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Clara Malagón, Maria Del Pilar Gomez, Catalina Mosquera, Camilo Vargas, Tatiana Gonzalez, Cristine Arango, Lorena Martin, Pilar Perez, Laura Amaya-Uribe, Nicolas Molano-Gonzalez, Juan-Manuel Anaya
Overt polyautoimmunity (PolyA) corresponds to the presence of more than one well-defined autoimmune disease (AD) manifested clinically in a single patient. The current study aimed to describe the main characteristics of juvenile PolyA in a pediatric rheumatology setting and analyze the chronological aspects, index cases, familial autoimmunity, and clustering pattern. This was a cross-sectional and multicenter study in which 313 children with overt PolyA were included. Patients were systematically interviewed and their medical records reviewed using a questionnaire that sought information about demographic, clinical, immunological, and familial characteristics...
February 14, 2019: Autoimmunity Reviews
Kazutaka Okita, Shingo Hatakeyama, Toshiaki Tanaka, Yoshinori Ikehata, Toshikazu Tanaka, Naoki Fujita, Yusuke Ishibashi, Hayato Yamamoto, Takahiro Yoneyama, Yasuhiro Hashimoto, Kazuaki Yoshikawa, Toshiaki Kawaguchi, Naoya Masumori, Hiroshi Kitamura, Chikara Ohyama
PURPOSE: To investigate the impact of the risk group disagreement between the Memorial Sloan Kettering Cancer Center (MSKCC) and the International Metastatic Renal Cell Carcinoma Database Consortium (IMDC) models on prognosis. PATIENTS AND METHODS: We retrospectively evaluated 176 patients with metastatic renal-cell carcinoma who were treated with tyrosine kinase inhibitors as first-line therapy in 5 hospitals between October 2008 and August 2018. The risk group classification differences between the MSKCC and the IMDC models were evaluated using criteria of agreement (identical risk group in both the MSKCC and IMDC models) and disagreement (not identical risk group in both the MSKCC and IMDC models)...
January 17, 2019: Clinical Genitourinary Cancer
Ichiro Yoshii, Kenichi Kitaoka, Kyuichi Hashimoto
BACKGROUND: Second osteoporotic fracture of the hip is a serious comorbidity that can directly cause mortality. Preventing its occurrence is particularly important in Japan, given its rapidly aging society. Here, the clinical characteristics of such recurrence were evaluated using the data of the Clinical Pathway with Regional Alliance (CPRA). METHODS: CPRA for hip fracture started in 2007 and has allowed intranet-based data sharing since July 2011. Data from this alliance, such as number of second cases, duration from initial fracture, Functional Impairment Measure (FIM), revised Hasegawa Dementia Scale (HDS-R) score, muscle force and range of motion of hip joint, and gait status (GS) were collected and statistically evaluated...
February 13, 2019: Journal of Orthopaedic Science: Official Journal of the Japanese Orthopaedic Association
Nusrath Fathima, Parimala Narne, Mohammed Ishaq
PURPOSE: Polymorphic variants of cytotoxic T-lymphocyte antigen-4 (CTLA-4) and forkhead box protein P3 (FOXP3) genes are implicated in dysregulated immune homeostasis and autoimmune disorders. We analyzed the association between CTLA-4 rs231775 and FOXP3 rs3761548, rs3761549 polymorphisms and predisposition to autoimmune thyroid disease (AITD), inclusive of Hashimoto's thyroiditis (HT) and Graves' disease (GD) in South-Indian population. METHODS: A total of 355 AITD subjects (comprising 275 HT and 80 GD) and 285 randomly selected age- and sex-matched control subjects were genotyped for the aforementioned polymorphisms by PCR-RFLP method...
February 15, 2019: Endocrine
Kota Inose, Kazuaki Tanaka, Takeshi Yamada, Hiroyuki Koshino, Masaru Hashimoto
Peribysins O (1), P (3), and Q (4) were isolated from Periconia macrospinosa KT3863. The relative configuration of the 6,7-epoxide of 1 was elucidated by performing quantitative NOE experiments. The structure of 2, which is a tautomer of 1 present in CDCl3 solutions in 5% abundance, was also fully characterized by NMR analysis. Their absolute configurations were independently determined by the modified Mosher's method (for 1 and 3), the electronic circular dichroism (ECD) exciton coupling theory after conversion into dibenzoate 9 (for 3), and theoretical ECD calculations (for 1, 3, and 4)...
February 15, 2019: Journal of Natural Products
Kosuke Hashimoto, Kyoichi Kaira, Kunihiko Kobayashi, Yoshitake Murayama, Hiroshi Kagamu
Spontaneous aspiration of a long tree twig as foreign body is an extremely rare condition. The presence of a permanent tracheal stoma in a laryngectomized patient should be considered as a predisposing factor for foreign body aspiration.
April 2019: Respirology Case Reports
Liyong Ma, Chengkuan Ma, Yuejun Liu, Xuguang Wang
Thyroid disease has now become the second largest disease in the endocrine field; SPECT imaging is particularly important for the clinical diagnosis of thyroid diseases. However, there is little research on the application of SPECT images in the computer-aided diagnosis of thyroid diseases based on machine learning methods. A convolutional neural network with optimization-based computer-aided diagnosis of thyroid diseases using SPECT images is developed. Three categories of diseases are considered, and they are Graves' disease, Hashimoto disease, and subacute thyroiditis...
2019: Computational Intelligence and Neuroscience
Ai Ohnishi, Kunio Hashimoto, Eriko Ozono, Michiyo Sasaki, Ayako Sakamoto, Kasumi Tashiro, Hiroyuki Moriuchi
A 14-year-old girl developed 4 episodes of anaphylaxis of unknown etiology, which required intramuscular adrenaline administration each time. She had eaten pizza and a cheeseburger immediately before the first 2 episodes, respectively, but had not eaten anything for several hours before the last 2 episodes. It turned out that she had eaten the same ice lolly 4 hours before the first 3 episodes and a Café au lait Swirkle (a half-frozen beverage) 4 hours before the last episode. We detected carboxymethylcellulose sodium as the only common ingredient in all anaphylactic episodes...
February 14, 2019: Pediatrics
Natsumi Namba, Aya Kawasaki, Ken-Ei Sada, Fumio Hirano, Shigeto Kobayashi, Hidehiro Yamada, Hiroshi Furukawa, Kota Shimada, Atsushi Hashimoto, Toshihiro Matsui, Kenji Nagasaka, Takahiko Sugihara, Aika Suzuki, Kunihiro Yamagata, Takayuki Sumida, Shigeto Tohma, Sakae Homma, Shoichi Ozaki, Hiroshi Hashimoto, Hirofumi Makino, Yoshihiro Arimura, Masayoshi Harigai, Naoyuki Tsuchiya
No abstract text is available yet for this article.
February 14, 2019: Annals of the Rheumatic Diseases
Noriaki Yamada, Yoshihiro Asano, Masashi Fujita, Satoru Yamazaki, Atsushi Inanobe, Norio Matsuura, Hatasu Kobayashi, Seiko Ohno, Yusuke Ebana, Osamu Tsukamoto, Saki Ishino, Ayako Takuwa, Hidetaka Kioka, Toru Yamashita, Norio Hashimoto, Dimitar P Zankov, Akio Shimizu, Masanori Asakura, Hiroshi Asanuma, Hisakazu Kato, Yuya Nishida, Yohei Miyashita, Haruki Shinomiya, Nobu Naiki, Kenshi Hayashi, Takeru Makiyama, Hisakazu Ogita, Katsuyuki Miura, Hirotsugu Ueshima, Issei Komuro, Masakazu Yamagishi, Minoru Horie, Koichi Kawakami, Tetsushi Furukawa, Akio Koizumi, Yoshihisa Kurachi, Yasushi Sakata, Tetsuo Minamino, Masafumi Kitakaze, Seiji Takashima
BACKGROUND: Bradyarrhythmia is a common clinical manifestation. Although the majority of cases are acquired, genetic analysis of families with bradyarrhythmia has identified a growing number of causative gene mutations. Since the only ultimate treatment for symptomatic bradyarrhythmia has been invasive surgical implantation of a pacemaker, the discovery of novel therapeutic molecular targets is necessary to improve prognosis and quality of life. METHODS: We investigated a family containing seven individuals with autosomal dominant bradyarrhythmias of sinus node dysfunction (SND), atrial fibrillation (AF) with slow ventricular response, and atrio-ventricular block (AV block)...
February 15, 2019: Circulation
Mariko So, Hirofumi Hashimoto, Reiko Saito, Yukiyo Yamamoto, Yasuhito Motojima, Hiromichi Ueno, Satomi Sonoda, Mitsuhiro Yoshimura, Takashi Maruyama, Koichi Kusuhara, Yoichi Ueta
The article Inhibition of ghrelin-induced feeding in rats by pretreatment with a novel dual orexin receptor antagonist, written by Mariko So, Hirofumi Hashimoto.
February 14, 2019: Journal of Physiological Sciences: JPS
Joanna Jackowska, Waldemar Wojnowski, Anna Hashimoto, Bogna Małaczyńska, Krzysztof Piersiala, Piotr Świdziński, Bożena Wiskirska-Woźnica, Małgorzata Wierzbicka
Mechanical debulking of laryngeal papillomas is associated with voice disorders due to impairment of the vocal fold's mucosa. Intraepithelial injection of cidofovir reduces damage to the laryngeal structures and thus improves vocal parameters. The aim of our study was to compare vocal quality before and after cidofovir and CO2 laser treatment by means of objective phoniatric parameters and to obtain evidence concerning voice outcomes. The vocal parameters of 42 patients with RRP were assessed before and after intralesional cidofovir and CO2 laser debulking treatment (Lumenis AcuPulse 40 CO2 laser, wavelength 10...
February 14, 2019: Lasers in Medical Science
Kenji Hashimoto
Inflammation plays a key role in the pathogenesis of a number of psychiatric and neurological disorders. Soluble epoxide hydrolases (sEH), enzymes present in all living organisms, metabolize epoxy fatty acids (EpFAs) to corresponding 1,2-diols by the addition of a molecule of water. Accumulating evidence suggests that sEH in the metabolism of polyunsaturated fatty acids (PUFAs) plays a key role in inflammation. Preclinical studies demonstrated that protein expression of sEH in the prefrontal cortex, striatum, and hippocampus from mice with depression-like phenotype was higher than control mice...
2019: Frontiers in Pharmacology
Michal Pawlak, Katarzyna Z Kedzierska, Maciej Migdal, Karim Abu Nahia, Jordan A Ramilowski, Lukasz Bugajski, Kosuke Hashimoto, Aleksandra Marconi, Katarzyna Piwocka, Piero Carninci, Cecilia L Winata
Organogenesis involves dynamic regulation of gene transcription and complex multipathway interactions. Despite our knowledge of key factors regulating various steps of heart morphogenesis, considerable challenges in understanding its mechanism still exist because little is known about their downstream targets and interactive regulatory network. To better understand transcriptional regulatory mechanism driving heart development and the consequences of its disruption in vivo, we performed time-series analyses of the transcriptome and genome-wide chromatin accessibility in isolated cardiomyocytes (CMs) from wild-type zebrafish embryos at developmental stages corresponding to heart tube morphogenesis, looping, and maturation...
February 13, 2019: Genome Research
Keiichi Muramatsu, Yasuhiro Tominaga, Takahiro Hashimoto, Toshihiko Taguchi
BACKGROUND: The trapeziometacarpal joint is the second most common site of osteoarthritis in the hand and the most frequent one to require surgery. Arthrodesis of the trapeziometacarpal joint is recognized as one of the valuable technique but unfortunately there has been wide variation in the union rate. The purpose of this study was to evaluate a new arthrodesis technique involving a cross-shaped bone graft and locking plate fixation. METHODS: Eleven male patients diagnosed as Eaton's stage III osteoarthritis of the trapeziometacarpal join were treated in our institute...
March 2019: Journal of Hand Surgery Asian-Pacific Volume
Ou Yamaguchi, Kyoichi Kaira, Atsuto Mouri, Ayako Shiono, Kosuke Hashimoto, Yu Miura, Fuyumi Nishihara, Yoshitake Murayama, Kunihiko Kobayashi, Hiroshi Kagamu
BACKGROUND: Re-challenge of erlotinib after gefitinib failure is reported to yield some benefit in patients with non-small cell lung cancer (NSCLC) harboring epidermal growth factor receptor (EGFR) mutation. However, little is known about the re-challenge of afatinib after 1st generate on EGFR tyrosine kinase inhibitor (TKI) failure. METHODS: From May 2015 to August 2018, 62 patients with advanced NSCLC harboring sensitive EGFR mutation received afatinib after gefitinib and/or erlotinib failure at our institution was included in our retrospective study...
February 13, 2019: Cancer Chemotherapy and Pharmacology
Masaaki Misawa, Hideki Hashimoto, Rajiv K Kalia, Syuji Matsumoto, Aiichiro Nakano, Fuyuki Shimojo, Jun Takada, Subodh Tiwari, Kenji Tsuruta, Priya Vashishta
Certain bacteria produce iron oxide material assembled with nanoparticles (NPs) that are doped with silicon (Fe:Si ~ 3:1) in ambient environment. Such biogenous iron oxides (BIOX) proved to be an excellent electrode material for lithium-ion batteries, but underlying atomistic mechanisms remain elusive. Here, quantum molecular dynamics simulations, combined with biomimetic synthesis and characterization, show rapid charging and discharging of NP within 100 fs, with associated surface lithiation and delithiation, respectively...
February 12, 2019: Scientific Reports
Kazutaka Ikegashira, Taku Ikenogami, Takayuki Yamasaki, Takahiro Oka, Yasunori Hase, Naoki Miyagawa, Koji Inagaki, Iichiro Kawahara, Yoshihisa Koga, Hiromasa Hashimoto
Optimization of novel azetidine compounds, which we had found as colony stimulating factor-1 receptor (CSF-1R) Type II inhibitors, provided JTE-952 as a clinical candidate with high cellular activity (IC50  = 20 nM) and good pharmacokinetics profile. JTE-952 was also effective against a mouse collagen-induced model of arthritis (mouse CIA-model). Additionally, the X-ray co-crystal structure of JTE-952 with CSF-1R protein was shown to be a Type II inhibitor, and the kinase panel assay indicated that JTE-952 had high kinase selectivity...
February 7, 2019: Bioorganic & Medicinal Chemistry Letters
Kotaro Hiramatsu, Takuro Ideguchi, Yusuke Yonamine, SangWook Lee, Yizhi Luo, Kazuki Hashimoto, Takuro Ito, Misa Hase, Jee-Woong Park, Yusuke Kasai, Shinya Sakuma, Takeshi Hayakawa, Fumihito Arai, Yu Hoshino, Keisuke Goda
Flow cytometry is an indispensable tool in biology for counting and analyzing single cells in large heterogeneous populations. However, it predominantly relies on fluorescent labeling to differentiate cells and, hence, comes with several fundamental drawbacks. Here, we present a high-throughput Raman flow cytometer on a microfluidic chip that chemically probes single live cells in a label-free manner. It is based on a rapid-scan Fourier-transform coherent anti-Stokes Raman scattering spectrometer as an optical interrogator, enabling us to obtain the broadband molecular vibrational spectrum of every single cell in the fingerprint region (400 to 1600 cm-1 ) with a record-high throughput of ~2000 events/s...
January 2019: Science Advances
Ken Nakamura, Kazuhiro Hashimoto
No abstract text is available yet for this article.
February 9, 2019: Circulation Journal: Official Journal of the Japanese Circulation Society
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