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Shao-Cong Sun

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https://read.qxmd.com/read/30775255/application-of-fluorescence-in-situ-hybridization-in-the-detection-of-bladder-transitional-cell-carcinoma-a-multi-center-clinical-study-based-on-chinese-population
#1
Liqun Zhou, Kaiwei Yang, Xuesong Li, Yi Ding, Dawei Mu, Hanzhong Li, Yong Yan, Jinyi Li, Dongwen Wang, Wei Li, Yulong Cong, Jiangping Gao, Kewei Ma, Yajun Xiao, Sheng Zhang, Hongyi Jiang, Weilie Hu, Qiang Wei, Xunbo Jin, Zhichen Guan, Qingyong Liu, Danfeng Xu, Xin Gao, Yongguang Jiang, Weimin Gan, Guang Sun, Qing Wang, Yanhui Liu, Jianquan Hou, Liping Xie, Xishuang Song, Fengshuo Jin, Jiafu Feng, Ming Cai, Zhaozhao Liang, Jie Zhang, Dingwei Ye, Lin Qi, Lulin Ma, Jianzhong Shou, Yuping Dai, Jianyong Shao, Ye Tian, Shizhe Hong, Tao Xu, Chuize Kong, Zefeng Kang, Yuexin Liu, Xun Qu, Benkang Shi, Shaobin Zheng, Yi Lin, Shujie Xia, Dong Wei, Jianbo Wu, Weiling Fu, Zhiping Wang, Jianbo Liang
Objective: To evaluate the diagnostic value of fluorescence in situ hybridization (FISH) in bladder cancer. Methods: We enrolled healthy volunteers and patients who were clinically suspected to have bladder cancer and conducted FISH tests and cytology examinations from August 2007 to December 2008. Receiver operating characteristic (ROC) curve analysis was performed and the area under curve (AUC) values were calculated for both the FISH and urine cytology tests...
January 2019: Asian Journal of Urology
https://read.qxmd.com/read/30770835/author-correction-fgl2-promotes-tumor-progression-in-the-cns-by-suppressing-cd103-dendritic-cell-differentiation
#2
Jun Yan, Qingnan Zhao, Konrad Gabrusiewicz, Ling-Yuan Kong, Xueqing Xia, Jian Wang, Martina Ott, Jingda Xu, R Eric Davis, Longfei Huo, Ganesh Rao, Shao-Cong Sun, Stephanie S Watowich, Amy B Heimberger, Shulin Li
The original version of this Article contained errors in the author affiliations. Qingnan Zhao, Xueqing Xia, Longfei Huo and Shulin Li were incorrectly associated with Beijing Institute for Brain Disorders, 100069, Beijing, China.This has now been corrected in both the PDF and HTML versions of the Article.
February 15, 2019: Nature Communications
https://read.qxmd.com/read/30683885/fgl2-promotes-tumor-progression-in-the-cns-by-suppressing-cd103-dendritic-cell-differentiation
#3
Jun Yan, Qingnan Zhao, Konrad Gabrusiewicz, Ling-Yuan Kong, Xueqing Xia, Jian Wang, Martina Ott, Jingda Xu, R Eric Davis, Longfei Huo, Ganesh Rao, Shao-Cong Sun, Stephanie S Watowich, Amy B Heimberger, Shulin Li
Few studies implicate immunoregulatory gene expression in tumor cells in arbitrating brain tumor progression. Here we show that fibrinogen-like protein 2 (FGL2) is highly expressed in glioma stem cells and primary glioblastoma (GBM) cells. FGL2 knockout in tumor cells did not affect tumor-cell proliferation in vitro or tumor progression in immunodeficient mice but completely impaired GBM progression in immune-competent mice. This impairment was reversed in mice with a defect in dendritic cells (DCs) or CD103+ DC differentiation in the brain and in tumor-draining lymph nodes...
January 25, 2019: Nature Communications
https://read.qxmd.com/read/30622699/cell-type-specific-function-of-traf2-and-traf3-in-regulating-type-i-ifn-induction
#4
Xiaoping Xie, Jin Jin, Lele Zhu, Zuliang Jie, Yanchuan Li, Baoyu Zhao, Xuhong Cheng, Pingwei Li, Shao-Cong Sun
Background: TRAF3 is known as a central mediator of type I interferon (IFN) induction by various pattern recognition receptors, but the in vivo function of TRAF3 in host defense against viral infection is poorly defined due to the lack of a viable mouse model. Results: Here we show that mice carrying conditional deletion of TRAF3 in myeloid cells or dendritic cells do not have a significant defect in host defense against vesicular stomatitis virus (VSV) infection...
2019: Cell & Bioscience
https://read.qxmd.com/read/30487606/fbxo38-mediates-pd-1-ubiquitination-and-regulates-anti-tumour-immunity-of-t-cells
#5
Xiangbo Meng, Xiwei Liu, Xingdong Guo, Shutan Jiang, Tingting Chen, Zhiqiang Hu, Haifeng Liu, Yibing Bai, Manman Xue, Ronggui Hu, Shao-Cong Sun, Xiaolong Liu, Penghui Zhou, Xiaowu Huang, Lai Wei, Wei Yang, Chenqi Xu
Dysfunctional T cells in the tumour microenvironment have abnormally high expression of PD-1 and antibody inhibitors against PD-1 or its ligand (PD-L1) have become commonly used drugs to treat various types of cancer1-4 . The clinical success of these inhibitors highlights the need to study the mechanisms by which PD-1 is regulated. Here we report a mechanism of PD-1 degradation and the importance of this mechanism in anti-tumour immunity in preclinical models. We show that surface PD-1 undergoes internalization, subsequent ubiquitination and proteasome degradation in activated T cells...
December 2018: Nature
https://read.qxmd.com/read/30327840/deficiency-of-lrp4-in-zebrafish-and-human-lrp4-mutation-induce-aberrant-activation-of-jagged-notch-signaling-in-fin-and-limb-development
#6
Jing Tian, Jinhui Shao, Cong Liu, Hsin-Yu Hou, Chih-Wei Chou, Mohammad Shboul, Guo-Qing Li, Mohammad El-Khateeb, Omar Q Samarah, Yao Kou, Yu-Hsuan Chen, Mei-Jen Chen, Zhaojie Lyu, Wei-Leng Chen, Yu-Fu Chen, Yong-Hua Sun, Yi-Wen Liu
Low-density lipoprotein receptor-related protein 4 (LRP4) is a multi-functional protein implicated in bone, kidney and neurological diseases including Cenani-Lenz syndactyly (CLS), sclerosteosis, osteoporosis, congenital myasthenic syndrome and myasthenia gravis. Why different LRP4 mutation alleles cause distinct and even contrasting disease phenotypes remain unclear. Herein, we utilized the zebrafish model to search for pathways affected by a deficiency of LRP4. The lrp4 knockdown in zebrafish embryos exhibits cyst formations at fin structures and the caudal vein plexus, malformed pectoral fins, defective bone formation and compromised kidney morphogenesis; which partially phenocopied the human LRP4 mutations and were reminiscent of phenotypes resulting form a perturbed Notch signaling pathway...
October 16, 2018: Cellular and Molecular Life Sciences: CMLS
https://read.qxmd.com/read/30301667/mir-30-family-reduction-maintains-self-renewal-and-promotes-tumorigenesis-in-nsclc-initiating-cells-by-targeting-oncogene-tm4sf1
#7
Yu-Shui Ma, Fei Yu, Xiao-Ming Zhong, Gai-Xia Lu, Xian-Ling Cong, Shao-Bo Xue, Wen-Ting Xie, Li-Kun Hou, Li-Juan Pang, Wei Wu, Wei Zhang, Le-Le Cong, Tie Liu, Hui-Deng Long, Ran Sun, Hong-Yan Sun, Zhong-Wei Lv, Chun-Yan Wu, Da Fu
Increasing evidence indicates that tumor-initiating cells (TICs) are responsible for the occurrence, development, recurrence, and development of the drug resistance of cancer. MicroRNA (miRNA) plays a significant functional role by directly regulating targets of TIC-triggered non-small-cell lung cancer (NSCLC), but little is known about the function of the miR-30 family in TICs. In this study, we found the miR-30 family to be downregulated during the spheroid formation of NSCLC cells, and patients with lower miR-30a/c expression had shorter overall survival (OS) and progression-free survival (PFS)...
September 13, 2018: Molecular Therapy: the Journal of the American Society of Gene Therapy
https://read.qxmd.com/read/30250187/nik-signaling-axis-regulates-dendritic-cell-function-in-intestinal-immunity-and-homeostasis
#8
Zuliang Jie, Jin-Young Yang, Meidi Gu, Hui Wang, Xiaoping Xie, Yanchuan Li, Ting Liu, Lele Zhu, Jianhong Shi, Lingyun Zhang, Xiaofei Zhou, Donghyun Joo, Hans D Brightbill, Yingzi Cong, Daniel Lin, Xuhong Cheng, Shao-Cong Sun
Dendritic cells (DCs) play an integral role in regulating mucosal immunity and homeostasis, but the signaling network mediating this function of DCs is poorly defined. We identified the noncanonical NF-κB-inducing kinase (NIK) as a crucial mediator of mucosal DC function. DC-specific NIK deletion impaired intestinal immunoglobulin A (IgA) secretion and microbiota homeostasis, rendering mice sensitive to an intestinal pathogen, Citrobacter rodentium. DC-specific NIK was required for expression of the IgA transporter polymeric immunoglobulin receptor (pIgR) in intestinal epithelial cells, which in turn relied on the cytokine IL-17 produced by TH 17 cells and innate lymphoid cells (ILCs)...
November 2018: Nature Immunology
https://read.qxmd.com/read/30247157/peli1-facilitates-virus-replication-and-promotes-neuroinflammation-during-west-nile-virus-infection
#9
Huanle Luo, Evandro R Winkelmann, Shuang Zhu, Wenjuan Ru, Elizabeth Mays, Jesus A Silvas, Lauren L Vollmer, Junling Gao, Bi-Hung Peng, Nathen E Bopp, Courtney Cromer, Chao Shan, Guorui Xie, Guangyu Li, Robert Tesh, Vsevolod L Popov, Pei-Yong Shi, Shao-Cong Sun, Ping Wu, Robyn S Klein, Shao-Jun Tang, Wenbo Zhang, Patricia V Aguilar, Tian Wang
The E3 ubiquitin ligase Pellino 1 (Peli1) is a microglia-specific mediator of autoimmune encephalomyelitis. Its role in neurotropic flavivirus infection is largely unknown. Here, we report that mice deficient in Peli1 (Peli1-/-) were more resistant to lethal West Nile virus (WNV) infection and exhibited reduced viral loads in tissues and attenuated brain inflammation. Peli1 mediates chemokine and proinflammatory cytokine production in microglia and promotes T cell and macrophage infiltration into the CNS. Unexpectedly, Peli1 was required for WNV entry and replication in mouse macrophages and mouse and human neurons and microglia...
November 1, 2018: Journal of Clinical Investigation
https://read.qxmd.com/read/30141123/effect-of-maternal-folic-acid-supplementation-on-prostatitis-risk-in-the-rat-offspring
#10
Jing Zhu, Yu-Ling Jia, Yong-Wei Luo, Dong-Yan Huang, Cong-Cong Shao, Lei Li, Li Zhou, Zu-Yue Sun
PURPOSE: Folic acid (FA) intake has increased to high levels in many countries for the prevention of neural tube defects. However, the impact of excess FA intake, particularly before and during pregnancy, requires further investigation. Our aim was to investigate the effect of maternal folic acid supplementation on prostatitis risk in the rat offspring. METHODS: Female SD rats were administrated with different doses of FA by oral gavage from 2 weeks prior to mating to GD14: 0 mg/kg (distilled water), 0...
November 2018: International Urology and Nephrology
https://read.qxmd.com/read/30140268/tumor-necrosis-factor-receptor-associated-factor-regulation-of-nuclear-factor-%C3%AE%C2%BAb-and-mitogen-activated-protein-kinase-pathways
#11
REVIEW
Jian-Hong Shi, Shao-Cong Sun
Tumor necrosis factor receptor (TNFR)-associated factors (TRAFs) are a family of structurally related proteins that transduces signals from members of TNFR superfamily and various other immune receptors. Major downstream signaling events mediated by the TRAF molecules include activation of the transcription factor nuclear factor κB (NF-κB) and the mitogen-activated protein kinases (MAPKs). In addition, some TRAF family members, particularly TRAF2 and TRAF3, serve as negative regulators of specific signaling pathways, such as the noncanonical NF-κB and proinflammatory toll-like receptor pathways...
2018: Frontiers in Immunology
https://read.qxmd.com/read/30128145/dopaminergic-neurons-show-increased-low-molecular-mass-protein-7-activity-induced-by-6-hydroxydopamine-in-vitro-and-in-vivo
#12
Ming-Shu Mo, Gui-Hua Li, Cong-Cong Sun, Shu-Xuan Huang, Lei Wei, Li-Min Zhang, Miao-Miao Zhou, Zhuo-Hua Wu, Wen-Yuan Guo, Xin-Ling Yang, Chao-Jun Chen, Shao-Gang Qu, Jian-Xing He, Ping-Yi Xu
Background: Abnormal expression of major histocompatibility complex class I (MHC-I) is increased in dopaminergic (DA) neurons in the substantia nigra (SN) in Parkinson's disease (PD). Low-molecular-mass protein 7 (β5i) is a proteolytic subunit of the immunoproteasome that regulates protein degradation and the MHC pathway in immune cells. Methods: In this study, we investigated the role of β5i in DA neurons using a 6-hydroxydopamine (6-OHDA) model in vitro and vivo ...
2018: Translational Neurodegeneration
https://read.qxmd.com/read/30116335/changes-in-bone-mineral-density-and-bone-metabolic-indexes-in-ankylosing-spondylitis-mouse-model-complicated-with-osteoporosis
#13
Zi-Bing Hu, Bo Wei, Shao-Ke Wu, Jie-Cong Sun, Min Xiang, Zhong-Min Zhang
Changes in bone mineral density and bone metabolic indexes in a model of ankylosing spondylitis (AS) mice complicated with osteoporosis (OP) were investigated. BLAB/c mice were used as the subjects. AS was induced using proteoglycan, and OP was induced using tail suspension method. The mice were randomly divided into four groups: AS group, OP group, AS + OP group and negative control group. Changes in bone mineral density, bone strength, serum calcium (Ca), phosphorus, alkaline phosphatase (ALP) and tartrate-resistant acid phosphatase (TRACP), in mice of each group were detected and compared...
August 2018: Experimental and Therapeutic Medicine
https://read.qxmd.com/read/30115741/metabolic-control-of-regulatory-t-cell-stability-and-function-by-traf3ip3-at-the-lysosome
#14
Xiaoyan Yu, Xiao-Lu Teng, Feixiang Wang, Yuhan Zheng, Guojun Qu, Yan Zhou, Zhilin Hu, Zhongqiu Wu, Yuzhou Chang, Lei Chen, Hua-Bing Li, Bing Su, Liming Lu, Zhiduo Liu, Shao-Cong Sun, Qiang Zou
Metabolic programs are crucial for regulatory T (T reg) cell stability and function, but the underlying mechanisms that regulate T reg cell metabolism are elusive. Here, we report that lysosomal TRAF3IP3 acts as a pivotal regulator in the maintenance of T reg cell metabolic fitness. T reg-specific deletion of Traf3ip3 impairs T reg cell function, causing the development of inflammatory disorders and stronger antitumor T cell responses in mice. Excessive mechanistic target of rapamycin complex 1 (mTORC1)-mediated hyper-glycolytic metabolism is responsible for the instability of TRAF3IP3-deficient T reg cells...
September 3, 2018: Journal of Experimental Medicine
https://read.qxmd.com/read/30054854/deubiquitinases-as-pivotal-regulators-of-t-cell-functions
#15
REVIEW
Xiao-Dong Yang, Shao-Cong Sun
T cells efficiently respond to foreign antigens to mediate immune responses against infections but are tolerant to self-tissues. Defect in T cell activation is associated with severe immune deficiencies, whereas aberrant T cell activation contributes to the pathogenesis of diverse autoimmune and inflammatory diseases. An emerging mechanism that regulates T cell activation and tolerance is ubiquitination, a reversible process of protein modification that is counter-regulated by ubiquitinating enzymes and deubiquitinases (DUBs)...
August 2018: Frontiers of Medicine
https://read.qxmd.com/read/30054192/7%C3%AE-methyl-substituent-is-a-structural-locus-associated-with-activity-cliff-for-nepenthone-analogues
#16
Hui-Jiao Sun, Yu-Hua Wang, Cong-Min Yuan, Ling-Hui Kong, Xue-Jun Xu, Yu-Jun Wang, Hai-Hao Wu, Cheng Lin, Yuan-Yuan Qian, Huo-Ming Huang, Li Xiao, Xiao Liu, Qian He, Sheng-Yang Fang, Deng-Qi Xue, Xi-Cheng Yang, Hao Chen, Yi-Lin Zheng, Lan Zheng, Lin-Qian Yu, Qiong Xie, Wei Fu, Wei Li, Jing-Gen Liu, Zhui-Bai Qiu, Li-Ming Shao
With the purpose of identifying novel selective κ opioid receptor (KOR) antagonists as potential antidepressants from nepenthone analogues, starting from N-nor-N-cyclopropylmethyl-nepenthone (SLL-020ACP), a highly selective and potent KOR agonist, a series of 7β-methyl-nepenthone analogues was conceived, synthesized and assayed on opioid receptors based on the concept of hybridization. According to the pharmacological results, the functional reversal observed in orvinol analogues by introduction of 7β-methyl substituent could not be reproduced in nepenthone analogues...
August 7, 2018: Bioorganic & Medicinal Chemistry
https://read.qxmd.com/read/30022064/tbk-binding-protein-1-regulates-il-15-induced-autophagy-and-nkt-cell-survival
#17
Lele Zhu, Xiaoping Xie, Lingyun Zhang, Hui Wang, Zuliang Jie, Xiaofei Zhou, Jianhong Shi, Shuli Zhao, Boxiang Zhang, Xuhong Cheng, Shao-Cong Sun
The cytokine IL-15 mediates development and survival of immune cells, including natural killer T (NKT) cells, but the underlying mechanism of IL-15 function is incompletely understood. Here we show that IL-15 induces autophagy in NKT cells with a mechanism that involves a crucial signaling component, TBK-binding protein 1 (Tbkbp1). Tbkbp1 facilitates activation of the autophagy-initiating kinase Ulk1 through antagonizing the inhibitory action of mTORC1. This antagonization involves the recruitment of an mTORC1-opposing phosphatase to Ulk1...
July 18, 2018: Nature Communications
https://read.qxmd.com/read/29789521/triad3a-induces-the-degradation-of-early-necrosome-to-limit-ripk1-dependent-cytokine-production-and-necroptosis
#18
Norah A Alturki, Scott McComb, Ardeshir Ariana, Dikchha Rijal, Robert G Korneluk, Shao-Cong Sun, Emad Alnemri, Subash Sad
Understanding the molecular signaling in programmed cell death is vital to a practical understanding of inflammation and immune cell function. Here we identify a previously unrecognized mechanism that functions to downregulate the necrosome, a central signaling complex involved in inflammation and necroptosis. We show that RipK1 associates with RipK3 in an early necrosome, independent of RipK3 phosphorylation and MLKL-induced necroptotic death. We find that formation of the early necrosome activates K48-ubiquitin-dependent proteasomal degradation of RipK1, Caspase-8, and other necrosomal proteins...
May 22, 2018: Cell Death & Disease
https://read.qxmd.com/read/29726618/metformin-s-antitumour-and-anti-angiogenic-activities-are-mediated-by-skewing-macrophage-polarization
#19
Ji-Chang Wang, Xin Sun, Qiang Ma, Gui-Feng Fu, Long-Long Cong, Hong Zhang, De-Fu Fan, Jun Feng, Shao-Ying Lu, Jian-Lin Liu, Guang-Yue Li, Pei-Jun Liu
Beneficial effects of metformin on cancer risk and mortality have been proved by epidemiological and clinical studies, thus attracting research interest in elucidating the underlying mechanisms. Recently, tumour-associated macrophages (TAMs) appeared to be implicated in metformin-induced antitumour activities. However, how metformin inhibits TAMs-induced tumour progression remains ill-defined. Here, we report that metformin-induced antitumour and anti-angiogenic activities were not or only partially contributed by its direct inhibition of functions of tumour and endothelial cells...
May 4, 2018: Journal of Cellular and Molecular Medicine
https://read.qxmd.com/read/29669287/zranb1-is-an-ezh2-deubiquitinase-and-a-potential-therapeutic-target-in-breast-cancer
#20
Peijing Zhang, Zhenna Xiao, Shouyu Wang, Mutian Zhang, Yongkun Wei, Qinglei Hang, Jongchan Kim, Fan Yao, Cristian Rodriguez-Aguayo, Baochau N Ton, Minjung Lee, Yumeng Wang, Zhicheng Zhou, Liyong Zeng, Xiaoyu Hu, Sarah E Lawhon, Ashley N Siverly, Xiaohua Su, Jia Li, Xiaoping Xie, Xuhong Cheng, Liang-Chiu Liu, Hui-Wen Chang, Shu-Fen Chiang, Gabriel Lopez-Berestein, Anil K Sood, Junjie Chen, M James You, Shao-Cong Sun, Han Liang, Yun Huang, Xianbin Yang, Deqiang Sun, Yutong Sun, Mien-Chie Hung, Li Ma
Although EZH2 enzymatic inhibitors have shown antitumor effects in EZH2-mutated lymphoma and ARID1A-mutated ovarian cancer, many cancers do not respond because EZH2 can promote cancer independently of its histone methyltransferase activity. Here we identify ZRANB1 as the EZH2 deubiquitinase. ZRANB1 binds, deubiquitinates, and stabilizes EZH2. Depletion of ZRANB1 in breast cancer cells results in EZH2 destabilization and growth inhibition. Systemic delivery of ZRANB1 small interfering RNA (siRNA) leads to marked antitumor and antimetastatic effects in preclinical models of triple-negative breast cancer (TNBC)...
April 17, 2018: Cell Reports
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