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https://read.qxmd.com/read/30873890/prediction-of-treatment-outcome-and-relapse-in-inflammatory-bowel-disease
#1
Jun Kato, Takeichi Yoshida, Sakiko Hiraoka
Prediction of treatment outcome and clinical relapse in patients with inflammatory bowel disease (IBD), either ulcerative colitis (UC) or Crohn's disease (CD), is particularly important because therapeutics for IBD are not always effective and patients in remission could frequently relapse. Because undergoing endoscopy for the purpose is sometimes invasive and burdensome to patients, the performance of surrogate biomarkers has been investigated. Areas covered: We particularly featured the performance of patient symptoms, blood markers including C-reactive protein (CRP), fecal markers including fecal calprotectin (Fcal) and fecal immunochemical test (FIT) for prediction of endoscopic mucosal healing (MH) and prediction of relapse...
March 15, 2019: Expert Review of Clinical Immunology
https://read.qxmd.com/read/30871587/comparative-virulence-of-caribbean-brazilian-and-european-isolates-of-toxoplasma-gondii
#2
Clare M Hamilton, Lauren Black, Solange Oliveira, Alison Burrells, Paul M Bartley, Renata Pimentel B Melo, Francesca Chianini, Javier Palarea-Albaladejo, Elisabeth A Innes, Patrick J Kelly, Frank Katzer
BACKGROUND: Toxoplasma gondii is a zoonotic parasite of global importance. The outcome of infection in humans can depend on a number of factors including the infecting stage of the parasite, inoculating dose and virulence of the infecting strain. Molecular epidemiological studies have demonstrated an abundance of atypical strains of T. gondii in South America, many of which have been associated with more severe sequelae of infection. The aim of this study was to compare the virulence of T...
March 14, 2019: Parasites & Vectors
https://read.qxmd.com/read/30868534/apolipoprotein-a1-and-fibronectin-fragments-as-markers-of-cure-for-the-chagas-disease
#3
Elizabeth Ruiz-Lancheros, Makan Golizeh, Momar Ndao
Chagas disease (CD), endemic from Latin America, affects more than 8 million people, and the disease keeps spreading around the world due to population migrations. The treatment options for CD are currently limited to two drugs, benznidazole (BZ) and nifurtimox (Nfx), which are often unsatisfactory in chronically infected patients. To date, the only accepted marker of the cure is seroconversion (the disappearance of Trypanosoma cruzi antibodies in the patient's serum), which can take decades to occur, if ever...
2019: Methods in Molecular Biology
https://read.qxmd.com/read/30868530/assessing-parasite-load-in-chagas-disease-patients-by-quantitative-multiplex-real-time-pcr
#4
Juan Carlos Ramírez, Otacilio da Cruz Moreira
The development of accurate diagnostic tools and surrogate markers of parasitological response to treatment are priorities in Chagas disease (CD) research. For years, the detection of Trypanosoma cruzi DNA by PCR has proved to be useful in some clinical scenarios like acute CD, including cases of congenital transmission, CD reactivation in immunosuppressed patients, and posttreatment follow-up. In that sense, the implementation of quantitative real-time PCR (qPCR) assays was an important step in the development of more reliable tools for CD molecular diagnostics and treatment follow-up...
2019: Methods in Molecular Biology
https://read.qxmd.com/read/30865950/most-important-prognostic-values-to-predict-major-adverse-cardiovascular-cerebrovascular-and-renal-events-in-patients-with-chronic-kidney-disease-including-hemodialysis-for-2-years
#5
Takuji Toyama, Shu Kasama, Makito Sato, Hirokazu Sano, Tetsuya Ueda, Toyoshi Sasaki, Takehiro Nakahara, Tetsuya Higuchi, Yoshito Tsushima, Masahiko Kurabayashi
Patients with chronic kidney disease (CKD) have an increased risk of adverse cardiovascular/cerebrovascular events. The aim of this study is to clarify whether stress myocardial perfusion single-photon emission computed tomography (SPECT) could predict cardiovascular/cerebrovascular events. In the Gunma-CKD SPECT Study, a multicenter prospective cohort trial, 311 patients with CKD (estimated glomerular filtration rate < 60 min/mL/1.73 m2) including 50 patients on hemodialysis underwent stress 99mTc-tetrofosmin SPECT for suspected ischemic heart disease and were followed for 2 years...
March 13, 2019: Cardiology
https://read.qxmd.com/read/30862087/electrochemical-immunosensor-based-on-nanoelectrode-ensembles-for-the-serological-analysis-of-igg-type-tissue-transglutaminase
#6
Henok B Habtamu, Tarcisio Not, Luigina De Leo, Sara Longo, Ligia M Moretto, Paolo Ugo
Celiac disease (CD) is a gluten-dependent autoimmune disorder affecting a significant percentage of the general population, with increasing incidence particularly for children. Reliable analytical methods suitable for the serological diagnosis of the disorder are urgently required for performing both the early diagnosis and the follow-up of a patient adhering to a gluten-free diet. Herein we report on the preparation and application of a novel electrochemical immunosensor based on the use of ensembles of gold nanoelectrodes (NEEs) for the detection of anti-tissue transglutaminase (anti-tTG), which is considered one reliable serological marker for CD...
March 11, 2019: Sensors
https://read.qxmd.com/read/30856390/indirubin-3-monoxime-prevents-aberrant-activation-of-gsk-3%C3%AE-nf-%C3%AE%C2%BAb-and-alleviates-high-fat-high-fructose-induced-a%C3%AE-aggregation-gliosis-and-apoptosis-in-mice-brain
#7
C Sathiya Priya, R Vidhya, K Kalpana, C V Anuradha
Deciphering the molecular mechanisms of amyloid pathology and glial cell-mediated neuroinflammation, offers a novel avenue for therapeutic intervention against neurodegeneration. Recent findings demonstrate a crucial link between activation of glycogen synthase kinase-3β (GSK-3β), amyloid deposition and a neuroinflammatory state. However, studies demonstrating the pharmacological effects of GSK-3β inhibition and the interlinked molecular mechanisms still remain elusive. The present study explores whether high fat-high fructose diet (HFFD)-induced neuropathological changes could be alleviated by indirubin-3'-monoxime (IMX), a GSK-3β inhibitor...
March 7, 2019: International Immunopharmacology
https://read.qxmd.com/read/30851117/znf133-is-associated-with-infliximab-responsiveness-in-patients-with-inflammatory-bowel-diseases
#8
Eun Suk Jung, Ko-Woon Choi, Seung Won Kim, Matthias Hübenthal, Sören Mucha, Jihye Park, Zewon Park, David Ellinghaus, Stefan Schreiber, Andre Franke, Woo Yong Oh, Jae Hee Cheon
BACKGROUND AND AIM: Infliximab has been widely prescribed for treating inflammatory bowel disease (IBD). However, the response rates to infliximab differ among patients. Therefore, we aimed to identify the genetic and clinical markers that predict infliximab response. METHODS: A total of 139 Korean patients with IBD who received infliximab were classified according to infliximab response as follows: (1) primary response vs. nonresponse and (2) sustained response vs...
March 9, 2019: Journal of Gastroenterology and Hepatology
https://read.qxmd.com/read/30851071/reduced-lung-cancer-burden-by-selective-immunomodulators-elicits-improvements-in-muscle-proteolysis-and-strength-in-cachectic-mice
#9
Anna Salazar-Degracia, Paula Granado-Martínez, Aïna Millán-Sánchez, Jun Tang, Alba Pons-Carreto, Esther Barreiro
Identification of to what extent tumor burden influences muscle mass independently of specific treatments for cancer-cachexia remains to be elucidated. We hypothesized that reduced tumor burden by selective treatment of tumor with immunomodulators may exert beneficial effects on muscle wasting and function in mice. Body and muscle weight, grip strength, physical activity, muscle morphometry, apoptotic nuclei, troponin-I systemic levels, interleukin-6, proteolytic markers, and tyrosine release, and apoptosis markers were determined in diaphragm and gastrocnemius muscles of lung cancer (LP07 adenocarcinoma cells) mice (BALB/c) treated with monoclonal antibodies (mAbs), against immune check-points and pathways (CD-137, cytotoxic T-lymphocyte associated protein-4, programed cell death-1, and CD-19; N = 10/group)...
March 9, 2019: Journal of Cellular Physiology
https://read.qxmd.com/read/30850899/distribution-of-potentially-harmful-elements-in-soils-around-a-large-coal-fired-power-plant
#10
Flavio Manoel Rodrigues da Silva Júnior, Paula Florêncio Ramires, Marina Dos Santos, Elisa Rosa Seus, Maria Cristina Flores Soares, Ana Luíza Muccillo-Baisch, Nicolai Mirlean, Paulo Roberto Martins Baisch
An understanding of the spatial distribution and contribution of a power plant to local soil contamination is important for the planning of soil use and prioritizing remedial actions for public safety. Consequently, the aim of this study was to map the spatial distribution of potentially hazardous elements (PHEs; Cu, Pb, Zn, Ni, Cr, Fe, Mn, Cd, As, and Se) in soils around a large (796 MW) coal-fired power plant in Brazil. For the purpose, 33 soil samples were collected in the area within a radius of approximately 17...
March 8, 2019: Environmental Geochemistry and Health
https://read.qxmd.com/read/30840918/daily-oligofructose-enriched-inulin-intake-impacts-bone-turnover-markers-but-not-the-cytokine-profile-in-pediatric-patients-with-celiac-disease-on-a-gluten-free-diet-results-of-a-randomised-placebo-controlled-pilot-study
#11
Natalia Drabińska, Elżbieta Jarocka-Cyrta, Dagmara Złotkowska, Paweł Abramowicz, Urszula Krupa-Kozak
BACKGROUND: Bone metabolism disturbances are commonly observed in patients with newly diagnosed celiac disease (CD). The only available treatment for CD-the intake of a gluten-free diet (GFD)-has been found to be insufficient in effectively improving bone health in some patients. Therefore, there is an urgent need to modify the GFD so as to allow for the provision of all the necessary nutrients and improved absorption. Prebiotics intake reportedly improves the absorption of bone-related vitamin D and calcium as well as bone metabolism...
March 3, 2019: Bone
https://read.qxmd.com/read/30825423/protective-effects-of-anthocyanins-from-bilberry-extract-in-rats-exposed-to-nephrotoxic-effects-of-carbon-tetrachloride
#12
Dejan Popović, Gordana Kocić, Vuka Katić, Zorica Jović, Aleksandra Zarubica, Ljubinka Janković Veličković, Valentina Nikolić, Andrija Jović, Braca Kundalić, Violeta Rakić, Nataša Poklar Ulrih, Mihaela Skrt, Danka Sokolović, Ljubomir Dinić, Marko Stojanović, Aleksandar Milosavljević, Veličković Filip, Dušan Sokolović
This study examined the nephroprotective effects of 15 different anthocyanins from the bilberry extract on the acute kidney injury caused by CCl4 . The acute nephrotoxicity in rats was induced 24 h after the treatment with a single dose of CCl4 (3 ml/kg, i.p.).The nephroprotective effects of the anthocyanins were examined in the animals that had been given the bilberry extract in a single dose of 200 mg of anthocyanins/kg daily, 7 days orally, while on the seventh day, 3 h after the last dose of anthocyanins, the animals received a single dose of CCl4 (3 ml/kg, i...
February 27, 2019: Chemico-biological Interactions
https://read.qxmd.com/read/30825284/the-expression-of-microvesicles-in-leukemia-prognostic-approaches
#13
Ali Ehsanpour, Najmaldin Saki, Marziye Bagheri, Masumeh Maleki Behzad, Saeid Abroun
Microvesicles (MVs) are the smallest subclass of the extracellular vesicles (EVs) spontaneously secreted by the external budding from the cell membranes in physiologic and pathologic conditions. The MVs derived from leukemic cells (LCs) can be detected by the expression of specific cluster of differentiation (CD) markers indicating their cellular origin while they can transfer different agents such as microRNAs, cytokines, and chemokines. The secretion of these agents from MVs can affect the vital processes of LCs such as cell cycle, proliferation, differentiation, and apoptosis...
July 2019: Cell Journal
https://read.qxmd.com/read/30821045/manipulation-of-lipid-metabolism-during-normothermic-machine-perfusion-effect-of-defatting-therapies-on-donor-liver-functional-recovery
#14
Yuri L Boteon, Joseph Attard, Amanda Pcs Boteon, Lorraine Wallace, Gary Reynolds, Stefan Hubscher, Darius F Mirza, Hynek Mergental, Ricky H Bhogal, Simon C Afford
BACKGROUND: Strategies to increase steatotic donor livers' utilisation are required to tackle the mortality on the transplant waiting list. We aimed to test the efficacy of pharmacological enhancement of the lipid metabolism of human livers during ex-situ normothermic machine perfusion to promote defatting and improve the functional recovery of the organs. METHODS: Ten livers discarded because of steatosis were allocated to a defatting group that had the perfusate supplemented with a combination of drugs to enhance lipid metabolism or a control group that received perfusion fluid with vehicle only...
February 28, 2019: Liver Transplantation
https://read.qxmd.com/read/30810912/usefulness-of-rheumatoid-factor-as-an-immunological-and-prognostic-marker-in-pss-patients
#15
Maria Maślińska, Małgorzata Mańczak, Brygida Kwiatkowska
INTRODUCTION: The rheumatoid factor (RF) is present in numerous autoimmune disorders, although its role in many of them remains a subject of research. The study assesses the role of RF as an immunological and prognostic factor in the primary Sjögren's syndrome (pSS). METHODS: Seventy-five pSS patients (mean age 50.03 ± 15.1), 65 (87%) females, and 10 (13%) males. WBC, CRP, RF, ESR, gammaglobulins, C4, C3 component of complement, cryoglobulins, ANA, anti-SS-A, and anti-SS-B antibodies were determined...
February 27, 2019: Clinical Rheumatology
https://read.qxmd.com/read/30808519/myelodysplastic-syndrome-related-alterations-of-mapk-signaling-in-the-of-bone-marrow-of-experimental-mice-including-stem-progenitor-compartment
#16
Suchismita Daw, Aditya Law, Sujata Law
Myelodysplastic syndrome is considered globally as heterogenous group of neoplasm which often proclaims leukemic progression. The heterogeneity is reflected not only in clinical manifestations of the disease but also in salient causes of disease development. In spite of multiple therapeutic modalities, shortfall towards treatment of this disorder still persists. The focal point of tussle suggested toward defects, which are not confined to any unifying cellular signalling. The pathobiology of the disease often experiences an intriguing paradox involving 'hyperproliferative bone marrow with pancytopenic peripheral blood'...
February 23, 2019: Acta Histochemica
https://read.qxmd.com/read/30803709/cellular-systems-biology-identifies-dynamic-trophoblast-populations-in-early-human-placentas
#17
Frances T M Wong, Chenchia Lin, Brian J Cox
INTRODUCTION: The human placenta is accessible in early developmental stages and affords a unique opportunity to investigate human organogenesis and the dynamics of transitory cell populations in human placenta development. METHODS: The cell surface proteomic profile of early trophoblast cells of first trimester human placentas was quantified using a high throughput flow cytometry screen of 370 Cluster of Differentiation (CD) antigens. Targeted investigation of candidate trophoblast progenitor populations was done through immunohistochemistry, multi-color flow cytometry, and genome wide expression analysis...
January 15, 2019: Placenta
https://read.qxmd.com/read/30803177/-clinical-characteristics-and-t-lymphocyte-subsets-in-48-acquired-immune-deficiency-syndrome-patients-with-cytomegalovirus-infections
#18
C H Jia, L Wang, F H Jing, J Xie, Z F Qiu, T S Li, W Lyu
Objective: To investigate the clinical features and T lymphocytes subsets in patients with acquired immune deficiency syndrome (AIDS) and cytomegalovirus (CMV) infection. Methods: A total of 48 hospitalized patients with human immunodeficiency virus (HIV)-1/AIDS and CMV infections were recruited at Peking Union Medical College Hospital from Jan 2010 to Aug 2017. Their clinical features and immune function were retrospectively analyzed. Patients with only HIV/AIDS in previous study were recruited as controls...
March 1, 2019: Zhonghua Nei Ke za Zhi [Chinese Journal of Internal Medicine]
https://read.qxmd.com/read/30801121/the-unsolved-link-of-genetic-markers-and-crohn-s-disease-progression-a-north-american-cohort-experience
#19
Sarah O'Donnell, Krzysztof Borowski, Osvaldo Espin-Garcia, Raquel Milgrom, Boyko Kabakchiev, Joanne Stempak, Deepah Panikkath, Bertus Eksteen, Wei Xu, A Hillary Steinhart, Gil Kaplan, Dermot McGovern, Mark Silverberg
BACKGROUND: While progress has been made in the identification of Crohn's disease (CD) susceptibility loci, efforts to identify a genetic basis for disease progression have been less fruitful. The specific aim of this study was to build upon the major genetic advances made in IBD by applying genome-wide technologies toward predicting disease progression in CD. METHODS: Crohn's disease cases (n = 1495) from 3 IBD centers were reviewed by experienced physicians. Clinical and demographic details were collected, focusing on the time to first disease progression...
February 25, 2019: Inflammatory Bowel Diseases
https://read.qxmd.com/read/30798186/the-association-between-lead-and-cadmium-co-exposure-and-renal-dysfunction
#20
Xiao Chen, Guoying Zhu, Zhongqiu Wang, Hao Zhou, Ping He, Yongkang Liu, Taiyi Jin
Both cadmium (Cd) and lead (Pb) exposure can induce kidney damage. However, the effects of combined exposure to Cd and Pb on renal function at environmental levels have not been fully clarified. In this study we investigated the renal function in a Chinese population co-exposed to Cd and Pb. A total of 331 subjects (215 women and 116 men), living in either a control or a polluted area, were included in this study. Cd and Pb in blood and urine (BCd, BPb, UCd, and UPb), and kidney effect markers including urinary N-acetyl-β-D-glucosaminidase (UNAG) and estimated glomerular filtration rate (eGFR), were determined, and the association between exposure markers and renal effect biomarkers were analyzed...
February 21, 2019: Ecotoxicology and Environmental Safety
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