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Gel augmentation

Yukitoshi Kaizawa, Austin Franklin, Jacinta Leyden, Anthony W Behn, U Serdar Tulu, Daniel Leon, Zhen Wang, Geoffrey D Abrams, James Chang, Paige M Fox
Rotator cuff (RTC) repair outcomes are unsatisfactory due to the poor healing capacity of the tendon bone interface (TBI). In our preceding study, tendon hydrogel (tHG), which is a type I collagen rich gel derived from human tendons, improved biomechanical properties of the TBI in a rat chronic RTC injury model. Here we investigated whether adipose-derived stem cell (ASC)-seeded tHG injection at the repair site would further improve RTC healing. Rats underwent bilateral supraspinatus tendon detachment. Eight weeks later injured supraspinatus tendons were repaired with one of four treatments...
February 12, 2019: Journal of Orthopaedic Research: Official Publication of the Orthopaedic Research Society
Nicole A Borchard, Sachi S Dholakia, Carol H Yan, David Zarabanda, Andrew Thamboo, Jayakar V Nayak
BACKGROUND: Empty nose syndrome (ENS) is a debilitating condition associated with inferior turbinate tissue loss. Surgical augmentation of the inferior meatus has been proposed to treat ENS, although efficacy data with validated, disease-specific questionnaires is limited. Instead we evaluated submucosal injection of a transient, resorbable filler into the inferior meatus to favorably alter nasal aerodynamics in ENS patients. METHODS: Patients with a history of inferior turbinate reduction, diagnosed with ENS via Empty Nose Syndrome 6-Item Questionnaire (ENS6Q) and cotton testing, were enrolled and underwent submucosal injection of carboxymethylcellulose/glycerin gel (Prolaryn®) into the inferior meatuses between July 2014 and May 2018...
February 4, 2019: International Forum of Allergy & Rhinology
N Basic-Jukic, M Ratkovic, D Radunovic, Z Kastelan
Silicone may, like any other adjuvant, induce an inflammatory reaction and diseases. There is no data about its use in renal transplant recipients. Increased immunogenicity of silicon may manifest by activation of both the innate and the adaptive immune system cells what promotes a chronic pro-inflammatory response. Dendritic cells, macrophages, fibroblasts and T-cells have all been found at the capsule/silicone implant contact zone. Additionally, silicon may induce mononuclear cells to secrete proinflammatory cytokines IL-1β, IL-6 and TNF-α...
February 2019: Medical Hypotheses
Shivani Singh, Kharidi Laxman Vandana
Background: In the present era, demand of beauty and esthetics has increased rapidly. Interdental papilla construction, especially in the esthetic zone, is one of the most challenging tasks. Interdental papilla loss might occur due to several reasons as a consequence of periodontal surgery, trauma, and others. Aim and Objective: The present study was aimed to prepare economically feasible injectable form of hyaluronic acid (HA) gel in three different concentrations - 1%, 2%, and 5% HA to evaluate its efficacy in the enhancement of deficient interdental papilla (IDP)...
January 2019: Journal of Indian Society of Periodontology
Joan Vandeputte
Objective: Hyaluronic acid (HA) volumizer injection into subcutaneous and deep tissue layers is increasingly used for nonsurgical volume loss correction. Information on optimal techniques, safety, and medium- to long-term satisfaction is limited. This study evaluated cohesive polydensified matrix® HA volumizer CPM-26 (Modélis® Shape or Belotero® Volume) across different indications. Design: This study was a retrospective chart review and included a patient questionnaire given at six months posttreatment and during long-term assessment (mean: 3...
December 2018: Journal of Clinical and Aesthetic Dermatology
Ryo Uchimido, Eric P Schmidt, Nathan I Shapiro
The glycocalyx is a gel-like layer covering the luminal surface of vascular endothelial cells. It is comprised of membrane-attached proteoglycans, glycosaminoglycan chains, glycoproteins, and adherent plasma proteins. The glycocalyx maintains homeostasis of the vasculature, including controlling vascular permeability and microvascular tone, preventing microvascular thrombosis, and regulating leukocyte adhesion.During sepsis, the glycocalyx is degraded via inflammatory mechanisms such as metalloproteinases, heparanase, and hyaluronidase...
January 17, 2019: Critical Care: the Official Journal of the Critical Care Forum
Hugo Perrin, Antonin Eddi, Stefan Karpitschka, Jacco H Snoeijer, Bruno Andreotti
The functionality of adhesives relies on their response under the application of a load. Yet, it has remained a challenge to quantitatively relate the macroscopic dynamics of peeling to the dissipative processes inside the adhesive layer. Here we investigate the peeling of a reversible adhesive made of a polymer gel, measuring the relationship between the peeling force, the peeling velocity, and the geometry of the interface at small-scale. Experiments are compared to a theory based on the linear viscoelastic response of the adhesive, augmented with an elastocapillary regularization approach...
January 11, 2019: Soft Matter
Shahida Perween, Minhal Abidi, Abul Faiz Faizy, Moinuddin
Methylglyoxal (MGO) is a highly reactive α-oxoaldehyde. It reacts with basic amino acids of the proteins to form advanced glycation end products (AGEs). Fibrinogen is a soluble multi-domain glycoprotein whose major function is to form fibrin clots that prevent blood loss upon vascular injury. In the present study, fibrinogen was incubated with varying concentration of MGO for 7 days followed by its biochemical and biophysical analysis. Glycated plasma fibrinogen (MGO-fibrinogen); exhibited hyperchromicity, a drop in tryptophan and intrinsic fluorescence, augmented AGE-specific fluorescence and melting temperature...
January 5, 2019: International Journal of Biological Macromolecules
Ryosuke Hishimura, Tomohiro Onodera, Kazutoshi Hontani, Rikiya Baba, Kentaro Homan, Shinji Matsubara, Zenta Joutoku, WooYoung Kim, Takayuki Nonoyama, Takayuki Kurokawa, Jian Ping Gong, Norimasa Iwasaki
BACKGROUND: One of the most important limitations of osteochondral autograft transplantation (OAT) is the adverse effect on donor sites in the knee. To decrease the number and/or size of osteochondral defects, we devised a method with biomaterial implantation after OAT. HYPOTHESIS: OAT augmented by ultrapurified alginate (UPAL) gel enhances cartilage repair capacity. STUDY DESIGN: Controlled laboratory study. METHODS: Seventy-five osteochondral defects in rabbits were divided into 3 groups: osteochondral defects with OAT alone, defects with OAT augmented by UPAL gel (combined group), and defects without intervention as controls...
January 9, 2019: American Journal of Sports Medicine
Eran Hadad, Doron Klein, Yaakov Seligman, Itay Wiser, Lior Heller
BACKGROUND: Breast augmentation is one of the most common aesthetic procedures performed worldwide. One of the worst associated complications is implant rupture, a topic that will be addressed in the present study. The risk of developing silicone gel breast implant rupture following breast augmentation is associated with multiple factors, including: older generation implant, increased implant age, implant type, specific manufacturer, severe capsular contracture (Baker grade III or IV), and the presence of local symptoms...
November 22, 2018: Journal of Plastic, Reconstructive & Aesthetic Surgery: JPRAS
Ayman Al-Talib, Yasmeen Haseeb, Muhammad Chohan, Abdulaziz Al-Mulhim
OBJECTIVE: This study sought to evaluate the safety of induction of labour with prostaglandin E2 (PGE2 ) gel in grand multigravida (GMG) women and to compare the labour outcome of GMG women with that of women who never had a previous Caesarean section (CS). METHODS: This prospective cohort study (Canadian Task Force Classification II-2) evaluated induction of labour with 1 mg of PGE2 gel in 96 GMG women with one previous CS (study group) and in 104 GMG women without previous CS (control group)...
December 18, 2018: Journal of Obstetrics and Gynaecology Canada: JOGC, Journal D'obstétrique et Gynécologie du Canada: JOGC
Rubem Lang Stümpfle, Pedro Salomão Piccinini, Lucas Figueras Pereira-Lima, André Alves Valiati
Simultaneous augmentation-mastopexy can achieve excellent patient and surgeon satisfaction but continues to pose a challenge, with revision rates of up to 25%. Recurrent ptosis and poor overall breast shape are 2 common reasons for reoperation, whereas some of the most feared complications is breast implant exposure, infection, and loss secondary to wound breakdown; excessively large implants or too much tension during closure are possible contributing factors. We describe a technique for augmentation-mastopexy combining a muscle-splitting pocket for implant placement along with an inferior flap, which helps secure the implant in place and provides coverage in case of wound dehiscence...
December 18, 2018: Annals of Plastic Surgery
Priyatma P Khincha, Jurga Pikturnaite, Ajay L Mahajan
Breast asymmetry is a common finding in developing adolescents. In select cases, there is maldevelopment of 1 or both breasts, which persists into adulthood and causes significant negative impact on life. Various surgical techniques (eg, breast augmentation/reduction) and nonsurgical techniques (eg, bras/gel inserts) are currently in practice to achieve breast symmetry. We describe a unique case of a young lady with Poland's syndrome, who presented with a lateralized right breast. We have used a V-Y advancement flap, along with a breast implant, to medialize the breast and achieve symmetry in contour and volume, followed by medialization of the nipple areolar complex...
October 2018: Plastic and Reconstructive Surgery. Global Open
Yu M Zhou, Huma E Chaudhry, Amar Shah, Janna Andrews
Breast augmentation is the most common cosmetic surgery in the United States. Squamous cell carcinoma (SCC) of the breast raises suspicion of possibly metastatic origin. Here, we report an unusual case of implant-associated SCC of the breast post silicone gel breast implant. The patient is a 46-year-old female with SCC of the breast. She initially had silicone gel breast implantation for breast augmentation in 1995. She had multiple revisions due to swelling and hardening. In 2016, she underwent bilateral prosthesis explantation and bilateral capsulectomy...
October 3, 2018: Curēus
Hyun Jee Lee, Yoon Ho Roh, Hyeon Ung Kim, Sun Min Kim, Ki Wan Bong
In response to a growing demand for simultaneous detection of multiple proteins in a single sample, multiplex immunoassay platforms have emerged at the forefront of proteomic analysis. In particular, detections using graphically encoded hydrogel microparticles synthesized via flow lithography have received attention for integrating a hydrogel, a substrate that can provide enhanced kinetics and high loading capacity, into the bead-based multiplex platform. Currently, the method of microparticle functionalization involves copolymerization of antibodies with the gel during particle synthesis...
December 18, 2018: Lab on a Chip
M Ines Burgos, Aylen Ochoa, María A Perillo
The effect on protein conformation and thermal stability was studied for β-Galactosidase (β-Gal) encapsulated in the nanopores of a silicate matrix (Eβ-Gal ). Circular dichroism spectra showed that, compared with the enzyme in buffer (Sβ-Gal ), Eβ-Gal exhibited a higher content of α-helix structure. Heating Eβ-Gal up to 75 °C caused a decrease in the content of β-sheet structure and additional augments on Eβ-Gal components attributed to helical content, instead of the generalized loss of the ellipticity signal observed with Sβ-Gal ...
November 26, 2018: Biochemical and Biophysical Research Communications
Morgana Souza Marques, Κarine Modolon Zepon, Julia Maia Heckler, Fernando Dal Pont Morisso, Marcos Marques da Silva Paula, Luiz Alberto Κanis
In this study, polysaccharide-based hydrogel wound dressings containing in situ synthesized gold nanoparticles (AuNPs) were prepared by using a simple, fast and green protocol. The prepared hydrogels were characterized with UV-vis and infrared spectroscopy (FT-IR), and dynamic light scattering (DLS). The rheological and swelling properties and the feasibility to scale-up the wound dressing production from the lamination of the prepared hydrogel on non-woven fabric were also investigated. UV-vis spectra confirmed the AuNPs synthesis and the DLS results exhibited an increase in the size of AuNPs with increasing the initial Au3+ concentration...
November 26, 2018: International Journal of Biological Macromolecules
Antonio Carlos Abramo, Marcio Scartozzoni, Thiago Walmsley Lucena, Romulo Grechi Sgarbi
BACKGROUND: Rippling and implant edge visibility after breast augmentation depends on several factors. Among the most relevant are breast soft tissue thickness, particularly the retroareolar mammary parenchyma, and implant profile. They were correlates to prevent these occurrences. METHODS: Thirty patients underwent breast augmentation through subfascial dissection involving the pectoralis, serratus, external oblique, and rectus abdominis fascias. The thickness of the retroareolar mammary parenchyma distributed patients into two groups...
November 27, 2018: Aesthetic Plastic Surgery
Sun Tae Ahn, Tae Il Kwak, Kwang Sung Park, Je Jong Kim, Du Geon Moon
Despite the controversy regarding penile augmentation (PA), glans penis augmentation (GPA) is used in penile reconstructive surgery in selected patients with small glans penis. Since 2003, injectable hyaluronic acid (HA) gel has been used for GPA. The attractiveness of HA gel fillers and interest in this technique have led to the use of other fillers for GPA, particularly irreversible fillers that improve the longevity of HA gels. Conversely, indirect glans augmentation via implantation of dermofat grafts or scaffolds between the corpus spongiosum and the distal tip of the corpus cavernosum is used to overcome poor longevity of the gel and glans surface undulation, which are the primary limitations of GPA using HA gel...
November 26, 2018: International Journal of Impotence Research
Murat Akand, Levent Civcik, Ahmet Buyukaslan, Emre Altintas, Erdinc Kocer, Mustafa Koplay, Tibet Erdogru
PURPOSE: We describe a novel technique that uses mathematical calculation software, 3-dimensional (3D) modeling and augmented reality (AR) technology for access during percutaneous nephrolithotomy (PCNL) and report our first preliminary results in two different ex-vivo models. METHODS: Novel software was created in order to calculate access point and angle by using pre-operative computed tomography (CT) obtained in 50 patients. Two scans, 27 s and 10 min after injection of contrast agent, were taken in prone PCNL position...
November 24, 2018: International Urology and Nephrology
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