Zhuxian Wang, Hongkai Chen, Tao Liang, Yi Hu, Yaqi Xue, Yufan Wu, Quanfu Zeng, Yixin Zheng, Yinglin Guo, Zeying Zheng, Dan Zhai, Peiyi Liang, Chunyan Shen, Cuiping Jiang, Li Liu, Qun Shen, Hongxia Zhu, Qiang Liu
Licorice flavonoids (LFs) are derived from perennial herb licorice and have been attaining a considerable interest in cosmetic and skin ailment treatments. However, some LFs compounds exhibited poor permeation and retention capability, which restricted their application. In this paper, we systematically investigated and compared the enhancement efficacy and mechanisms of different penetration enhancers (surfactants) with distinct lipophilicity or "heat and cool" characteristics on ten LFs compounds. Herein, the aim was to unveil how seven different enhancers modified the stratum corneum (SC) surface and influence the drug-enhancers-skin interaction, and to relate these effects to permeation enhancing effects of ten LFs compounds...
November 19, 2023: Drug Delivery and Translational Research