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V Bodolica, M Spraggon
OBJECTIVES: The purpose of this article was twofold. We aimed to both clarify the multidimensional notion of patient empowerment (PE) and conduct a comprehensive survey of PE-related literature in the specific context of the United Arab Emirates (UAE). STUDY DESIGN: The study objectives were achieved by means of a two-phased systematic review of the literature on PE and associated dimensions. METHODS: The first phase consisted in the database search for recent review articles on the construct of PE that were published in the past five years...
March 13, 2019: Public Health
Mai Thi Ngoc Pham, Hoang Quoc Anh, Xuan Truong Nghiem, Binh Minh Tu, Thi Nhung Dao, My Hang Nguyen
The emission profiles and levels of unintentionally produced persistent organic pollutants (U-POPs) comprising polychlorinated dibenzo-p-dioxins/furans (PCDD/Fs) and dioxin-like polychlorinated biphenyls (dl-PCBs) were comprehensively investigated in flue gas released from 20 facilities belonging to 11 thermal industrial processes in Vietnam. Levels and patterns of PCDD/Fs and dl-PCBs in flue gas samples varied widely between sectors and different facilities in the same sector, suggesting different formation mechanisms involved...
March 7, 2019: Chemosphere
Francisco J Marco-Gracia
BACKGROUND: Many societies and their medical practitioners throughout the world have historically linked lunar phases to the frequency of births. During more recent decades, academics have discussed this alleged relationship using modern data, obtaining differing results. OBJECTIVES: The purpose of this study is to analyse the relationship between the phases of the moon and the frequency of deliveries in a rural historical context without electricity, and among women of low nutritional status...
March 2, 2019: European Journal of Obstetrics, Gynecology, and Reproductive Biology
Hyuncheol Bryant Kim, Suejin A Lee, Wilfredo Lim
Health screening provides information on disease risk and diagnosis, but whether this promotes health is unclear. We estimate the impacts of information provided by Korea's National Health Screening Program by applying a regression discontinuity design around different biomarker thresholds of diabetes, obesity, and hyperlipidemia risk using administrative data that includes medical claims, biomarkers, and behavioral surveys over four years after screening. Generally, we find limited responses to disease risk information alone...
March 1, 2019: Journal of Health Economics
Jafar Bakhshaie, Andrew H Rogers, Brooke Y Kauffman, Nhan Tran, Julia D Buckner, Joseph W Ditre, Michael J Zvolensky
The non-medical use of prescription opioids is an area of increasing public health concern, particularly among young college-age adults (ages 18-25) who demonstrate an increased risk of opioid-related problems. Negative mood states are consistently associated with more severe non-medical use of opioid. Emotion dysregulation defined an impaired ability to understand, evaluate, and differentiate one's emotions, and access strategies to regulate them could play an explanatory role in this association. The present study examined the potential explanatory role of emotion dysregulation in the relationship between negative affectivity and non-medical use of prescription opioid among a racially/ethnically diverse young adult sample (N = 2080, 78...
March 8, 2019: Addictive Behaviors
Huan He, Xiaoxiao Gao, Xiaomin Wang, Xin Li, Xiaoxue Jiang, Zhehui Xie, Ke Ma, Jun Ma, Kazuo Umezawa, Yuyang Zhang
This study is aimed to further investigate the anti-atopic dermatitis (AD) activities of dehydroxymethylepoxyquinomicin (DHMEQ) ointment and compare its effect with that of tacrolimus ointment based on the previous study that DHMEQ improves AD-like lesions. AD were induced by 2,4-dinitroclilorobenzene/oxazolone (DNCB/OX) repeatedly on the ears of BABL/C mice while medical tape was additionally used to disrupt stratum corneum in order to exacerbate the lesions. The mice were randomly divided into groups, which are normal, vehicle, DHMEQ (0...
March 13, 2019: International Immunopharmacology
Hamidreza Mahmoudi, Kamran Balighi, Soheil Tavakolpour, Maryam Daneshpazhooh
During the recent decade, several studies have confirmed the high efficacy of targeting the CD20 molecules using rituximab (RTX). Recently, RTX has been suggested as the first-line treatment of pemphigus vulgaris (PV). In this study, the records of all the PV patients, who had received RTX in Autoimmune Bullous Diseases Research Center, Tehran University of Medical Sciences between the 2009 and 2017, have been reviewed for any sign of disease worsening within three months after treatment. We have observed three PV patients from 612 RTX-exposed patients, who had experienced worsening of disease more than one time after discrete RTX cycles after the first infusion of RTX...
March 12, 2019: International Immunopharmacology
Rebecca L Casarez, Emily Barlow, Sriram M Iyengar, Jair C Soares, Thomas D Meyer
OBJECTIVES: Spouses and partners of individuals with bipolar disorder (BD) experience significant burden. As there are some limitations to standard psychosocial caregiver interventions, mobile health technology (mHealth) may be a way to reduce burden and improve well-being in these caregivers. The purpose of this study was to explore how the well-being of spouses or partners of patients with BD can be improved through mHealth technology. METHODS: Using a qualitative design, we conducted five focus groups and one in-depth individual interview to collect information from participants about what they would expect from such a device...
March 6, 2019: Journal of Affective Disorders
Chun-Hong Liu, Li-Rong Tang, Yue Gao, Guang-Zhong Zhang, Bin Li, Meng Li, Marie Woelfer, Walter Martin, Lihong Wang
BACKGROUND: Patients with major depressive disorder (MDD) can frequently develop new depressive episodes after remission. However, the neural mechanisms underlying the increased risk for depressive relapse remain unclear. Herein, we aimed to explore whether the specific changes to regional and inter-regional spontaneous brain activities within DMN are associated with the course of episodes in pooled MDD patients. METHODS: Resting-state functional magnetic resonance imaging was performed on patients with single-episode MDD (SEMDD, n = 30) and multiple-episode MDD (MEMDD, n = 54), and 71 age-, gender-, and educational level-matched healthy controls (HCs)...
March 5, 2019: Journal of Affective Disorders
Gabrielle Crépeau-Gendron, Hilary K Brown, Carrie Shorey, Robert Madan, Claudia Szabuniewicz, Samantha Koh, Shelley Veinish, Linda Mah
BACKGROUND: Although the US Food and Drug Administration (FDA) recommended upper limits for citalopram dosing in older adults due to risk of corrected-QT (QTc) prolongation, which was adopted, and extended to escitalopram by Health Canada, the scientific basis is unclear. The objective of this study was to assess the relationship between citalopram/escitalopram dosages and QTc interval in a real-world geriatric setting. METHODS: We reviewed electronic health records at a university-affiliated geriatric health care center, over a 7-year period, to identify patients prescribed citalopram and escitalopram, who had an ECG within 90 days of initiation or dosage change...
February 26, 2019: Journal of Affective Disorders
Joshua C Black, Gabrielle E Bau, Travis Rosen, M Soledad Cepeda, Gregory P Wedin, Jody L Green, Richard C Dart
OBJECTIVE: To assess changes in mortality rates in extended-release and long-acting (ER/LA) opioid analgesics after the implementation of the Risk Evaluation and Mitigation Strategy (REMS). SETTING: All drug poisoning deaths in three states: Florida, Oregon, and Washington. Data were obtained through state vital records offices and the Researched Abuse, Diversion and Addiction-Related Surveillance System Medical Examiner Program. METHODS: Using cause-of-death literal text from death certificates, individual opioid active pharmaceutical ingredients (APIs) involved in each death were identified using rules-based natural language processing...
March 16, 2019: Pain Medicine: the Official Journal of the American Academy of Pain Medicine
Heather C King, Natalie Spritzer, Nahla Al-Azzeh
INTRODUCTION: The Indo-Asia-Pacific region has the highest incidence of natural disasters world-wide. Since 2000, approximately 1.6 billion people in this region have been affected by earthquakes, volcanos, tsunamis, typhoons, cyclones, and large-scale floods. The aftermath of disasters can quickly overwhelm available resources, resulting in loss of basic infrastructure, shelter, health care, food and water, and ultimately, loss of life.Over the last 12 years, US military forces have collaborated with countries throughout the Indo-Asia-Pacific region to enhance disaster preparedness and management during shipboard global health engagement missions...
March 16, 2019: Military Medicine
Brian A Moore, Willie J Hale, Paul S Nabity, Tyler R Koehn, Donald McGeary, Alan L Peterson
INTRODUCTION: Headaches are one of the world's most common disabling conditions. They are also both highly prevalent and debilitating among military personnel and can have a significant impact on fitness for duty. Hemiplegic migraines are an uncommon, yet severely incapacitating, subtype of migraine with aura for which there has been a significant increase amongst US military personnel over the past decade. To date, there has not been a scientific report on hemiplegic migraine in United States military personnel...
March 16, 2019: Military Medicine
S Bühler, V K Jaeger, S Adler, B Bannert, C Brümmerhoff, A Ciurea, O Distler, J Franz, C Gabay, N Hagenbuch, C Herzog, P Hasler, K Kling, D Kyburz, R Müller, M J Nissen, C A Siegrist, P M Villiger, U A Walker, C Hatz
OBJECTIVES: We aimed to assess the safety and immunogenicity of a diphtheria/tetanus vaccine booster dose in three different patient groups with rheumatic diseases on a variety of immunosuppressive/immunomodulatory medications compared with healthy controls (HCs). METHODS: We conducted a multi-centre prospective cohort study in Switzerland. We enrolled patients with RA, axial SpA/PsA, vasculitis (Behçet's disease, ANCA-associated vasculitis) and HCs. Diphtheria/tetanus vaccination was administered according to the Swiss vaccination recommendations...
March 15, 2019: Rheumatology
Yong Li, Luyan Zou, Tao Li, Dengni Lai, Yanyang Wu, Si Qin
Momordica grosvenori is a valuable edible plant with medicinal purposes, and it is widely used in medicated diets and traditional Chinese medicine in Asia. Mogroside V (MV), the main bioactive component from M. grosvenori, is commonly used as a natural sweetener. M. grosvenori extracts have been reported to exert potent anti-inflammatory property, however the underlying molecular mechanism still remains unknown. In the present study, the biological effect of MV in inflammation was investigated in lipopolysaccharide (LPS)-stimulated RAW264...
March 16, 2019: Acta Biochimica et Biophysica Sinica
Amaryllis Chryssi Malegiannaki, Dimitra Katsarou, Antonios Liolios, Vasiliki Zisi
Individuals with Down Syndrome (DS) are commonly characterized by unique neurocognitive and neurobehavioural profiles that emerge within specific stages in the developmental continuum. A plethora of studies have confirmed DS's relationship to premature aging and subsequent cognitive decline. Due to having three copies of the amyloid precursor protein (APP) gene which results in amyloid-beta plaque deposition, the cognitive decline often resembles the decline observed in Alzheimer's disease. More specifically, as individuals with DS mature in age (>40) they experience a dramatic increase in difficulties in several cognitive domains, such as language, visuo-spatial abilities, executive functions, working memory, etc...
January 2019: Hellenic Journal of Nuclear Medicine
Veronica Falcone, Grammata Kotzaeridi, Melanie Hanne Breil, Ingo Rosicky, Tina Stopp, Gülen Yerlikaya-Schatten, Michael Feichtinger, Wolfgang Eppel, Peter Husslein, Andrea Tura, Christian S Göbl
BACKGROUND: An early identification of the risk groups might be beneficial in reducing morbidities in patients with gestational diabetes mellitus (GDM). Therefore, this study aimed to assess the biochemical predictors of glycemic conditions, in addition to fasting indices of glucose disposal, to predict the development of GDM in later stage and the need of glucose-lowering medication. METHODS: A total of 574 pregnant females (103 with GDM and 471 with normal glucose tolerance [NGT]) were included...
March 12, 2019: Diabetes & Metabolism Journal
Yoo Ri Chung, Kyoung Hwa Ha, Hyeon Chang Kim, Sang Jun Park, Kihwang Lee, Dae Jung Kim
BACKGROUND: To investigate the effects of dipeptidyl peptidase-4 inhibitor (DPP4i) as add-on medications to metformin on progression of diabetic retinopathy (DR) in patients with type 2 diabetes mellitus, compared with sulfonylurea (SU) or thiazolidinedione (TZD). METHODS: We identified 4,447 patients with DPP4i, 6,136 with SU, and 617 with TZD in addition to metformin therapy from the database of Korean National Health Insurance Service between January 2013 and December 2015...
February 20, 2019: Diabetes & Metabolism Journal
Tae Yang Yu, Sang Man Jin, Jae Hwan Jee, Ji Cheol Bae, Moon Kyu Lee, Jae Hyeon Kim
BACKGROUND: It has not been determined whether changes in serum uric acid (SUA) level are associated with incident metabolic syndrome (MetS). The aim of the current study was to investigate the relationship between changes in SUA level and development of MetS in a large number of subjects. METHODS: In total, 13,057 subjects participating in a medical health check-up program without a diagnosis of MetS at baseline were enrolled. Cox proportional hazards models were used to test the independent association of percent changes in SUA level with development of MetS...
February 21, 2019: Diabetes & Metabolism Journal
Ji Hoon Na, Young Mock Lee
BACKGROUND AND PURPOSE: There is an increasing rate of presentations by transient and adult patients (TAPs) to pediatric emergency departments (PED-EDs). TAPs with neurologic diseases (N-TAPs) comprise most of these patients. We investigated this trend and compared the characteristics of N-TAPs with those of pediatric patients with neurologic diseases (N-PEDs) who presented to the PED-ED of a tertiary-care hospital in Korea. METHODS: We reviewed the medical records of neurologic patients who presented to the PED-ED of a single tertiary-care hospital from 2013 to 2017...
March 11, 2019: Journal of Clinical Neurology
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