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https://read.qxmd.com/read/30777748/functionalization-of-silk-fibroin-electrospun-scaffolds-via-bmsc-affinity-peptide-grafting-through-oxidative-self-polymerization-of-dopamine-for-bone-regeneration
#1
Jiannan Wu, Lingyan Cao, Yang Liu, Ao Zheng, Delong Jiao, Deliang Zeng, Xiao Wang, David L Kaplan, Xinquan Jiang
Electrospun scaffolds have been broadly studied to enhance bone regeneration because of the ability to simulate the structure and biological functions of the extracellular matrix. Polydopamine (PDA) is used to coat various surfaces at a slightly basic pH (8-8.5) and spontaneously reacts with nucleophilic functional groups. It is suitable for surface modifications of scaffolds correlated with bone formation. E7 is a newly discovered peptide with specific affinity for bone marrow mesenchymal stem cells (BMSCs)...
February 19, 2019: ACS Applied Materials & Interfaces
https://read.qxmd.com/read/30775902/investigation-of-fibronectin-binding-protein-fbp-and-panton-valentine-leukocidin-pvl-viulance-factors-in-clinical-methicillin-sensitive-and-resistant-staphylococcus-aureus-strains
#2
Neslihan Cihanoglu, Riza Adaleti, Yasar Nakipoglu
BACKGROUND: We aimed to investigate the frequency of fibronectin binding protein (FBP), which is part of the first step of adhesion, and Panton-Valentine leukocidin (PVL) toxin, which contributes to the destruction of host leukocytes and tissue necrosis, in clinical S. aureus strains. METHODS: One hundred S. aureus strains were included in the study and distributed as follows; 33 from skinwound swabs and catheter tips (SWCT), 33 from body fluid and secretion specimens (BSFS) such as tracheal aspirate, sputum, and pleural effusion fluid, 18 from tissue biopsy specimens (TBS), 10 specimens from blood, and related specimens (BRS) such as bone marrow, and cerebral spinal fluid, and six specimens from mucosal membrane of pharynx, nose, and vagina (MMS)...
January 1, 2019: Clinical Laboratory
https://read.qxmd.com/read/30772515/a-strong-tough-and-osteoconductive-hydroxyapatite-mineralized-polyacrylamide-dextran-hydrogel-for-bone-tissue-regeneration
#3
Ju Fang, Pengfei Li, Xiong Lu, Liming Fang, Xiaoying Lv, Fuzeng Ren
The design of hydrogels with adequate mechanical properties and excellent bioactivity, osteoconductivity, and capacity for osseointegration is essential to bone repair and regeneration. However, it is challenging to integrate all these properties into one bone scaffold. Herein, we developed a strong, tough, osteoconductive hydrogel by a facile one-step micellar copolymerization of acrylamide and urethacrylate dextran (Dex-U), followed by the in situ mineralization of hydroxyapatite (HAp) nanocrystals. We show that the soft, flexible, and hydrophobically associated polyacrylamide (PAAm) network is strengthened by the stiff crosslinked Dex-U phase, and that the mineralized HAp simultaneously improves the mechanical properties and osteoconductivity...
February 14, 2019: Acta Biomaterialia
https://read.qxmd.com/read/30768237/calcium-binding-polymer-coated-poly-lactide-co-glycolide-microparticles-for-sustained-release-of-quorum-sensing-inhibitors-to-prevent-biofilm-formation-on-hydroxyapatite-surfaces
#4
Minji Kang, Sungwhan Kim, Heejin Kim, Youngjun Song, Dongwook Jung, Sunah Kang, Ji-Hun Seo, Sohee Nam, Yan Lee
Quorum sensing (QS) inhibitor-based therapy is an attractive strategy to inhibit bacterial biofilm formation without excessive induction of antibiotic resistance. Thus, we designed Ca2+ -binding poly(lactide- co-glycolide) (PLGA) microparticles that can maintain a sufficient concentration of QS inhibitors around hydroxyapatite (HA) surfaces in order to prevent biofilm formation on HA-based dental or bone tissues or implants and, therefore, subsequent pathogenesis. Poly(butyl methacrylate- co-methacryloyloxyethyl phosphate) (PBMP) contains both Ca2+ -binding phosphomonoester groups and PLGA-interacting butyl groups...
February 15, 2019: ACS Applied Materials & Interfaces
https://read.qxmd.com/read/30763586/homoharringtonine-potentiates-the-antileukemic-activity-of-arsenic-trioxide-against-acute-myeloid-leukemia-cells
#5
Ping Chen, Weiwu Zhan, Bin Wang, Peidong You, Qing Jin, Diyu Hou, Xiaoting Wang, Ruolan You, Hong Zou, Yuanzhong Chen, Huifang Huang
Relapse of minimal residual disease (MRD) is a major problem after conventional chemotherapy in patients with acute myeloid leukemia (AML). The bone marrow stroma can protect AML cells from insults of chemotherapy, partly contributing to AML relapse. Arsenic trioxide (ATO) is the main component of arsenical traditional Chinese medicines and has been widely used for the treatment of hematologic malignancies particularly acute promyelocytic leukemia over the past three decades. ATO acts through a direct arsenic binding to cysteine residues in zinc fingers located in promyelocytic leukemia protein (PML), thus killing the leukemia stem cells (LSCs)...
February 11, 2019: Experimental Cell Research
https://read.qxmd.com/read/30760844/mmp-9-affects-gene-expression-in-chronic-lymphocytic-leukemia-revealing-cd99-as-an-mmp-9-target-and-a-novel-partner-in-malignant-cell-migration-arrest
#6
Noemí Aguilera-Montilla, Elvira Bailón, Rebeca Uceda-Castro, Estefanía Ugarte-Berzal, Andrea Santos, Alejandra Gutiérrez-González, Cristina Pérez-Sánchez, Philippe E Van den Steen, Ghislain Opdenakker, José A García-Marco, Angeles García-Pardo
We previously showed that MMP-9 contributes to CLL pathology by regulating cell survival and migration and that, when present at high levels, MMP-9 induces cell arrest. To further explore the latter function, we studied whether MMP-9 influences the gene-expression profile in CLL. Microarray analyses rendered 131 differentially expressed genes in MEC-1 cells stably transfected with MMP-9 (MMP-9-cells) versus cells transfected with empty vector (Mock-cells). Ten out of twelve selected genes were also differentially expressed in MEC-1 cells expressing the catalytically inactive MMP-9MutE mutant (MMP-9MutE-cells)...
February 13, 2019: Oncogene
https://read.qxmd.com/read/30759863/carbon-fiber-reinforced-peek-composites-based-on-3d-printing-technology-for-orthopedic-and-dental-applications
#7
Xingting Han, Dong Yang, Chuncheng Yang, Sebastian Spintzyk, Lutz Scheideler, Ping Li, Dichen Li, Jürgen Geis-Gerstorfer, Frank Rupp
Fused deposition modeling (FDM) is a rapidly growing three-dimensional (3D) printing technology and has great potential in medicine. Polyether-ether-ketone (PEEK) is a biocompatible high-performance polymer, which is suitable to be used as an orthopedic/dental implant material. However, the mechanical properties and biocompatibility of FDM-printed PEEK and its composites are still not clear. In this study, FDM-printed pure PEEK and carbon fiber reinforced PEEK (CFR-PEEK) composite were successfully fabricated by FDM and characterized by mechanical tests...
February 12, 2019: Journal of Clinical Medicine
https://read.qxmd.com/read/30742027/molecular-signature-of-human-bone-marrow-derived-mesenchymal-stromal-cell-subsets
#8
Selim Kuçi, Zyrafete Kuçi, Richard Schäfer, Gabriele Spohn, Stefan Winter, Matthias Schwab, Emilia Salzmann-Manrique, Thomas Klingebiel, Peter Bader
In the current study we compared the molecular signature of expanded mesenchymal stromal cells (MSCs) derived from selected CD271+ bone marrow mononuclear cells (CD271-MSCs) and MSCs derived from non-selected bone marrow mononuclear cells by plastic adherence (PA-MSCs). Transcriptome analysis demonstrated for the first time the upregulation of 115 and downregulation of 131 genes in CD271-MSCs. Functional enrichment analysis showed that the upregulated genes in CD271-MSCs are significantly enriched for extracellular matrix (tenascin XB, elastin, ABI family, member 3 (NESH) binding protein, carboxypeptidase Z, laminin alpha 2 and nephroblastoma overexpressed) and cell adhesion (CXCR7, GPNMB, MYBPH, SVEP1, ARHGAP6, TSPEAR, PIK3CG, ABL2 and NCAM1)...
February 11, 2019: Scientific Reports
https://read.qxmd.com/read/30740238/-in-vitro-and-in-vivo-analysis-of-the-biocompatibility-of-two-novel-and-injectable-calcium-phosphate-cements
#9
Dan Meng, Limin Dong, Yafei Yuan, Qingsong Jiang
Calcium phosphate cements (CPCs) have been widely used as bone graft substitutes for many years. The aim of this study was to evaluate the biocompatibility of two novel injectable, bioactive cements: β-tricalcium phosphate (β-TCP)/CPC and chitosan microsphere/CPC in vitro and in vivo. This was accomplished by culturing mouse pre-osteoblastic cells (MC3T3-E1) on discs and pastes of CPCs. Cell growth, adhesion, proliferation and differentiation were assessed by 3-(4, 5-dimethylthiazol-2-yl)-2, 5-diphenyltetrazolium bromide and alkaline phosphatase assays as well as by scanning electron microscopy and fluorescence...
February 2019: Regenerative Biomaterials
https://read.qxmd.com/read/30739764/prevention-of-arthrofibrosis-during-knee-repair-by-extracorporeal-shock-wave-therapy-preliminary-study-in-rabbits
#10
Yufeng Zhou, Kai Yang
INTRODUCTION: Surgery or trauma may induce extensive arthrofibrosis around joints and tendon for the restrictive range of motion. Although some approaches were proposed, this problem is not solved satisfactorily. Extracorporeal shock wave therapy (ESWT) has been used for orthopedic, musculoskeletal, and fibrotic disorders. Whether it could prevent the formation of arthrofibrosis during the joint repair is unknown. METHODS: Intra-articular adhesions were created in the right knee of the rabbit by cortical bone shaving and subsequent cast immobilization...
February 2, 2019: Injury
https://read.qxmd.com/read/30739563/immobilization-of-bone-morphogenetic-protein-2-to-gelatin-avidin-modified-hydroxyapatite-composite-scaffolds-for-bone-regeneration
#11
Cheng-Hsin Cheng, Yi-Hui Lai, Yi-Wen Chen, Chun-Hsu Yao, Kuo-Yu Chen
Bone scaffold surface characterization is important for improving cell adhesion, migration, and differentiation. In this study, bone morphogenetic protein-2 (BMP-2) was immobilized to the surface of the gelatin/hydroxyapatite composite using avidin-biotin binding system to produce a bone-tissue engineering scaffold. Firstly, hydroxyapatite particles reacted with hexamethylene diisocyanate and then the terminal group was converted into a primary amine group. Avidin was then immobilized on the surfaces of hydroxyapatite particles using N-ethyl-N'-(3-(dimethylamino)propyl) carbodiimide and N-hydroxysuccinimide as coupling agents...
February 10, 2019: Journal of Biomaterials Applications
https://read.qxmd.com/read/30739425/-in-vitro-study-of-bone-morphogenetic-protein-2-gelatin-chitosan-hydrogel-sustained-release-system-composite-hydroxyapatite-zirconium-dioxide-foam-ceramics-and-induced-pluripotent-stem-cells-derived-mesenchymal-stem-cells
#12
Le Chai, Renfu Quan, Jintao Hu, Xiaolong Huang, Jianlan Lü, Can Zhang, Rui Qiu, Bingbing Cai
Objective: To construct bone morphogenetic protein 2 (BMP-2) gelatin/chitosan hydrogel sustained-release system, co-implant with induced pluripotent stem cells (iPS) derived mesenchymal stem cells (MSCs) to hydroxyapatite (HA)/zirconium dioxide (ZrO 2 ) bio porous ceramic foam, co-culture in vitro , and to explore the effect of sustained-release system on osteogenic differentiation of iPS-MSCs. Methods: BMP-2 gelatin/chitosan hydrogel microspheres were prepared by water-in-oil solution...
February 1, 2019: Chinese Journal of Reparative and Reconstructive Surgery
https://read.qxmd.com/read/30738901/development-of-genipin-crosslinked-and-fucoidan-adsorbed-nano-hydroxyapatite-hydroxypropyl-chitosan-composite-scaffolds-for-bone-tissue-engineering
#13
Hsien-Tsung Lu, Tzu-Wei Lu, Chien-Ho Chen, Fwu-Long Mi
Hydroxypropyl chitosan (HPCS) has recently attracted increasing attention in biomedical applications because it has enhanced water solubility, excellent biocompatibility, and better antioxidant and antibacterial activities compared with chitosan. However, HPCS doesn't meet the mechanical strength requirement in bone tissue engineering and is not suitable for cell adhesion and growth because of its hydrophilic nature and low crystallinity. In this study, nano-scaled hydroxyapatite (n-HA) and HPCS were synthesized, respectively, and then n-HA/HPCS nanocomposite scaffolds were developed by incorporating n-HA into HPCS matrix accompanied with crosslinking of HPCS by a naturally occurring compound, genipin (GP), which in turn greatly altered the hydrophilicity and mechanical properties...
February 7, 2019: International Journal of Biological Macromolecules
https://read.qxmd.com/read/30736898/allogeneic-platelet-rich-plasma-serves-as-a-scaffold-for-articular-cartilage-derived-chondroprogenitors
#14
Elizabeth Vinod, Deepak Vinod Francis, Soosai Manickam Amirtham, Solomon Sathishkumar, P R J V C Boopalan
Limited self-restorative ability of the cartilage has necessitated the use of cell and tissue engineering based therapies. Recent advances in the isolation, expansion and characterization of articular cartilage derived chondroprogenitors(CPs) has gained popularity in its role for cartilage repair. Platelet rich plasma (PRP) is a reliable biological scaffold for in-vitro and in-vivo studies with reported therapeutic applications in cartilage and bone pathologies. The aim of this study was to evaluate whether human allogeneic PRP could serve as a biological scaffold for chondroprogenitors (CPs) in cartilage repair...
February 2019: Tissue & Cell
https://read.qxmd.com/read/30736330/traf6-silencing-attenuates-multiple-myeloma-cell-adhesion-to-bone-marrow-stromal-cells
#15
Jonathan J Morgan, Roisin M McAvera, Lisa J Crawford
The bone marrow (BM) microenvironment plays an important role in supporting proliferation, survival and drug resistance of Multiple Myeloma (MM) cells. MM cells adhere to bone marrow stromal cells leading to the activation of tumour-promoting signaling pathways. Activation of the NFκB pathway, in particular, is central to the pathogenesis of MM. Tumour necrosis factor receptor-associated factor 6 (TRAF6) is a key mediator of NFκB activation and has previously been highlighted as a potential therapeutic target in MM...
February 6, 2019: International Journal of Molecular Sciences
https://read.qxmd.com/read/30734555/a-ph-triggered-self-assembled-and-bioprintable-hybrid-hydrogel-scaffold-for-mesenchymal-stem-cell-based-bone-tissue-engineering
#16
Chen Zhao, Nader Taheri Qazvini, Monirosadat Sadati, Zongyue Zeng, Shifeng Huang, Ana Losada De La Lastra, Linghuan Zhang, Yixiao Feng, Wei Liu, Bo Huang, Bo Zhang, Zhengyu Dai, Yi Shen, Xi Wang, Wenping Luo, Bo Liu, Yan Lei, Zhenyu Ye, Ling Zhao, Daigui Cao, Lijuan Yang, Xian Chen, Aravind Athiviraham, Michael J Lee, Jennifer M Wolf, Russell R Reid, Matthew Tirrell, Wei Huang, Juan J de Pablo, Tong-Chuan He
Effective bone tissue engineering can restore bone and skeletal functions that are impaired by traumas and/or certain medical conditions. Bone is a complex tissue and functions through orchestrated interactions between cells, biomechanical forces and biofactors. To identify ideal scaffold materials for effective mesenchymal stem cell (MSC)-based bone tissue regeneration, here we develop and characterize a composite nanoparticle hydrogel by combining carboxymethyl chitosan (CMCh) and amorphous calcium phosphate (ACP) (designated as CMCh-ACP hydrogel)...
February 8, 2019: ACS Applied Materials & Interfaces
https://read.qxmd.com/read/30734535/pgs-scaffolds-promote-the-in-vivo-survival-and-directional-differentiation-of-bone-marrow-mesenchymal-stem-cells-restoring-the-morphology-and-function-of-wounded-rat-uterus
#17
Bang Xiao, Wenjun Yang, Dong Lei, Jinfeng Huang, Yupeng Yin, Yiqing Zhu, Zhengwei You, Fang Wang, Shuhan Sun
Intrauterine adhesion (IUA) causing infertility and recurrent miscarriage of reproductive female mammals usually results from endometrium injury. Nevertheless, there is no efficient therapeutic method to avoid IUA. Bone marrow derived mesenchymal stem cells (BMSCs) are an important cell source for tissue regeneration. This study designs and explores the ability of BMSC-loaded elastic poly(glycerol sebacate) (PGS) scaffold to prevent IUA and compares the effect of PGS with poly(lactic-co-glycolic acid) (PLGA) and collagen scaffolds in resumption of damaged rat uteruses...
February 7, 2019: Advanced Healthcare Materials
https://read.qxmd.com/read/30732128/correlation-between-high-frequency-ultrasonography-of-patients-with-early-rheumatoid-arthritis-and-anti-ccp-antibody
#18
Jie Yang, Qinghe Shao, Jieyan Wu
OBJECTIVES: To study the correlation between high-frequency ultrasonography of patients with early rheumatoid arthritis (RA) and anti-cyclic citrullinated peptide (CCP) antibody. METHODS: Two wrists, 1st to 5th metacarpal phalangeal (MCP) and 1st to 5th proximal interphalangeal (PIP) joints of 53 early RA patients treated from October 2015 to October 2017 and 30 healthy subjects were examined by high-frequency ultrasonography. The thicknesses of synovial membrane, sheaths of 1st to 5th extensor tendons, flexor tendons and ulnar wrist extensor tendons were measured...
February 2019: Medicine (Baltimore)
https://read.qxmd.com/read/30722019/epidermal-growth-factor-like-repeats-of-scube1-derived-from-platelets-are-critical-for-thrombus-formation
#19
Wei-Ju Liao, Meng-Ying Wu, Chen-Chung Peng, Yi-Chung Tung, Ruey-Bing Yang
Aims: SCUBE1 (signal peptide-CUB-EGF domain-containing protein 1), expressed in endothelial cells (ECs) and platelets, exists in soluble or membrane forms. We previously showed that soluble SCUBE1 is a biomarker for platelet activation and also an active participant of thrombosis. However, whether the adhesive module of its EGF-like repeats is essential and the specific contribution of SCUBE1 synthesized in ECs or platelets to thrombosis in vivo remain unclear. Methods and Results: We generated new mutant (∆2) mice lacking the entire EGF-like repeats to evaluate the module's functional importance during thrombogenesis in vivo...
February 5, 2019: Cardiovascular Research
https://read.qxmd.com/read/30721783/modifying-decellularized-aortic-valve-scaffolds-with-stromal-cell-derived-factor-1%C3%AE-loaded-proteolytically-degradable-hydrogel-for-recellularization-and-remolding
#20
Jinchi Dai, Weihua Qiao, Jiawei Shi, Chungen Liu, Xingjian Hu, Nianguo Dong
Decellularized matrix is of great interest as a scaffold for the tissue engineering heart valves due to its naturally three-dimensional structure and bioactive composition. A primary challenge of tissue engineered heart valves based on decellularized matrix is to grow a physiologically appropriate cell population within the leaflet tissue. In this study, a composite scaffold was fabricated by the combination of a porous matrix metalloproteinase (MMP) degradable poly (ethylene glycol) (PEG) hydrogel that were loaded with stromal cell-derived factor-1α (SDF-1α) and a mechanically supportive decellularized porcine aortic valve...
February 2, 2019: Acta Biomaterialia
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