Aleksandra Górska, Maria Urbanowicz, Łukasz Grochowalski, Michał Seweryn, Marta Sobalska-Kwapis, Tomasz Wojdacz, Magdalena Lange, Marta Gruchała-Niedoszytko, Justyna Jarczak, Dominik Strapagiel, Magdalena Górska-Ponikowska, Iwona Pelikant-Małecka, Leszek Kalinowski, Bogusław Nedoszytko, Danuta Gutowska-Owsiak, Marek Niedoszytko
Mastocytosis is a clinically heterogenous, usually acquired disease of the mast cells with a survival time that depends on the time of onset. It ranges from skin-limited to systemic disease, including indolent and more aggressive variants. The presence of the oncogenic KIT p. D816V gene somatic mutation is a crucial element in the pathogenesis. However, further epigenetic regulation may also affect the expression of genes that are relevant to the pathology. Epigenetic alterations are responsible for regulating the expression of genes that do not modify the DNA sequence...
September 10, 2023: International Journal of Molecular Sciences