Patrick M Wise, Augustine M Saiz, Justin Haller, Joseph C Wenke, Thomas Schaer, Prism Schneider, Saam Morshed, Chelsea S Bahney
Orthopaedic trauma remains a leading cause of patient morbidity, mortality, and global health care burden. Although significant advances have been made in the diagnosis, treatment, and rehabilitation of these injuries, complications such as malunion, nonunion, infection, disuse muscle atrophy and osteopenia, and incomplete return to baseline function still occur. The significant inherent clinical variability in fracture care such as differing patient demographics, injury patterns, and treatment protocols make standardized and replicable study, especially of cellular and molecular based mechanisms, nearly impossible...
March 2024: OTA international: the open access journal of orthopaedic trauma