Xiaonan Liu, Thomas J Littlejohns, Jelena Bešević, Fiona Bragg, Lei Clifton, Jennifer A Collister, Eirini Trichia, Laura J Gray, Kamlesh Khunti, David J Hunter
AIMS: We evaluated whether incorporating information on ethnic background and polygenic risk enhanced the Leicester Risk Assessment (LRA) score for predicting 10-year risk of type 2 diabetes. METHODS: The sample included 202,529 UK Biobank participants aged 40-69 years. We computed the LRA score, and developed two new risk scores using training data (80% sample): LRArev, which incorporated additional information on ethnic background, and LRAprs, which incorporated polygenic risk for type 2 diabetes...
March 29, 2024: Diabetes & Metabolic Syndrome