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Functional symptoms

Jie Fan, Ivy F Tso, Daniel F Maixner, Tessa Abagis, Luis Hernandez-Garcia, Stephan F Taylor
BACKGROUND: The present study tested the hypothesis that network segregation, a graph theoretic measure of functional organization of the brain, is correlated with treatment response in patients with major depressive disorder (MDD) undergoing repetitive transcranial magnetic stimulation (rTMS). METHODS: Network segregation, calculated from resting state functional magnetic resonance imaging scans, was measured in 32 patients with MDD who entered a sham-controlled, double-blinded, randomized trial of rTMS to the left dorsolateral prefrontal cortex, and a cohort of 20 healthy controls (HCs)...
February 13, 2019: NeuroImage: Clinical
D Tolomeo, A Rubegni, M Severino, F Pochiero, C Bruno, D Cassandrini, A Madeo, S Doccini, M Pedemonte, A Rossi, F D'Amore, M A Donati, M Di Rocco, F M Santorelli, C Nesti
Complex I (CI) is the largest component of the mitochondrial respiratory chain (MRC) and it is made up of 7 mitochondrial DNA (mtDNA)-encoded and at least 38 nuclear DNA-encoded subunits. Isolated CI deficiency is the most common single enzyme deficiency in the heterogeneous group of MRC disorders and it is a relatively common etiology of Leigh-like syndrome (LS). With a few exceptions, descriptions of the clinical spectrum of specific mutations in CI are scarce. We here present three unrelated Italian children who harbored the homoplasmic m...
February 6, 2019: Journal of the Neurological Sciences
Burcu Çevik, Öykü Mançe-Çalışır, Eşref Cem Atbaşoğlu, Meram Can Saka, Köksal Alptekin, Alp Üçok, Burcu Sırmatel, Sinan Gülöksüz, Ajlan Tükün, Jim van Os, Güvem Gümüş-Akay
Compared to the general population, individuals diagnosed with Schizophrenia (SCZ) experience a higher frequency and an earlier onset of chronic medical disorders, resulting in a reduction in life expectancy by an average of 15-25 years. Recently, it has been hypothesized that SCZ is a syndrome of accelerated aging. Childhood adversity was also associated with the pathogenesis and course of SCZ. Our hypothesis was that both SCZ patients and their unaffected siblings would have shorter telomere length (TL) compared to of non-clinical controls...
February 8, 2019: Journal of Psychiatric Research
Daisuke Nishi, Kuan-Pin Su, Kentaro Usuda, Jane Pei-Chen Chang, Kei Hamazaki, Tamaki Ishima, Yo Sano, Hiroe Ito, Keiich Isaka, Yoshiyuki Tachibana, Shinji Tanigaki, Tomo Suzuki, Kenji Hashimoto, Yutaka J Matsuoka
BACKGROUND: Omega-3 polyunsaturated fatty acids (PUFAs) reduce depressive symptoms through an anti-inflammatory effect, and injection of both omega-3 PUFAs and estradiol (E2) induces antidepressant-like effects in rats by regulating the expression of inflammatory cytokines. The aims of this study were to examine the association of increased E2 during pregnancy with depressive symptoms and with inflammatory cytokines in women who were and were not supplemented with omega-3 PUFAs. METHODS: Pregnant women with Edinburgh Postnatal Depression Scale scores ≥ 9 were recruited at 12-24 weeks of gestation...
February 15, 2019: Brain, Behavior, and Immunity
Sinisa Maslovara, Silva Butkovic-Soldo, Mihaela Peric, Ivana Pajic Matic, Anamarija Sestak
BACKGROUND: The minimal number of studies have documented the impact of Vestibular rehabilitation (VR) on the recovery rate of patients with Chronic Unilateral Vestibular Hypofunction (CUVH) and Bilateral Vestibular Hypofunction (BVH). OBJECTIVES: The goal of the study was to show and compare the impact of vestibular rehabilitation (VR) in patients with CUVH and BVH. METHODS: We analysed the data of 30 patients with CUVH and 20 with BVH treated with VR...
February 7, 2019: NeuroRehabilitation
Kieran J Marston, Belinda M Brown, Stephanie R Rainey-Smith, Jeremiah J Peiffer
The global population is aging at an unprecedented rate giving rise to a greater prevalence of age-related illnesses such as dementia and vascular disease. Dementia affects approximately 47 million individuals globally with projections of 130 million by the year 2050. Late-onset Alzheimer's disease is the most common form of dementia, accounting for approximately 75% of all cases and is characterized by a progressive decline in cognitive function, memory, and cerebral volume. The pathogenesis of Alzheimer's disease is poorly understood; however, aging, genetics, and an individual's diet and lifestyle over several decades appear to be key determinants...
February 13, 2019: Journal of Alzheimer's Disease: JAD
G Peggy McFall, Kirstie L McDermott, Roger A Dixon
BACKGROUND: Non-demented cognitive aging trajectories are characterized by vast level and slope differences and a spectrum of outcomes, including dementia. OBJECTIVE: The goal of AD risk management (and its corollary, promoting healthy brain aging) is aided by two converging objectives: 1) classifying dynamic distributions of non-demented cognitive trajectories, and 2) identifying modifiable risk-elevating and risk-reducing factors that discriminate stable or normal trajectory patterns from declining or pre-impairment patterns...
February 11, 2019: Journal of Alzheimer's Disease: JAD
Mine Koruyucu, Duygu Yaman, Figen Seymen, Korkud Demirel, Koray Gençay
The aim of this article was to review the literature and present a case of regional odontodysplasia (ROD) with special emphasis on clinical and radiographic features. A 6-year-old girl was referred to our department with the chief complaint of missing her permanent maxillary left central incisor, lateral incisor, and both of her canines. The gingiva of the involved region was enlarged, fibrous, and tense. Radiographic examination showed abnormal tooth formation and shortened roots. After 3 years of follow up with temporary prosthetic rehabilitation, periodontal surgery was performed...
May 2018: European oral research
Juan Pablo Borges Rodrigues Maricevich, Auricelio B Cezar-Junior, Edilson Xavier de Oliveira-Junior, Jose Arthur Morais Veras E Silva, Jorge Vicente Lopes da Silva, Amanda Amorin Nunes, Nivaldo S Almeida, Hildo Rocha Cirne Azevedo-Filho
Background: Cranial reconstruction surgery is a procedure used as an attempt to reestablish the cranial bone anatomy. This study evaluates the symptomatic and aesthetic improvement of patients with cranial defects secondary to decompressive craniectomies after cranial reconstruction with customized polymethyl methacrylate (PMMA) prostheses. Secondly, we aim to divide our experience in the production of these prostheses with a low-cost method. Methods: A prospective study was carried out with patients submitted to cranioplasty at the Hospital da Restauração between 2014 and 2017...
2019: Surgical Neurology International
Jennifer M T A Meessen, Marta Fiocco, Claudia S Leichtenberg, Thea P M Vliet Vlieland, P Eline Slagboom, Rob G H H Nelissen
Introduction: Up to 33% and 25% of patients with end-stage hip and knee osteoarthritis (OA) are considered frail by the Groningen Frailty Indicator (GFI). This study aims to assess whether frail patients have lower functional gains after arthroplasty and to assess GFI as a tool to discriminate between good and adverse change score. Materials and Methods: Patients with end-stage hip/knee OA scheduled for arthroplasty were recruited from the Longitudinal Leiden Orthopaedics Outcomes of Osteo-Arthritis Study ...
2019: Geriatric Orthopaedic Surgery & Rehabilitation
Lucia Rota, Carolina Pellegrini, Laura Benvenuti, Luca Antonioli, Matteo Fornai, Corrado Blandizzi, Antonino Cattaneo, Emanuela Colla
Background: Gastrointestinal dysfunction can affect Parkinson's disease (PD) patients long before the onset of motor symptoms. However, little is known about the relationship between gastrointestinal abnormalities and the development of PD. Contrary to other animal models, the human A53T alpha-synuclein (αS) transgenic mice, Line G2-3, develops αS-driven neurological and motor impairments after 9 months of age, displaying a long presymptomatic phase free of central nervous system (CNS) dysfunction...
2019: Translational Neurodegeneration
Mitra Hariri, Sara Zohdi
New evidence suggests that low serum Vitamin D may cause nonalcoholic fatty liver disease (NAFLD). Hypovitaminosis D is associated with the severity and incidence of NAFLD. The objective of this study was to conduct a systematic review on randomized controlled trials (RCTs) assessing the effect of Vitamin D on serum metabolic profile among NAFLD patients. Databases including PubMed, Institute for Scientific Information Web of Science, Scopus, and Google Scholar were searched up to November 2016. RCTs which studied Vitamin D effect on metabolic profiles and liver function, and conducted among adults were included...
2019: International Journal of Preventive Medicine
Nguyen Xuan Thanh, Philip Jacobs, Jason Suggett, Andrew McIvor, Alan Kaplan
Background: The Aerobika® oscillating positive expiratory pressure (OPEP) device is a hand-held, drug-free medical device that has been shown to improve lung function and improve health-related quality of life in patients with chronic obstructive pulmonary disease (COPD). We estimated the cost-effectiveness of this device among postexacerbation COPD patients in the Canadian healthcare system. Methods: We performed a cost-utility analysis using a Markov model to compare both costs and outcome of patients with COPD who had recently experienced an exacerbation between 2 treatment arms: patients who used the Aerobika® device and patients who did not use the Aerobika® device...
2019: Canadian Respiratory Journal: Journal of the Canadian Thoracic Society
Vatika Harlalka, Raju S Bapi, P K Vinod, Dipanjan Roy
Resting-state functional connectivity (FC) analyses have shown atypical connectivity in autism spectrum disorder (ASD) as compared to typically developing (TD). However, this view emerges from investigating static FC overlooking the whole brain transient connectivity patterns. In our study, we investigated how age and disease influence the dynamic changes in functional connectivity of TD and ASD. We used resting-state functional magnetic resonance imaging (rs-fMRI) data stratified into three cohorts: children (7-11 years), adolescents (12-17 years), and adults (18+ years) for the analysis...
2019: Frontiers in Human Neuroscience
Theresa Coles, Kristina Chen, Lauren Nelson, Nimanee Harris, Montserrat Vera-Llonch, Alan Krasner, Susan Martin
Purpose: To conduct an initial psychometric evaluation of the reliability and validity of the Hypoparathyroidism Symptom Diary (HPT-SD). Patients and methods: Data were collected during a cross-sectional, observational study. Participants with self-reported hypoparathyroidism (HPT) completed the HPT-SD, the Functional Assessment in Cancer Therapy-Cognitive Function (FACT-Cog), the Functional Assessment of Chronic Illness Therapy-Fatigue (FACIT-Fatigue), and the Hospital Anxiety and Depression Scale (HADS) measures...
2019: Patient related Outcome Measures
Yang Yang, Shengru Liang, Yuqian Li, Fei Gao, Yuan Cao, Xiaoyu Zhao, Guodong Gao, Lihong Li
Background: Both protective and therapeutic functions of insulin-like growth factor-1 (IGF-1) in brain injury have been reported, but its effects on cognitive sequelae after septic encephalopathy (SE) remain unclear. Materials and methods: This study was divided into three parts, and a septic model was built by cecal ligation and puncture (CLP). First, survival analysis was performed, and IGF-1's effects on long-term cognition and depressive emotion were assessed...
2019: Neuropsychiatric Disease and Treatment
Navin Kaushal, Francis Langlois, Laurence Desjardins-Crépeau, Martin S Hagger, Louis Bherer
Background: Older adults are at risk of multiple chronic diseases, most of which could be prevented by engaging in regular physical activity. Frailty is a state of increased vulnerability to diseases. Worsening symptoms of frailty, such as decrease in physical functionality, can compromise health-related quality of life (HR-QOL). Previous findings suggest that frailty moderates the relationship between physical activity and HR-QOL, yet intervention findings are limited, particularly in dose-response analyses...
2019: Clinical Interventions in Aging
Ewelina Bąk, Czesław Marcisz, Adriana Borodzicz, Danuta Sternal, Sylwia Krzemińska
Purpose: The main purpose of this study was to compare the level of health-related quality of life (HRQoL) using Nottingham Health Profile (NHP) in Polish patients with rheumatoid arthritis (RA) during therapy applying disease-modifying antirheumatic drugs (DMARDs) with conventional synthetics (csDMARDs) or with csDMARDs in combination with biological drugs (bDMARDs). The second purpose was to analyze the correlation between the domain values of NHP and the demographic and clinical parameters, functional efficiency, and mood...
2019: Patient Preference and Adherence
Tilemachos Koutouratsas, Theodora Kalli, Georgios Karamanolis, Maria Gazouli
Functional gastrointestinal disorders (FGID) are heterogeneous disorders with a variety of clinical manifestations, primarily defined by signs and symptoms rather than a definite underlying cause. Their pathophysiology remains obscure and, although it is expected to differ according to the specific FGID, disruptions in the brain-gut axis are now thought to be a common denominator in their pathogenesis. The hormone ghrelin is an important component of this axis, exerting a wide repertoire of physiological actions, including regulation of gastrointestinal motility and protection of mucosal tissue...
February 7, 2019: World Journal of Gastroenterology: WJG
Caroline J Bell, James A Foulds, L John Horwood, Roger T Mulder, Joseph M Boden
BACKGROUND: The extent to which exposure to childhood sexual and physical abuse increases the risk of psychotic experiences in adulthood is currently unclear.AimsTo examine the relationship between childhood sexual and physical abuse and psychotic experiences in adulthood taking into account potential confounding and time-dynamic covariate factors. METHOD: Data were from a cohort of 1265 participants studied from birth to 35 years. At ages 18 and 21, cohort members were questioned about childhood sexual and physical abuse...
March 2019: British Journal of Psychiatry: the Journal of Mental Science
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