keyword
https://read.qxmd.com/read/36457255/the-impact-of-diabetes-in-intermittent-claudication-a-prospective-cohort-study
#21
JOURNAL ARTICLE
Anabelle Mizzi, Kevin Cassar, Catherine J Bowen, Liberato Camilleri, Cynthia Formosa
The aim of this study was to determine the lower-limb outcome in patients with intermittent claudication (IC) and to identify predictors for deterioration. This study employed a prospective observational cohort single-centre design. One hundred fifty patients with IC attending a vascular surgery unit for the first time were recruited. Lower limb perfusion was assessed utilising ankle brachial index (ABI) measures, toe-brachial index (TBI) measures, Doppler waveform analysis and the walking impairment questionnaire...
December 1, 2022: International Journal of Lower Extremity Wounds
https://read.qxmd.com/read/36386037/evaluation-of-the-icd-10-system-in-coding-revascularisation-procedures-in-patients-with-peripheral-arterial-disease-in-england-a-retrospective-cohort-study-using-national-administrative-and-clinical-databases
#22
JOURNAL ARTICLE
Panagiota Birmpili, Eleanor Atkins, Qiuju Li, Amundeep S Johal, Sam Waton, Robin Williams, Arun D Pherwani, David A Cromwell
Background: Many studies evaluating care in hospitals in England use the Hospital Episode Statistics (HES) administrative database. The aim of this study was to explore whether the International Classification of Diseases 10th Revision (ICD-10) system used by HES supported the evaluation of care received by patients with peripheral arterial disease (PAD) who had revascularisation. Methods: This retrospective cohort study used records on patients who had revascularisation for PAD between 1st January 2017 and 31st December 2019 in England, collected prospectively in the National Vascular Registry (NVR) and linked to HES...
January 2023: EClinicalMedicine
https://read.qxmd.com/read/36064461/topical-and-intravenous-administration-of-human-umbilical-cord-mesenchymal-stem-cells-in-patients-with-diabetic-foot-ulcer-and-peripheral-arterial-disease-a-phase-i-pilot-study-with-a-3-year-follow-up
#23
JOURNAL ARTICLE
Che Zhang, Li Huang, Xiaofen Wang, Xiaoya Zhou, Xiaoxian Zhang, Ling Li, Jieying Wu, Meng Kou, Cheguo Cai, Qizhou Lian, Xihui Zhou
BACKGROUND: Diabetic foot ulcer (DFU) is a serious chronic complication of diabetes mellitus that contributes to 85% of nontraumatic lower extremity amputations in diabetic patients. Preliminary clinical benefits have been shown in treatments based on mesenchymal stem cells for patients with DFU or peripheral arterial disease (PAD). However, the long-term safety and benefits are unclear for patients with both DFU and PAD who are not amenable to surgical revascularization. METHODS: In this phase I pilot study, 14 patients with PAD and incurable DFU were enrolled to assess the safety and efficacy of human umbilical cord mesenchymal stem cell (hUC-MSC) administration based on conservative treatments...
September 5, 2022: Stem Cell Research & Therapy
https://read.qxmd.com/read/35945333/major-adverse-cardiovascular-and-limb-events-in-people-with-diabetes-treated-with-glp-1-receptor-agonists-vs-sglt2-inhibitors
#24
JOURNAL ARTICLE
Donna Shu-Han Lin, An-Li Yu, Hao-Yun Lo, Cheng-Wei Lien, Jen-Kuang Lee, Wen-Jone Chen
AIMS/HYPOTHESIS: This study aimed to assess the real-world outcomes of people with diabetes mellitus treated with glucagon-like peptide-1 receptor agonists (GLP1RAs) compared with those treated with sodium-glucose cotransporter 2 inhibitors (SGLT2is) in terms of major adverse cardiovascular and limb events. Peripheral artery disease is a common cause of morbidity in people with diabetes. Previous cardiovascular outcome trials have demonstrated the benefits of GLP1RAs and SGLT2is for reducing various cardiovascular events, but the safety and efficacy of these drugs on limb outcomes remain subject to debate and ambiguity...
December 2022: Diabetologia
https://read.qxmd.com/read/35864261/below-the-ankle-arterial-disease-a-new-marker-of-coronary-artery-disease-in-patients-with-diabetes-and-foot-ulcers
#25
JOURNAL ARTICLE
Marco Meloni, Alfonso Bellia, Laura Giurato, Davide Lauro, Luigi Uccioli
AIM: The aim of the current study is to evaluate the association between below-the-ankle (BTA) arterial disease and coronary artery disease (CAD) in patients with diabetic foot ulcers (DFUs). METHODS: The study group was composed of patients with an active neuro-ischaemic DFUs managed in a tertiary care diabetic foot clinic. All patients received a pre-set limb salvage protocol including lower limb revascularization. By a retrospective analysis of individual angiograms, patients were divided in two groups: below-the-ankle (BTA) and above-the-ankle (ATA) arterial disease groups...
October 2022: Acta Diabetologica
https://read.qxmd.com/read/35766298/routinely-ultrasound-surveillance-improves-outcome-after-endovascular-treatment-of-peripheral-arterial-disease-propensity-matched-comparisons-of-clinical-outcomes-after-ultrasound-or-clinical-haemodynamic-based-surveillance-programs
#26
JOURNAL ARTICLE
Carlos Martínez-Rico, Xavier Martí-Mestre, Dolors Cervellera-Pérez, Ricard Ramos-Izquierdo, Jonas Eiberg, Ramon Vila-Coll
BACKGROUND: Endovascular treatment (EVT) has replaced open repair as the first option in intermittent claudication (IC) and chronic limb-threatening ischaemia (CLTI) in several centres. However, evidence of the most optimal post-procedural surveillance strategy is sparse. This study aimed to compare two routine surveillance programs after EVT of IC/CLTI: clinical and haemodynamic assessment (CHA) vs duplex ultrasound (DUS) and clinical/haemodynamic assessment in combination. METHODS: Between February 2012 and December 2015, all patients with EVT of IC/CLTI were allocated to either CHA or DUS-based routine surveillance programs...
June 29, 2022: International Angiology: a Journal of the International Union of Angiology
https://read.qxmd.com/read/35484725/indications-for-and-outcomes-of-major-lower-limb-amputations-at-a-tertiary-referral-centre-in-australia
#27
JOURNAL ARTICLE
Timothy Shiraev, Madeleine de Boer, Raffi Qasabian
OBJECTIVES: Major amputations are classically associated with significant morbidity and mortality. With the increasing prevalence of risk factors for amputation, namely, diabetes and peripheral arterial disease, we sought to identify the major indications for lower limb amputation in an Australian cohort. A secondary aim was to assess the outcomes, namely, mortality, of amputees over the previous decade. METHODS: This study assessed all patients undergoing major lower limb amputations between 2012 and 2020...
April 28, 2022: Vascular
https://read.qxmd.com/read/35446698/acute-limb-ischaemia-not-an-uncommon-complication-of-covid-19-infection
#28
JOURNAL ARTICLE
U Vasudeva Rao, M D Wasim, P Rajeev, S Rai, K Pradeep Kumar
A new variant of coronavirus (2019-nCoV) causing acute respiratory distress in humans was identified for the first time in 2019, in Wuhan, China. One of the many complications of infection with this coronavirus is hypercoagulopathy, resulting in acute thrombosis; often leading to acute limb ischaemia. Herein, we report 20 cases of COVID-19 with peripheral arterial thrombosis involving either upper or lower limbs. Some patients underwent vascular procedures and most had to undergo amputation at some level. All the cases ( n =20) were referred to us during the 8-month period June 2020 to March 2021...
July 2022: Annals of the Royal College of Surgeons of England
https://read.qxmd.com/read/34913631/prevalence-of-voyager-pad-trial-exclusion-criteria-in-unselected-patients-undergoing-lower-limb-revascularization
#29
JOURNAL ARTICLE
Maria A Moll, Daniela Zwerger, Kristina J Grassl, Werner Westreicher, Sabrina B Neururer, Clemens W Moll, Sabine H Wipper, Josef Klocker
BACKGROUND: The VOYAGER PAD trial investigated data on dual pathway inhibition after lower limb revascularization for peripheral arterial disease (PAD). Multiple exclusion criteria were applied. However, neither data on the prevalence of exclusion criteria nor on the total number of patients screened for inclusion was discussed. METHODS: We performed a single-center prospective observational study in unselected PAD patients undergoing lower limb revascularization...
February 2022: International Angiology: a Journal of the International Union of Angiology
https://read.qxmd.com/read/34849576/the-perceive-quantitative-study-prediction-of-risk-and-communication-of-outcome-following-major-lower-limb-amputation-protocol-for-a-collaborative-study
#30
JOURNAL ARTICLE
Brenig L Gwilym, Cherry-Ann Waldron, Emma Thomas-Jones, Ryan Preece, Sarah Milosevic, Lucy Brookes-Howell, Philip Pallmann, Debbie Harris, Ian Massey, Jo Burton, Philippa Stewart, Katie Samuel, Sian Jones, David Cox, Adrian Edwards, Chris Twine, David C Bosanquet
BACKGROUND: Accurate prediction of outcomes following surgery with high morbidity and mortality rates is essential for informed shared decision-making between patients and clinicians. It is unknown how accurately healthcare professionals predict outcomes following major lower-limb amputation (MLLA). Several MLLA outcome-prediction tools have been developed. These could be valuable in clinical practice, but most require validation in independent cohorts before routine clinical use can be recommended...
November 9, 2021: BJS Open
https://read.qxmd.com/read/34839183/diabetic-foot-ulcer-classification-using-mapped-binary-patterns-and-convolutional-neural-networks
#31
JOURNAL ARTICLE
Nora Al-Garaawi, Raja Ebsim, Abbas F H Alharan, Moi Hoon Yap
Diabetic foot ulcer (DFU) is a major complication of diabetes and can lead to lower limb amputation if not treated early and properly. In addition to the traditional clinical approaches, in recent years, research on automation using computer vision and machine learning methods plays an important role in DFU classification, achieving promising successes. The most recent automatic approaches to DFU classification are based on convolutional neural networks (CNNs), using solely RGB images as input. In this paper, we present a CNN-based DFU classification method in which we showed that feeding an appropriate feature (texture information) to the CNN model provides a complementary performance to the standard RGB-based deep models of the DFU classification task, and better performance can be obtained if both RGB images and their texture features are combined and used as input to the CNN...
November 24, 2021: Computers in Biology and Medicine
https://read.qxmd.com/read/34747267/an-observational-clinical-trial-examining-the-effect-of-topical-oxygen-therapy-natrox-%C3%A2-on-the-rates-of-healing-of-chronic-diabetic-foot-ulcers-otonal-trial
#32
JOURNAL ARTICLE
Tjun Yip Tang, Manfred Y Q Mak, C J Q Yap, J E C Boey, Sze Ling Chan, Shereen X Y Soon, I A B Ishak, R W L Lee, Xin Jie Soh, Wan Xi Goh
Natrox™ topical oxygen therapy (TOT) ( Inotec AMD Ltd , Hertfordshire, UK) employs a small battery-powered "oxygen generator" to concentrate atmospheric oxygen and feeds pure, moist, oxygen through a fine, soft tube to a dressing-like "oxygen distribution system", which is placed over the wound and is held in place by a conventional dressing. The aim was to determine the effectiveness of Natrox™ for non-healing diabetic foot ulcers (DFU) over a 3-month period.Longitudinal, single-arm, open prospective registry study using 12 weeks of TOT using a 4 week run-in period...
November 6, 2021: International Journal of Lower Extremity Wounds
https://read.qxmd.com/read/34501432/foot-revascularization-avoids-major-amputation-in-persons-with-diabetes-and-ischaemic-foot-ulcers
#33
JOURNAL ARTICLE
Marco Meloni, Daniele Morosetti, Laura Giurato, Matteo Stefanini, Giorgio Loreni, Marco Doddi, Andrea Panunzi, Alfonso Bellia, Roberto Gandini, Enrico Brocco, José Luis Lazaro-Martinez, Davide Lauro, Luigi Uccioli
The study aims to evaluate the effectiveness of foot revascularization in persons with diabetic foot ulcers (DFUs) and below-the-ankle (BTA) arterial disease. Consecutive patients referred for a new active ischaemic DFU requiring lower limb revascularization were considered. Among those, only patients with a BTA arterial disease were included. Revascularization procedures were retrospectively analysed: in the case of successful foot revascularization (recanalization of pedal artery, or plantar arteries or both) or not, patients were respectively divided in two groups, successful foot perfusion (SFP) and failed foot perfusion (FFP)...
September 2, 2021: Journal of Clinical Medicine
https://read.qxmd.com/read/34481898/procedural-and-12-month-in-hospital-costs-of-primary-infra-popliteal-bypass-surgery-infra-popliteal-best-endovascular-treatment-and-major-lower-limb-amputation-for-chronic-limb-threatening-ischaemia
#34
JOURNAL ARTICLE
Matthew A Popplewell, Lazaros Andronis, Huw Ob Davies, Lewis Meecham, Lisa Kelly, Gareth Bate, Andrew W Bradbury
BACKGROUND: Chronic limb threatening ischaemia (CLTI) is a growing global problem due to the widespread use of tobacco and increasing prevalence of diabetes. Although the financial consequences are considerable, few studies have compared the relative cost-effectiveness of different CLTI management strategies. The Bypass versus Angioplasty in Severe Ischaemia of the Leg (BASIL)-2 trial is randomising CLTI patients to primary infra-popliteal (IP) vein bypass surgery (BS) or best endovascular treatment (BET) and includes a comprehensive within-trial cost-utility analysis...
September 2, 2021: Journal of Vascular Surgery
https://read.qxmd.com/read/34410267/frequency-of-limb-salvage-after-infra-inguinal-bypass-for-chronic-limb-threatening-ischaemia-in-diabetics-a-retrospective-study
#35
JOURNAL ARTICLE
Zia Ur Rehman
A study was conducted to assess the number of limbs salvaged among diabetic patients with chronic limb-threatening ischaemia after infra-inguinal bypass surgeries at a low- to middle-income country (LMIC) hospital. It was a retrospective chart review of diabetic patients who underwent infra-inguinal bypass for lower leg revascularisation for chronic limb-threatening ischaemia at the Section of Vascular Surgery, Aga Khan University Hospital, Karachi (Pakistan) from January 2008 till April 2019. Diabetic patients with chronic limb-threatening ischaemia had a salvage rate of 90...
July 2021: JPMA. the Journal of the Pakistan Medical Association
https://read.qxmd.com/read/34370138/early-and-eighteen-month-clinical-outcomes-of-first-uk-case-of-percutaneous-deep-vein-arterialisation-pdva-to-treat-no-option-chronic-limb-threatening-ischemia-using-the-limflow-system
#36
JOURNAL ARTICLE
Symeon Lechareas, Kaji Sritharan, R G Mc Williams
BACKGROUND: Chronic limb-threatening ischaemia (CLTI) in cases where there are no further standard treatment options for limb salvage represents the most advanced stage of peripheral arterial disease. For these "no-option" CLTI patients, an experimental treatment of foot vein arterialisation (FVA) was first described in 1912, however, it was never widely adopted as outcomes varied significantly most likely due to the complexity of the surgical intervention and lack of standardisation...
August 9, 2021: CVIR Endovascular
https://read.qxmd.com/read/34259103/trimetazidine-ameliorates-hindlimb-ischaemic-damage-in-type-2-diabetic-mice
#37
JOURNAL ARTICLE
Yan Yang, Qinqin Xu, Tao Li, Shiying Shao
BACKGROUND: Ischaemia caused by lower extremity artery stenosis is the main cause of peripheral artery disease (PAD) in patients with diabetes. Trimetazidine (TMZ) has traditionally been used as an anti-ischaemic drug for coronary artery disease. The effect of TMZ on PAD in a diabetic animal model and the underlying molecular mechanisms remain unclear. METHODS: The db/db mice were challenged with femoral artery ligation (FAL), followed by TMZ treatment for 2 weeks...
December 2021: Annals of Medicine
https://read.qxmd.com/read/34216710/long-term-mortality-in-patients-undergoing-lower-limb-revascularization-with-paclitaxel-eluting-devices
#38
JOURNAL ARTICLE
Francesco Liistro, Paolo Angioli, Matteo Rocco Reccia, Kenneth Ducci, Giovanni Falsini, Maurizio Pieroni, Giorgio Ventoruzzo, Alessia Scatena, Leonardo Bolognese
BACKGROUND: Paclitaxel-eluting devices (PED) reduce restenosis and target lesion revascularization (TLR) in femoropopliteal intervention. Recent data suggest a two-fold increased long-term mortality in patients treated with PED. The aim of our study is to evaluate if endovascular therapy (EVT) with PED increases mortality risk in patients with symptomatic lower limb peripheral artery disease (PAD) compared to non-eluting devices (NED). METHODS: The study is a retrospective, single-center registry on patients undergoing EVT for PAD from January 2009 to June 2018...
September 15, 2021: International Journal of Cardiology
https://read.qxmd.com/read/34195865/major-adverse-cardiovascular-and-limb-events-in-patients-with-diabetes-treated-with-glp-1-receptor-agonists-vs-dpp-4-inhibitors
#39
JOURNAL ARTICLE
Donna Shu-Han Lin, Jen-Kuang Lee, Wen-Jone Chen
AIMS/HYPOTHESIS: The safety and efficacy of glucagon-like peptide-1 receptor agonists (GLP1RAs) and dipeptidyl peptidase-4 inhibitors (DPP4is) in major cardiovascular adverse events were previously examined in cardiovascular outcome trials. However, the effects of these drugs on adverse limb outcomes were poorly examined. This study aimed to determine the real-world outcomes of patients with diabetes mellitus receiving GLP1RAs as compared with those receiving DPP4is in terms of major adverse cardiovascular and limb events...
September 2021: Diabetologia
https://read.qxmd.com/read/34112741/distribution-of-peripheral-arterial-disease-in-patients-undergoing-endovascular-revascularization-for-chronic-limb-threatening-ischaemia-insights-from-the-vascular-quality-initiative-in-singapore
#40
JOURNAL ARTICLE
Shereen X Y Soon, Ankur Patel, Tze Tec Chong, Charyl J Q Yap, Hsien Ts'ung Tay, Kiang Hiong Tay, Chandramohan Sivanathan, Tjun Y Tang
This study aimed to examine the distribution of lower limb atherosclerotic lesions in a multi-ethnic Asian cohort with chronic limb threatening ischemia (CLTI) from Singapore. The Society for Vascular Surgery Vascular Quality Initiative registry database was used to identify 265 CLTI patients who underwent percutaneous angioplasty between June 2019 and December 2019, of whom 171 (64.5%) were male, and the mean age was 67.9±11.0 years. The majority were diabetic (84.5%) and 145 (54.7%) had chronic kidney disease (CKD)...
June 11, 2021: Vascular Specialist International
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