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https://read.qxmd.com/read/30773021/inhibition-of-s-adenosylhomocysteine-hydrolase-induces-endothelial-dysfunction-via-epigenetic-regulation-of-p66shc-mediated-oxidative-stress-pathway
#1
Yunjun Xiao, Junjie Xia, Jinquan Cheng, Haiyan Huang, Yani Zhou, Xifei Yang, Xuefen Su, Yuebin Ke, Wenhua Ling
BACKGROUND: Elevated levels of S-adenosylhomocysteine (SAH), the precursor of homocysteine, are positively associated with the risk of cardiovascular disease, and with development and progression of atherosclerosis. However, the role of SAH in endothelial dysfunction is unclear. METHODS: Apolipoprotein E-deficient ( apoE-/- ) mice received dietary supplementation with SAH hydrolase (SAHH) inhibitor adenosine dialdehyde (ADA), or were intravenously injected with a retrovirus expressing SAHH short hairpin RNA (shRNA)...
February 18, 2019: Circulation
https://read.qxmd.com/read/30772435/occurrence-of-microcystin-lr-in-vegetated-lagoons-used-for-urban-runoff-management
#2
Xiao-Yu Peng, Yan-Kui Tang, Wei-Wei Yang, Yu-Nong Chen, Yan Zhou, Yang Yuan, Yin-Feng Huang, Lu Liu
Phytoremediation with aquatic macrophyte has been considered as an eco-friendly technique for controlling harmful cyanobacteria outbreak and proven to be effective. The conventional water quality parameters are frequently measured to evaluate the effectiveness of phytoremediation. However, the concentration of microcystin-leucine-arginine (MC-LR) in different vegetated water still remains uncertain. In this study, the contents of MC-LR in four macrophyte-vegetated lagoons were determined by solid phase extraction and ultra-high-performance liquid chromatography with tandem mass spectrometry technology...
February 14, 2019: Toxicon: Official Journal of the International Society on Toxinology
https://read.qxmd.com/read/30772376/recombinant-protein-purification-in-baculovirus-infected-rachiplusia-nu-larvae-an-approach-towards-a-rational-design-of-downstream-processing-strategies-based-on-chromatographic-behavior-of-proteins
#3
G J Mc Callum, M B Arregui, I Smith, L F Bracco, F Wolman, O Cascone, A M Targovnik, M V Miranda
Expression of recombinant proteins with baculovirus-infected insect larvae is a scarcely investigated alternative in comparison to that in insect cell lines, a system with growing popularity in the field of biotechnology. The aim of this study was to investigate the chromatographic behavior and physicochemical properties of the proteome of Rachiplusia nu larvae infected with recombinant Autographa californica multiple nucleopolyhedrosis virus (AcMNPV), in order to design rational purification strategies for the expression of heterologous proteins in this very complex and little-known system, based on the differential absorption between target recombinant proteins and the system's contaminating ones...
February 14, 2019: Protein Expression and Purification
https://read.qxmd.com/read/30772047/primary-and-secondary-prevention-of-preterm-birth-a-review-of-systematic-reviews-and-ongoing-randomized-controlled-trials
#4
REVIEW
Anca Matei, Gabriele Saccone, Joshua P Vogel, Anthony B Armson
BACKGROUND: Preterm birth (PTB) is a leading cause of perinatal morbidity and mortality. Interventions aimed at preventing PTB can be classified as primary, secondary, or tertiary prevention. OBJECTIVE: To conduct a review of systematic reviews on the effectiveness and safety of primary and secondary preterm birth prevention interventions. SEARCH STRATEGY: A systematic literature search of the Cochrane, PubMed/Medline, EMBASE and CINAHL databases was conducted on 2 September 2015, and updated on 21 November 2016...
January 25, 2019: European Journal of Obstetrics, Gynecology, and Reproductive Biology
https://read.qxmd.com/read/30771310/luteolin-induced-coronary-arterial-relaxation-involves-activation-of-the-myocyte-voltage-gated-k-channels-and-inward-rectifier-k-channels
#5
Weiping Li, Miaomiao Dong, Pengmei Guo, Yu Liu, Yixin Jing, Rui Chen, Mingsheng Zhang
AIMS: Luteolin has been shown to be beneficial to cardiovascular tissues and organs. We aimed to study its vasospasmolytic effects against various vasoconstrictors in the isolated rat coronary arteries (RCAs) and its electrophysiological effects on K+ currents via voltage-gated potassium (Kv) channels and inward rectifier potassium (Kir) channels in freshly isolated rat coronary arterial smooth muscle cells (RCASMCs). MAIN METHODS: The vascular tone of the endothelium-denuded RCAs was recorded by a wire myograph...
February 13, 2019: Life Sciences
https://read.qxmd.com/read/30770460/esa1-is-involved-in-embryo-sac-abortion-in-interspecific-hybrid-progeny-of-rice
#6
Jingjing Hou, Caihong Cao, Yini Ruan, Yanyan Deng, Yaxin Liu, Kun Zhang, Lubin Tan, Zuofeng Zhu, Hongwei Cai, Fengxia Liu, Hongying Sun, Ping Gu, Chuanqing Sun, Yongcai Fu
The emergence of sterile individuals in the hybrid backcross progeny of wild and cultivated rice limits the use of wild rice alleles for improving cultivated rice, but the molecular mechanisms underlying this sterility remain unclear. Here, we identified the semi-sterile introgression line YIL42, derived from a cross between the indica rice variety Teqing (Oryza sativa L.) and Oryza rufipogon Griff. accession YJCWR (Yuanjiang common wild rice), which exhibits semi-sterility. Using positional cloning, we isolated EMBRYO SAC ABORTION 1 (ESA1), which encodes a nuclear-membrane localized protein containing an armadillo (ARM) repeat domain...
February 15, 2019: Plant Physiology
https://read.qxmd.com/read/30765803/comparative-physiological-and-metabolic-analysis-reveals-a-complex-mechanism-involved-in-drought-tolerance-in-chickpea-cicer-arietinum-l-induced-by-pgpr-and-pgrs
#7
Naeem Khan, Asghari Bano, M Atikur Rahman, Jia Guo, Zhiyu Kang, Md Ali Babar
The plant growth promoting rhizobacteria (PGPR) and plant growth regulators (PGRs) can be applied to improve the growth and productivity of plants, with potential to be used for genetic improvement of drought tolerance. However, for genetic improvement to be achieved, a solid understanding of the physiological and biochemical changes in plants induced by PGPR and PGR is required. The present study was carried out to investigate the role of PGPR and PGRs on the physiology and biochemical changes in chickpea grown under drought stress conditions and their association with drought tolerance...
February 14, 2019: Scientific Reports
https://read.qxmd.com/read/30763805/inhibition-of-the-alternative-complement-pathway-accelerates-repair-processes-in-the-murine-model-of-choroidal-neovascularization
#8
Nathaniel Parsons, Balasubramaniam Annamalai, Elisabeth Obert, Gloriane Schnabolk, Stephen Tomlinson, Bärbel Rohrer
Age-related macular degeneration (AMD) is the leading cause of blindness in the US. Polymorphisms in complement components are associated with increased AMD risk, and it has been hypothesized that an overactive complement system is partially responsible for AMD pathology. Choroidal neovascularization (CNV) has two phases, injury/angiogenesis and repair/fibrosis. Complement activation has been shown to be involved in the angiogenesis phase of murine CNV, but has not been investigated during repair. Anaphylatoxin (C3a and C5a) signaling in particular has been shown to be involved in both tissue injury and repair in other models...
February 11, 2019: Molecular Immunology
https://read.qxmd.com/read/30763652/glutaminergic-tonic-action-potentiate-mpp-induced-hydroxyl-radical-production-in-rat-striatum
#9
Toshio Obata
The effect of glycine on 1-methyl-4-phenylpyridinium ion (MPP+ )-induced hydroxyl radical (•OH) formation in the extracellular fluid of rat striatum were investigated. Rats were anesthetized and sodium salicylate in Ringer's solution (0.5 nmol/μl/min) was infused through a microdialysis probe to detect the generation of •OH as reflected by the non-enzymatic formation of 2,3-dihydroxybenzoic acid (2,3-DHBA) in rat striatum. MPP+ (5 mmol/L) produced an increase in •OH formation. When glycine (1 mmol/L) was infused into the rat striatum through a microdialysis probe after MPP+ treatment, the marked in the level of 2,3-DHBA was observed in the brain dialysate...
February 11, 2019: Neuroscience Letters
https://read.qxmd.com/read/30763082/a-two-enzyme-pathway-links-l-arginine-to-nitric-oxide-in-n-nitroso-biosynthesis
#10
Haiyan He, Alyssa C Henderson, Yi-Ling Du, Katherine S Ryan
Nitric oxide (NO) has wide-ranging roles in biology, but less is known about its role in building chemical diversity. Here we report a new route to NO from the biosynthetic pathway to the N-nitroso compound streptozocin. We show that the N-nitroso of streptozocin comes from biosynthetic reassembly of L-arginine, with the guanidino nitrogens forming a nitrogen-nitrogen bond. To understand this biosynthetic process, we identify the biosynthetic gene cluster of streptozocin and demonstrate that free L-arginine is N-methylated by StzE to give Nω -monomethyl-L-arginine...
February 14, 2019: Journal of the American Chemical Society
https://read.qxmd.com/read/30762135/atmospheric-depositions-affect-the-growth-patterns-of-scots-pines-pinus-sylvestris-l-a-long-term-cause-effect-monitoring-study-using-biomarkers
#11
Horst Schulz, Wolfgang Beck, Angela Lausch
Recording the causes, effects, and effect mechanisms of vegetation health is crucial to understand process-pattern interactions in ecosystem processes. NOX and SOX in the form of air pollution are both triggers and sources of vegetation health that can have an effect on the local or the global level and whose impacts need to be monitored. In this study, the growth patterns in Scots pines (Pinus sylvestris L.) were studied in the context of changing atmospheric depositions in the lowlands of north-eastern Germany...
February 14, 2019: Environmental Monitoring and Assessment
https://read.qxmd.com/read/30761631/leucine-induced-promotion-of-post-absorptive-eaa-utilization-and-hepatic-gluconeogenesis-contributes-to-protein-synthesis-in-skeletal-muscle-of-dairy-calves
#12
Chen Zheng, Junhu Yao, Long Guo, Yangchun Cao, Ziqi Liang, Xinjian Yang, Chuanjiang Cai
The high rate of protein synthesis in skeletal muscle of dairy calves can benefit their first lactation even lifetime milk yield. Since the rate of protein synthesis is relatively low in the post-absorptive state, the aim of this research was to determine whether leucine supplementation could increase the post-absorptive essential amino acid (EAA) utilization and protein synthesis in the skeletal muscle. Ten male neonatal dairy calves (38 ± 3 kg) were randomly assigned to either the control (CON, no leucine supplementation, n = 5) or supplementation with 1...
February 13, 2019: Journal of Animal Physiology and Animal Nutrition
https://read.qxmd.com/read/30760669/characterizing-water-behavior-in-%C3%AE-gel-%C3%AE-type-hydrated-crystal-formed-from-monohexadecyl-phosphate-and-l-arginine
#13
Keisuke Tanaka, Yuki Hirai, Toshiyuki Suzuki, Masaaki Akamatsu, Kenichi Sakai, Hideki Sakai
Monohexadecyl phosphate, neutralized by L-arginine (C16MP-Arg), forms an α-gel (α-type hydrated crystal) with water. In this study, we characterized the behavior of water in the C16MP-Arg α-gel system by means of small/wide angle X-ray scattering (SWAXS), Fourier transform infrared spectroscopy (FT-IR), differential scanning calorimetry (DSC), and 1 H nuclear magnetic resonance (NMR) spectroscopy. An increased water concentration resulted in an increase in the d-spacing of the lamellar bilayers as well as an increased wavenumber for the O-H stretching vibration peak...
February 13, 2019: Journal of Oleo Science
https://read.qxmd.com/read/30756538/-recombinant-expression-of-crassostrea-gigas-defensin-in-pichia-pastoris-and-its-antibacterial-activity
#14
Xu Cui, Yan Tao, Qianghou Wang, Yali Zhang, Qianqian Yan
Defensins are endogenous cationic antimicrobial peptides rich in arginine and cysteine residues. They are important immune factors resisting pathogenic bacteria infection for mollusks. The 43 amino acid residues near the carboxyl terminal for Crassostrea gigas defensin (CgD) form its mature peptide region, responsible for the biological activity of CgD. First, two target genes, CgDH⁺ (with 6×His-tag at 3' end) and CgDH- (without 6×His-tag at 3' end) were separated and amplified by RT-PCR with specific primers from Crassostrea gigas mantle...
January 25, 2019: Sheng Wu Gong Cheng Xue Bao, Chinese Journal of Biotechnology
https://read.qxmd.com/read/30754621/gastroprotection-of-calein-d-against-ethanol-induced-gastric-lesions-in-mice-role-of-prostaglandins-nitric-oxide-and-sulfhydryls
#15
María Elena Sánchez-Mendoza, Yaraset López-Lorenzo, Leticia Cruz-Antonio, Audifás-Salvador Matus-Meza, Yolanda Sánchez-Mendoza, Jesús Arrieta
Peptic ulcers are currently treated with various drugs, all having serious side effects. The aim of this study was to evaluate the gastroprotective activity of calein D (from Calea urticifolia ), a sesquiterpene lactone with a germacrane skeleton. Gastric lesions were induced in mice by administering ethanol (0.2 mL) after oral treatment with calein D at 3, 10 and 30 mg/kg, resulting in 13.15 ± 3.44%, 77.65 ± 7.38% and 95.76 ± 2.18% gastroprotection, respectively, to be compared with that of the control group...
February 11, 2019: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://read.qxmd.com/read/30746556/elucidating-the-mechanism-of-absorption-of-fast-acting-insulin-aspart-the-role-of-niacinamide
#16
Jonas Kildegaard, Stephen T Buckley, Rasmus H Nielsen, Gro K Povlsen, Torben Seested, Ulla Ribel, Helle B Olsen, Svend Ludvigsen, Claus B Jeppesen, Hanne H F Refsgaard, Kristian M Bendtsen, Niels R Kristensen, Susanne Hostrup, Jeppe Sturis
PURPOSE: Fast-acting insulin aspart (faster aspart) is a novel formulation of insulin aspart containing two additional excipients: niacinamide, to increase early absorption, and L-arginine, to optimize stability. The aim of this study was to evaluate the impact of niacinamide on insulin aspart absorption and to investigate the mechanism of action underlying the accelerated absorption. METHODS: The impact of niacinamide was assessed in pharmacokinetic analyses in pigs and humans, small angle X-ray scattering experiments, trans-endothelial transport assays, vascular tension measurements, and subcutaneous blood flow imaging...
February 11, 2019: Pharmaceutical Research
https://read.qxmd.com/read/30745862/bidirectional-effects-of-pyrrolidine-dithiocarbamate-on-severe-acute-pancreatitis-in-a-rat-model
#17
Huan Yang, ShuCan Ma, Yu Guo, DongLai Cui, JinFeng Yao
Introduction: The mechanism by which intestinal mucosal barrier is damaged in severe acute pancreatitis (SAP)-associated impairment is not fully understood. Methods: We established an l-arginine-induced SAP rat model, pretreated with or without pyrrolidine dithiocarbamate (PDTC). Hematoxylin and eosin staining was performed to evaluate the pathological alterations. Western blotting was conducted to detect the expression of autophagy-related proteins. Oxidative stress was assessed by the levels of malondialdehyde and superoxide dismutase...
January 2019: Dose-response: a Publication of International Hormesis Society
https://read.qxmd.com/read/30745372/resistance-to-two-vinylglycine-antibiotic-analogs-is-conferred-by-inactivation-of-two-separate-amino-acid-transporters-in-erwinia-amylovora
#18
Derek D N Smith, Ashley N Williams, Jennifer N Verrett, Nathanael T Bergbusch, Viola Manning, Kristin Trippe, John Stavrinides
Erwinia amylovora is the causal agent of fire blight of apple and pear trees. Several bacteria have been shown to produce antibiotics that antagonize E. amylovora including pantocins, herbicolins, dapdiamides, and the vinylglycines, 4-formylaminooxyvinylglycine (FVG) and 4-aminoethoxyvinylglycine (AVG). Pantoea ananatis BRT175 was previously shown to exhibit antibiotic activity against E. amylovora via the production of Pantoea Natural Product 1 (PNP-1), later shown to be FVG; however, exposure of E. amylovora to FVG results in spontaneously resistant mutants...
February 11, 2019: Journal of Bacteriology
https://read.qxmd.com/read/30745281/biosensor-for-direct-bioelectrocatalysis-detection-of-nitric-oxide-using-nitric-oxide-reductase-incorporated-in-carboxylated-single-walled-carbon-nanotubes-lipidic-3-bilayer-nanocomposite
#19
Filipa O Gomes, Luísa B Maia, Joana A Loureiro, Maria Carmo Pereira, Cristina Delerue-Matos, Isabel Moura, José J G Moura, Simone Morais
An enzymatic biosensor based on nitric oxide reductase (NOR; purified from Marinobacter hydrocarbonoclasticus) was developed for nitric oxide (NO) detection. The biosensor was prepared by deposition onto a pyrolytic graphite electrode (PGE) of a nanocomposite constituted by carboxylated single-walled carbon nanotubes (SWCNTs), a lipidic bilayer [1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine (DOPE), 1,2-di-(9Z-octadecenoyl)-3-trimethylammonium-propane (DOTAP), 1,2-distearoyl-sn-glycero-3-phosphoethanolamine-polyethylene glycol (DSPE-PEG)] and NOR...
February 5, 2019: Bioelectrochemistry
https://read.qxmd.com/read/30744849/l-lysine-l-arginine-l-cysteine-synergistically-improves-the-color-of-cured-sausage-with-nano-2-by-hindering-myoglobin-oxidation-and-promoting-nitrosylmyoglobin-formation
#20
Cheng Ning, Linxian Li, Hongmei Fang, Fei Ma, Yuxiang Tang, Cunliu Zhou
This study aimed to evaluate the effects of l-lysine (Lys)/l-arginine (Arg)/l-cysteine (Cys) on the color of cured sausage and the possible mechanism underlying these effects. The results indicated that the combined addition of Arg/Lys/Cys and NaNO2 effectively increased the a* values and nitroso pigment content but decreased the MetMb(Fe3+ ) content in cured sausage, compared with the individual addition of Arg/Lys/Cys and NaNO2 . The cured sausage treated with combined Arg/Lys/Cys and NaNO2 contained significantly lower residual nitrite than those treated with only NaNO2 ...
June 30, 2019: Food Chemistry
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