Neill K J Adhikari, Madiha Hashmi, Bharath Kumar Tirupakuzhi Vijayaraghavan, Rashan Haniffa, Abi Beane, Steve A Webb, Derek C Angus, Anthony C Gordon, Deborah J Cook, Gordon H Guyatt, Lindsay R Berry, Elizabeth Lorenzi, Paul R Mouncey, Carly Au, Ruxandra Pinto, Julie Ménard, Sheila Sprague, Marie-Hélène Masse, David T Huang, Daren K Heyland, Alistair D Nichol, Colin J McArthur, Angelique de Man, Farah Al-Beidh, Djillali Annane, Matthew Anstey, Yaseen M Arabi, Marie-Claude Battista, Scott Berry, Zahra Bhimani, Marc J M Bonten, Charlotte A Bradbury, Emily B Brant, Frank M Brunkhorst, Aidan Burrell, Meredith Buxton, Maurizio Cecconi, Allen C Cheng, Dian Cohen, Matthew E Cove, Andrew G Day, Lennie P G Derde, Michelle A Detry, Lise J Estcourt, Elizabeth O Fagbodun, Mark Fitzgerald, Herman Goossens, Cameron Green, Alisa M Higgins, Thomas E Hills, Nao Ichihara, Devachandran Jayakumar, Salmaan Kanji, Muhammad Nasir Khoso, Patrick R Lawler, Roger J Lewis, Edward Litton, John C Marshall, Daniel F McAuley, Anna McGlothlin, Shay P McGuinness, Zoe K McQuilten, Bryan J McVerry, Srinivas Murthy, Rachael L Parke, Jane C Parker, Luis Felipe Reyes, Kathryn M Rowan, Hiroki Saito, Nawal Salahuddin, Marlene S Santos, Christina T Saunders, Christopher W Seymour, Manu Shankar-Hari, Timo Tolppa, Tony Trapani, Alexis F Turgeon, Anne M Turner, Andrew A Udy, Frank L van de Veerdonk, Ryan Zarychanski, François Lamontagne
IMPORTANCE: The efficacy of vitamin C for hospitalized patients with COVID-19 is uncertain. OBJECTIVE: To determine whether vitamin C improves outcomes for patients with COVID-19. DESIGN, SETTING, AND PARTICIPANTS: Two prospectively harmonized randomized clinical trials enrolled critically ill patients receiving organ support in intensive care units (90 sites) and patients who were not critically ill (40 sites) between July 23, 2020, and July 15, 2022, on 4 continents...
October 25, 2023: JAMA