Agnieszka Matuszewska, Beata Nowak, Wojciech Niżański, Maria Eberhardt, Kinga Domrazek, Anna Nikodem, Benita Wiatrak, Krzysztof Zduniak, Kamil Olejnik, Anna Merwid-Ląd, Tomasz Tomkalski, Diana Jędrzejuk, Ewa Szeląg, Marzenna Podhorska-Okołów, Aleksandra Piotrowska, Izabela Jęśkowiak, Agata Heinrich, Maria Rutkowska, Wojciech Dziewiszek, Tomasz Sozański, Joanna Kwiatkowska, Paulina Jawień, Marek Bolanowski, Adam Szeląg
Highly active antiretroviral therapy (HAART) is used in HIV-infected patients. Alongside the prolongation of patients' life, adverse side effects associated with long-term therapy are becoming an increasing problem. Therefore, optimizing of HAART is extremely important. The study is aimed at evaluating the toxicity of abacavir and etravirine in monotherapy on the reproductive system, liver, kidneys, and bones in young, sexually mature, male rats. Thirty-six 8-week-old male Wistar rats randomized into three 12-animal groups received either normal saline (control), abacavir 60 mg/kg (AB group), or etravirine 40 mg/kg (ET group) once daily for 16 weeks...
2021: Oxidative Medicine and Cellular Longevity