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https://read.qxmd.com/read/30754026/multi-day-multi-sensor-ambulatory-monitoring-of-gastric-electrical-activity
#1
Niranchan Paskaranandavadivel, Timothy R Angeli, Tabitha Manson, Abigail Stocker, Lindsay McElmurray, Greg O'Grady, Thomas Abell, Leo K Cheng
Bioelectrial signals known as slow waves play a key role in coordinating gastric motility. Slow wave dysrhythmias have been associated with a number of functional motility disorders. However, there have been limited human recordings obtained in the consious state or over an extended period of time. This study aimed to evaluate a robust ambulatory recording platform.
 Approach: A commercially available multi-sensor recording system (Shimmer 3, ShimmerSensing) was applied to acquire slow wave information from the stomach of six humans and four pigs...
February 12, 2019: Physiological Measurement
https://read.qxmd.com/read/30716006/an-algorithmic-approach-to-nutritional-difficulties-in-people-with-developmental-disabilities
#2
Suma Chennubhotla, Rebecca Hertog, John E Williams, Debra Hanna, Thomas L Abell
With the increasing survival rate of people with developmental disabilities into adulthood and later life, nutritional support and feeding of these individuals frequently becomes a critical problem which must be addressed by their caregivers and healthcare providers. Problems surrounding mealtimes include difficulty with the mechanisms of feeding as well as medical complications including aspiration and gastrointestinal dysmotility. No comprehensive guidelines exist to aid caregivers and healthcare providers regarding the issues in feeding and nutrition in this population...
February 2019: Intellectual and Developmental Disabilities
https://read.qxmd.com/read/30710976/irregular-reflection-of-spark-generated-shock-pulses-from-a-rigid-surface-mach-zehnder-interferometry-measurements-in-air
#3
Maria M Karzova, Thomas Lechat, Sébastien Ollivier, Didier Dragna, Petr V Yuldashev, Vera A Khokhlova, Philippe Blanc-Benon
The irregular reflection of weak acoustic shock waves, known as the von Neumann reflection, has been observed experimentally and numerically for spherically diverging waves generated by an electric spark source. Two optical measurement methods are used: a Mach-Zehnder interferometer for measuring pressure waveforms and a Schlieren system for visualizing shock fronts. Pressure waveforms are reconstructed from the light phase difference measured by the interferometer using the inverse Abel transform. In numerical simulations, the axisymmetric Euler equations are solved using finite-difference time-domain methods and the spark source is modeled as an instantaneous energy injection with a Gaussian shape...
January 2019: Journal of the Acoustical Society of America
https://read.qxmd.com/read/30706646/gastroparesis-syndromes-response-to-electrical-stimulation
#4
Thomas L Abell, Archana Kedar, Abigail Stocker, Karen Beatty, Lindsay McElmurray, Michael Hughes, Hani Rashed, William Kennedy, Gwen Wendelschafer-Crabb, Xiu Yang, Mostafa Fraig, Endashaw Omer, Ed Miller, Michael Griswold, Christina Pinkston
BACKGROUND AND AIMS: Factors underlying gastroparesis are not well defined, nor is the mechanism of action of gastric electrical stimulation (GES). We hypothesized that GES acts via several mechanisms related to underlying disordered pathophysiology. METHODS: We studied 43 consecutive eligible patients with gastroparetic symptoms, previously evaluated by two methods in each of five core areas: inflammatory, autonomic, enteric, electrophysiologic, and hormonal; and also categorized by GI symptoms, metabolic status, illness quantification, and gastric physiology...
January 31, 2019: Neurogastroenterology and Motility: the Official Journal of the European Gastrointestinal Motility Society
https://read.qxmd.com/read/30688295/fused-filament-fabrication-fff-of-metal-ceramic-components
#5
Johannes Abel, Uwe Scheithauer, Thomas Janics, Stefan Hampel, Santiago Cano, Axel Müller-Köhn, Anne Günther, Christian Kukla, Tassilo Moritz
Technical ceramics are widely used for industrial and research applications, as well as for consumer goods. Today, the demand for complex geometries with diverse customization options and favorable production methods is increasing continuously. With fused filament fabrication (FFF), it is possible to produce large and complex components quickly with high material efficiency. In FFF, a continuous thermoplastic filament is melted in a heated nozzle and deposited below. The computer-controlled print head is moved in order to build up the desired shape layer by layer...
January 11, 2019: Journal of Visualized Experiments: JoVE
https://read.qxmd.com/read/30672396/capital-interplays-and-social-inequalities-in-health
#6
Gerry Veenstra, Thomas Abel
We explore the ramifications of applying Pierre Bourdieu's theory of capitals to epidemiological research on socioeconomic health inequalities. Capitals are resources used by individuals and groups to maintain and enhance their positions in the social order. The notion of capital interplay refers to the interconnectedness of multiple forms of capital in the production of good health. We provide definitions of economic, cultural and social capitals and describe a variety of causally distal processes-namely, capital acquisition, multiplier and transmission interplays-from which new hypotheses can be developed to guide future study of socioeconomic health inequalities in modern societies...
January 23, 2019: Scandinavian Journal of Public Health
https://read.qxmd.com/read/30670639/accelerating-changes-in-ice-mass-within-greenland-and-the-ice-sheet-s-sensitivity-to-atmospheric-forcing
#7
Michael Bevis, Christopher Harig, Shfaqat A Khan, Abel Brown, Frederik J Simons, Michael Willis, Xavier Fettweis, Michiel R van den Broeke, Finn Bo Madsen, Eric Kendrick, Dana J Caccamise, Tonie van Dam, Per Knudsen, Thomas Nylen
From early 2003 to mid-2013, the total mass of ice in Greenland declined at a progressively increasing rate. In mid-2013, an abrupt reversal occurred, and very little net ice loss occurred in the next 12-18 months. Gravity Recovery and Climate Experiment (GRACE) and global positioning system (GPS) observations reveal that the spatial patterns of the sustained acceleration and the abrupt deceleration in mass loss are similar. The strongest accelerations tracked the phase of the North Atlantic Oscillation (NAO)...
January 22, 2019: Proceedings of the National Academy of Sciences of the United States of America
https://read.qxmd.com/read/30629069/controlling-the-fluorescence-properties-of-nitrogen-vacancy-centers-in-nanodiamonds
#8
Christian Laube, Thomas Oeckinghaus, Jan Lehnert, Jan Griebel, Wolfgang Knolle, Andrej Denisenko, Axel Kahnt, Jan Meijer, Jörg Wrachtrup, Bernd Abel
Control over the formation and fluorescence properties of nitrogen vacancy (NV) centers in nanodiamonds (NDs) is an important factor for their use in medical and sensor applications. However, reports providing a deep understanding of the potential factors influencing these properties are rare and focus only on a few influencing factors. The current contribution targets this issue and we report a comprehensive study of the fluorescence properties of NVs in nanodiamonds as a function of electron irradiation fluence and surface termination...
January 10, 2019: Nanoscale
https://read.qxmd.com/read/30552651/use-of-decision-modelling-in-economic-evaluations-of-diagnostic-tests-an-appraisal-and-review-of-health-technology-assessments-in-the-uk
#9
REVIEW
Yaling Yang, Lucy Abel, James Buchanan, Thomas Fanshawe, Bethany Shinkins
Diagnostic tests play an important role in the clinical decision-making process by providing information that enables patients to be identified and stratified to the most appropriate treatment and management strategies. Decision analytic modelling facilitates the synthesis of evidence from multiple sources to evaluate the cost effectiveness of diagnostic tests. This study critically reviews the methods used to model the cost effectiveness of diagnostic tests in UK National Institute for Health Research (NIHR) Health Technology Assessment (HTA) reports...
December 14, 2018: PharmacoEconomics Open
https://read.qxmd.com/read/30525253/the-effect-of-gastric-electrical-stimulation-on-small-bowel-motility-in-patients-with-gastroparesis-and-concomitant-pancreatic-and-small-bowel-dysfunction-from-animal-model-to-human-application
#10
Patrick McKenzie, Abigail Stocker, Peng Du, Christopher Lahr, Leo K Cheng, Lindsay McElmurray, Archana Kedar, Benjamin Boatright, Hamza Hassan, Michael Hughes, Endashaw Omer, Bikash Bhandari, Thomas L Abell
BACKGROUND/AIMS: Patients with gastroparesis often have biliary/pancreatic and small bowel symptoms but the effects of gastric electrical stimulation on small bowel electrical activity of the mid-gut have not been studied. Animal model aim: Establish gastric and upper small bowel/biliary slow wave activity relationships with electrical stimulation. Human study aim: Demonstrate improvement in symptoms associated with proximal small bowel dysmotility in gastric stimulated patients. MATERIALS AND METHODS: Animal model: In vivo evoked responses of duodenal and Sphincter of Oddi measures recorded during gastric electrical stimulation in a nonsurvival swine model (N = 3)...
December 7, 2018: Neuromodulation: Journal of the International Neuromodulation Society
https://read.qxmd.com/read/30510260/honey-bee-royalactin-unlocks-conserved-pluripotency-pathway-in-mammals
#11
Derrick C Wan, Stefanie L Morgan, Andrew L Spencley, Natasha Mariano, Erin Y Chang, Gautam Shankar, Yunhai Luo, Ted H Li, Dana Huh, Star K Huynh, Jasmine M Garcia, Cole M Dovey, Jennifer Lumb, Ling Liu, Katharine V Brown, Abel Bermudez, Richard Luong, Hong Zeng, Victoria L Mascetti, Sharon J Pitteri, Jordon Wang, Hua Tu, Marco Quarta, Vittorio Sebastiano, Roel Nusse, Thomas A Rando, Jan E Carette, J Fernando Bazan, Kevin C Wang
Royal jelly is the queen-maker for the honey bee Apis mellifera, and has cross-species effects on longevity, fertility, and regeneration in mammals. Despite this knowledge, how royal jelly or its components exert their myriad effects has remained poorly understood. Using mouse embryonic stem cells as a platform, here we report that through its major protein component Royalactin, royal jelly can maintain pluripotency by activating a ground-state pluripotency-like gene network. We further identify Regina, a mammalian structural analog of Royalactin that also induces a naive-like state in mouse embryonic stem cells...
December 4, 2018: Nature Communications
https://read.qxmd.com/read/30487585/author-correction-differential-expression-pattern-of-co-inhibitory-molecules-on-cd4-t-cells-in-uncomplicated-versus-complicated-malaria
#12
Annemieke Abel, Christiane Steeg, Francis Aminkiah, Otchere Addai-Mensah, Marylyn Addo, Nicola Gagliani, Christian Casar, Denis Dekugmen Yar, Ellis Owusu-Dabo, Thomas Jacobs, Maria Sophia Mackroth
A correction to this article has been published and is linked from the HTML and PDF versions of this paper. The error has not been fixed in the paper.
November 29, 2018: Scientific Reports
https://read.qxmd.com/read/30467042/systematic-review-of-the-role-of-cytoreductive-nephrectomy-in-the-targeted-therapy-era-and-beyond-an-individualized-approach-to-metastatic-renal-cell-carcinoma
#13
REVIEW
Bimal Bhindi, E Jason Abel, Laurence Albiges, Karim Bensalah, Stephen A Boorjian, Siamak Daneshmand, Jose A Karam, Ross J Mason, Thomas Powles, Axel Bex
CONTEXT: The role of cytoreductive nephrectomy (CN) in the management of metastatic renal cell carcinoma (mRCC) in the targeted therapy (TT) era is controversial. OBJECTIVE: To assess if CN versus no CN is associated with improved overall survival (OS) in patients with mRCC treated in the TT era and beyond, characterize the morbidity of CN, identify prognostic and predictive factors, and evaluate outcomes following treatment sequencing. EVIDENCE ACQUISITION: Medline, EMBASE, and Cochrane databases were searched from inception to June 4, 2018 for English-language clinical trials, cohort studies, and case-control studies evaluating patients with mRCC who underwent and those who did not undergo CN...
October 25, 2018: European Urology
https://read.qxmd.com/read/30451847/author-correction-substantiating-freedom-from-parasitic-infection-by-combining-transmission-model-predictions-with-disease-surveys
#14
Edwin Michael, Morgan E Smith, Moses N Katabarwa, Edson Byamukama, Emily Griswold, Peace Habomugisha, Thomson Lakwo, Edridah Tukahebwa, Emmanuel S Miri, Abel Eigege, Evelyn Ngige, Thomas R Unnasch, Frank O Richards
The original version of this Article contained an error in the spelling of Emily Griswold, which was incorrectly given as Emily Grisworld. This error has now been corrected in both the PDF and HTML versions of the Article.
November 19, 2018: Nature Communications
https://read.qxmd.com/read/30439392/functional-and-immunogenic-characterization-of-diverse-hcv-glycoprotein-e2-variants
#15
Tanvi Khera, Patrick Behrendt, Dorothea Bankwitz, Richard J P Brown, Daniel Todt, Mandy Doepke, Abdul Ghafoor Khan, Kai Schulze, John Law, Michael Logan, Darren Hockman, Jason Alexander Ji-Xhin Wong, Leona Dold, Victor Gonzalez-Motos, Ulrich Spengler, Abel Viejo-Borbolla, Luisa Ströh, Thomas Krey, Alexander W Tarr, Eike Steinmann, Michael P Manns, Florian Klein, Carlos A Guzman, Joseph Marcotrigiano, Michael Houghton, Thomas Pietschmann
BACKGROUND AND AIMS: Induction of cross-reactive antibodies targeting conserved epitopes of the envelope proteins E1E2 is a key requirement for an HCV vaccine. Conserved epitopes like the viral CD81-binding site are targeted by rare broadly neutralizing antibodies. However, these viral segments are occluded by variable regions and glycans. We aimed to identify antigens exposing conserved epitopes and to characterize their immunogenicity. METHODS: We created HCV variants with mutated glycosylation sites and/or hypervariable region 1 (HVR1)...
November 12, 2018: Journal of Hepatology
https://read.qxmd.com/read/30406962/compositional-response-of-amazon-forests-to-climate-change
#16
Adriane Esquivel-Muelbert, Timothy R Baker, Kyle G Dexter, Simon L Lewis, Roel J W Brienen, Ted R Feldpausch, Jon Lloyd, Abel Monteagudo-Mendoza, Luzmila Arroyo, Esteban Álvarez-Dávila, Niro Higuchi, Beatriz S Marimon, Ben Hur Marimon-Junior, Marcos Silveira, Emilio Vilanova, Emanuel Gloor, Yadvinder Malhi, Jerôme Chave, Jos Barlow, Damien Bonal, Nallaret Davila Cardozo, Terry Erwin, Sophie Fauset, Bruno Hérault, Susan Laurance, Lourens Poorter, Lan Qie, Clement Stahl, Martin J P Sullivan, Hans Ter Steege, Vincent Antoine Vos, Pieter A Zuidema, Everton Almeida, Edmar Almeida de Oliveira, Ana Andrade, Simone Aparecida Vieira, Luiz Aragão, Alejandro Araujo-Murakami, Eric Arets, Gerardo A Aymard C, Plínio Barbosa Camargo, Jorcely G Barroso, Frans Bongers, Rene Boot, José Luís Camargo, Wendeson Castro, Victor Chama Moscoso, James Comiskey, Fernando Cornejo Valverde, Antonio Carlos Lola da Costa, Jhon Del Aguila Pasquel, Tony Di Fiore, Luisa Fernanda Duque, Fernando Elias, Julien Engel, Gerardo Flores Llampazo, David Galbraith, Rafael Herrera Fernández, Eurídice Honorio Coronado, Wannes Hubau, Eliana Jimenez-Rojas, Adriano José Nogueira Lima, Ricardo Keichi Umetsu, William Laurance, Gabriela Lopez-Gonzalez, Thomas Lovejoy, Omar Aurelio Melo Cruz, Paulo S Morandi, David Neill, Percy Núñez Vargas, Nadir C Pallqui, Alexander Parada Gutierrez, Guido Pardo, Julie Peacock, Marielos Peña-Claros, Maria Cristina Peñuela-Mora, Pascal Petronelli, Georgia C Pickavance, Nigel Pitman, Adriana Prieto, Carlos Quesada, Hirma Ramírez-Angulo, Maxime Réjou-Méchain, Zorayda Restrepo Correa, Anand Roopsind, Agustín Rudas, Rafael Salomão, Natalino Silva, Javier Silva Espejo, James Singh, Juliana Stropp, John Terborgh, Raquel Thomas, Marisol Toledo, Armando Torres-Lezama, Luis Valenzuela Gamarra, Peter J van de Meer, Geertje van der Heijden, Peter van der Hout, Rodolfo Vasquez Martinez, Cesar Vela, Ima Célia Guimarães Vieira, Oliver L Phillips
Most of the planet's diversity is concentrated in the tropics, which includes many regions undergoing rapid climate change. Yet, while climate-induced biodiversity changes are widely documented elsewhere, few studies have addressed this issue for lowland tropical ecosystems. Here we investigate whether the floristic and functional composition of intact lowland Amazonian forests have been changing by evaluating records from 106 long-term inventory plots spanning 30 years. We analyse three traits that have been hypothesized to respond to different environmental drivers (increase in moisture stress and atmospheric CO2 concentrations): maximum tree size, biogeographic water-deficit affiliation and wood density...
November 8, 2018: Global Change Biology
https://read.qxmd.com/read/30404771/dual-use-of-a-patient-portal-and-clinical-video-telehealth-by-veterans-with-mental-health-diagnoses-retrospective-cross-sectional-analysis
#17
Erica A Abel, Stephanie L Shimada, Karen Wang, Christine Ramsey, Melissa Skanderson, Joseph Erdos, Linda Godleski, Thomas K Houston, Cynthia A Brandt
BACKGROUND: Access to mental health care is challenging. The Veterans Health Administration (VHA) has been addressing these challenges through technological innovations including the implementation of Clinical Video Telehealth, two-way interactive and synchronous videoconferencing between a provider and a patient, and an electronic patient portal and personal health record, My HealtheVet. OBJECTIVE: This study aimed to describe early adoption and use of My HealtheVet and Clinical Video Telehealth among VHA users with mental health diagnoses...
November 7, 2018: Journal of Medical Internet Research
https://read.qxmd.com/read/30404035/ethnic-racial-and-sex-differences-in-etiology-symptoms-treatment-and-symptom-outcomes-of-patients-with-gastroparesis
#18
Henry P Parkman, Goro Yamada, Mark L Van Natta, Katherine Yates, William L Hasler, Irene Sarosiek, Madhusudan Grover, Ron Schey, Thomas L Abell, Kenneth L Koch, Braden Kuo, John Clarke, Gianrico Farrugia, Linda Nguyen, William J Snape, Laura Miriel, James Tonascia, Frank Hamilton, Pankaj J Pasricha, Richard W McCallum
BACKGROUND & AIMS: Gastroparesis is a chronic disorder of the stomach characterized by nausea, vomiting, early satiety, postprandial fullness, and abdominal pain. There is limited information on gastroparesis in minority populations. We assessed ethnic, racial, and sex variations in the etiology, symptoms, quality of life, gastric emptying, treatments, and symptom outcomes of patients with gastroparesis. METHODS: We collected information from the National Institutes of Health Gastroparesis Consortium on 718 adult patients, from September 2007 through December 2017...
November 4, 2018: Clinical Gastroenterology and Hepatology
https://read.qxmd.com/read/30396529/gastric-electrical-stimulator-for-treatment-of-gastroparesis
#19
REVIEW
Hadi Atassi, Thomas L Abell
Patients with gastroparesis sometimes suffer from intractable nausea and vomiting, abdominal pain, and bloating, as well as a host of other symptoms that can often be difficult to control. Initially, patients are treated conservatively; some do well with conservative management but unfortunately some do not. Over the years, studies have shown the benefits of gastric electrical stimulation, which often results in symptomatic improvement and improvement in gastric emptying times. This article discusses the history of gastric electrical stimulation and its use in clinical practice to help those suffering from gastroparesis that is refractory to conservative medical management...
January 2019: Gastrointestinal Endoscopy Clinics of North America
https://read.qxmd.com/read/30344806/efficacy-of-gastric-electrical-stimulation-for-gastroparesis-us-european-comparison
#20
Jordan Burlen, Matt Runnels, Minesh Mehta, Stina Andersson, Philippe Ducrotte, Guillaume Gourcerol, Greger Lindberg, Greg Fullarton, Hasse Abrahamsson, Amar Al-Juburi, Chris Lahr, Hani Rashed, Thomas Abell
Background: Gastric electrical stimulation (GES) is used in both the US and Europe, but little research has investigated the demographics of gastroparesis patients receiving GES by geographic location. Methods: We compared data from 380 patients, 296 female and 84 males, mean age 42 years, 246 idiopathic (ID), 107 diabetic (DM), and 27 post-surgical (PS). The statistical significance was calculated by Chi-square test and a P-value obtained for ID, DM, and PS. The statistical significance was calculated by Fischer exact test and a P-value obtained comparing male vs...
October 2018: Gastroenterology Research
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