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https://read.qxmd.com/read/30892157/treatments-for-iron-deficiency-id-prospective-organic-iron-fortification
#1
Dan Wan, Qinghua Wu, Hengjia Ni, Gang Liu, Zheng Ruan, Yulong Yin
Iron deficiency, one of the most common nutritional deficient disorders, frequently affects infants, adolescents and pregnant women and impairs growth, development and immune responses. Iron deficiency may also be secondary to gastrointestinal conditions such as gastrectomy and inflammatory bowel disease, as well as cancer and chronic uremia. Iron supplementation is the most commonly selected treatment option for iron deficiency. This review summarizes the iron compounds currently recommended for the iron fortification of foods and for clinical use...
March 18, 2019: Current Pharmaceutical Design
https://read.qxmd.com/read/30876056/near-infrared-optics-of-nanoparticles-embedded-silica-thin-films
#2
Yanpei Tian, Alok Ghanekar, Lijuan Qian, Matthew Ricci, Xiaojie Liu, Gang Xiao, Otto Gregory, Yi Zheng
This work investigates experimentally the near-infrared optical properties of SiO2 thin film embedded with tungsten (W) nanoparticles at varying volume fractions. The samples are prepared by using the technique of magnetron sputtering. The formation and distribution of W nanoparticles are characterized using transmission electron microscopy, and the volume fraction of W nanoparticles is validated by Auger electron spectroscopy. Near- and mid-infrared diffuse reflectance measurements are conducted using Fourier transform infrared spectroscopy...
February 18, 2019: Optics Express
https://read.qxmd.com/read/30871612/risk-factors-of-atrial-fibrillation-occurring-after-radical-surgery-of-esophageal-carcinoma
#3
Jun Tang, Jian-Zhu Zhao, Kai-Ming Ren, Fu-Shuang Zheng, Xi-Wen Wang, Hai-Jun Liu, Jun-Gang Zhao, Ji-Bin Lu
BACKGROUND: Atrial fibrillation (AF) is a common complication after radical surgery of esophageal cancer. The aim of this study was to explore AF risk factors after radical surgery of esophageal carcinoma. METHOD: The data of 335 patients with esophageal cancer who were admitted in our hospital from January 2014 to August 2016 for the first time were retrospectively analyzed. We retrieved the papers in some data banks using the search terms including English and Chinese search terms, and obtained 13 factors which were mentioned in more than 6 papers...
March 14, 2019: Journal of Cardiothoracic Surgery
https://read.qxmd.com/read/30867820/microporous-polysaccharide-multilayer-coated-bcp-composite-scaffolds-with-immobilised-calcitriol-promote-osteoporotic-bone-regeneration-both-in-vitro-and-in-vivo
#4
Qian Tang, Zhichao Hu, Haiming Jin, Gang Zheng, XingFang Yu, Gang Wu, Haixiao Liu, Zhenzhong Zhu, Huazi Xu, Changqing Zhang, Liyan Shen
Incorporating a biomimetic coating and integrating osteoinductive biomolecules into basic bone substitutes are two common strategies to improve osteogenic capabilities in bone tissue engineering. Currently, the underlying mechanism of osteoporosis (OP)-related deficiency of osteogenesis remains unclear, and few treatments target at OP-related bone regeneration. Herein, we describe a self-assembling polyelectrolyte multilayered (PEM) film coating with local immobilisation of calcitriol (Cal) in biphasic calcium phosphate (BCP) scaffolds to promote osteoporotic bone regeneration by targeting the calcium sensing receptor (CaSR)...
2019: Theranostics
https://read.qxmd.com/read/30862559/changes-of-t-lymphocyte-subsets-in-patients-with-hiv-negative-symptomatic-neurosyphilis
#5
Li-Li Liu, Wen-Na Liu, Xiao-Yong Jiang, Jun-Ren, Mei-Hua Chen, Zhao-Ji Liu, Yong Lin, Shao-Gang Zhu, Li-Rong Lin, Wei-Hong Zheng, Jiang-Hua Yan, Tian-Ci Yang
OBJECTIVES: The host immune response could be an imperative factor in the pathogenesis of neurosyphilis, but the role of T lymphocyte subsets remains unclear. In the present study, we assessed the CD4+ T and CD8+ T cell subsets in the peripheral blood of patients with HIV-negative symptomatic neurosyphilis and then explored the clinical application value of neurosyphilis. METHODS: In total, 24 patients with HIV-negative symptomatic neurosyphilis and 22 patients with syphilis/non-neurosyphilis were included in this study and cerebrospinal fluid (CSF) and blood samples were obtained...
March 9, 2019: Microbial Pathogenesis
https://read.qxmd.com/read/30858362/whole-genome-resequencing-reveals-brassica-napus-origin-and-genetic-loci-involved-in-its-improvement
#6
Kun Lu, Lijuan Wei, Xiaolong Li, Yuntong Wang, Jian Wu, Miao Liu, Chao Zhang, Zhiyou Chen, Zhongchun Xiao, Hongju Jian, Feng Cheng, Kai Zhang, Hai Du, Xinchao Cheng, Cunming Qu, Wei Qian, Liezhao Liu, Rui Wang, Qingyuan Zou, Jiamin Ying, Xingfu Xu, Jiaqing Mei, Ying Liang, You-Rong Chai, Zhanglin Tang, Huafang Wan, Yu Ni, Yajun He, Na Lin, Yonghai Fan, Wei Sun, Nan-Nan Li, Gang Zhou, Hongkun Zheng, Xiaowu Wang, Andrew H Paterson, Jiana Li
Brassica napus (2n = 4x = 38, AACC) is an important allopolyploid crop derived from interspecific crosses between Brassica rapa (2n = 2x = 20, AA) and Brassica oleracea (2n = 2x = 18, CC). However, no truly wild B. napus populations are known; its origin and improvement processes remain unclear. Here, we resequence 588 B. napus accessions. We uncover that the A subgenome may evolve from the ancestor of European turnip and the C subgenome may evolve from the common ancestor of kohlrabi, cauliflower, broccoli, and Chinese kale...
March 11, 2019: Nature Communications
https://read.qxmd.com/read/30853353/genomic-and-transcriptomic-landscape-of-triple-negative-breast-cancers-subtypes-and-treatment-strategies
#7
Yi-Zhou Jiang, Ding Ma, Chen Suo, Jinxiu Shi, Mengzhu Xue, Xin Hu, Yi Xiao, Ke-Da Yu, Yi-Rong Liu, Ying Yu, Yuanting Zheng, Xiangnan Li, Chenhui Zhang, Pengchen Hu, Jing Zhang, Qi Hua, Jiyang Zhang, Wanwan Hou, Luyao Ren, Ding Bao, Bingying Li, Jingcheng Yang, Ling Yao, Wen-Jia Zuo, Shen Zhao, Yue Gong, Yi-Xing Ren, Ya-Xin Zhao, Yun-Song Yang, Zhenmin Niu, Zhi-Gang Cao, Daniel G Stover, Claire Verschraegen, Virginia Kaklamani, Anneleen Daemen, John R Benson, Kazuaki Takabe, Fan Bai, Da-Qiang Li, Peng Wang, Leming Shi, Wei Huang, Zhi-Ming Shao
We comprehensively analyzed clinical, genomic, and transcriptomic data of a cohort of 465 primary triple-negative breast cancer (TNBC). PIK3CA mutations and copy-number gains of chromosome 22q11 were more frequent in our Chinese cohort than in The Cancer Genome Atlas. We classified TNBCs into four transcriptome-based subtypes: (1) luminal androgen receptor (LAR), (2) immunomodulatory, (3) basal-like immune-suppressed, and (4) mesenchymal-like. Putative therapeutic targets or biomarkers were identified among each subtype...
February 19, 2019: Cancer Cell
https://read.qxmd.com/read/30853309/advancement-in-tpl2-regulated-innate-immune-response
#8
REVIEW
Ming-Hao Yan, Jun-Hong Hao, Xue-Gang Zhang, Chao-Chao Shen, Da-Jun Zhang, Ke-Shan Zhang, Hai-Xue Zheng, Xiang-Tao Liu
Tumor progression locus 2 (TPL2) is a serine/threonine kinase that belongs to the MAP3K family. The activated TPL2 regulates the innate immune-relevant signaling pathways, such as ERK, JNK, and NF-κB, and the differentiation of immune cells, for example, CD4+ T and NK cells. Therefore, TPL2 plays a critical role in regulating the innate immune response. The present review summarizes the recent advancements in the TPL2-regulated innate immune response.
March 5, 2019: Immunobiology
https://read.qxmd.com/read/30848011/vesicular-antibodies-a-bioactive-multifunctional-combination-platform-for-targeted-therapeutic-delivery-and-cancer-immunotherapy
#9
Xue Liu, Chao Liu, Zizheng Zheng, Siyuan Chen, Xin Pang, Xinchu Xiang, Jixian Tang, En Ren, Yuanzhi Chen, Min You, Xiaoyong Wang, Xiaoyuan Chen, Wenxin Luo, Gang Liu, Ningshao Xia
The ability to selectively kill cancerous cell populations while leaving healthy cells unaffected is a key goal in oncology. The use of nanovesicles (NVs) as chemotherapeutic delivery vehicles has been recently proven successful, yet monotherapy with monomodalities remains a significant limitation for solid tumor treatment. Here, as a proof of principle, a novel cell-membrane-derived NVs that can display full-length monoclonal antibodies (mAbs) is engineered. The high affinity and specificity of mAb for tumor-specific antigens allow these vesicular antibodies (VAs) to selectively deliver a cytotoxic agent to tumor cells and exert potent inhibition effects...
March 7, 2019: Advanced Materials
https://read.qxmd.com/read/30847744/sinomenine-attenuates-cartilage-degeneration-by-regulating-mir-223-3p-nlrp3-inflammasome-signaling
#10
Hai-Chao Dong, Pei-Nan Li, Chang-Jian Chen, Xin Xu, Hong Zhang, Gang Liu, Lian-Jie Zheng, Peng Li
Sinomenine (SIN) has been shown to protect against IL-1β-induced chondrocyte apoptosis in vitro. However, the role of SIN in the anterior cruciate ligament transection (ACLT)-induced osteoarthritis (OA) mouse model and its underlying molecular mechanisms remain unclear. In the present study, the protective effect of SIN on ACLT-induced articular cartilage degeneration and IL-1β-induced chondrocyte apoptosis miR-223-3p/NLRP3 signaling regulation was investigated. Safranin O staining was performed to evaluate the pathological changes of articular cartilage...
March 7, 2019: Inflammation
https://read.qxmd.com/read/30838172/-pparg-rs3856806-c-t-polymorphism-increased-the-risk-of-colorectal-cancer-a-case-control-study-in-eastern-chinese-han-population
#11
Jing Lin, Yu Chen, Wei-Feng Tang, Chao Liu, Sheng Zhang, Zeng-Qing Guo, Gang Chen, Xiong-Wei Zheng
Purpose: Functional variants in the peroxisome proliferator-activated receptor gamma ( PPARG ) and PPARG co-activator 1 ( PPARGC1 ) family (e.g., PPARGC1A and PPARGC1B ) genes were predicted to confer susceptibility to colorectal cancer (CRC). The aim of the present study was to explore the relationship between PPARG, PPARGC1A, PPARGC1B polymorphism and the risk of CRC. Patients and methods: We conducted a case-control study with 1,003 CRC cases and 1,303 controls. We selected the PPARG rs3856806 C>T, PPARGC1A rs2970847 C>T, rs8192678 C>T, rs3736265 G>A and PPARGC1B rs7732671 G>C and rs17572019 G>A SNPs to assess the relationship between PPARG, PPARGC1A, PPARGC1B their variants and risk of CRC...
2019: Frontiers in Oncology
https://read.qxmd.com/read/30825190/identification-of-tak-632-and-its-analogues-as-potent-inhibitors-of-necroptosis-by-targeting-ripk1-and-ripk3
#12
Xiaofei Chen, Chunlin Zhuang, Yibin Ren, Hao Zhang, Xia Qin, Longmiao Hu, Jing Fu, Zhenyuan Miao, Yifeng Chai, Zheng-Gang Liu, Haibing Zhang, Zhenyu Cai, Hong-Yang Wang
BACKGROUND AND PURPOSE: Necroptosis is a form of programmed, caspase-independent cell death that is mediated by receptor-interacting protein kinases, RIPK1 and RIPK3, and the mixed lineage kinase domain-like (MLKL). Necroptosis contributes to the pathophysiology of various inflammatory, infectious and degenerative diseases. Thus, identification of small molecule inhibitors for necroptosis has broad therapeutic relevance. Herein, we identified that TAK-632 was an inhibitor of necroptosis and further generated a more selective, highly potent analogue by targeting RIPK1 and RIPK3...
March 1, 2019: British Journal of Pharmacology
https://read.qxmd.com/read/30799039/acetylation-blocks-cgas-activity-and-inhibits-self-dna-induced-autoimmunity
#13
Jiang Dai, Yi-Jiao Huang, Xinhua He, Ming Zhao, Xinzheng Wang, Zhao-Shan Liu, Wen Xue, Hong Cai, Xiao-Yan Zhan, Shao-Yi Huang, Kun He, Hongxia Wang, Na Wang, Zhihong Sang, Tingting Li, Qiu-Ying Han, Jie Mao, Xinwei Diao, Nan Song, Yuan Chen, Wei-Hua Li, Jiang-Hong Man, Ai-Ling Li, Tao Zhou, Zheng-Gang Liu, Xue-Min Zhang, Tao Li
The presence of DNA in the cytoplasm is normally a sign of microbial infections and is quickly detected by cyclic GMP-AMP synthase (cGAS) to elicit anti-infection immune responses. However, chronic activation of cGAS by self-DNA leads to severe autoimmune diseases for which no effective treatment is available yet. Here we report that acetylation inhibits cGAS activation and that the enforced acetylation of cGAS by aspirin robustly suppresses self-DNA-induced autoimmunity. We find that cGAS acetylation on either Lys384, Lys394, or Lys414 contributes to keeping cGAS inactive...
February 8, 2019: Cell
https://read.qxmd.com/read/30794921/aromatic-monoterpenoid-glycosides-from-rattan-stems-of-schisandra-chinensis-and-their-neuroprotective-activities
#14
Yan Liu, Jiang-Tao Guo, Zhi-Bin Wang, Zu-Yi Li, Gui-Xue Zheng, Yong-Gang Xia, Bing-You Yang, Hai-Xue Kuang
Six new monoterpenoid glycosides, including thymoquinol 5-O-α-L-arabinopyranosyl-(1 → 6)-β-D-glucopyranoside (1), cuminic acid 7-O-α-D-arabinofuranosyl-(1 → 6)-β-d-glucopyranosyl ester (2), p-cymene 7-O-α-D-arabinofuranosyl-(1 → 6)-β-D-glucopyranoside (3), p-methylhyd- ratropic acid 9-O-α-D-arabinofuranosyl-(1 → 6)-β-d-glucopyranosyl ester (4), (R)-p-cymene 9-O-α- D-arabinofuranosyl-(1 → 6)-β-D-glucopyranoside (5), and (R)-p-cymene 9-O-β-D-apiofuranosyl-(1 → 6)-β-D-glucopyranoside (6), together with three known compounds, such as (R)-p-cymene 9-O-β-D-glucopyranoside (7), thymoquinol 5-O-β-D-glucopyranoside (8), and thymoquinol 2-O-β-D-glucopyranoside (9) were isolated from the 70%-EtOH extract of Schisandra chinensis rattan stems...
February 19, 2019: Fitoterapia
https://read.qxmd.com/read/30792863/international-consensus-on-natural-orifice-specimen-extraction-surgery-noses-for-colorectal-cancer
#15
Xu Guan, Zheng Liu, Antonio Longo, Jian-Chun Cai, William Tzu-Liang Chen, Lu-Chuan Chen, Ho-Kyung Chun, Joaquim Manuel da Costa Pereira, Sergey Efetov, Ricardo Escalante, Qing-Si He, Jun-Hong Hu, Cuneyt Kayaalp, Seon-Hahn Kim, Jim S Khan, Li-Jen Kuo, Atsushi Nishimura, Fernanda Nogueira, Junji Okuda, Avanish Saklani, Ali A Shafik, Ming-Yin Shen, Jung-Tack Son, Jun-Min Song, Dong-Hui Sun, Keisuke Uehara, Gui-Yu Wang, Ye Wei, Zhi-Guo Xiong, Hong-Liang Yao, Gang Yu, Shao-Jun Yu, Hai-Tao Zhou, Suk-Hwan Lee, Petr V Tsarkov, Chuan-Gang Fu, Xi-Shan Wang
In recent years, natural orifice specimen extraction surgery (NOSES) in the treatment of colorectal cancer has attracted widespread attention. The potential benefits of NOSES including reduction in postoperative pain and wound complications, less use of postoperative analgesic, faster recovery of bowel function, shorter length of hospital stay, better cosmetic and psychological effect have been described in colorectal surgery. Despite significant decrease in surgical trauma of NOSES have been observed, the potential pitfalls of this technique have been demonstrated...
February 2019: Gastroenterology Report
https://read.qxmd.com/read/30792309/a-caspr1-atp1b3-protein-interaction-modulates-plasma-membrane-localization-of-na-k-atpase-in-brain-microvascular-endothelial-cells
#16
Shu-Hong Zhang, Dong-Xin Liu, Li Wang, Yu-Hua Li, Yan-Hua Wang, Hu Zhang, Zheng-Kang Su, Wen-Gang Fang, Xiao-Xue Qin, De-Shu Shang, Bo Li, Xiao-Ning Han, Wei-Dong Zhao, Yu-Hua Chen
Contactin-associated protein 1 (CASPR1 or CNTNAP1) was recently reported to be expressed in brain microvascular endothelial cells (BMECs), the major component of the blood-brain barrier. To investigate CASPR1's physiological role in BMECs, here we used CASPR1 as a bait in a yeast two-hybrid screen to identify CASPR1-interacting proteins and identified the β3 subunit of Na+ /K+ -ATPase (ATP1B3) as a CASPR1-binding protein. Using recombinant and purified CASPR1, RNAi, GST-pull down, immunofluorescence and -precipitation, and Na+ /K+ -ATPase activity assays, we found that ATP1B3's core proteins, but not its glycosylated forms, interact with CASPR1, which was primarily located in the endoplasmic reticulum of BMECs...
February 21, 2019: Journal of Biological Chemistry
https://read.qxmd.com/read/30786863/genome-wide-investigation-of-the-ap2-erf-gene-family-in-tartary-buckwheat-fagopyum-tataricum
#17
Moyang Liu, Wenjun Sun, Zhaotang Ma, Tianrun Zheng, Li Huang, Qi Wu, Gang Zhao, Zizhong Tang, Tongliang Bu, Chenglei Li, Hui Chen
BACKGROUND: AP2/ERF transcription factors perform indispensable functions in various biological processes, such as plant growth, development, biotic and abiotic stresses responses. The AP2/ERF transcription factor family has been identified in many plants, and several AP2/ERF transcription factors from Arabidopsis thaliana (A. thaliana) have been functionally characterized. However, little research has been conducted on the AP2/ERF genes of tartary buckwheat (Fagopyum tataricum), which is an important edible and medicinal crop...
February 20, 2019: BMC Plant Biology
https://read.qxmd.com/read/30746376/intravenous-leiomyomatosis-with-different-surgical-approaches-three-case-reports
#18
Jie He, Zheng-Bo Chen, San-Ming Wang, Mu-Biao Liu, Zhi-Gang Li, Hai-Yan Li, Gang Zhao
BACKGROUND: Intravenous leiomyomatosis (IVL) is a rare and complicated disease, which requires surgery by a multidisciplinary team. However, the optimal surgical approach has not been determined. CASE SUMMARY: Here we report three cases of IVL treated with different surgical approaches. All patients presented with circulation symptoms. Two patients had lower extremity edema and the other had cardiopalmus. The diagnosis of IVL was confirmed based on the imagining examinations and pathological findings...
February 6, 2019: World Journal of Clinical Cases
https://read.qxmd.com/read/30741975/human-macrophages-survive-and-adopt-activated-genotypes-in-living-zebrafish
#19
Colin D Paul, Alexus Devine, Kevin Bishop, Qing Xu, William J Wulftange, Hannah Burr, Kathryn M Daly, Chaunte Lewis, Daniel S Green, Jack R Staunton, Swati Choksi, Zheng-Gang Liu, Raman Sood, Kandice Tanner
The inflammatory response, modulated both by tissue resident macrophages and recruited monocytes from peripheral blood, plays a critical role in human diseases such as cancer and neurodegenerative disorders. Here, we sought a model to interrogate human immune behavior in vivo. We determined that primary human monocytes and macrophages survive in zebrafish for up to two weeks. Flow cytometry revealed that human monocytes cultured at the physiological temperature of the zebrafish survive and differentiate comparable to cohorts cultured at human physiological temperature...
February 11, 2019: Scientific Reports
https://read.qxmd.com/read/30741936/tradd-regulates-perinatal-development-and-adulthood-survival-in-mice-lacking-ripk1-and-ripk3
#20
John P Dowling, Mohamed Alsabbagh, Christina Del Casale, Zheng-Gang Liu, Jianke Zhang
TRADD is an adaptor for TNFR1-induced apoptosis and NFκB activation. However, TRADD-deficient mice undergo normal development and contain normal lymphoid populations, which contrasts with an embryonic defect in mice lacking FADD, the shared adaptor mediating apoptosis. Recent studies indicate FADD suppresses embryonic necroptosis mediated by RIPK1. TRADD was suggested to also mediate necroptosis. Here we report that targeting TRADD fails to rescue Fadd-/- embryos from necroptosis, and ablation of TRADD rescues Ripk1-/- mice from perinatal lethality when RIPK3-mediated necroptosis is disabled...
February 11, 2019: Nature Communications
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