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https://read.qxmd.com/read/30871906/in-vitro-analysis-of-micronized-cartilage-stability-in-the-knee-effect-of-fibrin-level-defect-size-and-defect-location
#1
Ljiljana Bogunovic, Nathan G Wetters, Akshay Jain, Brian J Cole, Adam B Yanke
PURPOSE: The purpose of the study is to assess the stability of a dehydrated cartilage allograft combined with platelet-rich plasma sealed with fibrin glue within trochlear and medial femoral condyle (MFC) chondral defects in a cadaver knee model. METHODS: Defects were made in the trochlea (20, 25, and 30 mm) and MFC (15, 20, and 25 mm) of 6 cadaver specimens. Allograft was applied utilizing 2 different techniques: (1) proud in which the fibrin level extends beyond surrounding cartilage and (2) recessed in which the fibrin level is even with or below the surrounding cartilage...
March 11, 2019: Arthroscopy: the Journal of Arthroscopic & related Surgery
https://read.qxmd.com/read/30870031/effect-of-low-intensity-pulsed-ultrasound-after-autologous-adipose-derived-stromal-cell-transplantation-for-bone-tendon-healing-in-a-rabbit-model
#2
Can Chen, Tao Zhang, Fei Liu, Jin Qu, Yang Chen, Silong Fan, Huabin Chen, Lunquan Sun, Chunfeng Zhao, Jianzhong Hu, Hongbin Lu
BACKGROUND: Low-intensity pulsed ultrasound (LIPUS), as a safe biophysiotherapy, can enhance bone-tendon (B-T) healing in vivo and induce osteogenic or chondrogenic differentiation of mesenchymal stromal cells in vitro. This study aimed to determine whether LIPUS can improve the efficacy of transplanted mesenchymal stromal cells on B-T healing. HYPOTHESIS: LIPUS can induce lineage-specific differentiation of transplanted adipose-derived stromal cells (ASCs) at the B-T healing site, thus resulting in superior healing quality when compared with LIPUS or ASCs alone...
March 2019: American Journal of Sports Medicine
https://read.qxmd.com/read/30826783/perilymphatic-fistula-and-pneumolabyrinth-without-temporal-bone-fracture-a-rare-entity
#3
Ana Sousa Menezes, Daniela Ribeiro, Daniel Alves Miranda, Sara Martins Pereira
Post-traumatic pneumolabyrinth is an uncommon clinical entity, particularly in the absence of temporal bone fracture. We report the case of a patient who presented to our emergency department with a headache, sudden left hearing loss and severe dizziness which began after a traumatic brain injury 3 days earlier. On examination, the patient presented signs of left vestibulopathy, left sensorineural hearing loss and positive fistula test, normal otoscopy and without focal neurological signs. The audiometry confirmed profound left sensorineural hearing loss...
March 1, 2019: BMJ Case Reports
https://read.qxmd.com/read/30806121/bone-conduction-hearing-in-the-blockage-of-oval-and-or-round-windows-in-cats
#4
Keguang Chen, Huiying Lyu, Lin Yang, Tianyu Zhang, Peidong Dai
BACKGROUND: Simple or non-syndromic types of oval window (OW) or round window (RW) atresia are relatively rare in clinical. Few studies have assessed bone conduction (BC) hearing in OW or RW atresia patients, with some reporting that BC hearing lies within the normal range, whereas others observing impaired BC hearing. AIMS/OBJECTIVES: This study explored the effect of blocking the OW and RW during BC in cat models. MATERIAL AND METHODS: Twenty-four cats were randomly divided into three immobilization groups (OW blockage, RW blockage, and OW + RW blockage) and control group...
February 26, 2019: Acta Oto-laryngologica
https://read.qxmd.com/read/30762019/use-of-a-combination-strategy-to-improve-neuroprotection-and-neuroregeneration-in-a-rat-model-of-acute-spinal-cord-injury
#5
Elisa García, Roxana Rodríguez-Barrera, Vinnitsa Buzoianu-Anguiano, Adrian Flores-Romero, Emanuel Malagón-Axotla, Marco Guerrero-Godinez, Estefanía De la Cruz-Castillo, Laura Castillo-Carvajal, Monserrat Rivas-Gonzalez, Paola Santiago-Tovar, Ivis Morales, Cesar Borlongan, Antonio Ibarra
Spinal cord injury is a very common pathological event that has devastating functional consequences in patients. In recent years, several research groups are trying to find an effective therapy that could be applied in clinical practice. In this study, we analyzed the combination of different strategies as a potential therapy for spinal cord injury. Immunization with neural derived peptides (INDP), inhibition of glial scar formation (dipyridyl: DPY), as well as the use of biocompatible matrix (fibrin glue: FG) impregnated with bone marrow mesenchymal stem cells (MSCs) were combined and then its beneficial effects were evaluated in the induction of neuroprotection and neuroregeneration after acute SCI...
June 2019: Neural Regeneration Research
https://read.qxmd.com/read/30759461/replacement-of-the-nasal-dorsum-with-a-diced-cartilage-glue-graft
#6
Abel-Jan Tasman
The reconstruction of the nasal dorsum after a hump resection is challenging if narrowing of the nose is to be avoided, the nasal skin is very thin, and the nasal bones are short. This report describes the replacement of the bony and cartilaginous nasal dorsum after resection with an anatomically shaped dorsal replacement graft of diced cartilage in fibrin glue. The technique is illustrated with a clinical case and sonographic morphometry of the nasal dorsum and tip. A modification of the diced cartilage glue graft for thin-skinned patients is presented...
February 2019: Facial Plastic Surgery: FPS
https://read.qxmd.com/read/30651054/decellularized-extracellular-matrix-microparticles-seeded-with-bone-marrow-mesenchymal-stromal-cells-for-the-treatment-of-full-thickness-cutaneous-wounds
#7
Amanda M Westman, Rachel L Goldstein, Gino Bradica, Scott M Goldman, Mark A Randolph, Joseph P Gaut, Joseph P Vacanti, David M Hoganson
Extracellular matrix materials mechanically dissociated into submillimeter particles have a larger surface area than sheet materials and enhanced cellular attachment. Decellularized porcine mesothelial extracellular matrix microparticles were seeded with bone marrow-derived mesenchymal stromal cells and cultured in a rotating bioreactor. The mesenchymal stromal cells attached and grew to confluency on the microparticles. The cell-seeded microparticles were then encapsulated in varying concentrations of fibrin glue, and the cells migrated rapidly off the microparticles...
January 16, 2019: Journal of Biomaterials Applications
https://read.qxmd.com/read/30551447/nano-hydroxy-apatite-chitosan-gelatin-scaffolds-enriched-by-a-combination-of-platelet-rich-plasma-and-fibrin-glue-enhance-proliferation-and-differentiation-of-seeded-human-dental-pulp-stem-cells
#8
Ali Sadeghinia, Soodabeh Davaran, Roya Salehi, Zahra Jamalpoor
The purpose of this study was to investigate the effects of Fibrin Glue (FG) and activated platelet-rich plasma (a-PRP) on the proliferation and osteogenic differentiation of human dental pulp stem cells (h-DPSCs). Therefore, we planned to investigate in vitro behavior of porous composite scaffolds based on chitosan-gelatin/nanohydroxyapatite (CS-G/nHA) treated with FG and a-PRP. The porous structure of CS-G/nHA was prepared using combination of particle leaching and freeze-drying methods. The a-PRP was prepared from the centrifugation of whole blood activated with calcium chloride...
January 2019: Biomedicine & Pharmacotherapy
https://read.qxmd.com/read/30544388/radiculoplasty-with-reconstruction-using-3d-printed-artificial-dura-mater-for-the-treatment-of-symptomatic-sacral-canal-cysts-two-case-reports
#9
Bin Liu, Zhenyu Wang, Guozhong Lin, Jia Zhang
RATIONALE: Currently, interventional injection of albumin glue and nerve sleeve plasty by cyst excision is the main treatment for sacral cysts. However, albumin glue can only be used in patients with partial cystic neck stenosis, and surgical treatment may result in postoperative complications such as numbness and cyst recurrence. Here, a modified radiculoplasty is presented, in which the lamina is restored with the nerve root wrapped with 3-dimensional (3D)-printed artificial dura mater...
December 2018: Medicine (Baltimore)
https://read.qxmd.com/read/30543731/transplantation-of-bone-marrow-derived-mesenchymal-stem-cells-platelet-rich-plasma-and-fibrin-glue-for-periodontal-regeneration
#10
Mahdieh Rezaei, Shahram Jamshidi, Anna Saffarpour, Mahdi Ashouri, Reza Rahbarghazi, Amir Reza Rokn, Pouriya Motahari
Appropriate regeneration of periodontal tissues is the primary purpose of periodontal disease treatment. The present study assessed the impact of three key regenerative elements-platelet-rich plasma (PRP), canine bone marrow mesenchymal stem cells (cBM-MSCs), and fibrin glue-on periodontal regeneration. In each of the study's five dogs, Class II furcation defects were established on the buccal surface of five teeth. One tooth (five total) from each dog was placed into one of five groups: (1) PRP + fibrin glue, (2) PRP + fibrin glue + cBM-MSCs, (3) fibrin glue, (4) cBM-MSCs + fibrin glue, and (5) control (no treatment)...
January 2019: International Journal of Periodontics & Restorative Dentistry
https://read.qxmd.com/read/30523143/osseous-versus-nonosseous-spinal-epidural-arteriovenous-fistulas-experiences-of-13-patients
#11
Y Song, S H Cho, D W Lee, J J Sheen, J H Shin, D C Suh
BACKGROUND AND PURPOSE: Spinal epidural arteriovenous fistulas are rare vascular malformations. We present 13 patients with spinal epidural arteriovenous fistulas, noting the various presenting symptom patterns, imaging findings related to bone involvement, and outcomes. MATERIALS AND METHODS: Among 111 patients with spinal vascular malformations in the institutional data base from 1993 to 2017, thirteen patients (11.7%) had spinal epidural arteriovenous fistulas...
January 2019: AJNR. American Journal of Neuroradiology
https://read.qxmd.com/read/30480634/a-step-by-step-procedure-for-bone-regeneration-using-calcium-phosphate-scaffolds-from-site-preparation-to-graft-placement
#12
Antonello Maria Messina, Luca Marini, Daniel S Oh, Ettore Marini
Hydroxyapatite (HA) is the main mineral component of bone and teeth. HA is often used as a bone substitute and especially in its granular form it is osteoconductive and osseointegrating as shown by many investigations in animals and humans. HA granules are used for filling bone defects, but they have poor handling qualities and retention at the surgical site, leading to graft voids between the granules and bone tissue and resulting in mechanical instability. Furthermore HA implantation is not constantly followed by favorable results, especially when it is carried out for augmentation of the alveolar ridge...
January 2019: Journal of Craniofacial Surgery
https://read.qxmd.com/read/30428307/modular-core-shell-polymeric-nanoparticles-mimicking-viral-structures-for-vaccination
#13
Bo Lou, Ans De Beuckelaer, Eger Boonstra, Dandan Li, Bruno G De Geest, Stefaan De Koker, Enrico Mastrobattista, Wim E Hennink
Recent advances in the development of protein-based vaccines have expanded the opportunities for preventing and treating both infectious diseases as well as cancer. However, the development of readily and efficient antigen delivery systems capable of stimulating strong cytotoxic T-lymphocyte (CTL) responses remains a challenge. With the attempt to closely mimic the properties of viruses in terms of their size and molecular organization, we constructed RNA (which is a ligand for Toll-like receptor 7 (TLR7) and TLR8) and antigen-loaded nanoparticles resembling the structural organization of viruses...
November 11, 2018: Journal of Controlled Release: Official Journal of the Controlled Release Society
https://read.qxmd.com/read/30418400/use-of-cyanoacrylate-glue-for-replacing-orbital-bone-after-lateral-orbitotomy-a-pilot-study
#14
Md Shahid Alam
No abstract text is available yet for this article.
November 2018: Ophthalmic Plastic and Reconstructive Surgery
https://read.qxmd.com/read/30412179/-a-variant-of-the-modification-of-the-rhinosurgical-intervention-with-the-use-of-the-hemostatic-glue
#15
A D Morozov
The objective of the present study was to evaluate the dynamics of the nasal breathing function and the quality of life in the patients following septoplastic surgery with the use of the classical method in comparison with the application of the latex tissue glue. The study included 58 patients presenting with diagnosis of deflected septum of the nose and vasomotor rhinitis. The following methods were employed for the purpose: anterior active rhinomanometry, evaluation of the transport function of the nasal cavity, and the questionnaire study for the determination of the patients' quality of life...
2018: Vestnik Otorinolaringologii
https://read.qxmd.com/read/30411215/a-new-affordable-and-easy-to-make-pelvic-model-for-training-in-complex-urogynecological-laparoscopic-procedures
#16
Tamara Serdinšek, Branka Žegura Andrić, Igor But
INTRODUCTION AND HYPOTHESIS: Our aim was to introduce a new affordable and easy-to-make pelvic model for training in complex urogynecological laparoscopic procedures. METHODS: We modified a commercial female pelvic model consisting of sacrum, coccyx, two hip bones, the pubic symphysis, the fifth lumbar vertebra with intervertebral disc, and certain pelvic ligaments. We used sponge foam paper, felt fabric pieces, chenille stems, foam, plastic ties, fabric glue, and a thick, coated wire to create pelvic floor, uterus/vaginal cuff, bladder, both ureters, and anterior longitudinal and pectineal ligaments...
November 8, 2018: International Urogynecology Journal
https://read.qxmd.com/read/30374697/establishment-of-widely-applicable-dna-extraction-methods-to-identify-the-origins-of-crude-drugs-derived-from-animals-using-molecular-techniques
#17
Hiroaki Nakanishi, Katsumi Yoneyama, Yoshie Hayashizaki, Masaaki Hara, Aya Takada, Kazuyuki Saito
We established widely applicable DNA extraction methods to identify the origins of crude drugs derived from animals. Twenty-one samples including 17 kinds of crude drug derived from animals were examined. DNA was extracted from most of the crude drugs by adjustment of the QIAamp® DNA Mini Kit. DNA extraction was performed successfully using phenol to remove impurities after applying a proteinase treatment. DNA extraction was performed successfully by decalcification treatment using ethylenediaminetetraacetic acid (EDTA), before applying the proteinase treatment for crude drugs having high calcium content, such as those from oyster shell and cuttlefish bone...
January 2019: Journal of Natural Medicines
https://read.qxmd.com/read/30340603/the-potent-anti-inflammatory-effect-of-guilu-erxian-glue-extracts-remedy-joint-pain-and-ameliorate-the-progression-of-osteoarthritis-in-mice
#18
Yen-Jung Chou, Jiunn-Jye Chuu, Yi-Jen Peng, Yu-Hsuan Cheng, Chin-Hsien Chang, Chieh-Min Chang, Hsia-Wei Liu
BACKGROUND: Osteoarthritis (OA) is a slow progressing, degenerative disorder of the synovial joints. Guilu Erxian Glue (GEG) is a multi-component Chinese herbal remedy with long-lasting favorable effects on several conditions, including articular pain and muscle strength in elderly men with knee osteoarthritis. The present study aimed to identify the effects of Guilu Erxian Paste (GE-P) and Liquid (GE-L) extracted from Guilu Erxian Glue in anterior cruciate ligament transection (ACLT)-induced osteoarthritis mice, and to compare the effectiveness of different preparations on knee cartilage degeneration during the progression of osteoarthritis...
October 19, 2018: Journal of Orthopaedic Surgery and Research
https://read.qxmd.com/read/30321966/a-prospective-evaluation-of-bone-marrow-aspirate-concentrate-and-microfracture-in-the-treatment-of-osteochondral-lesions-of-the-talus
#19
Evelyn P Murphy, Niall P McGoldrick, Mark Curtin, Stephen R Kearns
BACKGROUND: The term osteochondral lesion (OCL) refers to a defect involving the chondral surface and or subchondral bone. These lesions are associated with ankle injuries with bony and soft tissue and cause pain, decreased range of motion, swelling and impact adversely on quality of life. To date the standard treatment has been isolated microfracture (BMS). The aim of this study was to compare the outcomes of BMS alone to BMS augmented with bone marrow aspirate concentrate (BMAC) in the treatment of ankle OCLs...
February 22, 2018: Foot and Ankle Surgery: Official Journal of the European Society of Foot and Ankle Surgeons
https://read.qxmd.com/read/30283715/one-burr-hole-craniotomy-modified-presigmoid-approach-in-helsinki-neurosurgery
#20
Joham Choque-Velasquez, Juha Hernesniemi
Background: In this video abstract, we present a one burr-hole craniotomy for a modified presigmoid approach developed in Helsinki Neurosurgery to access the space extended to both middle and posterior fossa. Thus, indications for this approach are lesions that extend to both middle and posterior fossa, petroclival tumors, basilar tip aneurysms located extremely low below the posterior clinoid process, trunk basilar aneurysms, and bypass procedures from the P2 segment of the posterior cerebral artery...
2018: Surgical Neurology International
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