Joshua P H Neale, James T Pearson, Kate N Thomas, Hirotsugu Tsuchimochi, Hiroshi Hosoda, Masayasu Kojima, Takahiro Sato, Gregory T Jones, Adam P Denny, Lorna J Daniels, Dhananjie Chandrasekera, Ping Liu, Andre M van Rij, Rajesh Katare, Daryl O Schwenke
Type 2 diabetes is a prominent risk factor for peripheral artery disease (PAD). Yet, the mechanistic link between diabetes and PAD remains unclear. This study proposes that dysregulation of the endogenous hormone ghrelin, a potent modulator of vascular function, underpins the causal link between diabetes and PAD. Moreover, this study aimed to demonstrate the therapeutic potential of exogenous ghrelin in a diabetic mouse model of PAD. Standard ELISA analysis was used to quantify and compare circulating levels of ghrelin between (i) human diabetic patients with or without PAD (clinic) and (ii) db/db diabetic and non-diabetic mice (lab)...
August 12, 2020: Scientific Reports