keyword
https://read.qxmd.com/read/38534331/low-density-lipoprotein-cholesterol-decreases-the-expression-of-adenosine-a-2a-receptor-and-lipid-rafts-protein-flotillin-1-insights-on-cardiovascular-risk-of-hypercholesterolemia
#1
JOURNAL ARTICLE
Marie-Charlotte Chaptal, Marie Maraninchi, Giorgia Musto, Julien Mancini, Hedi Chtioui, Janine Dupont-Roussel, Marion Marlinge, Julien Fromonot, Nathalie Lalevee, Florian Mourre, Sophie Beliard, Régis Guieu, René Valero, Giovanna Mottola
High blood levels of low-density lipoprotein (LDL)-cholesterol (LDL-C) are associated with atherosclerosis, mainly by promoting foam cell accumulation in vessels. As cholesterol is an essential component of cell plasma membranes and a regulator of several signaling pathways, LDL-C excess may have wider cardiovascular toxicity. We examined, in untreated hypercholesterolemia (HC) patients, selected regardless of the cause of LDL-C accumulation, and in healthy participants (HP), the expression of the adenosine A2A receptor (A2A R), an anti-inflammatory and vasodilatory protein with cholesterol-dependent modulation, and Flotillin-1, protein marker of cholesterol-enriched plasma membrane domains...
March 11, 2024: Cells
https://read.qxmd.com/read/38463418/influence-of-blood-components-on-neuroinflammation-blood-brain-barrier-breakdown-and-functional-damage-after-acute-subdural-hematoma-in-rats
#2
JOURNAL ARTICLE
Daniel Jussen, Syamend Saeed, Tatjana Jablonski, Harald Krenzlin, Kristin Lucia, Tobias Kraemer, Oliver Kempski, Marcus Czabanka, Florian Ringel, Beat Alessandri
A central component of injury development after acute subdural hematoma (ASDH) is the increased intracranial pressure and consecutive mechanical reduction of cerebral blood flow (CBF). However, the role of different blood constituents in ASDH as additional lesioning factors remains unclear. This study examines the influence of blood components on neuroinflammation, blood-brain barrier (BBB) breakdown, and functional deficits in a rat model of ASDH. We infused corpuscular (whole blood, whole blood lysate, and red cell blood) and plasmatic (blood plasma, anticoagulated blood plasma, and aqueous isotonic solution) blood components into the subdural space while CBF was monitored...
2024: Neurotrauma reports
https://read.qxmd.com/read/38459993/an-investigation-of-gill-and-blood-carbonic-anhydrase-characteristics-in-three-basal-actinopterygian-species-alligator-gar-atractosteus-spatula-white-sturgeon-acipenser-transmontanus-and-senegal-bichir-polypterus-senegalus
#3
JOURNAL ARTICLE
Charlotte Nelson, Emily M Standen, Peter J Allen, Colin J Brauner
Many teleosts possess a unique set of respiratory characteristics allowing enhanced oxygen unloading to the tissues during stress. This system comprises three major components: highly pH sensitive haemoglobins (large Bohr and Root effects), rapid red blood cell (RBC) intracellular pH (pHi) protection, and a heterogeneous distribution of membrane-bound plasma-accessible carbonic anhydrase (paCA; absence in the gills). The first two components have received considerable research effort; however, the evolutionary loss of branchial paCA has received little attention...
March 9, 2024: Journal of Comparative Physiology. B, Biochemical, Systemic, and Environmental Physiology
https://read.qxmd.com/read/38440638/to-determine-the-efficacy-of-pentoxifylline-in-the-management-of-bell-s-palsy
#4
JOURNAL ARTICLE
Karthik Shamanna, Medha Krishnamurthy
BACKGROUND AND AIMS: Bell's palsy is an acute, unilateral, lower motor neuron peripheral facial paralysis. It is the most common cause of facial paralysis in the ages ranging from 13 to 65 years. It not only causes physical disfigurement of face but is also associated with social stigma and psychological trauma to the patient. In Bell's Palsy, there is hypoxic damage to the nerve due to reduced blood flow and cellular injury to the capillaries. Pentoxifylline is a phosphodiesterase inhibitor that increases the cAMP and cGMP levels at the site of the RBC cell membrane thereby improving the dexterity of the cell membrane allowing the RBCs to pass through the damaged and narrowed blood vessels thereby improving the perfusion and oxygen delivery to the damaged tissues...
February 2024: Indian Journal of Otolaryngology and Head and Neck Surgery
https://read.qxmd.com/read/38439294/nonlinear-optical-response-of-heme-solutions
#5
JOURNAL ARTICLE
Yujie Zhang, Huiwen Hao, Limin Song, Haiping Wang, Denghui Li, Domenico Bongiovanni, Jingyan Zhan, Ziheng Xiu, Daohong Song, Liqin Tang, Roberto Morandotti, Zhigang Chen
Heme is the prosthetic group for cytochrome that exists in nearly all living organisms and serves as a vital component of human red blood cells (RBCs). Tunable optical nonlinearity in suspensions of RBCs has been demonstrated previously, however, the nonlinear optical response of a pure heme (without membrane structure) solution has not been studied to our knowledge. In this work, we show optical nonlinearity in two common kinds of heme (i.e., hemin and hematin) solutions by a series of experiments and numerical simulations...
February 12, 2024: Optics Express
https://read.qxmd.com/read/38384987/development-of-ovalbumin-implants-with-different-spatial-configurations-for-treatment-of-peripheral-nerve-injury
#6
JOURNAL ARTICLE
Tiantian Zheng, Hongxia Gao, Yaqiong Liu, Shaolan Sun, Wenchao Guan, Linliang Wu, Yumin Yang, Guicai Li
Peripheral nerve injury (PNI) seriously affects the health and life of patients, and is an urgent clinical problem that needs to be resolved. Nerve implants prepared from various biomaterials have played a positive role in PNI, but the effect should be further improved and thus new biomaterials is urgently needed. Ovalbumin (OVA) contains a variety of bioactive components, low immunogenicity, tolerance, antimicrobial activity, non-toxicity and biodegradability, and has the ability to promote wound healing, cell growth and antimicrobial properties...
May 2024: Bioactive Materials
https://read.qxmd.com/read/38365484/a-diversity-covering-dico-plasmodium-vivax-apical-membrane-antigen-1-vaccine-adjuvanted-with-rfase-rsl10-yields-high-levels-of-growth-inhibitory-antibodies
#7
JOURNAL ARTICLE
Bart W Faber, Lee M Yeoh, Liriye Kurtovic, Wim E M Mol, Martin Poelert, Elly Smits, Roberto Rodriguez Garcia, Marjolein Mandalawi-Van der Eijk, Nicole van der Werff, Annemarie Voorberg-van der Wel, Edmond J Remarque, James G Beeson, Clemens H M Kocken
Plasmodium vivax malaria is increasingly recognized as a major global health problem and the socio-economic impact of P.vivax-induced burden is huge. Vaccine development against P. vivax malaria has been hampered by the lack of an in vitro culture system and poor access to P. vivax sporozoites. The recent generation of Plasmodium falciparum parasites that express a functional P. vivax AMA1 molecule has provided a platform for in vitro evaluation of PvAMA1 as a potential blood stage vaccine. Three so-called PvAMA1 Diversity Covering (DiCo) proteins were designed to assess their potential to induce a functional and broad humoral immune response to the polymorphic PvAMA1 molecule...
February 16, 2024: Vaccine
https://read.qxmd.com/read/38360666/acute-neutrophilic-vasculitis-leukocytoclasia-in-36-covid-19-autopsy-brains
#8
JOURNAL ARTICLE
Roy H Rhodes, Gordon L Love, Fernanda Da Silva Lameira, Maryam Sadough Shahmirzadi, Sharon E Fox, Richard S Vander Heide
BACKGROUND: Hypercytokinemia, the renin-angiotensin system, hypoxia, immune dysregulation, and vasculopathy with evidence of immune-related damage are implicated in brain morbidity in COVID-19 along with a wide variety of genomic and environmental influences. There is relatively little evidence of direct SARS-CoV-2 brain infection in COVID-19 patients. METHODS: Brain histopathology of 36 consecutive autopsies of patients who were RT-PCR positive for SARS-CoV-2 was studied along with findings from contemporary and pre-pandemic historical control groups...
February 15, 2024: Diagnostic Pathology
https://read.qxmd.com/read/38359037/eosinophils-of-patients-with-localized-and-diffuse-cutaneous-leishmaniasis-differential-response-to-leishmania-mexicana-with-insights-into-mechanisms-of-damage-inflicted-upon-the-parasites-by-eosinophils
#9
JOURNAL ARTICLE
Norma Salaiza-Suazo, Roxana Porcel-Aranibar, Isabel Cristina Cañeda-Guzmán, Adriana Ruiz-Remigio, Jaime Zamora-Chimal, José Delgado-Domínguez, Rocely Cervantes-Sarabia, Georgina Carrada-Figueroa, Baldomero Sánchez-Barragán, Victor Javier Leal-Ascencio, Armando Pérez-Torres, Héctor A Rodríguez-Martínez, Ingeborg Becker
Eosinophils are mainly associated with parasitic infections and allergic manifestations. They produce many biologically active substances that contribute to the destruction of pathogens through the degranulation of microbicidal components and inflammatory tissue effects. In leishmaniasis, eosinophils have been found within inflammatory infiltrate with protective immunity against the parasite. We analyzed the responses of eosinophils from patients with localized (LCL) and diffuse (DCL) cutaneous leishmaniasis, as well as from healthy subjects, when exposed to Leishmania mexicana...
2024: PloS One
https://read.qxmd.com/read/38279044/silica-nanoparticles-enhance-the-cyto-and-hemocompatibility-of-a-multilayered-extracellular-matrix-scaffold-for-vascular-tissue-regeneration
#10
JOURNAL ARTICLE
Leslie A Goldberg, Helena D Zomer, Calum McFetridge, Peter S McFetridge
PURPOSE: The limited availability of autologous vessels for vascular bypass surgeries is a major roadblock to treating severe cardiovascular diseases. Based on this clinical priority, our group has developed a novel engineered vascular graft by rolling human amniotic membranes into multilayered extracellular matrixes (ECM). When treated with silica nanoparticles (SiNP), these rolled scaffolds showed a significant improvement in their structural and mechanical properties, matching those from gold standard autologous grafts...
January 27, 2024: Biotechnology Letters
https://read.qxmd.com/read/38250883/haemato-immunological-response-of-immunized-atlantic-salmon-salmo-salar-to-moritella-viscosa-challenge-and-antigens
#11
JOURNAL ARTICLE
Maryam Ghasemieshkaftaki, Trung Cao, Ahmed Hossain, Ignacio Vasquez, Javier Santander
Winter ulcer disease is a health issue in the Atlantic salmonid aquaculture industry, mainly caused by Moritella viscosa . Although vaccination is one of the effective ways to prevent bacterial outbreaks in the salmon farming industry, ulcer disease related to bacterial infections is being reported on Canada's Atlantic coast. Here, we studied the immune response of farmed immunized Atlantic salmon to bath and intraperitoneal (ip) M. viscosa challenges and evaluated the immunogenicity of M. viscosa cell components...
January 10, 2024: Vaccines
https://read.qxmd.com/read/38228229/leech-extract-alleviates-idiopathic-pulmonary-fibrosis-by-tgf-%C3%AE-1-smad3-signaling-pathway
#12
JOURNAL ARTICLE
Yin Zhang, Yong-Bo Lu, Wei-Jie Zhu, Xiaoxi Gong, Rui Qian, Yi-Jing Lu, Yu Li, Wei-Feng Yao, Bei-Hua Bao, Yi Zhang, Li Zhang, Fang-Fang Cheng
ETHNOPHARMACOLOGICAL RELEVANCE: Leech, as a traditional Chinese medicine for the treatment of blood circulation and blood stasis, was also widely used to cure pulmonary fibrosis in China. In clinical practice, some traditional Chinese medicine preparation such as Shui Zhi Xuan Bi Hua Xian Tang and Shui Zhi Tong Luo Capsule composed of leech, could improve the clinical symptoms and pulmonary function in patients with idiopathic pulmonary fibrosis (IPF). However, the material basis of the leech in the treatment of IPF were not yet clear...
January 14, 2024: Journal of Ethnopharmacology
https://read.qxmd.com/read/38203193/high-throughput-measure-of-mitochondrial-superoxide-levels-as-a-marker-of-coronary-artery-disease-to-accelerate-drug-translation-in-patient-derived-endothelial-cells-using-opera-phenix-%C3%A2-technology
#13
JOURNAL ARTICLE
Weiqian E Lee, Marie Besnier, Elijah Genetzakis, Owen Tang, Katharine A Kott, Stephen T Vernon, Michael P Gray, Stuart M Grieve, Michael Kassiou, Gemma A Figtree
Improved human-relevant preclinical models of coronary artery disease (CAD) are needed to improve translational research and drug discovery. Mitochondrial dysfunction and associated oxidative stress contribute to endothelial dysfunction and are a significant factor in the development and progression of CAD. Endothelial colony-forming cells (ECFCs) can be derived from peripheral blood mononuclear cells (PBMCs) and offer a unique potentially personalised means for investigating new potential therapies targeting important components of vascular function...
December 19, 2023: International Journal of Molecular Sciences
https://read.qxmd.com/read/38158966/-comparative-characteristics-of-the-complement-system-in-patients-with-c3-glomerulopathy-and-atypical-hemolytic-uremic-syndrome-of-chronic-course-who-suffered-an-acute-episode-of-thrombotic-microangiopathy
#14
JOURNAL ARTICLE
V A Yurova, N L Kozlovskaya, L A Bobrova, L V Kozlov, S S Andina, K A Demyanova
AIM: To compare changes in the complement system in C3-glomerulopathy (C3-GP) and atypical hemolytic uremic syndrome (aHUS) after the relief of an acute episode of thrombotic microangiopathy. MATERIALS AND METHODS: The study included 8 patients diagnosed with C3-GP and 8 with aHUS in remission. The blood levels of the complement system components were determined: C3, C4, C3a, C5a, factor H (CFH), factor B (CFB), membrane-attacking complex (MAC), antibodies to C3b (anti-C3b-AT), the level of hemolytic activity (CH50), the content of factor D (CFD) in the urine...
August 17, 2023: Terapevticheskiĭ Arkhiv
https://read.qxmd.com/read/38151178/study-on-the-chemical-constituents-and-mechanism-of-kai-xin-san-based-on-uplc-q-exactive-ms-and-network-pharmacology
#15
JOURNAL ARTICLE
Bingxian Shang, Shuhe Jia, Tong Zhang, Feng Gao, Mingjun Lu, Kedian Chen, Jingyi Jiao, Ziqi Dai, Qi Zeng, Bing Xu, Haimin Lei
ETHNOPHARMACOLOGICAL RELEVANCE: Vascular disease (VD) is a kind of common disease harmful to the health of the middle-aged and elderly, which has the characteristics of long treatment cycle and high recurrence rate, and without effective method to treat so far. Traditional Chinese medicine (TCM) has the characteristics of multi-components and multi-targets to treat diseases. Kai-Xin-San is a TCM formula applied for treating psychiatric diseases such as depression in China for thousands of years, and it has been used in clinical treatment of VD...
December 25, 2023: Journal of Ethnopharmacology
https://read.qxmd.com/read/38092315/imperatorin-ameliorates-kidney-injury-in-diabetic-mice-by-regulating-the-tgf-%C3%AE-smad2-3-signaling-axis-epithelial-to-mesenchymal-transition-and-renal-inflammation
#16
JOURNAL ARTICLE
Sourav Kundu, Ankana Ghosh, Karan Singh Yadav, Madhav Nilakanth Mugale, Bidya Dhar Sahu
Diabetic nephropathy (DN) is a serious concern in patients with diabetes mellitus. Prolonged hyperglycemia induces oxidative damage, chronic inflammation, and build-up of extracellular matrix (ECM) components in the renal cells, leading to kidney structural and functional changes. Imperatorin (IMP) is a naturally occurring furanocoumarin derivative with proven antioxidative and anti-inflammatory properties. We investigated whether IMP could improve DN and employed high glucose (HG)-induced HK-2 cells and high-fat diet-fed streptozotocin (HFD/STZ)-generated DN experimental model in C57BL/6 J mice...
December 11, 2023: European Journal of Pharmacology
https://read.qxmd.com/read/38046569/use-of-reclaimed-urban-wastewater-for-the-production-of-hydroponic-barley-forage-water-characteristics-feed-quality-and-effects-on-health-status-and-production-of-lactating-cows
#17
JOURNAL ARTICLE
Luigi Ceci, Maria Alfonsa Cavalera, Francesco Serrapica, Antonio Di Francia, Felicia Masucci, Grazia Carelli
The safety of reclaimed urban wastewater (RUW) for the production of hydroponic barley forage (HBF) was evaluated in terms of effluent and forage characteristics, as well as the health and performance of lactating cows. The study was conducted on a dairy farm equipped with two hydroponic chambers producing approximately 620 kg/d of HBF as fed. For experimental purposes, HBF was produced using RUW collected from an aqueduct plant processing urban wastewater in a membrane bioreactor treatment chain. A feeding trial was carried out with HBF derived from RUW...
2023: Frontiers in Veterinary Science
https://read.qxmd.com/read/37948699/attenuation-of-ventriculomegaly-and-iron-overload-after-intraventricular-hemorrhage-by-membrane-attack-complex-inhibition
#18
JOURNAL ARTICLE
Katherine G Holste, Fenghui Ye, Sravanthi Koduri, Hugh J L Garton, Cormac O Maher, Richard F Keep, Ya Hua, Guohua Xi
OBJECTIVE: The pathophysiology of posthemorrhagic hydrocephalus (PHH) is not well understood, but recent data suggest blood components play a significant role. This study aimed to understand the timing of membrane attack complex (MAC) activation after intraventricular hemorrhage (IVH) and the effect of MAC inhibition on PHH development. METHODS: This study was composed of four parts. First, 24 young adult male rats underwent stereotactic intraventricular injection of autologous blood or saline and MRI on day 1, 3, or 7 after hemorrhage...
November 10, 2023: Journal of Neurosurgery
https://read.qxmd.com/read/37877715/molecular-mechanism-of-the-interaction-between-megalocytivirus-induced-virus-mock-basement-membrane-vmbm-and-lymphatic-endothelial-cells
#19
JOURNAL ARTICLE
Jian-Hui He, Wenjie Shen, Deyu Han, Muting Yan, Mengting Luo, Hengwei Deng, Shaoping Weng, Jianguo He, Xiaopeng Xu
The Megalocytivirus genus, family Iridoviridae, is a group of large DNA viruses that pose significant threats to marine and freshwater fishes. In tissues, the Megalocytivirus -infected cells are attached by a layer of lymphatic endothelial cells (LECs), constituting a unique histopathological phenomenon. Megalocytivirus induces the formation of an extracellular structure on the surface of infected cells that is functionally similar to the host basement membrane (BM), known as the virus-mock basement membrane (VMBM)...
October 25, 2023: Journal of Virology
https://read.qxmd.com/read/37800608/plasma-metabonomic-study-on-the-effect-of-para-%C3%A2-hydroxybenzaldehyde-intervention-in-a-rat-model-of-transient-focal-cerebral-ischemia
#20
JOURNAL ARTICLE
Xinglin Yu, Yuan Luo, Liping Yang, Xiaohua Duan
Gastrodia elata Blume has been widely used to treat various central and peripheral nerve diseases, and Para‑hydroxybenzaldehyde (PHBA) is one of the indicated components suggested to provide a neuroprotective effect. In our previous, it was shown that PHBA protected mitochondria against cerebral ischemia‑reperfusion (I/R) injury in rats. In the present study, how PHBA regulated the metabolic mechanism in blood following cerebral I/R was assessed to identify an effective therapeutic target for the prevention and treatment of ischemic stroke (IS)...
November 2023: Molecular Medicine Reports
keyword
keyword
161396
1
2
Fetch more papers »
Fetching more papers... Fetching...
Remove bar
Read by QxMD icon Read
×

Save your favorite articles in one place with a free QxMD account.

×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"

We want to hear from doctors like you!

Take a second to answer a survey question.