oficial de la Sociedad Española de Nutrición Parenteral y Enteral
Nicola Marchitto, F Sindona, Pasquale Mobilia, Serenella Gioia Dalmaso, Gianfranco Raimondi
OBJECTIVE: We evaluated the role of sacubitril/valsartan in heart rate variability, T-peak to T-end index, external cell mass, internal cell mass and total body water in elderly patients with heart failure with reduced ejection fraction (HFrEF). METHODS: Eleven elderly patients (9 males; mean age 77 years, range 70-87; 2 females, mean age 60 years, range 50-71) with HFrEF (<35%) were included in this analysis. Four patients presented moderate chronic kidney failure (creatinine clearance [CrCl] 30-59 mL/min) and four patients with diabetes (HbA1c >6...
March 2019: Current Medical Research and Opinion
Long Zhang, Zhaoxia Guo, Yan Wang, Jun Geng, Shuyi Han
This study was designed to delineate the effect of kaempferol (KF) on heart failure (HF) in diabetic rats. Streptozotocin-induced male diabetic rats received KF orally at 10 and 20 mg/kg for 42 consecutive days. In last 2 days of the experimental period, isoproterenol was subcutaneously injected at 85 mg/kg to induce HF. The hearts were processed for hemodynamic, biochemical, molecular, and histological investigations. Systolic blood pressure, diastolic blood pressure, and mean arterial blood pressure were elevated in KF-treated HF-induced diabetic rats...
March 12, 2019: Drug Development Research
Moises Rodriguez-Gonzalez, Maria Isabel Sanchez-Codez, Manuel Lubian-Gutierrez, Ana Castellano-Martinez
BACKGROUND: Myocarditis is an important cause of morbidity and mortality in children, leading to long-term sequelae including chronic congestive heart failure, dilated cardiomyopathy, heart transplantation, and death. The initial diagnosis of myocarditis is usually based on clinical presentation, but this widely ranges from the severe sudden onset of a cardiogenic shock to asymptomatic patients. Early recognition is essential in order to monitor and start supportive treatment prior to the development of severe adverse events...
March 6, 2019: World Journal of Clinical Cases
Maria Papathanasiou, Nikolaus Pizanis, Loukas Tsourelis, Achim Koch, Markus Kamler, Tienush Rassaf, Peter Luedike
Background: The prognostic utility of B-type natriuretic peptide (BNP) in heart failure is well recognized. Previous studies demonstrated that BNP levels decrease after left ventricular assist device (LVAD) implantation. We sought to investigate the predictive value of baseline and changes in BNP levels in LVAD recipients. Methods: BNP was measured in baseline and follow-up plasma samples from consecutive patients receiving a continuous-flow LVAD from 2010 through 2016...
January 2019: Journal of Thoracic Disease
M C J van Thor, L Ten Klooster, R J Snijder, M C Post, J J Mager
Background: To improve clinical outcome, patients with inoperable and residual chronic thromboembolic pulmonary hypertension (CTEPH) can be treated with riociguat. The aim of this study is to explore long-term outcomes and to compare our 'real world' data with previous research. Methods: We included all consecutive patients with technical inoperable and residual CTEPH, in whom riociguat therapy was initiated from January 2014 onwards, with patients followed till January 2019...
March 2019: IJC Heart & Vasculature
Kishan S Parikh, Talal Dahhan, Leigh Nicholl, Nicole Ruopp, Gina-Maria Pomann, Terry Fortin, Victor F Tapson, Sudarshan Rajagopal
The presence of pulmonary hypertension (PH) significantly worsens outcomes in patients with advanced sarcoidosis, but its optimal management is unknown. We aimed to characterize a large sarcoidosis-associated pulmonary hypertension (SAPH) cohort to better understand patient characteristics, clinical outcomes, and management strategies including treatment with PH therapies. Patients at Duke University Medical Center with biopsy-proven sarcoidosis and SAPH confirmed by right heart catheterization (RHC) were identified from 1990-2010...
March 11, 2019: Scientific Reports
Yi-Ting Tsai, Feng-Yen Lin, Chin-Sheng Lin, Shih-Hurng Loh, Chi-Yuan Li, Cheng-Yen Lin, Yi-Wen Lin, Chien-Sung Tsai
B-type natriuretic peptide (BNP) was approved by the US Food and Drug Administration in 2001 for the treatment of heart failure. However, the effects of BNP in clinical applications are controversial and uncertain. Recently, study indicated that high BNP levels are associated with an increased risk of developing atrial fibrillation. In this study, we investigated the direct effects of BNP on TNF-α-induced atrial fibrosis mice, as well as its effects on human atrial myofibroblasts. We found that injecting TNF-α-induced mice with recombinant human BNP enhanced atrial fibrosis via matrix metalloproteinase-2 (MMP-2) expression and collagen accumulation...
February 19, 2019: Translational Research: the Journal of Laboratory and Clinical Medicine
Fatemeh Jahanifar, Akram Astani, Shahnaz Shekarforoosh, Mohabbat Jamhiri, Fereshteh Safari, Farideh Zarei, Fatemeh Safari
BACKGROUND: The cellular and molecular mechanisms of cardioprotective effects of Vitamin D are poorly understood. Given the essential role of sirtuin-3 (SIRT3) as an endogenous negative regulator of cardiac hypertrophy, this study was designed to investigate the effect of 1, 25-dihydroxyvitamin D3 (calcitriol) on hypertrophy markers and SIRT3 mRNA and protein levels following angiotensin II induced - hypertrophy in cardiomyoblast H9c2 cells. METHODS: Rat cardiomyoblast H9c2 cells were treated for 48 hr with angiotensin II alone (Ang group) or in combination with 1, 10 and 100 nM of calcitriol (C + Ang groups)...
March 11, 2019: International Journal for Vitamin and Nutrition Research. Journal International de Vitaminologie et de Nutrition
Joe Gallagher, Darren McCormack, Shuaiwei Zhou, Fiona Ryan, Chris Watson, Kenneth McDonald, Mark T Ledwidge
AIMS: This study sought to review the literature for clinical prediction models for the diagnosis of patients with chronic heart failure in the community and to validate the models in a novel cohort of patients with a suspected diagnosis of chronic heart failure. METHODS AND RESULTS: MEDLINE and Embase were searched from 1946 to Q4 2017. Studies were eligible if they contained at least one multivariable model for the diagnosis of chronic heart failure applicable to the primary care setting...
March 10, 2019: ESC Heart Failure
N A Karoli, A V Borodkin, A P Rebrov
AIM: To elucidate clinical and diagnostic features of chronic heart failure (CHF) in patients with chronic obstructive pulmonary disease (COPD). MATERIALS AND METHODS: The study included 239 patients with COPD and 42 patients with CHF without COPD. The first subgroup consisted of 60 patients with a history of myocardial infarction (MI) and the second subgroup consisted of 79 patients without a history of MI. A general clinical examination, EchoCG, measurements of N-terminal pro B-type natriuretic peptide (NT-proBNP), galectin 3, and high-sensitivity C-reactive protein (hsCRP) were performed for all patients...
March 7, 2019: Kardiologiia
Yanrong Qian, Jinhui Feng, Dawei Fan, Yong Zhang, Xuan Kuang, Huan Wang, Qin Wei, Huangxian Ju
A sandwich-type photoelectrochemical (PEC) immunosensing platform was designed for detection of amino-terminal pro-B-type natriuretic peptide (NT-pro BNP). Thereinto, flower-like Bi2 WO6 /Ag2 S nanoparticles (F-Bi2 WO6 /Ag2 S) were employed as photoelectrochemical matrix, and graphene oxide and polydopamine composite (GO/PDA) were prepared as signal labels. In this proposal, Ag2 S was in-situ growth on the surface of F-Bi2 WO6 modified with thioglycolic acid (TGA). Specially, a cascade-like band-edge level between F-Bi2 WO6 and Ag2 S effectively improved the photocurrent conversion efficiency and enhanced the photocurrent response...
February 19, 2019: Biosensors & Bioelectronics
Yueyuan Li, Yaoguang Wang, Nuo Zhang, Dawei Fan, Lei Liu, Tao Yan, Xinglong Yang, Caifeng Ding, Qin Wei, Huangxian Ju
In this work, by using amorphous bimetallic sulfides of CoSnSx Pd as signal amplifier and magnetic material of Fe3 O4 @PPyAu as the substrate, we fabricated an electrochemical immunoassay for Nterminal prohormone of brain natriuretic peptide (NTpro BNP). CoSnSx was used as the signal amplifier of the immunosensor for the first time, which was synthesized by fast stoichiometric co-precipitation method. The binary sulfide was identified as an amorphous structure and performed apparent electrochemical behavior...
February 21, 2019: Biosensors & Bioelectronics
Jenny Stenberg, Jan Melin, Magnus Lindberg, Hans Furuland
INTRODUCTION: Fluid management in hemodialysis patients is a controversial topic. Brain natriuretic peptide (BNP) is secreted from the heart in response to volume overload, and may be a marker of overhydration in hemodialysis patients. Our aim was to investigate the correlation between BNP and overhydration in a cohort of hemodialysis patients, and to find out whether BNP and overhydration correlate in repeated measurements within individuals with elevated BNP. METHODS: The study was prospective, observational, and had a cross-sectional part and a longitudinal follow-up...
March 7, 2019: Hemodialysis International
Hans-Peter Brunner-La Rocca, Sandra Sanders-van Wijk
Normal brain natriuretic peptide (BNP) and N-terminal proBNP (NT-proBNP) levels are helpful in excluding chronic heart failure in the ambulatory setting, although they have been studied less well and possibly less accurately than in acute care. They may also be of help in screening patients at risk to intervene and reduce the development of heart failure. Natriuretic peptides are also excellent prognostic markers of chronic heart failure, but the clinical value of such prognostic information is less clear. One possible application for this information is guiding medical therapy in chronic heart failure...
February 2019: Cardiac failure review
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