keyword
Keywords (Muscle) AND (disuse or atroph...

(Muscle) AND (disuse or atrophy or immobilization)

https://read.qxmd.com/read/38500424/-comparison-of-talonavicular-cuneiform-joint-fusion-with-bone-grafting-and-without-bone-grafting-in-treatment-of-m%C3%A3-ller-weiss-disease
#21
JOURNAL ARTICLE
Baoli Zou, Wenbo Bai, Guodong Shen, Kaiting Zhang, Jingcheng Xu, Yongzhan Zhu
OBJECTIVE: To compare the effectiveness of talonavicular-cuneiform joint fusion with iliac bone grafting and without bone grafting in the treatment of Müller-Weiss diseases (MWD). METHODS: The clinical data of 44 patients (44 feet) with MWD who received talonavicular-cuneiform joint fusion between January 2017 and November 2022 and met the selection criteria was retrospectively analyzed. Among them, 25 patients were treated with structural iliac bone grafting (bone grafting group) and 19 patients without bone grafting (non-bone grafting group)...
March 15, 2024: Chinese Journal of Reparative and Reconstructive Surgery
https://read.qxmd.com/read/38497648/using-cleavage-under-targets-and-tagmentation-cut-tag-assay-in-mouse-myoblast-research
#22
JOURNAL ARTICLE
Yuefeng Li, Xiaofen Wu, Ping Hu
This protocol paper aims to provide the new researchers with the full details of using Cleavage Under Targets and Tagmentation (CUT&Tag) to profile the genomic locations of chromatin binding factors, histone marks, and histone variants. CUT&Tag protocols function very well with mouse myoblasts and freshly isolated muscle stem cells (MuSCs). They can easily be applied to many other cell types as long as the cells can be immobilized by Concanavalin-A beads. Compared to CUT&Tag, chromatin immunoprecipitation (ChIP) assays are time-consuming experiments...
March 1, 2024: Journal of Visualized Experiments: JoVE
https://read.qxmd.com/read/38496429/a-novel-variant-in-the-gne-gene-in-a-malian-patient-presenting-with-distal-myopathy
#23
Mahamadou Kotioumbe, Alassane B Maiga, Salia Bamba, Lassana Cissé, Salimata Diarra, Salimata Diallo, Abdoulaye Yalcouyé, Fousseyni Kané, Seybou H Diallo, Dramane Coulibaly, Thomas Coulibaly, Kékouta Dembélé, Boubacar Maiga, Cheick O Guinto, Guida Landouré
Background: GNE myopathy (GM) is a rare autosomal recessive disorder caused by variants in the GNE gene and characterized by progressive distal muscle weakness and atrophy. We report a novel variant in the GNE gene causing GM in a consanguineous Malian family. Case presentation: A 19-year-old male patient from a consanguineous family of Bambara ethnicity was seen for progressive walking difficulty and frequent falls. Neurological examination found distalmuscle weakness and atrophy and reduced tendon reflexes in four limbs...
March 7, 2024: Research Square
https://read.qxmd.com/read/38496299/quadriceps-muscle-atrophy-after-non-invasive-anterior-cruciate-ligament-injury-evidence-linking-to-autophagy-and-mitophagy
#24
JOURNAL ARTICLE
Sung Gi Noh, Ahram Ahn, Steven M Davi, Lindsey K Lepley, Oh Sung Kwon
Introduction: Anterior cruciate ligament (ACL) injury is frequently accompanied by quadriceps muscle atrophy, a process closely linked to mitochondrial health and mitochondria-specific autophagy. However, the temporal progression of key quadricep atrophy-mediating events following ACL injury remains poorly understood. To advance our understanding, we conducted a longitudinal study to elucidate key parameters in quadriceps autophagy and mitophagy. Methods: Long-Evans rats were euthanized at 7, 14, 28, and 56 days after non-invasive ACL injury that was induced via tibial compression overload; controls were not injured...
2024: Frontiers in Physiology
https://read.qxmd.com/read/38494747/rapid-eye-movement-sleep-behavior-disorder-and-its-relation-to-parkinson-s-disease-the-potential-of-graph-measures-as-brain-biomarkers-to-identify-the-underlying-physiopathology-of-the-disorder
#25
REVIEW
Milad Najafzadeh, Fatemeh Mohammadian, Sara Mirabian, Zohre Ganji, Hossein Akbari, Masoud Rezaie, Esmaeil Ranjbar, Hoda Zare, Shahrokh Nasseri, Luigi Ferini-Strambi
Rapid eye movement behavior disorder (RBD) is a parasomnia characterized by the loss of skeletal muscle atonia during the rapid eye movement (REM) sleep phase. On the other hand, idiopathic RDB (iRBD) is considered the prelude of the various α-synucleinopathies, including Parkinson's disease (PD), dementia with Lewy bodies and multiple system atrophy. Consequently, over 40% of patients eventually develop PD. Recent neuroimaging studies utilizing structural magnetic resonance imaging (s-MRI), diffusion-weighted imaging (DWI), and functional magnetic resonance imaging (fMRI) with graph theoretical analysis have demonstrated that patients with iRBD and Parkinson's disease have extensive brain abnormalities...
March 2024: Brain and Behavior
https://read.qxmd.com/read/38493058/neuroprotective-effects-of-niclosamide-on-disease-progression-via-inflammatory-pathways-modulation-in-sod1-g93a-and-fus-associated-amyotrophic-lateral-sclerosis-models
#26
JOURNAL ARTICLE
Martina Milani, Ilaria Della Valle, Simona Rossi, Paola Fabbrizio, Cassandra Margotta, Giovanni Nardo, Mauro Cozzolino, Nadia D'Ambrosi, Savina Apolloni
Amyotrophic lateral sclerosis (ALS) is a complex neurodegenerative disease influenced by genetic, epigenetic, and environmental factors, resulting in dysfunction in cellular and molecular pathways. The limited efficacy of current treatments highlights the need for combination therapies targeting multiple aspects of the disease. Niclosamide, an anthelminthic drug listed as an essential medicine, has been repurposed in clinical trials for different diseases due to its anti-inflammatory and anti-fibrotic properties...
March 15, 2024: Neurotherapeutics: the Journal of the American Society for Experimental NeuroTherapeutics
https://read.qxmd.com/read/38492879/skeletal-muscle-atrophy-after-sciatic-nerve-damage-mechanistic-insights
#27
REVIEW
Aarti Yadav, Rajesh Dabur
Sciatic nerve injury leads to molecular events that cause muscular dysfunction advancement in atrophic conditions. Nerve damage renders muscles permanently relaxed which elevates intracellular resting Ca2+ levels. Increased Ca2+ levels are associated with several cellular signaling pathways including AMPK, cGMP, PLC-β, CERB, and calcineurin. Also, multiple enzymes involved in the tricarboxylic acid cycle and oxidative phosphorylation are activated by Ca2+ influx into mitochondria during muscle contraction, to meet increased ATP demand...
March 14, 2024: European Journal of Pharmacology
https://read.qxmd.com/read/38492659/mechanical-and-signaling-responses-of-unloaded-rat-soleus-muscle-to-chronically-elevated-%C3%AE-myosin-activity
#28
JOURNAL ARTICLE
K V Sergeeva, S A Tyganov, K A Zaripova, R O Bokov, L V Nikitina, T S Konstantinova, G R Kalamkarov, B S Shenkman
It has been reported that muscle functional unloading is accompanied by an increase in motoneuronal excitability despite the elimination of afferent input. Thus, we hypothesized that pharmacological potentiation of spontaneous contractile soleus muscle activity during hindlimb unloading could activate anabolic signaling pathways and prevent the loss of muscle mass and strength. To investigate these aspects and underlying molecular mechanisms, we used β-myosin allosteric effector Omecamtiv Mekarbil (OM)...
March 14, 2024: Archives of Biochemistry and Biophysics
https://read.qxmd.com/read/38491417/novel-pip5k1c-variant-identified-in-a-chinese-pedigree-with-lethal-congenital-contractural-syndrome-3
#29
JOURNAL ARTICLE
Fang Zhang, Hongmei Guo, Xinlong Zhou, Zhengxi Deng, Qiuhong Xu, Qingming Wang, Haiming Yuan, Jianhua Luo
BACKGROUND: Biallelic pathogenic variants in PIP5K1C (MIM #606,102) lead to lethal congenital contractural syndrome 3 (LCCS3, MIM #611,369), a rare autosomal recessive genetic disorder characterized by small gestational age, severe multiple joint contractures and muscle atrophy, early death due to respiratory failure. Currently, 5 individuals with LCCS3 were reported and 5 pathogenic variants in PIP5K1C were identified. Here, we reported the two fetuses in a Chinese pedigree who displayed multiple joint contractures and other congenital anomalies...
March 15, 2024: BMC Pediatrics
https://read.qxmd.com/read/38488306/evaluating-disease-status-in-idiopathic-inflammatory-myopathies-with-quantitative-muscle-ultrasound
#30
JOURNAL ARTICLE
Jie Ying Tan, Cheng Yin Tan, Mohd Azly Yahya, Nortina Shahrizaila, Khean Jin Goh
INTRODUCTION/AIMS: Muscle strength, functional status, and muscle enzymes are conventionally used to evaluate disease status in idiopathic inflammatory myopathies (IIM). This study aims to investigate the role of quantitative muscle ultrasound in evaluating disease status in IIM patients. METHODS: Patients with IIM, excluding inclusion body myositis, were recruited along with age- and sex-matched healthy controls (HC). All participants underwent muscle ultrasound and clinical assessments...
March 15, 2024: Muscle & Nerve
https://read.qxmd.com/read/38488242/age-related-and-cancer-related-sarcopenia-is-there-a-difference
#31
JOURNAL ARTICLE
Federico Bozzetti
PURPOSE: The aim of this review is the attempt to differentiating the pathophysiologic and clinical features of the aging-related sarcopenia from cancer-related sarcopenia. In fact, there is some controversy among the experts mainly regarding two points: is always sarcopenia, even that aging-related one, the expression of a generalized disease or may exist independently and without major alteration of the muscle function? Are always aging-related and cancer-related sarcopenia completely separated entities? RECENT FINDINGS: Literature shows that sarcopenia, defined as simple skeletal muscle mass loss, may range from a mainly focal problem which is common in many healthy elderly people, to a component of a complex multiorgan syndrome as cancer cachexia...
March 14, 2024: Current Opinion in Clinical Nutrition and Metabolic Care
https://read.qxmd.com/read/38487922/restorative-effects-of-epicatechin-in-a-rodent-model-of-aging-induced-muscle-atrophy-underlying-mechanisms
#32
JOURNAL ARTICLE
Israel Ramirez-Sanchez, Viridiana Navarrete-Yañez, Lucia Ramirez, Leonor Galera, Enrique Mendez-Bolaina, Veronica Najera, Guillermo Ceballos, Francisco Villarreal
Sarcopenia is a progressive and generalized age-related skeletal muscle (SkM) disorder characterized by the accelerated loss of muscle mass (atrophy) and function. SkM atrophy is associated with increased incidence of falls, functional decline, frailty and mortality. In its early stage, SkM atrophy is associated with increased pro-inflammatory cytokine levels and proteasome-mediated protein degradation. These processes also link to the activation of atrophy associated factors and signaling pathways for which, there is a lack of approved pharmacotherapies...
March 15, 2024: Food & Function
https://read.qxmd.com/read/38487591/dietary-pyrroloquinoline-quinone-hinders-aging-progression-in-male-mice-and-d-galactose-induced-cells
#33
JOURNAL ARTICLE
Nur Syafiqah Mohamad Ishak, Midori Kikuchi, Kazuto Ikemoto
Background: Understanding and promoting healthy aging has become a necessity in the modern world, where life expectancy is rising. The prospective benefits of the antioxidant pyrroloquinoline quinone (PQQ) in healthy aging are promising. However, its role in aging remains unclear. Thus, this study aimed to investigate the effect of PQQ on preventing the progression of aging and to explore its underlying molecular mechanisms. Methods: Naturally aged C57BL/6J male mice were fed a normal diet with or without PQQ (20 mg/kg/day) for 10 weeks...
2024: Front Aging
https://read.qxmd.com/read/38487549/serum-myostatin-as-a-candidate-disease-severity-and-progression-biomarker-of-spinal-muscular-atrophy
#34
JOURNAL ARTICLE
Ana Letícia Amorim de Albuquerque, Júlia Kersting Chadanowicz, Giovanna Câmara Giudicelli, Ana Lucia Portella Staub, Arthur Carpeggiani Weber, Jordana Miranda De Souza Silva, Michele Michelin Becker, Thayne Woycinck Kowalski, Marina Siebert, Jonas Alex Morales Saute
The identification of biomarkers for spinal muscular atrophy is crucial for predicting disease progression, severity, and response to new disease-modifying therapies. This study aimed to investigate the role of serum levels of myostatin and follistatin as biomarkers for spinal muscular atrophy, considering muscle atrophy secondary to denervation as the main clinical manifestation of the disease. The study evaluated the differential gene expression of myostatin and follistatin in a lesional model of gastrocnemius denervation in mice, as well as in a meta-analysis of three datasets in transgenic mice models of spinal muscular atrophy, and in two studies involving humans with spinal muscular atrophy...
2024: Brain communications
https://read.qxmd.com/read/38487400/preclinical-models-of-orthopaedic-trauma-orthopaedic-research-society-ors-and-orthopaedic-trauma-association-ota-symposium-2022
#35
JOURNAL ARTICLE
Patrick M Wise, Augustine M Saiz, Justin Haller, Joseph C Wenke, Thomas Schaer, Prism Schneider, Saam Morshed, Chelsea S Bahney
Orthopaedic trauma remains a leading cause of patient morbidity, mortality, and global health care burden. Although significant advances have been made in the diagnosis, treatment, and rehabilitation of these injuries, complications such as malunion, nonunion, infection, disuse muscle atrophy and osteopenia, and incomplete return to baseline function still occur. The significant inherent clinical variability in fracture care such as differing patient demographics, injury patterns, and treatment protocols make standardized and replicable study, especially of cellular and molecular based mechanisms, nearly impossible...
March 2024: OTA international: the open access journal of orthopaedic trauma
https://read.qxmd.com/read/38484554/long-term-quality-of-life-follow-up-and-functional-impairment-study-in-patients-with-hirayama-disease
#36
JOURNAL ARTICLE
Adeel S Zubair, Rafid Mustafa, Brian Crum
Hirayama Disease (HD) is a focal motor neuron disorder generally affecting young adults with a male predominance who experience weakness and atrophy in distal upper extremity muscles in an asymmetric or unilateral pattern. Progression is insidious though significant weakness occurs during a progressive phase of the disease over 2-5 years. The long-term outcome of HD is not as well-known and, thus, this study presents self-reported outcomes from HD patients years after a diagnosis. Thirty HD patients reported quality of life (QOL) and other functional outcome measures after a mean of just over 11 years from diagnosis...
March 11, 2024: Journal of the Neurological Sciences
https://read.qxmd.com/read/38484275/clinical-reasoning-a-19-month-old-girl-with-infantile-onset-myopathy-and-white-matter-changes
#37
JOURNAL ARTICLE
Gurnoor Lail, Victoria M Siu, Andrew Leung
We describe the case of a 19-month-old girl presenting with gross motor delays, hypotonia, diminished deep tendon reflexes, hyperCKaemia, extensive white matter changes on MRI brain, and electromyography studies consistent with myopathy. The differential diagnosis for infantile-onset hypotonia and muscle weakness is broad. It includes numerous subtypes of genetic disorders, including congenital muscular dystrophies, congenital myopathies, congenital myasthenic syndromes, spinal muscular atrophy, single-gene genetic syndromes, and inborn errors of metabolism...
April 9, 2024: Neurology
https://read.qxmd.com/read/38483114/foxp1-represses-mef2a-in-striated-muscle
#38
JOURNAL ARTICLE
Sydney Steiman, Tetsuaki Miyake, John C McDermott
Myocyte enhancer factor 2 (MEF2) proteins are involved in multiple developmental, physiological, and pathological processes in vertebrates. Protein-protein interactions underlie the plethora of biological processes impacted by MEF2A, necessitating a detailed characterization of the MEF2A interactome. A nanobody based affinity-purification/mass spectrometry strategy was employed to achieve this goal. Specifically, the MEF2A protein complexes were captured from myogenic lysates using a GFP-tagged MEF2A protein immobilized with a GBP-nanobody followed by LC-MS/MS proteomic analysis to identify MEF2A interactors...
March 14, 2024: Molecular and Cellular Biology
https://read.qxmd.com/read/38482807/a-histological-examination-of-the-effects-of-ferula-elaeochytris-extract-on-kidney-and-liver-tissues-in-myoglobinuric-acute-renal-failure
#39
JOURNAL ARTICLE
Fatma Yıldız, Meltem Güngör, Perihan Sezginer, Tiince Aksak
Myoglobinuric acute renal failure (MARF) is a structural and functional disorder that occurs in the kidney following the release of muscle cell contents into the circulation. In this present study, possible protective and curative effects of Ferula elaeochytris extract against kidney and liver damage in experimentally induced MARF in a rat model were investigated. 3-4 Month-old, 200-250 g Sprague Dawley rats were divided into 8 equal groups with 7 rats per group. Group I was a no-intervention Control group...
March 14, 2024: Biotechnic & Histochemistry: Official Publication of the Biological Stain Commission
https://read.qxmd.com/read/38482791/biogelx-ikvav-is-an-innovative-hpl-adsc-delivery-strategy-to-improve-peripheral-nerve-repair
#40
JOURNAL ARTICLE
Martino Guiotto, Alison Clayton, Ryan Morgan, Wassim Raffoul, Andrew Hart, Mathis O Riehle, Pietro Summa
Adipose-derived stem cells (ADSC) are nowadays one of the most exploited cells in regenerative medicine. They are fast growing, capable of enhancing axonal elongation, support and locally stimulate Schwann cells (SC) and protect de-innervated muscles from atrophy after a peripheral nerve injury. With the aim of developing a bio-safe, clinically translatable cell-therapy, we assessed the effect of ADSC pre-expanded with human platelet lysate (hPL) in an in vivo rat model, delivering the cells into a 15 mm critical-size sciatic nerve defect embedded within a laminin-peptide-functionalised hydrogel (Biogelx-IKVAV) wrapped by a poly-"ℇ" -caprolactone (PCL) nerve conduit...
March 14, 2024: Tissue Engineering. Part A
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