Lisiani Saur, Laura Tartari Neves, Samuel Greggio, Gianina Teribele Venturin, Cristina Maria Moriguchi Jeckel, Jaderson Costa Da Costa, Karine Bertoldi, Bruna Schallenberger, Ionara Rodrigues Siqueira, Régis Gemerasca Mestriner, Léder Leal Xavier
Acute treatment with ketamine, an NMDA receptor antagonist, has been reported to be efficacious in treating depression. The goal of our study was to evaluate ketamine treatment in an animal model of another important psychiatric disease, post-traumatic stress disorder (PTSD). Fifty-eight male rats were initially divided into four groups: Control+Saline (CTRL+SAL), Control+Ketamine (CTRL+KET), PTSD+Saline (PTSD+SAL) and PTSD+Ketamine (PTSD+KET). To mimic PTSD we employed the inescapable footshock protocol. The PTSD animals were classified according to freezing behavior duration into "extreme behavioral response" (EBR) or "minimal behavioral response" (MBR)...
September 29, 2017: Neuroscience Letters