Ethan T Whitman, Calen P Ryan, Wickliffe C Abraham, Angela Addae, David L Corcoran, Maxwell L Elliott, Sean Hogan, David Ireland, Ross Keenan, Annchen R Knodt, Tracy R Melzer, Richie Poulton, Sandhya Ramrakha, Karen Sugden, Benjamin S Williams, Jiayi Zhou, Ahmad R Hariri, Daniel W Belsky, Terrie E Moffitt, Avshalom Caspi
Biological aging is the correlated decline of multi-organ system integrity central to the etiology of many age-related diseases. A novel epigenetic measure of biological aging, DunedinPACE, is associated with cognitive dysfunction, incident dementia, and mortality. Here, we tested for associations between DunedinPACE and structural MRI phenotypes in three datasets spanning midlife to advanced age: the Dunedin Study (age=45 years), the Framingham Heart Study Offspring Cohort (mean age=63 years), and the Alzheimer's Disease Neuroimaging Initiative (mean age=75 years)...
January 24, 2024: Neurobiology of Aging