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blood group membrane components

Dongsha Shi, Yanying Dong, Pengfei Dai, Juan Gao, Jingjing Yin, Ming Xie
Hantaviruses is the major causative agents of hemorrhagic fever with renal syndrome (HFRS) in humans, which is characterized by increased capillary permeability. Dentin matrix protein 1 (DMP1) has been shown to degrade components of the basal membrane and interendothelial junctions via matrix metalloproteinase-9. To study the changes of serum DMP1 in HFRS, we determined the concentration of DMP1 using sandwich enzyme-linked immunosorbent assay. We found that serum DMP1 concentrations increased significantly, and reached peak value during the oliguric phase and in the critical group in HFRS patients...
February 5, 2019: Microbes and Infection
Amol K Bhandage, Zhe Jin, Sergiy V Korol, Atieh S Tafreshiha, Priya Gohel, Charlotte Hellgren, Daniel Espes, Per-Ola Carlsson, Inger Sundström-Poromaa, Bryndis Birnir
Calcium (Ca2+) is an important ion in physiology and is found both outside and inside cells. The intracellular concentration of Ca2+ is tightly regulated as it is an intracellular signal molecule and can affect a variety of cellular processes. In immune cells Ca2+ has been shown to regulate e.g. gene transcription, cytokine secretion, proliferation and migration. Ca2+ can enter the cytoplasm either from intracellular stores or from outside the cells when Ca2+ permeable ion channels in the plasma membrane open...
2018: PloS One
I E Vereshchagin, V I Ganyukov, R S Tarasov, N A Kochergin, D L Shukevich, O L Barbarash
Analysed herein are the in-hospital and remote (12 months) results of transcutaneous coronary interventions (TCI) carried out in patients with non-ST elevation acute coronary syndrome (nSTE-ACS) and multivessel coronary artery disease with the use of extracorporeal membrane oxygenation (ECMO). From 2013 to 2015, the study included a total of 18 patients with nSTE-ACS and multivessel coronary artery disease who had been denied "open" surgical myocardial revascularization. The mean values (scores) of the scales in the group were as follows: GRACE - 119...
2018: Angiologii︠a︡ i Sosudistai︠a︡ Khirurgii︠a︡, Angiology and Vascular Surgery
Jiawen Chen, Wei Cheng, Shuning Chen, Wenqin Xu, Jinhuo Lin, Haiqing Liu, Qinhui Chen
Quick hemostasis plays a very important role in preventing hemorrhagic shock and death by controlling blood loss from trauma in civil and military accidents. An ideal quick hemostat should have tissue-adhesive functional groups, clotting factor activating components, and a plasma non-permeable hydrophobic layer. Inspired by the adhesive behavior of mussels, a novel efficient hemostat of urushiol-functionalized mesoporous silica nanoparticles (MSN@U) with a core-shell structure was synthesized and their hemostatic performance was evaluated for the first time...
December 13, 2018: Nanoscale
Jin Ma, Ke Kang, Yujia Zhang, Qiangying Yi, Zhongwei Gu
In this work, we presented the ternary nanoparticles [pCBMA(CD-D/DOX)] based on peptide dendritic carbon dots (CDs) to realize tumor-specific drug delivery and high efficient cancer therapy. The versatile nanoparticles could achieve "stealth" delivery in blood due to the anti-fouling zwitterion coating. Meanwhile, charge changes of the zwitterions could be moderated during their transportation toward/inside tumor cells, where subtle environmental pH variations acted as potent stimuli to actualize desired functions...
November 26, 2018: ACS Applied Materials & Interfaces
Rosaria Notariale, Adriana Basile, Elena Montana, Nunzia Colonna Romano, Maria Grazia Cacciapuoti, Francesco Aliberti, Renato Gesuele, Francesca De Ruberto, Sergio Sorbo, Gian Carlo Tenore, Marco Guida, Katrina V Good, Juan Ausió, Marina Piscopo
The major acid-soluble protein components of the mussel Mytilus galloprovincialis sperm chromatin consist of the protamine-like proteins PL-II, PL-III and PL-IV, an intermediate group of sperm nuclear basic proteins between histones and protamines. The aim of this study was to investigate the bactericidal activity of these proteins since, to date, there are reports on bactericidal activity of protamines and histones, but not on protamine-like proteins. We tested the bactericidal activity of these proteins against Gram-positive bacteria: Enterococcus faecalis and two different strains of Staphylococcus aureus, as well as Gram-negative bacteria: Proteus mirabilis, Proteus vulgaris, Pseudomonas aeruginosa, Salmonella typhmurium, Enterobacter aerogenes, Enterobacter cloacae, and Escherichia coli...
November 17, 2018: Acta Biochimica Polonica
R I Stryuk, Y V Brytkova, S A Berns, P V Krikunov, O V Tatarinova, A S Tektova, M M Osmanova, T B Ivanova, E L Barkova, O L Kozhukhovskaya
PURPOSE: to identify early markers of development of cardiovascular diseases (CVD) in women. MATERIALS AND METHODS: Female firstdegree relatives from 39 families formed 2 groups: families (n=19) containing mothers with arterial hypertension (AH) (group 1) and healthy daughters (group 1a); families (n=20) containing practically heathy mothers (group 2) and healthy daughters (group 2a). We assessed data of anamnesis, including registration of cardiovascular risk factors, and family history of CVD...
June 2018: Kardiologiia
Yan Xu, Jian-Fei Fu, Jia-Hui Chen, Zhuang-Wei Zhang, Zu-Quan Zou, Li-Yuan Han, Qi-Hang Hua, Jin-Shun Zhao, Xiao-Hong Zhang, Yu-Juan Shan
Sulforaphane (SFN) is a dietary component with multiple bioactivities; however, its role in obesity-related metabolic derangement remains unclear. Here, the effect of SFN on the glucose intolerance of obese mice and the underlying mechanism were determined. C57B/6J male mice were randomly divided into two groups, having free access to water and a normal-fat diet (ND, n = 6) or a high-fat diet (HFD, n = 33) for 8 weeks; thereafter twelve mice having the greatest weight gain among the HFD-fed mice were considered as obese mice...
September 19, 2018: Food & Function
Berta Esteban-Fernández de Ávila, Weiwei Gao, Emil Karshalev, Liangfang Zhang, Joseph Wang
In the past decade, versatile micro- and nanosized machines have emerged as active agents for large-scale detoxification, sensing, microfabrication, and many other promising applications. Micromachines have also been envisioned as the next advancement in dynamic therapy with numerous proof-of-concept studies in drug delivery, microsurgery, and detoxification. However, the practical use of synthetic micromotors in the body requires the development of fully biocompatible designs facilitating micromotor movement in biological fluids of diverse composition and displaying desired functions in specific locations...
September 18, 2018: Accounts of Chemical Research
Steen K Fagerberg, Parth Patel, Lars W Andersen, Xiaowen Lui, Michael W Donnino, Helle A Praetorius
BACKGROUND: Pore-forming proteins released from bacteria or formed as result of complement activation are known to produce severe cell damage. Inhibition of purinergic P2X receptors markedly reduces damage inflicted by cytolytic bacterial toxin and after complement activation in both erythrocytes and monocytes. P2X expression generally shows variation throughout the population. Here, we investigate correlation between P2X receptor abundance in blood cell plasma membranes and haematocrit during sepsis, in patients admitted to the emergency department (ED) or intensive care unit (ICU)...
August 2, 2018: Critical Care: the Official Journal of the Critical Care Forum
Peng Li, Jian-Nong Wang, Jin-Cai Hou, Jian-Hua Fu, Jian-Xun Liu
The hawthorn leaves have the effect of activating blood, removing blood stasis, regulating qi through the veins, dissolving turbidity and lowering lipid. Procyanidinis is one of its main active components and plays an important role in regulating vasoactivity. Previous studies showed that the regulating effect of procyanidins was related to its regulation on nitric oxide secretion from vascular endothelial cells, and this effect was dependent on the extracellular calcium concentration, suggesting that the changes in intracellular calcium ion concentration in endothelial cells may play a key role in this process...
June 2018: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
Xu-Lin Liu, Wen-Ping Liu, Li-Li Wang, Liang Feng
Diabetic nephropathy (DN) is closely related to immune-mediated inflammatory damage. Pyrrosiae folium is used commonly for the urinary system diseases with a good efficacy, which contains abundant flavonoids (SWHT). This study was performed to investigate the therapeutic effect of SWHT on DN and its effect on inflammatory response. In this study, the main active components of SWHT were identified by high performance liquid chromatography (HPLC). The results showed that SWHT mainly contained mangiferin and isomucoside...
June 2018: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
Jihan Hussein, Mehrez E El-Naggar, Yasmin Abdel Latif, Dalia Medhat, Mona El Bana, Eman Refaat, Safaa Morsy
OBJECTIVE: To investigate and compare between the effect of both silver nanoparticles (AgNPs) and zinc oxide nanoparticles (ZnONPs) on insulin signaling pathway and insulin sensitivity in experimental diabetes. Preparation of AgNPs and ZnONPs in their solid state were carried out using pullulan (Natural polymer) as both reducing and stabilizing agent. The synthesis of these nanoparticles in a large scale were carried out without using any solvents. The experimental male albino rats received diluted solutions of AgNPs and ZNONPs...
October 1, 2018: Colloids and Surfaces. B, Biointerfaces
Wei Wu, Wei Hu, Wen-Bei Han, Ying-Lu Liu, Yue Tu, Hai-Ming Yang, Qi-Jun Fang, Mo-Yi Zhou, Zi-Yue Wan, Ren-Mao Tang, Hai-Tao Tang, Yi-Gang Wan
Huangkui capsule (HKC), a Chinese modern patent medicine extracted from Abelmoschus manihot (L.) medic, has been widely applied to clinical therapy in the early diabetic nephropathy (DN) patients. However, it remains elusive whether HKC can ameliorate the inchoate glomerular injuries in hyperglycemia. Recently the activation of phosphatidylinositol-3-kinase (PI3K)/serine-threonine kinase (Akt)/mammalian target of rapamycin (mTOR) signaling and its downstream regulator, 70-kDa ribosomal protein S6 kinase (p70S6K), play important roles in the early glomerular pathological changes of DN including glomerular hypertrophy, glomerular basement membrane (GBM) thickening and mild mesangial expansion...
2018: Frontiers in Pharmacology
Lajos Szente, Ashutosh Singhal, Andras Domokos, Byeongwoon Song
Cyclodextrins (CDs) are cyclic oligosaccharides; the most common CDs contain six, seven, or eight glucose units called α-CDs, β-CDs, and γ-CDs, respectively. The use of CDs in biomedical research is increasing due to their ability to interact with membrane lipids as well as a wide variety of poorly water-soluble molecules. We assessed the impact of CD cavity size, occupancy, and substitutions on cytotoxicity and cholesterol homeostasis. The potency of CD-mediated cytotoxicity was in the order of β-CDs, α-CDs, and γ-CDs...
May 20, 2018: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
Sandra W Jacobson, R Colin Carter, Christopher D Molteno, Ernesta M Meintjes, Marjanne S Senekal, Nadine M Lindinger, Neil C Dodge, Steven H Zeisel, Christopher P Duggan, Joseph L Jacobson
BACKGROUND: Choline, an essential nutrient, serves as a methyl-group donor for DNA methylation and is a constituent of the neurotransmitter acetylcholine and a precursor to major components of cell membranes. Findings from animal studies suggest that choline supplementation during pregnancy can mitigate adverse effects of prenatal alcohol exposure on growth and neurocognitive function. We conducted a randomized, double-blind exploratory trial to examine feasibility and acceptability of a choline supplementation intervention during pregnancy...
July 2018: Alcoholism, Clinical and Experimental Research
Patrick Orlando, Sonia Silvestri, Roberta Galeazzi, Roberto Antonicelli, Fabio Marcheggiani, Ilenia Cirilli, Tiziana Bacchetti, Luca Tiano
OBJECTIVES: Physical exercise significantly impacts the biochemistry of the organism. Ubiquinone is a key component of the mitochondrial respiratory chain and ubiquinol, its reduced and active form, is an emerging molecule in sport nutrition. The aim of this study was to evaluate the effect of ubiquinol supplementation on biochemical and oxidative stress indexes after an intense bout of exercise. METHODS: 21 male young athletes (26 + 5 years of age) were randomized in two groups according to a double blind cross-over study, either supplemented with ubiquinol (200 mg/day) or placebo for 1 month...
December 2018: Redox Report: Communications in Free Radical Research
Yamato Kikkawa, Yurie Enomoto-Okawa, Aiko Fujiyama, Takeshi Fukuhara, Nozomi Harashima, Yumika Sugawara, Yoichi Negishi, Fumihiko Katagiri, Kentaro Hozumi, Motoyoshi Nomizu, Yuji Ito
Antibody-drug conjugates (ADCs) are attractive in cancer therapy because they can directly bind to cancer cells and provide anticancer activity. To kill cancer cells with ADCs, the target antigens are required not only to be highly and/or selectively expressed on cancer cells but also internalized by the cells. CD239, also known as the Lutheran blood group glycoprotein (Lu) or basal cell adhesion molecule (B-CAM), is a specific receptor for laminin α5, a major component of basement membranes. Here, we show that CD239 is strongly expressed in a subset of breast cancer cells and internalized into the cells...
April 26, 2018: Scientific Reports
Cecilia Zazueta, Mabel Buelna-Chontal, Arturo Macías-López, Nadia G Román-Anguiano, Héctor González-Pacheco, Natalia Pavón, Rashidi Springall, Alberto Aranda-Frausto, Rafael Bojalil, Alejandro Silva-Palacios, Rodrigo Velázquez-Espejel, Sonia Galvan Arzate, Francisco Correa
Cytidine-5'-diphosphocholine (CDP-choline) participates as an intermediary in the synthesis of phosphatidylcholine, an essential component of cellular membranes. Citicoline treatment has shown beneficial effects in cerebral ischemia, but its potential to diminish reperfusion damage in liver has not been explored. In this work, we evaluated the hepatoprotective effect of citicoline and its possible association with inflammatory/oxidative stress and mitochondrial function because they are the main cellular features of reperfusion damage...
August 2018: Liver Transplantation
Dai Cheng, Jinlei Tang, Xuerui Wang, Xinyu Zhang, Shuo Wang
Al contamination becomes a growing problem in human society. Accumulation of Al in blood could destroy the structure and disorder function of erythrocyte, and finally cause blood diseases. In the present study, AlCl3 and Al(malt)3 are respectively used in the erythrocyte system, in order to investigate the comparative toxic effect on erythrocyte fragility, the influence on cellular biochemical components and lipid peroxidation level. We find that the osmotic fragility, the number of Heinz bodies, the content of MDA and advanced oxidation protein product of the AlCl3 treated erythrocytes were higher than the Al(malt)3 treated erythrocytes at the same concentrations of Al(Ⅲ)...
August 15, 2018: Ecotoxicology and Environmental Safety
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