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Yi-Chuan Xiao

Chuan-Ming Xie, Mingjia Tan, Xiao-Tong Lin, Di Wu, Yihan Jiang, Ye Tan, Haomin Li, Yuanyuan Ma, Xiufang Xiong, Yi Sun
FBXW7 is a tumor suppressive E3 ligase, whereas RAS-ERK and mechanistic target of rapamycin kinase (mTORC1) are two major oncogenic pathways. Whether and how FBXW7 regulates these two oncogenic pathways are unknown. Here, we showed that SHOC2, a RAS activator, is a FBXW7 substrate. Growth stimuli trigger SHOC2 phosphorylation on Thr507 by the mitogen-activated protein kinase (MAPK) signal, which facilitates FBXW7 binding for ubiquitylation and degradation. FBXW7-mediated SHOC2 degradation terminates the RAS-MAPK signals and inhibits proliferation...
March 12, 2019: Cell Reports
Chuan-Xia Zhang, Shu-Biao Ye, Jian-Jiao Ni, Ting-Ting Cai, Yi-Na Liu, Dai-Jia Huang, Hai-Qiang Mai, Qiu-Yan Chen, Jia He, Xiao-Shi Zhang, Yi-Xin Zeng, Jiang Li, Jun Cui
Stimulator of interferon genes (STING), a major adaptor protein in antiviral innate immune signaling, is considered as one of the most important regulators of antiviral and antitumor immunity. Although STING agonists are now intensively studied in clinical trials as a new class of adjuvants to boost cancer immunotherapy, the tumor-intrinsic role of the STING pathway in shaping the tumor microenvironment remains controversial. Here, we discovered that STING plays a vital role in regulation of myeloid-derived suppressor cell (MDSC) differentiation and antitumor immunity in Epstein-Barr virus (EBV)-associated nasopharyngeal carcinoma (NPC)...
February 28, 2019: Cell Death and Differentiation
Tao Wan, Xiao-Feng Zhang, Chao Liang, Chuan-Wen Liao, Jia-Yi Li, Yan-Ming Zhou
BACKGROUND: Neoadjuvant therapy (NAT) before radical excision has become the preferred initial option for locally advanced digestive cancers such as esophageal cancer (EC), esophagogastric junction adenocarcinoma (EGJAC), gastric adenocarcinoma (GAC), rectal cancer (RC), and pancreatic cancer (PC). Although some patients reportedly achieve a pathologic complete response (pCR) after neoadjuvant therapy, the published data are inconsistent regarding whether pCR yields a survival benefit...
February 25, 2019: Annals of Surgical Oncology
Jin Chuan Wei, Tian Yi Xu, Jing Wu, Xiao Feng Song
Recursive splicing refers to the biological process that long introns are removed in multiple steps during pre-mRNA splicing. In comparison to large introns (>10 kb), most introns in higher eukaryotic genomes are removed in one step during transcription. Previous studies have revealed that recursive splicing events play important roles in many biological processes, including the pathogenesis and development of diseases. In recent years, more researchers have focused on recursive splicing events and found that recursive splicing occurs in Drosophila and many other vertebrates...
February 20, 2019: Yi Chuan, Hereditas
Di Wu, Wen-Yi Zhou, Xiao-Tong Lin, Lei Fang, Chuan-Ming Xie
OBJECTIVE: Bufalin has been reported to kill various types of cancer including human colorectal cancer. Our previous study demonstrated that bufalin induced cell death via autophagy in HT-29 and Caco-2 colon cancer cells, but the action of bufalin remains unclear. This study was conducted to investigate the role of bufalin in other colon cancer HCT-116 and SW620 cells as well as its potential mechanism. METHODS: The effect of bufalin in HCT-116 and SW620 colon cancer cells was detected by assessing cell viability and cell death...
February 19, 2019: Drug and Chemical Toxicology
Hai-Bo Li, Jing Zhang, Xiao-Mei Li, Shao-Yi Zhou, Chuan-Qiang Niu, Zhen-Yin Liu, Li-Gong Lu
The aim of the present retrospective study was to investigate the clinical safety and efficacy of absolute ethanol combined with n-butyl cyanoacrylate sclerotherapy in the treatment of Puig's classified advanced venous malformation. Sclerotherapy was performed in 121 children (52 males and 69 females; age range, 5 months to 16 years) with venous malformations under general anesthesia between April 2009 and October 2014 at the Department of Interventional Radiology and Vascular Anomalies, Guangzhou Women and Children's Medical Center, Guangzhou, China...
February 2019: Experimental and Therapeutic Medicine
Chuan-Xin Cui, Yi-Quan Li, Yu-Jia Sun, Yi-Long Zhu, Jin-Bo Fang, Bing Bai, Wen-Jie Li, Shan-Zhi Li, Yi-Zhen Ma, Xiao Li, Wei-Hua Wang, Ning-Yi Jin
PURPOSE: Apoptin can specifically kill cancer cells but has no toxicity to normal cells. Human telomerase reverse transcriptase (hTERT) acts as a tumor-specific promoter, triggering certain genes to replicate or express only in tumor cells, conferring specific replication and killing abilities. This study aimed to investigate the anticancer potential of the recombinant adenovirus Ad-apoptin-hTERTp-E1a (Ad-VT) in prostate cancer. METHODS: The pGL4.51 plasmid was used to transfect PC-3 cells to construct tumor cells stably expressing luciferase (PC-3-luc)...
January 18, 2019: Urologic Oncology
Hui-Yi Wang, Qiao-Yun Long, Shan-Bo Tang, Qiong Xiao, Chuan Gao, Quan-Yi Zhao, Qing-Lan Li, Mei Ye, Lei Zhang, Lian-Yun Li, Min Wu
Hippo pathway is involved in tumorigenesis, and its regulation in cytosol has been extensively studied, but its regulatory mechanisms in the nuclear are not clear. In the current study, using a FBS-inducing model following serum starvation, we identified KDM3A, a demethylase of histone H3K9me1/2, as a positive regulator for hippo target genes. KDM3A promotes gene expression through two mechanisms, one is to upregulate YAP1 expression, and the other is to facilitate H3K27ac on the enhancers of hippo target genes...
January 15, 2019: Nucleic Acids Research
Xiao-Jian Zhang, Han-Zhong Deng, Nan Liu, Yi-Chuan Gong, Zhi-Qiang Liu, Yu-Guo Zheng
Asymmetric synthesis of chiral epichlorohydrin (ECH) from 1,3-dichloro-2-propanol (1,3-DCP) using halohydrin dehalogenases (HHDHs) is of great value due to the 100% theoretical yield and high enantioselectivity. The vital problem in the asymmetric synthesis is to prepare optically pure ECH. In this study, key amino acid residues located at halide ion channels of HheC (P175S/W249P) (HheCPS ) were modified to regulate the kinetic parameters. HheCPS I81W, F86N and V94R were constructed with the corresponding halide ion channels destroyed...
December 27, 2018: Bioresource Technology
Yu Gang Liu, Yong Sheng Teng, Ping Cheng, Hui Kong, Yi Pin Lv, Fang Yuan Mao, Xiao Long Wu, Chuan Jie Hao, Weisan Chen, Shi Ming Yang, Jin Yu Zhang, Liu Sheng Peng, Ting Ting Wang, Bin Han, Qiang Ma, Quan Ming Zou, Yuan Zhuang
Cathepsin C (CtsC) functions as a central coordinator for activation of many serine proteases in immune cells. However, CtsC expression in gastric epithelial cells and its role in Helicobacter pylori infection remain unclear. Real-time PCR, Western blot, and immunohistochemistry analyses identified that CtsC was decreased in gastric mucosa of H. pylori-infected patients and mice. Isolated gastric epithelial cells and cell lines were stimulated with H. pylori and/or TGF-β1 showed that down-regulation of CtsC in gastric epithelial cells largely depended on H...
December 31, 2018: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
Wan-Hong Zhao, Jie Liu, Bai-Yan Wang, Yin-Xia Chen, Xing-Mei Cao, Yun Yang, Yi-Lin Zhang, Fang-Xia Wang, Peng-Yu Zhang, Bo Lei, Liu-Fang Gu, Jian-Li Wang, Nan Yang, Ru Zhang, Hui Zhang, Ying Shen, Ju Bai, Yan Xu, Xu-Geng Wang, Rui-Li Zhang, Li-Li Wei, Zong-Fang Li, Zhen-Zhen Li, Yan Geng, Qian He, Qiu-Chuan Zhuang, Xiao-Hu Fan, Ai-Li He, Wang-Gang Zhang
BACKGROUND: Chimeric antigen receptor (CAR) T cell therapy has demonstrated proven efficacy in some hematologic cancers. We evaluated the safety and efficacy of LCAR-B38M, a dual epitope-binding CAR T cell therapy directed against 2 distinct B cell maturation antigen epitopes, in patients with relapsed/refractory (R/R) multiple myeloma (MM). METHODS: This ongoing phase 1, single-arm, open-label, multicenter study enrolled patients (18 to 80 years) with R/R MM...
December 20, 2018: Journal of Hematology & Oncology
Ben-Rui Zhao, Bao-Quan Yao, Chuan-Peng Qian, Gao-You Liu, Yi Chen, Rui-Xue Wang, Tong-Yu Dai, Xiao-Ming Duan
A high-efficiency and high-brightness Ho:YAG master-oscillator power-amplifier (MOPA) system dual-end pumped by Tm:YLF lasers was demonstrated. The maximum output power of 231 W at a wavelength of 2090.7 nm was achieved with pulse repetition frequency of 10 kHz and pulse width of 22.9 ns, corresponding to pulse energy of 23.1 mJ and peak power of ∼1  MW. The extraction efficiency of the amplifier system was more than 60%. The beam quality factor M2 was measured to be ∼1.05. Using the Ho:YAG MOPA system as the pump source, the ZnGeP2 optical parametric oscillator delivered an output power of 110 W, corresponding to slope efficiency of 62%...
December 15, 2018: Optics Letters
Jun Xiao, Jian-Hong Zhong, Sheng-Hong Wei, Zai-Sheng Ye, Fu-Sheng Gong, Chang Wang, Yi Zeng, Lu-Chuan Chen
BACKGROUND: Cancer associated fibroblasts (CAFs) are known to be crucial constituents of cancer microenvironment (CME) and play an important role in initiation, progression and metastasis of various types of cancer, such as oral cancer, pancreatic cancer, and gastric cancer. CAFs are usually derived from normal fibroblasts (NFs), but the mechanism of the transition in gastric cancer has not yet been fully elucidated. METHODS: qRT-PCR and western blot were employed to investigate differences of miR-141 and STAT4 expression respectively...
November 28, 2018: Experimental and Molecular Pathology
Gui-Yuan Xiao, Bin Peng, Ying Hu, Dou Qu, Min-Qing Lai, Yu Gong, Feng-Lan Zhao, Hong Yi, Yu Jia, Wei-Kang Zhou, Shan-Chuan Lei, Sha-Li Wang, Jing Xia, Deng-Zhi Lv, Shan Geng, Rong-Li Bai, Xiao-Ni Zhong
With the objective of investigating the characteristics influencing high-risk sexual behaviours in elderly men (60-74 years of age) in Chongqing, China, a total of 1433 healthy elderly men with sexual intercourse frequencies of one to six times/month who were willing to participate in the questionnaires were studied at four hospitals. We measured serum testosterone levels and performed follow-ups every six months, with a total of 1128 elderly men followed up after two years. We also investigated socio-economic and demographic characteristics (age, education, income, location, marital status and number of marriages), types of sexual partners, age differences with fixed sexual partners, frequency of sexual intercourse, combined basic age-related diseases, sexually transmitted infections (STIs) education, elderly self-care ability and high-risk sexual behaviours (frequency of sexual intercourse and number of sexual partners) using questionnaires...
November 28, 2018: International Journal of STD & AIDS
Tian-Ju Wan, Yi-Chuan Yu, Xiao-Gang Zhao, Ping Tang, Yong-Shu Gong
Background: Some patients still complain of residual dizziness after successful canalith repositioning procedure (CRP) for benign paroxysmal positional vertigo (BPPV). Previous study found that compared to the low-dose betahistine, the high-dose betahistine could yield better efficacy in treating residual dizziness. Therefore, this study was conducted to assess whether the addition of cognitive behavioral therapy (CBT) could make low-dose betahistine produce similar results to high-dose betahistine in treating residual dizziness...
2018: Neuropsychiatric Disease and Treatment
Z K Lin, W J Song
Wu Jinshou()[(1785-1795)-(1844-1851)]once wanted to take the imperial examination, but in late Qing Dynasty, under the depressed situation of economics and politics, he was trapped in countryside as many lower intellectuals, and chose medicine as another way to earn a living. In fact, he was both a doctor and a literatus. He kept friends with scholars, such as Zhang Tingji, Yao Wentian, Lu Changchun, Wei Guangfu, and scholar-physicians like Chen XIshu, Lu zeng and also Xu Jin's family, famous doctors at that time...
July 28, 2018: Zhonghua Yi Shi za Zhi, Chinese Journal of Medical History
Chuan-Yi Peng, Yan-Ling Zhang, Wei Song, Ya-Ning Lv, Qian Xu, Ping Zheng, Zhu-Zheng Zhang, Xiao-Chun Wan, Ru-Yan Hou, Hui-Mei Cai
BACKGROUND: Confirmation of food labeling that claims production in a small geographic region is critical to traceability, quality control and brand protection. In the current study, isotope ratio mass spectrometry (IRMS) was used to generate profiles of δ13 C and δ15 N to determine if the stable isotope signatures of Keemun black tea differ within the three counties that claim production. Other factors (cultivar type, leaf maturity and manufacturing process) were considered for their potential effects...
November 9, 2018: Journal of the Science of Food and Agriculture
Jiang-Nan Wu, Wei-Rong Gu, Xi-Rong Xiao, Yi Zhang, Xiao-Tian Li, Chuan-Min Yin
BACKGROUND/OBJECTIVES: Gestational weight gain (GWG) recommendations for pregnant women with gestational diabetes mellitus (GDM) in China are lacking. The present study aims to examine whether specific GWG targets for women with GDM can improve pregnancy outcomes in comparison with GWG according to the Institute of Medicine (IOM) targets. SUBJECTS/METHODS: Pregnant women diagnosed with GDM were selected from a retrospective cohort study of 8299 singleton pregnant women aged 18-45 years in 2012 (n = 1820)...
October 30, 2018: European Journal of Clinical Nutrition
Jun-Chi Xu, Fei Gao, Yi-An Liu, Xiao-Long Zhang, Hui Chen, Xiao-Yan Zhu, Hua-Feng Song, Feng Qian, Ming Li, Chen Yang, Chuan-Wu Zhu, Ping Xu
This study analysed the biological significance of TLT-2 on CD8+ T cells in hepatitis B patients and provided a theoretical basis for the potential role of TLT-2 as an immune regulator. Flow cytometry sorting, isobaric tags for relative and absolute quantitation and short hairpin RNAs were used to analyse the function of TLT-2 on CD8+ T cells in hepatitis B patients. The TLT-2 expression levels in the acute hepatitis B and chronic hepatitis B groups were significantly higher than that in the healthy control group and were positively correlated with ALT and AST...
October 25, 2018: Clinical and Experimental Medicine
Yi-Ning Qiu, Guo-Hui Wang, Fen Zhou, Jin-Jin Hao, Li Tian, Long-Fei Guan, Xiao-Kun Geng, Yu-Chuan Ding, He-Wen Wu, Ke-Zhong Zhang
BACKGROUND: The increasing epidemic of fine particulate matter (PM2.5) is a serious threat to human health. It induces the occurrence of liver fibrosis, but its molecular mechanism is not yet clear. The molecular mechanisms of PM2.5 inducing liver fibrosis were investigated in this study. METHODS: The cell viability of LX-2 cells and primary hepatic stellate cells (HSCs) was detected using 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay...
January 15, 2019: Ecotoxicology and Environmental Safety
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