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(Muscle) AND (Hypertrophy or growth or gain or accumulation)

Christopher Latella, Cassio V Ruas, Ricardo N O Mesquita, Kazunori Nosaka, Janet L Taylor
Tensiomyography (TMG) has gained popularity as a tool to quantify muscle contractile properties. However, it is unclear whether joint angle and inter-stimulus interval influence the test-retest reliability of TMG. Fifteen participants (13M/2F; 29.5 ± 7.4 y) underwent TMG recording of the biceps brachii (BB) at 10°, 45° and 90° of elbow flexion with 10 and 20 s inter-stimulus rest intervals in a randomised order on two separate days. The intra-class correlation coefficient (ICC2,1 ) and 95% confidence interval (95%CI) were calculated for delay time (Td), contraction time (Tc), sustain time (Ts), relaxation time (Tr) and maximal displacement (Dm)...
February 12, 2019: Journal of Electromyography and Kinesiology
Nader Tarabeih, Adel Shalata, Svetlana Trofimov, Alexander Kalinkovich, Gregory Livshits
The development of low back pain (LBP) is often associated with obesity and sarcopenia. However, the mechanisms of this association remain unclear. To clarify this, we measured circulating levels of a selected panel of soluble factors, presumably involved in obesity and sarcopenia pathogenesis, and correlated them with several LBP-related characteristics, taking into account body composition and other relevant covariates. In the cross-sectional study of 1078 individuals, we collected data on self-reported LBP, body composition (including fat and skeletal muscle mass) assessed by the bioimpedance method and anthropometrically, and measured plasma levels of several cytokines by ELISA...
February 15, 2019: Cytokine
Christopher T Griffin, Lauren S Bano, Alan H Turner, Nathan D Smith, Randall B Irmis, Sterling J Nesbitt
Understanding growth patterns is central to properly interpreting paleobiological signals in tetrapods, but assessing skeletal maturity in some extinct clades may be difficult when growth patterns are poorly constrained by a lack of ontogenetic series. To overcome this difficulty in assessing the maturity of extinct archosaurian reptiles-crocodylians, birds and their extinct relatives-many studies employ bone histology to observe indicators of the developmental stage reached by a given individual. However, the relationship between gross morphological and histological indicators of maturity has not been examined in most archosaurian groups...
2019: PeerJ
Chetan P Phadke, Luciana Vierira, Sunita Mathur, Gerson Cipriano, Farooq Ismail, Chris Boulias
Background: Passive leg cycling is an important clinical tool available for rehabilitation after spinal cord injury (SCI). Passive cycling can be used to derive exercise-related benefits in patients with poor motor control. There have been a number of studies examining the effects of passive cycling on a variety of outcomes. There is need for a systematic assessment of the cycling parameters and the associated clinical changes in cardiovascular, neuromuscular, and musculoskeletal outcomes after passive cycling...
2019: Topics in Spinal Cord Injury Rehabilitation
Mamata Joysowal, B N Saikia, Runjun Dowarah, S Tamuly, D Kalita, K B Dev Choudhury
Aim: The experiment was conducted to evaluate the effect of swine-origin probiotic Pediococcus acidilactici FT28 on growth, nutrient utilization, health status, meat quality and intestinal morphology in growing female pigs. Materials and Methods: Pigs (n=27) were distributed into three groups (3 replicates of 3 each) and supplemented with basal diet either without probiotics (C) or with a probiotic of dairy-based ( Lactobacillus acidophilus NCDC-15; TLact ) or swine based ( P...
December 2018: Veterinary World
Diah Gemala Ibrahim, Ji-Ae Ko, Wakana Iwata, Hideaki Okumichi, Yoshiaki Kiuchi
Scar formation is the most common cause for failure of glaucoma filtration surgery because of increased fibroblast proliferation and activation. We have now examined the effect of Y-27632, a Rho-associated protein kinase (ROCK) inhibitor, on postsurgical scarring formation in human Tenon fibroblasts (HTFs). Collagen gel contraction assay was used to compare contractility activity of Y-27632 with several antiglaucoma drugs. Immunofluorescence and western blotting were used to examine expression of scar formation-related factors...
February 18, 2019: Cell Biochemistry and Function
Jimin Park, Hyunseon Seo, Hae Won Hwang, Jonghoon Choi, Kyeongsoo Kim, Goeen Jeong, Eun Shil Kim, Hyung-Seop Han, Yeon-Wook Jung, Youngmin Seo, Hojeong Jeon, Hyun-Kwang Seok, Yu-Chan Kim, Myoung-Ryul Ok
Despite significant advances in the design of metallic materials for bare metal stents (BMSs), restenosis induced by the accumulation of smooth muscle cells (SMCs) has been a major constraint on improving the clinical efficacy of stent implantation. Here, a new strategy for avoiding this issue utilizing hydrogen peroxide (H2O2) generated by the galvanic coupling of nitinol (NiTi) stents and biodegradable magnesium-zinc (Mg-Zn) alloys is reported. The amount of H2O2 released is carefully optimized via the biodegradability engineering of the alloys and by controlling the immersion time to selectively inhibit the proliferation and function of SMCs without harming vascular endothelial cells (VECs)...
February 18, 2019: Langmuir: the ACS Journal of Surfaces and Colloids
Martin Johnson, Mohamed Trebak
Cardiorespiratory disease, which includes systemic arterial hypertension, restenosis, atherosclerosis, pulmonary arterial hypertension, asthma, and chronic obstructive pulmonary disease (COPD) are highly prevalent and devastating diseases with limited therapeutic modalities. A common pathophysiological theme to these diseases is cellular remodeling, which is contributed by changes in expression and activation of ion channels critical for either excitability or growth. Calcium (Ca2+ ) signaling and specifically ORAI Ca2+ channels have emerged as significant regulators of smooth muscle, endothelial, epithelial, platelet, and immune cell remodeling...
February 8, 2019: Cell Calcium
Zhixiang Gu, Hua Mu, Haohao Shen, Kangyu Deng, Dong Liu, Mengxi Yang, Yue Zhang, Wenbing Zhang, Kangsen Mai
The present study was conducted to investigate the metabolic responses of glucose and lipid in large yellow croaker Larimichthys crocea (initial weight, 36.80 ± 0.39 g) to high level of dietary soybean oil. Three isonitrogenous (46% crude protein) and isolipidic (13% crude lipid) experimental diets were designed, with 100% fish oil (FO), 50% fish oil and 50% soybean oil (FS) and 100% soybean oil (SO), respectively. After a 12-week growth trial, the results showed that compared with FO group, contents n-6 PUFAs increased while the n-3 PUFAs decreased significantly both in liver and muscle in FS and SO groups...
February 14, 2019: Comparative Biochemistry and Physiology. Part B, Biochemistry & Molecular Biology
Wen Wu, Wei Zhang, Mihyun Choi, Jinjing Zhao, Ping Gao, Min Xue, Harold A Singer, David Jourd'heuil, Xiaochun Long
Injury-induced stenosis is a serious vascular complication. We previously reported that p38α (MAPK14), a redox-regulated p38MAPK family member was a negative regulator of the VSMC contractile phenotype in vitro. Here we evaluated the function of VSMC-MAPK14 in vivo in injury-induced neointima hyperplasia and the underlying mechanism using an inducible SMC-MAPK14 knockout mouse line (iSMC-MAPK14-/- ). We show that MAPK14 expression and activity were induced in VSMCs after carotid artery ligation injury in mice and ex vivo cultured human saphenous veins...
February 6, 2019: Redox Biology
Tae-Hwan Yoon, Sung-Jae Kim, Chong-Hyuk Choi, Soon-Phil Yoon, Yong-Min Chun
PURPOSE: To investigate whether subscapularis integrity and compensatory teres, minor hypertrophy is associated with maintaining relatively good function and tolerable pain levels during non-operative treatment. METHODS: This study included 108 patients with irreparable, massive rotator cuff tears involving at least two tendons and stage III or IV muscle hypotrophy and fatty infiltration on oblique sagittal magnetic resonance imaging, in which even a partial repair does not seem feasible...
February 15, 2019: Knee Surgery, Sports Traumatology, Arthroscopy: Official Journal of the ESSKA
Paulina Podkalicka, Olga Mucha, Jozef Dulak, Agnieszka Loboda
Duchenne muscular dystrophy (DMD) represents one of the most devastating types of muscular dystrophies which affect boys already at early childhood. Despite the fact that the primary cause of the disease, namely the lack of functional dystrophin is known already for more than 30 years, DMD still remains an incurable disease. Thus, an enormous effort has been made during recent years to reveal novel mechanisms that could provide therapeutic targets for DMD, especially because glucocorticoids treatment acts mostly symptomatic and exerts many side effects, whereas the effectiveness of genetic approaches aiming at the restoration of functional dystrophin is under the constant debate...
February 15, 2019: Cellular and Molecular Life Sciences: CMLS
Manchi Rajesh, Biju Sam Kamalam, Alexander Ciji, Md Shabaz Akhtar, Nityanand Pandey, Subodh Gupta, Debajit Sarma, Narrotam Prasad Sahu, Atul Kumar Singh
In vertebrates, myogenic regulatory factors (MRFs) play an important role in muscle growth through the processes of cell determination and differentiation. Herein, we report the molecular characterisation of two MRFs, myogenin (myog) and myogenic factor 6 (myf6) in Indian snow trout Schizothorax richardsonii. The full length mRNA sequence of Srmyog and Srmyf6 was 1437 and 1296 bp, with an ORF of 762 and 720 bp, encoding a putative protein of 253 and 239 amino acids, respectively. In silico analysis and predicted tertiary protein structure revealed that both these nuclear localized MRFs contained the highly conserved basic helix loop helix motif, to potentially aid in dimerization with functional partners and DNA binding...
February 12, 2019: Comparative Biochemistry and Physiology. Part A, Molecular & Integrative Physiology
Daniel Munro, Cécile Baldy, Matthew E Pamenter, Jason R Treberg
Naked mole-rats (NMRs) are mouse-sized mammals that exhibit an exceptionally long lifespan (>30 vs. <4 years for mice), and resist aging-related pathologies such as cardiovascular and pulmonary diseases, cancer, and neurodegeneration. However, the mechanisms underlying this exceptional longevity and disease resistance remain poorly understood. The oxidative stress theory of aging posits that (a) senescence results from the accumulation of oxidative damage inflicted by reactive oxygen species (ROS) of mitochondrial origin, and (b) mitochondria of long-lived species produce less ROS than do mitochondria of short-lived species...
February 15, 2019: Aging Cell
Eran Nizri, Shoshi Bar-David, Asaf Aizic, Neta Sternbach, Guy Lahat, Ido Wolf, Joseph Klausner
OBJECTIVES: Pancreatic ductal adenocarcinoma (PDAC) is characterized by a peritumoral proliferation of fibroblasts and extracellular matrix production known as desmoplasia. We aimed to study desmoplasia in PDAC lymph node (LN) metastases. METHODS: We evaluated LNs from 66 patients with PDAC and LN metastases. We used immunohistochemistry and real-time polymerase chain reaction to phenotype the desmoplastic response. RESULTS: Desmoplasia was identified in 57% of patients with LN metastases (Des+)...
February 14, 2019: Pancreas
Li-Huang Zha, Jun Zhou, Tang-Zhiming Li, Hui Luo, Men-Qiu Zhang, Sheng Li, Zai-Xin Yu
Phosphoinositide 3-kinase (PI3K) activation plays a critical role in the pulmonary vascular remodeling of pulmonary hypertension (PH). The nucleotide-oligomerization domain (NOD)-like receptor subfamily C3 (NLRC3) inhibits proliferation and inflammation via PI3K signaling in cancer. We previously showed NLRC3 was significantly reduced in PH patients, but the mechanism of function remains unclear. This study aimed to determine the potential role of NLRC3 in PH. We found that NLRC3 was downregulated in the pulmonary arteries of PH animal models and platelet-derived growth factor-BB (PDGF-BB) stimulated pulmonary arterial smooth muscle cells (PASMCs)...
February 14, 2019: Journal of Cellular Physiology
Zhihuan Tian, Chuanzhen Jiao
BACKGROUND: Molting is a critical developmental process for crustaceans, during which the claw muscles undergo periodic atrophy and restoration. But the mechanism underlying this special muscle reshuffle around ecdysis is not yet thoroughly understood. OBJECTIVE: To investigate the molecular mechanism underlying the muscle's reshuffle over the molting cycle of Chinese mitten crab Eriocheir sinensis. METHODS: The Illumina high-throughput sequencing technique were used to sequence the transcriptome of the whole claw muscles from Chinese mitten crab Eriocheir sinensis in three molting stages (inter-molt C stage, pre-molt D3-4 and post-molt A-B stage); the de novo assembly, annotation and functional evaluation of the contigs were performed with bioinformatics tools...
February 14, 2019: Genes & Genomics
Michał Wilk, Małgorzata Michalczyk, Artur Gołaś, Michał Krzysztofik, Adam Maszczyk, Adam Zając
The aim of this study was to determine the effect of carbohydrate-protein supplementation with whey protein (CHO-PROw) after resistance training, and casein protein (PROc) before bedtime on the concentration of growth hormone (GH), insulin (I) and insulin-like growth factor (IGF-1), as well as serum creatine kinase (CK) activity. Twelve strength trained male subjects (age: 25.8 ± 4.7 years; training experience 6.1 ± 0.79 years; body mass 75.9 ± 2.7 kg; body height 171.8 ± 13.3 cm) were recruited for the study...
December 2018: Biology of Sport
Florent Dufour, Linda Silina, Hélène Neyret-Kahn, Aura Moreno-Vega, Clémentine Krucker, Narjesse Karboul, Marion Dorland-Galliot, Pascale Maillé, Elodie Chapeaublanc, Yves Allory, Nicolas Stransky, Hélène Haegel, Thierry Menguy, Vanessa Duong, François Radvanyi, Isabelle Bernard-Pierrot
BACKGROUND: Muscle-invasive bladder cancer (MIBC) is an aggressive neoplasm with poor prognosis, lacking effective therapeutic targets. Oncogenic dependency on members of the TAM tyrosine kinase receptor family (TYRO3, AXL, MERTK) has been reported in several cancer types, but their role in bladder cancer has never been explored. METHODS: TAM receptor expression was evaluated in two series of human bladder tumours by gene expression (TCGA and CIT series), immunohistochemistry and western blotting analyses (CIT series)...
February 15, 2019: British Journal of Cancer
Esther Fernández-Simón, Ana Carrasco-Rozas, Eduard Gallardo, Sebastián Figueroa-Bonaparte, Izaskun Belmonte, Irene Pedrosa, Elena Montiel, Xavier Suárez-Calvet, Jorge Alonso-Pérez, Sonia Segovia, Claudia Nuñez-Peralta, Jaume Llauger, Mercedes Mayos, Isabel Illa, Jordi Díaz-Manera
Adult onset Pompe disease is a genetic disorder characterized by slowly progressive skeletal and respiratory muscle weakness. Symptomatic patients are treated with enzymatic replacement therapy with human recombinant alfa glucosidase. Motor functional tests and spirometry are commonly used to follow patients up. However, a serological biomarker that correlates with the progression of the disease could improve follow-up. We studied serum concentrations of TGFβ, PDGF-BB, PDGF-AA and CTGF growth factors in 37 adult onset Pompe patients and 45 controls...
February 14, 2019: Scientific Reports
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