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Vitamin AND D AND Testosterone

Luke A Robles, Karen Dawe, Richard M Martin, Julian P T Higgins, Sarah J Lewis
BACKGROUND: Evidence from studies on prostate cancer progression have identified vitamin D to be a potentially important nutrient. However, the World Cancer Research Fund and American Institute for Cancer Research have reported the quality of this evidence to be limited and warrant further investigation. We plan to use the recently developed WCRF International/University of Bristol mechanistic systematic review framework to determine whether the observed association between vitamin D and prostate cancer exists through a plausible biological pathway...
February 12, 2019: Systematic Reviews
Michael Samoszuk, Abraham Morgentaler, Mark de Groot, Wouter van Solinge, Yu Li, Fiona Adair, Imo Hoefer, Saskia Haitjema
Testosterone has effects on many organs and systems. The purpose of this study was to test the hypothesis that low testosterone is associated with changes in various non-cardiovascular biomarkers in men older than 40 who were tested for possible hypogonadism. We extracted data from 9939 outpatient men who were over 40 years old (median age 56) and who also had concurrent laboratory measurements of total testosterone and one or more biomarkers of interest: estradiol, uric acid, prostate-specific antigen (PSA), sex-hormone binding globulin (SHBG), luteinizing hormone, creatinine, bone alkaline phosphatase (BAP), creatine kinase, hemoglobin A1c, and 25-hydroxy-vitamin D, and body mass index (BMI)...
January 22, 2019: International Journal of Impotence Research
Vahidreza Ostadmohammadi, Mehri Jamilian, Fereshteh Bahmani, Zatollah Asemi
OBJECTIVE: The aim of this study was to determine the effect of vitamin D and probiotic co-administration on mental health, hormonal, inflammatory and oxidative stress parameters in women with polycystic ovary syndrome (PCOS). METHODS: This randomized, double-blinded, placebo-controlled clinical trial was carried out on 60 subjects, aged 18-40 years old. Subjects were randomly allocated to take either 50,000 IU vitamin D every 2 weeks plus 8 × 109  CFU/day probiotic (n = 30) or placebo (n = 30) for 12 weeks...
January 21, 2019: Journal of Ovarian Research
Polly Zhang, Adam Schatz, Babatunde Adeyemi, David Kozminski, JoEllen Welsh, Martin Tenniswood, Wei-Lin Winnie Wang
Vitamin D3 and its receptor are responsible for controlling energy expenditure in adipocytes and have direct roles in the transcriptional regulation of energy metabolic pathways. This phenomenon also has a significant impact on the etiology of prostate cancer (PCa). Using several in vitro models, the roles of vitamin D3 on energy metabolism and its implication in primary, early and late invasive PCa was investigated. BODIPY staining and qPCR analyses show that 1,25-dihydroxyvitamin D3 (1,25(OH)2 D3 ) up-regulates de novo lipogenesis in PCa cells by orchestrating transcriptional regulation that affects cholesterol and lipid metabolic pathways...
January 18, 2019: Journal of Steroid Biochemistry and Molecular Biology
Zeeshan Javed, Maria Papageorgiou, Harshal Deshmukh, Eric S Kilpatrick, Vincent Mann, Lynsey Corless, George Abouda, Alan S Rigby, Stephen L Atkin, Thozhukat Sathyapalan
Polycystic ovary syndrome (PCOS) increases the risk of metabolic syndrome and non-alcoholic-fatty-liver disease (NAFLD). Vitamin D supplementation may exert positive effects on liver biochemistry in patients with NAFLD; however, its effects on PCOS are unknown. This randomized, double-blind, placebo-controlled study explored the effect of vitamin D supplementation on cardiovascular risk factors (high-sensitivity C-reactive protein ( hs -CRP), weight, body mass index (BMI), lipid profile, glucose levels, insulin levels, the homeostatic model assessment-insulin resistance (HOMA-IR), hormones (free androgen index (FAI), testosterone, sex hormone binding globulin (SHBG), and liver markers (alanine aminotransferase (ALT), hyaluronic acid (HA), N-terminal pro-peptide of type III procollagen (PIIINP), tissue inhibitor of metallo-proteinases-1 (TIMP-1), and the enhanced liver fibrosis (ELF) score)...
January 17, 2019: Nutrients
Leila Hadjadj, Éva Pál, Anna Monori-Kiss, Réka Eszter Sziva, Ágnes Korsós-Novák, Eszter Mária Horváth, Rita Benkő, Attila Magyar, Péter Magyar, Zoltán Benyó, György L Nádasy, Szabolcs Várbíró
Vitamin D (vitD) insufficiency affects 1 billion people worldwide. Androgen excess (AE) occurs in 8% of fertile females. There are few data about the combined effect of vitD deficiency and AE on the early biomechanical changes of cerebral arterioles in fertile-aged female. Forty-six adolescent female Wistar rats (21-28 day-old, weighing 90-110 g) were grouped randomly in four groups: vitD supplemented groups with and without transdermal testosterone (T) treatment, as well as vitD deficient groups also with and without transdermal T (n = 11 or 12, in all cases)...
January 9, 2019: Gynecological Endocrinology
Jyotsna Pundir, David Charles, Luca Sabatini, Danielle Hiam, Sonia Jitpiriyaroj, Helena Teede, Arri Coomarasamy, Lisa Moran, Shakila Thangaratinam
BACKGROUND: Polycystic ovary syndrome (PCOS) is a major contributor to subfertility, diabetes and cardiovascular disease in women. The role of non-pharmacological interventions to prevent these outcomes has been reported in many systematic reviews, but robust conclusions have not been made due to variations in the scope, quality and findings of these reviews. OBJECTIVE AND RATIONALE: Our aim was to provide an overview of existing evidence on the effects of non-pharmacological interventions in women with PCOS on fertility and non-fertility outcomes by a review of existing systematic reviews...
January 4, 2019: Human Reproduction Update
C Antinozzi, F Marampon, P Sgrò, V Tombolini, A Lenzi, C Crescioli, L Di Luigi
PURPOSE: Skeletal muscle (Skm) plays a key role in regulating energetic metabolism through glucose homeostasis. Several hormones such as Testosterone (T) and Vitamin D (VD) have been shown to affect energy-dependent cell trafficking by determining Insulin (I)-like effects. AIM: To elucidate possible hormone-related differences on muscular metabolic control, we analyzed and compared the effects of T and elocalcitol (elo), a VD analogue, on the activation of energy-dependent cell trafficking, metabolism-related-signal transduction pathways and transcription of gene downstream targets...
January 1, 2019: Journal of Endocrinological Investigation
Engy Bakeer, Rasha Radwan, Ahmed El Mandoury, Abdullah Abd El Rahman, Mohamed Gad, Sahar Abd El Maksoud
Background: Recent studies have highlighted the role of anti-Müllerian hormone (AMH) in numerous ovarian disorders. Polycystic Ovary Syndrome (PCOS) is one of the major causes of infertility in Egypt. Several reports have linked PCOS with vitamin D deficiency. This investigation illustrates the possibility of using serum AMH for PCOS diagnosis in infertile Egyptian females, determines the variables affecting it and correlates it with serum 25(OH)D, testosterone, dyslipidemia and anthropometric parameters...
December 2018: Journal of Medical Biochemistry
Fatih Özkaya, Azam Demirel
OBJECTIVES: According to the WorldHealth Organization (WHO) definition, infertility is "thefailure of a sexually active, non-contracepting couple toachieve pregnancy in one year" and is a complicateddisorder with its medical, psychosocial and economicaspects. There is some proof that vitamin D deficiencyhas important effects on the male reproductive system.There are numerous animal trials and a limited numberof human trials investigating this topic. In our study, thepurpose is to consider vitamin D deficiency as a causeof infertility and investigate the relationship of serum vitaminD levels and infertility primarily in our region whereexposure to sunlight is relatively low...
December 2018: Archivos Españoles de Urología
Juan Mielgo-Ayuso, Julio Calleja-González, Aritz Urdampilleta, Patxi León-Guereño, Alfredo Córdova, Alberto Caballero-García, Diego Fernandez-Lázaro
INTRODUCTION: Deficient levels of 25-hydroxyvitamin D (25(OH)D) (<30 ng/mL) may compromise health and athletic performance. Supplementation with oral vitamin D can favor the state of iron metabolism, and testosterone and cortisol as an indicator of muscle recovery of the athlete with a deficiency. The main aim of this study was to evaluate the influence of eight weeks of supplementation with 3000 IU/day of vitamin D on the hematological and iron metabolism profile, as well as on the analytical values of testosterone and cortisol on elite male traditional rowers...
December 12, 2018: Nutrients
J X Wang, Y Yu, M T Han, G G Wang, S M Yang, W Wang, H Li
Objective: To analyze the effect of insufficient intake of vitamin D (VD) on sperm quality and male fertility and to discuss the mechanism of the effect. Methods: VD deficiency mice were fed with VD-deficient diet and light-sheltered. The sperm motility, morphology, ultrastructure, testicular pathology, sex hormones and fertility of normal and VD-deficient mice were analyzed to investigate the effects of VD deficiency on male reproduction. Results: Compared with the normal group, the mice with VD deficiency had lower sperm concentration[(128±53) ×10(6)/ml vs( 58±15) ×10(6)/ml, P <0...
December 11, 2018: Zhonghua Yi Xue za Zhi [Chinese medical journal]
Han-Joo Maeng, Trang Nguyen Kieu Doan, In-Soo Yoon
1α,25-Dihydroxyvitamin D3 (also called 1,25(OH)2 D3 or calcitriol) is the biologically active form of vitamin D, which functions as a ligand to the vitamin D receptor (VDR). It was previously reported that intestinal cytochrome P450 3A (CYP3A) expression was altered by 1,25(OH)2 D3 -mediated VDR activation. However, to clarify whether the change in CYP3A subfamily expression by VDR activation can affect metabolic function, further evidence is needed to prove the effect of 1,25(OH)2 D3 treatment on CYP3A-mediated drug metabolism and pharmacokinetics...
December 10, 2018: Drug Development Research
Mellar P Davis, Rajiv Panikkar
Clinicians often believe that cachexia is caused by cancer and anorexia as a toxicity of chemotherapy or targeted anti-cancer agents. It is now recognized that chemotherapy and certain targeted agents cause sarcopenia which reduce physical function and quality of life. Pre-treatment sarcopenia predicts chemotherapy toxicity, reduced response, increased disability, poor anti-tumor response and survival. Though bioelectrical impedance and dual energy X-ray absorptiometry (DEXA) scans have been used in the past for body composition measurements, CT scan cuts at the level of the 3rd lumbar vertebral body with measurement of skeletal muscle and visceral and subcutaneous fat areas has become standard...
September 7, 2018: Annals of Palliative Medicine
Leila Hadjadj, Anna Monori-Kiss, Eszter M Horváth, Andrea Heinzlmann, Attila Magyar, Réka E Sziva, Zsuzsanna Miklós, Éva Pál, János Gál, István Szabó, Zoltán Benyó, György L Nádasy, Szabolcs Várbíró
Vitamin D (VitD) hypovitaminosis and androgen excess (AE) are both risk factors for cardiovascular diseases in fertile women. However, the possible early interaction between AE and VitD status is not clear. Our goal was to describe how VitD status influences early changes in the biomechanical reactivity of small coronary arterioles in adult female rats after transdermal testosterone treatment. Forty-six adolescent, 90-110-gram-weighed female Wistar rats were randomly grouped into 4 groups. Twenty-four animals received an optimal VitD-supplemented diet, from which 12 animals underwent transdermal testosterone treatment...
November 28, 2018: Microvascular Research
Vibha Singhal, Kathryn E Ackerman, Amita Bose, Landy Paola Torre Flores, Hang Lee, Madhusmita Misra
Objective: Transdermal, but not oral, estrogen replacement improves bone mineral density (BMD) in athletes with oligo-amenorrhea (OA). Our objective was to determine mechanisms that may explain the impact of route of estrogen administration on bone outcomes. Methods: 73 OA between 14-25 years old received (i) a 17β-estradiol transdermal patch continuously with cyclic oral micronized progesterone (PATCH), (ii) a combined ethinyl estradiol and desogestrel pill (PILL), or (iii) no estrogen/progesterone (NONE) for 12-months...
November 23, 2018: Journal of Clinical Endocrinology and Metabolism
Elisabeth Lerchbaum, Christian Trummer, Verena Theiler-Schwetz, Martina Kollmann, Monika Wölfler, Annemieke C Heijboer, Stefan Pilz, Barbara Obermayer-Pietsch
PURPOSE: It has been hypothesized that vitamin D is associated with androgen levels in men. We, therefore, aimed to evaluate whether vitamin D supplementation increases serum total testosterone (TT) levels in men with low TT levels at baseline. METHODS: The Graz Vitamin D&TT-RCT is a single-center, double-blind, randomized placebo-controlled trial conducted between March 2013 and November 2017 at the endocrine outpatient clinic at the Medical University of Graz, Austria...
November 20, 2018: European Journal of Nutrition
John S Fitzgerald, Joanna Orysiak, Patrick B Wilson, Joanna Mazur-Różycka, Zbigniew Obminski
The identification of the vitamin D receptor in tissues related to testosterone and cortisol production, in conjunction with the observed correlations between vitamin D levels and these hormones in the general population, suggest vitamin D may influence testosterone and cortisol concentrations in athletes. A cross-sectional study design was used to evaluate the association between 25(OH)D and testosterone and cortisol concentrations in young male ice hockey players ( n = 50). All athletes were recruited during October from the Sosnowiec area, Poland (50° N)...
September 2018: Biology of Sport
Barbara Grzechocinska, Damian Warzecha, Iwona Szymusik, Janusz Sierdzinski, Mirosław Wielgos
INTRODUCTION: Vitamin D (VD) plays a crucial role in calcium metabolism as well as immunological and endocrine homeostasis. Previous studies revealed strong inverse correlation between VD levels and insulin resistance, parathyroid dysfunctions and autoimmune thyroid disease. Insufficient evidence concerns its dependency of ovarian hormones. Malfunctioning of the ovaries results in menstrual disorders that are one of the most common endocrine impairments in young women of reproductive age...
September 4, 2018: Neuro Endocrinology Letters
Forough Saki, Seyed Reza Kasaee, Faezeh Sadeghian, Pedram Talezadeh, Gholam Hossein Ranjbar Omrani
Testosterone is an essential hormone to maintain bone integrity; however, the effect of aromatase enzyme in androgen-induced bone maintenance remains somewhat unclear. The present study evaluated the effect of testosterone itself and combined with letrozole, an aromatase inhibitor, on bone mineral density of male rats. Total of 48 male rats were divided into 4 equal groups (n = 12/group); sham group, O: orchiectomy, O + T: orchiectomized rats treated with testosterone, O + T + L: orchiectomized rats treated with combination of testosterone and letrozole...
November 3, 2018: Journal of Bone and Mineral Metabolism
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