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Taghreed A Ibrahim, Rabab A El Dib, Hanan M Al-Youssef, Musarat Amina
It was deemed of interest to investigate Antidesm bunius aerial parts from phytochemical and biological points of view due to limited previous studies. Isolation and identification of phenolic compounds and evaluation of the potential antimicrobial and cytotoxic effects of A. bunius aerial parts was investigated. The petroleum ether (PEE) and 80% EtOH extracts (EE), as well as, n-hexane (HF), CHCl3 (CF), EtOAc (EAF), n-BuOH (BF) and H2O soluble fractions (WF) of the latter were prepared. Phytochemical study has been performed for isolation and identification of the major polyphenols...
January 2019: Pakistan Journal of Pharmaceutical Sciences
Raana Mahmood, Rahila Ikram, Ghazala H Rizwani, Humera Khatoon
The study is conducted to observe and investigate the effects of oral dosing of methanolic extracts of Cuminum nigrum (L) and Centratherum anthelminticum (L) on neuropharmacological activities of mice. Methanolic extracts of Cuminum nigrum (L) and Centratherum anthelminticum (L) were soluble in Dimethyl sulphoxide (DMSO) i.e. an organic solvent, so it is used in this study. Screening for anxiolytic and antidepressant effects were performed using open field test, head dip test, stationary rod test, cage crossing test, light and dark box and swimming- induced depression test...
January 2019: Pakistan Journal of Pharmaceutical Sciences
Christian W Keller, Isaak Quast, Marinos C Dalakas, Jan D Lünemann
Patients with acute and chronic inflammatory demyelinating neuropathies exhibit elevated serum and cerebrospinal fluid (CSF) levels of terminal complement activation products and therapeutic inhibition of complement activation is currently tested for its safety and efficacy in patients with Guillain-Barré syndrome (GBS). Here, we determined serum levels of the complement activation products C3a, C5a and the soluble terminal complement complex (sTCC) in 39 individuals with chronic inflammatory demyelinating polyneuropathy (CIDP) who participated in one of the largest ever conducted clinical trial in patients with CIDP (ICE trial) and received Intravenous Immunoglobulin (IVIG) or placebo (albumin) in 3 week intervals for up to 24 weeks...
February 10, 2019: Journal of Neuroimmunology
Lijie Zhou, Wei-Qin Zhuang, Yashika De Costa, Siqing Xia
With the rapid development and application of consumer products containing nanoparticles (NPs), especially titanium dioxide (TiO2 ) NPs, the potential effects of suspended NPs on wastewater treatment has been a concern over the recent years. This study investigated the potential effects of suspended TiO2 NPs on activated sludge flocculation properties in a membrane bioreactor (MBR). Results showed that suspended TiO2 NPs inhibited the viability of activated sludge flocs, and led to bacterial protein secretion for bacterial protection, causing an overall protein increase of soluble microbial products...
February 11, 2019: Chemosphere
Minyi Ren, Dan Wang, Shiming Ding, Liyuan Yang, Shiwei Xu, Chenye Yang, Yan Wang, Chaosheng Zhang
Differences in trophic status can lead to different water quality and sediment geochemistry characteristics, influencing antimony (Sb) mobility in sediments and its release into the water column. In this study, seasonal sampling was conducted in algal- and macrophyte-dominated zones of Lake Taihu, China. High-resolution dialysis (HR-Peeper) and diffusive gradients in thin films (DGT) techniques were used to measure soluble Sb and DGT-labile Sb in the sediment-water profiles at a 4 mm vertical resolution. Results showed that total Sb in sediments from the two zones were on average 3...
February 5, 2019: Chemosphere
Sivaramakrishnan Ramadurai, Ananiy Kohut, Nirod Kumar Sarangi, Oksana Zholobko, Vladimir A Baulin, Andriy Voronov, Tia E Keyes
Macromolecules of amphiphilic invertible polymers (AIPs) are capable of self-assembly into micellar assemblies of various morphologies in solvents of different polarities. The micellar assemblies in aqueous media are capable of encapsulating poorly aqueous soluble cargo and can undergo inverse conformational change and cargo release in contact with non-polar media, including potentially, cell membranes. Thus, invertible micellar assemblies have significant potential in drug delivery and related domains. However, to date there have been few investigations into their interactions with lipid membranes...
January 30, 2019: Journal of Colloid and Interface Science
Fahimeh Bayat, Ali Reza Karimi
The fabrication of a new antibacterial system is an essential medical requirement to treat wounds caused by multidrug-resistant Gram-negative bacteria, mostly Pseudomonas aeruginosa. Antibacterial photodynamic therapy (APDT) is an encouraging therapy modality for bacterial infection. Anyhow, the applications of most photosensitizers are restricted by their poor water solubility and their inefficiency in disruption of the outer membrane of Gram-negative bacteria. In this context, zinc phthalocyanine-colistin (ZnPc-Col) conjugate as a new photosensitizer was synthesized in the hope of improving interaction of phthalocyanine with the surface of Gram-negative bacteria...
February 14, 2019: International Journal of Biological Macromolecules
Diandra de Andrades, Natália G Graebin, Marina Kimiko Kadowaki, Marco A Z Ayub, Roberto Fernandez-Lafuente, Rafael C Rodrigues
Three β-glucosidases (Pectinex Ultra SP-L, Pectinex Ultra Clear and homemade preparation from Aspergillus niger) were immobilized using different strategies: ionic adsorption on aminated (MANAE)-agarose beads at pH 5, 7, and 9, followed by biocatalysts modification with glutaraldehyde, or on glutaraldehyde pre-activated supports. The pH of the immobilization was altered to allow different enzyme molecule orientations on the support surface. The biocatalysts from Pectinex Ultra SP-L showed the highest thermal and operational stabilities when immobilized on MANAE-agarose-glutaraldehyde at pH 7...
February 14, 2019: International Journal of Biological Macromolecules
Min Gou, Hao Wu, Ahmed S M Saleh, Luzhen Jing, Yu Liu, Kun Zhao, Chunyan Su, Bo Zhang, Hao Jiang, Wenhao Li
The influence of repeated and continuous dry heat treatments on structural, physicochemical, and digestive properties of sweet potato starch was investigated. The results showed that the original A-type crystallinity of sweet potato starch remained unchanged after dry heat treatments. The light transmittance, gelatinization temperature, and pasting temperature of sweet potato starch increased; while the pasting viscosities, swelling power, and solubility decreased after dry heat treatments. Relative crystallinity, solubility, swelling power, light transmittance, and thermal parameter values (To , Tp , Tc , ΔT) were found to be significantly higher for the continuous dry heat (CDH) treated starch than those of the repeated dry heat (RDH) treated starch after treatment for the same duration...
February 14, 2019: International Journal of Biological Macromolecules
Ampa Jimtaisong, Thapanee Sarakonsri
Chitosan-bentonite clay composite was prepared for use as adsorbent matrix of water-soluble natural dyes. The addition of chitosan resulted in a relatively rough texture of the composite compared with bentonite. XRD analysis showed that a basal d001 -space value of the composite (15.545 Å) is higher than that of bentonite clay (14.525 Å) which indicates that chitosan was intercalated into the layer of clay. FT-IR and SEM measurement also suggested that new compound was formed. Water soluble dye extracted from sappanwood was adsorbed onto chitosan-bentonite clay composite at 81...
February 14, 2019: International Journal of Biological Macromolecules
G J Mc Callum, M B Arregui, I Smith, L F Bracco, F Wolman, O Cascone, A M Targovnik, M V Miranda
Expression of recombinant proteins with baculovirus-infected insect larvae is a scarcely investigated alternative in comparison to that in insect cell lines, a system with growing popularity in the field of biotechnology. The aim of this study was to investigate the chromatographic behavior and physicochemical properties of the proteome of Rachiplusia nu larvae infected with recombinant Autographa californica multiple nucleopolyhedrosis virus (AcMNPV), in order to design rational purification strategies for the expression of heterologous proteins in this very complex and little-known system, based on the differential absorption between target recombinant proteins and the system's contaminating ones...
February 14, 2019: Protein Expression and Purification
Zitao Zhong, Li Jia
Polydopamine-polyethyleneimine (PDA-PEI) copolymer dots were prepared under mild conditions via the self-polymerization of dopamine and cross-linking with branched PEI (BPEI). The molecular weight of BPEI, mass ratio of dopamine to BPEI, and pH of reaction medium had significant influences on the quantum yield of PDA-PEI copolymer dots. Under the optimized conditions, the synthesized PDA-PEI copolymer dots have an average size of 9.4 ± 2.2 nm in diameter with good water dispersibility. The quantum yield is 12...
May 15, 2019: Talanta
Li Su, Xinai Yu, Yuqi Miao, Guojiang Mao, Wenpei Dong, Suling Feng, Siman Liu, Like Yang, Kaige Zhang, Hua Zhang
Nanozymes' activities could be regulated by a simple and effective pH change in an in situ manner. In this work, for the first time, the peroxidase-like activity of Ni/Co layered double hydroxides (LDHs) was regulated via the alkaline-promoted reaction of fluorogenic substrate homovanillic acid and H2 O2 , and a promising tool for pH sensing was developed over the pH range of 8.3-9.6. As peroxidase nanozyme model, Ni/Co LDHs showed ease of preparation, low-cost, and water-solubility, which played an important role in this luminescence system...
May 15, 2019: Talanta
Pengfei Gao, Min Li, Yan Zhang, Chuan Dong, Guomei Zhang, Lihong Shi, Gao Li, Mingjian Yuan, Shaomin Shuang
In this study, we have developed a facile, rapid one-pot strategy for synthesis of orange fluorescent gold nanoclusters (MBISA-AuNCs) at room temperature by using 2-Mercapto-5-benzimidazolesulfonic acid (MBISA) as both reducing and protecting reagent. The prepared AuNCs exhibited prominent advantages including high fluorescent quantum yield, good water solubility, excellent biocompatibility and low toxicity. Based on these superior properties, the AuNCs have been multi-talented applied in cell imaging, hydrogen sulfide detection and pH sensing...
May 15, 2019: Talanta
Pei-Hsun Wu, Yi-Ching Cheng, Haon-Yao Chen, Ti-Wen Chueh, Hui-Chen Chen, Li-Hsun Huang, Zhong-Xian Wu, Tsung-Min Hsieh, Chao-Chin Chang, Ping-Yi Yang, Cheng-Fang Lin, Chang-Ping Yu
Control of organic matter, nutrients and disinfection byproduct formation is a major challenge for the drinking water treatment plants on Matsu Islands, Taiwan, receiving source water from the eutrophic reservoirs. A pilot entrapped biomass reactor (EBR) system was installed as the pretreatment process to reduce organic and nitrogen contents into the drinking water treatment plant. The effects of hydraulic retention time (HRT) and combination of preceding physical treatment (ultraviolet and ultrasound) on the treatment performance were further evaluated...
February 4, 2019: Environmental Pollution
Seonki Lee, Stanislaus Raditya Suwarno, Bryan Wei Hong Quek, Lanhee Kim, Bing Wu, Tzyy Haur Chong
In this study, permeate quality, membrane performance, and microbial community in a gravity-driven microfiltration (GDM) reactor and a biofiltration (BF) + GDM reactor for seawater reverse osmosis (RO) desalination pretreatment were compared at both lab-scale and pilot-scale. The presence of BF column was more efficient in removing soluble organic substances by biosorption/biodegradation, leading to superior permeate quality from BF + GDM and subsequently lower RO fouling than GDM. Compared to the biofilm-saturated anthracite media, the granular activated carbon media in BF improved the assimilable organic substances removal in BF + GDM...
February 4, 2019: Water Research
Min Gan, Chunyao Gu, Jijuan Ding, Jianyu Zhu, Xinxing Liu, Guanzhou Qiu
Hexavalent chromium (Cr(VI)) is an environmental concern due to the carcinogenic and mutagenic effect on living organisms. Sulfide minerals based Cr(VI) reduction is an economical and efficient strategy for Cr(VI) remediation. In this study, Cr(VI) reduction through the synergistic effect between chemoautotrophic bacteria and sulfide mineral is systematically investigated. Sulfide minerals dissolution and Cr(VI) reduction performance highly depends on mineral acid soluble property. Cr(VI) reduction capacity of pyrrhotite, pyrite, marcasite and sphalerite was 50, 104, 104 and 44 mg/g (Cr(VI)/mineral) respectively in the biotic system...
February 13, 2019: Ecotoxicology and Environmental Safety
Thorsteinn Loftsson, Phennapha Saokham, André Rodrigues Sá Couto
Cyclodextrins (CDs) are oligosaccharides that self-assemble in aqueous solutions to form transient clusters, nanoparticles and small microparticles. The critical aggregation concentration (cac) of the natural αCD, βCD and γCD in pure aqueous solutions was estimated to be 25, 8 and 9 mg/ml, respectively. The cac of 2-hydroxypropyl-β-cyclodextrin (HPβCD), that consists of mixture of isomers, was estimated to be significantly higher or 118 mg/ml. Addition of chaotropic agents (i.e. that disrupts non-covalent bonds such as hydrogen bonds) to the aqueous media increases the cac...
February 13, 2019: International Journal of Pharmaceutics
Shakhawath Hossain, Aleksei Kabedev, Albin Parrow, Christel Bergström, Per Larsson
In this review we will discuss how computational methods, and in particular classical molecular dynamics simulations, can be used to calculate solubility of pharmaceutically relevant molecules and systems. To the extent possible, we focus on the non-technical details of these calculations, and try to show also the added value of a more thorough and detailed understanding of the solubilization process obtained by using computational simulations. Although the main focus is on classical molecular dynamics simulations, we also provide the reader with some insights into other computational techniques, such as the COSMO-method, and also discuss Flory-Huggins theory and solubility parameters...
February 13, 2019: European Journal of Pharmaceutics and Biopharmaceutics
Guan-Yi Xu, Ai-Mei Liao, Ji-Hong Huang, Jian-Guo Zhang, Kiran Thakur, Zhao-Jun Wei
Potato peel was used for the extraction of three types of polysaccharides (PW, PAL, and PAC) using water, alkaline, and acid treatments, respectively. The structure of the PP polysaccharides was examined by means of Fourier transform infrared spectroscopy (FT-IR) analysis and Gas chromatography-mass spectrometry (GC-MS). The results suggest that the extracted polysaccharides constituted essentially three functional groups; CO, CH, and OH. The polysaccharides were comprised of low proportions of proteins, 17-23% uronic acids, and approximately 70% carbohydrates...
February 13, 2019: International Journal of Biological Macromolecules
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