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Lpa and il-1 beta

Long Shuang Huang, Panfeng Fu, Priya Patel, Anantha Harijith, Tianjiao Sun, Yutong Zhao, Joe G N Garcia, Jerold Chun, Viswanathan Natarajan
Idiopathic pulmonary fibrosis is a devastating disease characterized by alveolar epithelial cell injury, the accumulation of fibroblasts/myofibroblasts, and the deposition of extracellular matrix proteins. Lysophosphatidic acid (LPA) signaling through its G protein-coupled receptors is critical for its various biological functions. Recently, LPA and LPA receptor 1 were implicated in lung fibrogenesis. However, the role of other LPA receptors in fibrosis remains unclear. Here, we use a bleomycin-induced pulmonary fibrosis model to investigate the roles of LPA2 in pulmonary fibrogenesis...
December 2013: American Journal of Respiratory Cell and Molecular Biology
M Krishnaveni, S Jayachandran
Crude ethyl acetate extracts from marine bacterial isolates Staphylococcus arlettae KP2 (GenBank accession No. EU594442) and Planococcus maritimus KP8 (GenBank accession No. EU594443) isolated from Andaman seas were studied for their anti-inflammatory effect by lymphocyte proliferation assay (LPA) employing peripheral blood mononuclear cells (PBMCs). The crude extracts from both the bacteria down regulated the synthesis of inflammatory mediators such as tumor necrosis factor-alpha (TNF-alpha), interleukin-1beta (IL-1beta) and cyclooxygenase-2 (COX-2), besides markedly inhibiting p38 mitogen activated protein (MAP) kinase...
August 2009: Biomedicine & Pharmacotherapy
Donghong He, Viswanathan Natarajan, Randi Stern, Irina A Gorshkova, Julian Solway, Ernst Wm Spannhake, Yutong Zhao
We have demonstrated that LPA (lysophosphatidic acid)-induced IL (interleukin)-8 secretion was partly mediated via transactivation of EGFR [EGF (epidermal growth factor) receptor] in HBEpCs (human bronchial epithelial primary cells). The present study provides evidence that LPA-induced transactivation of EGFR regulates COX (cyclo-oxygenase)-2 expression and PGE(2) [PG (prostaglandin) E(2)] release through the transcriptional factor, C/EBPbeta (CCAAT/enhancer-binding protein beta), in HBEpCs. Treatment with LPA (1 microM) stimulated COX-2 mRNA and protein expression and PGE(2) release via G(alphai)-coupled LPARs (LPA receptors)...
May 15, 2008: Biochemical Journal
Nikhil M Urs, Andrew P Kowalczyk, Harish Radhakrishna
Lysophosphatidic acid (LPA) stimulates cells by activation of five G-protein-coupled receptors, termed LPA 1-5. The LPA 1 receptor is the most widely expressed and is a major regulator of cell migration. In this study, we show that phorbol ester (PMA)-induced internalization of the LPA(1) receptor requires clathrin AP-2 complexes, protein kinase C, and a distal dileucine motif (amino acids 352 and 353) in the cytoplasmic tail but not beta-arrestin. Agonist-dependent internalization of LPA 1, however, requires a cluster of serine residues (amino acids 341-347) located proximal to the dileucine motif, beta-arrestin, and to a lesser extent clathrin AP-2...
February 29, 2008: Journal of Biological Chemistry
Chi-Lun Chang, Mu-En Lin, Hsien-Yeh Hsu, Chao-Ling Yao, Shiaw-Min Hwang, Chien-Yuan Pan, Chi-Yen Hsu, Hsinyu Lee
Lysophosphatidic acid (LPA), a low-molecular-weight lysophospholipid enriched in platelets and mildly oxidized low-density lipoproteins, is known to regulate inflammation and atherosclerosis by binding to its cognate receptors. In this study, we reported that LPA upregulated interleukin-1 beta (IL-1 beta) expression in mouse J774A.1 macrophages. By using pharmacological inhibitors, it was suggested that G(i)/Rho activation and subsequent reactive oxygen species (ROS) production were involved in IL-1 beta induction...
May 2008: Journal of Biomedical Science
Toshiyuki Umata
Heparin-binding epidermal growth factor-like growth factor(HB-EGF), which belongs to the EGF family, is a critical growth factor for a number of physiological and pathological processes, such as wound healing and cardiac hypertrophy. HB-EGF is synthesized as a membrane-anchored form(pro-HB-EGF), and pro-HB-EGF is cleaved at the cell surface to yield soluble HB-EGF by a mechanism called "ectodomain shedding". Soluble HB-EGF has mitogenic activity. Ectodomain shedding of proHB-EGF is induced by stimuli, including 12-O-tetradecanoylphorbol-13-acetate(TPA), a ligand for seven-transmembrane G protein-coupled receptors(GPCR), stress and inflammatory cytokine...
March 1, 2004: Journal of UOEH
B L Spangelo, W D Jarvis
Interleukin-6 (IL-6) is a B-cell differentiation-inducing cytokine that affects the secretion of several neuroendocrine hormones. Normal rat anterior pituitary (AP) cells synthesize and release IL-6, suggesting a paracrine role for the stimulation of AP hormone release by this cytokine. We have previously reported that IL-1 beta enhances IL-6 release and phospholipase A2 (PLA2)-mediated hydrolysis of phosphatidylcholine (PC) in AP cells. Because lysophosphatidylcholine (LPC) may function as a second messenger for IL-1 beta, we have investigated the effects of exogenous LPC on IL-6 release from AP cells in vitro...
October 1996: Endocrinology
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