Jinhui Wang, Junbo Zou, Yajun Shi, Nan Zeng, Dongyan Guo, He Wang, Chongbo Zhao, Fei Luan, Xiaofei Zhang, Jing Sun
BACKGROUND: Cardiovascular disease (CVD) remains the leading cause of morbidity and mortality worldwide, imposing an enormous economic burden on individuals and human society. Laboratory studies have identified several drugs that target mitophagy for the prevention and treatment of CVD. Only a few of these drugs have been successful in clinical trials, and most studies have been limited to animal and cellular models. Furthermore, conventional drugs used to treat CVD, such as antiplatelet agents, statins, and diuretics, often result in adverse effects on patients' cardiovascular, metabolic, and respiratory systems...
February 24, 2024: Phytomedicine