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Raïsa Carmen, Galit B Yom-Tov, Inneke Van Nieuwenhuyse, Bram Foubert, Yishai Ofran
MOTIVATION: Patients with hematological malignancies are susceptible to life-threatening infections after chemotherapy. The current study aimed to evaluate whether management of such patients in dedicated inpatient and emergency wards could provide superior infection prevention and outcome. METHODS: We have developed an approach allowing to retrieve infection-related information from unstructured electronic medical records of a tertiary center. Data on 2,330 adults receiving 13,529 chemotherapy treatments for hematological malignancies were identified and assessed...
2019: PloS One
Ekrem İslamoğlu, Çağatay Özsoy, Hakan Anıl, Yasin Aktaş, Mutlu Ateş, Murat Savaş
OBJECTIVE: To report our initial experience and short-term results in post-chemotherapy robot-assisted retroperitoneal lymph node dissection (RA-RPLND) for advanced testicular cancer. MATERIAL AND METHODS: We analyzed prospectively collected data of 5 patients who underwent post-chemotherapy RA-RPLND between August 2017 and May 2018. All patients had a diagnosis of non-seminomatous germ cell tumor (NSGCT) of testis and received three or four cycles of BEP chemotherapy for their clinical stage IIC disease before the surgery...
December 20, 2018: Turkish Journal of Urology
Song Yao, Qiang Hu, Sarah Kerns, Li Yan, Adedayo A Onitilo, Jamal Misleh, Kelley Young, Lianlian Lei, Javier Bautista, Mostafa Mohamed, Supriya G Mohile, Christine B Ambrosone, Song Liu, Michelle C Janelsins
BACKGROUND: Little is known about the effects of chemotherapeutic drugs on DNA methylation status of leukocytes, which may be predictive of treatment benefits and toxicities. Based on a prospective national study, we characterize the changes in leukocyte DNA methylome from pre- to post-chemotherapy (approximately 4 months apart) in 93 patients treated for early stage breast cancer and 48 matched non-cancer controls. We further examined significant methylation changes with perceived cognitive impairment, a clinically significant problem related to cancer and chemotherapy...
March 12, 2019: Clinical Epigenetics
Nick W Liu, Katie S Murray, S Machele Donat, Harry W Herr, Bernard H Bochner, Guido Dalbagni
Purpose: While a definitive cure can be achieved by radical cystectomy and pelvic lymph node dissection in select patients with regional lymphadenopathy, the benefit remains uncertain in patients who present with non-regional metastases. We analyzed the survival outcomes of post-chemotherapy retroperitoneal lymph node dissection. Materials and Methods: We reviewed our institutional database and identified 13 patients with radiographically evident or biopsy proven retroperitoneal nodal metastases with a significant response to chemotherapy...
January 31, 2019: Bladder Cancer
Omar Alhalabi, Hind Rafei, Amishi Shah, Arlene Siefker-Radtke, Matthew Campbell, Jianjun Gao
PURPOSE OF REVIEW: Advanced urothelial carcinoma is a heterogeneous disease with high burden of morbidity, mortality, and cost. Significant progress has been made in understanding the biology of the disease and the development of immunotherapies and targeted therapies. In this review, we summarize the current and future therapeutic approaches in the management of urothelial carcinoma. RECENT FINDINGS: Advances in immune checkpoint inhibitors resulted in the Food and Drug Administration (FDA) approvals of atezolizumab in 2016, and pembrolizumab, avelumab, durvalumab, and nivolumab in 2017 for the treatment of advanced urothelial carcinoma...
March 5, 2019: Current Opinion in Oncology
Ferdinand Wagner, Boris M Holzapfel, Laure Martine, Jacqui McGovern, Christoph A Lahr, Melanie Boxberg, Peter M Prodinger, Susanne Grässel, Daniela Loessner, Dietmar W Hutmacher
The quest for predictive tumor markers for osteosarcoma (OS) has not well progressed over the last two decades due to a lack of preclinical models. The aim of this study was to investigate if microenvironmental modifications in an original humanized in vivo model alter the expression of OS tumor markers. Human bone micro-chips and bone marrow, harvested during hip arthroplasty, were implanted at the flanks of NOD/scid mice. We administered recombinant human bone morphogenetic protein 7 (rhBMP-7) in human bone micro-chips/bone marrow group I in order to modulate bone matrix and bone marrow humanization...
March 2, 2019: Acta Biomaterialia
Martina Vivoda Tomšič, Sotirios Bisdas, Viljem Kovač, Igor Serša, Katarina Šurlan Popovič
BACKGROUND: Malignant pleural mesothelioma (MPM) is a rare and aggressive thoracic malignancy that is difficult to cure. Dynamic contrast-enhanced (DCE) MRI is a functional imaging technique used to analyze tumor microvascular properties and to monitor therapy response. Purpose of this study was to compare two tracer kinetic models, the extended Tofts (ET) and the adiabatic approximation tissue homogeneity model (AATH) for analysis of DCE-MRI and examine the value of the DCE parameters to predict response to chemotherapy in patients with MPM...
February 27, 2019: Cancer Imaging: the Official Publication of the International Cancer Imaging Society
Sagar Bhalerao, Rajnish Nagarkar, Aditya Adhav
Astroblastoma is an uncommon neuroepithelial primary tumor of the brain which is of uncertain origin. We present a case of high-grade astroblastoma in an 18-year-old female with a severe headache, loss of appetite, vomiting and generalized weakness. The patient had undergone a right frontoparietal craniotomy. Large subfalcine meningioma was excised. The lesion was suspected to be a meningioma. Primary radiological investigation revealed a 6.8 cm × 5.8 cm × 5.4 cm lesion. Although the radiological and intraoperative findings were of an extra-axial tumor, the histology and immunophenotype was of an astroblastoma...
February 28, 2019: CNS Oncology
Vedang Murthy, Carlton Johnny, Robert Huddart
No abstract text is available yet for this article.
February 27, 2019: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
Ashu Gandhi, Ellen Copson, Diana Eccles, Lorraine Durcan, Anthony Howell, Julie Morris, Sacha Howell, Sarah McDiarmid, Katharine Sellers, D Gareth Evans, Michelle Harvie
AIM: In breast cancer patients, post chemotherapy weight gain is linked with increased risk of cancer recurrence. We prospectively studied a cohort of premenopausal women receiving contemporary chemotherapy following a diagnosis of breast cancer to examine factors predicting weight increase. METHODS: Between May 2005 and January 2008, 523 patients from the Prospective Outcomes in Sporadic versus Hereditary (POSH) breast cancer study entered this sub-study comparing weight prior to chemotherapy and weight and waist/hip measurements 12-months following chemotherapy...
February 15, 2019: Breast: Official Journal of the European Society of Mastology
Michael A Feuerstein, Leah Goldstein, Brieyona Reaves, Arony Sun, Michael Goltzman, Bradley A Morganstern, Ahmad Shabsigh, Dean F Bajorin, Jonathan E Rosenberg, S Machele Donat, Harry W Herr, Vincent P Laudone, Thomas M Atkinson, Yuelin Li, Guido Dalbagni, Bruce Rapkin, Bernard H Bochner
PURPOSE: To evaluate patient-reported outcomes (PROs) for bladder cancer patients undergoing neoadjuvant chemotherapy (NAC) prior to radical cystectomy (RC) using longitudinal data and propensity-matched scoring analyses. METHODS: 155 patients with muscle-invasive bladder cancer scheduled for RC completed the European Organization for Research and Treatment of Cancer questionnaires, EORTC QLQ-C30, EORTC QLQ-BLM30, Fear of Recurrence Scale, Mental Health Inventory and Satisfaction with Life Scale within 4 weeks of surgery...
February 23, 2019: World Journal of Urology
Omar F Khan, Ellen Cusano, Soundouss Raissouni, Mica Pabia, Johanna Haeseker, Nicholas Bosma, Jenny J Ko, Haocheng Li, Aalok Kumar, Michael M Vickers, Patricia A Tang
BACKGROUND: Cognitive impairment is commonly reported in patients receiving chemotherapy, but the acuity of onset is not known. This study utilized the psychomotor vigilance test (PVT) and trail-making test B (TMT-B) to assess cognitive impairment immediately post-chemotherapy. METHODS: Patients aged 18-80 years receiving first-line intravenous chemotherapy for any stage of breast or colorectal cancer were eligible. Patient symptoms, peripheral neuropathy and Stanford Sleepiness Scale were assessed...
February 14, 2019: BMC Cancer
Chunfeng Yu, Wei Liu, Yuejun Mu, Aihua Hou, Yin Li
BACKGROUND: To observe clinical effects of Shen Cao granules on thrombocytopenia in patients with gastrointestinal cancer undergoing chemotherapy. PATIENTS AND METHODS: Patients under a FOLFIRI chemotherapy regimen (n = 92) were randomly divided into study and control groups (n = 46 for each group) and were given 10 g of Shen Cao granules and a placebo, respectively, once daily on chemotherapy treatment days. Platelet counts were measured every other day and any adverse reaction recorded during the study and at follow-up...
January 2019: Integrative Cancer Therapies
Kazuhiro Kitajima, Toru Nakamichi, Seiki Hasegawa, Kozo Kuribayashi, Koichiro Yamakado
Talc pleurodesis has been reported to increase fluorodeoxyglucose (FDG) uptake in the high attenuation areas of pleural thickening, making it difficult to distinguish between benign granulomatous inflammatory processes and malignancies, which may therefore interfere with the post-chemotherapy disease evaluation on FDG-positron emission tomography/computed tomography (PET/CT). We present two cases of malignant pleural mesothelioma treated with talc pleurodesis and neoadjuvant chemotherapy (NAC) before pleurectomy/decortication in which post-NAC FDG-PET/CT showed intense FDG uptakes in the high attenuation areas of pleural thickening with false positive result, whereas post-NAC 11 C-choline PET/CT showed mild choline uptake of pleural talc deposit, which did not interfere with the post-chemotherapy disease evaluation...
November 28, 2018: Curēus
Atiya Allarakha, Yan Gao, Hong Jiang, Pei-Jun Wang
Breast cancer (BC) research has been evolving tremendously on all fronts, whether it being for imaging, pathology, oncology, pharmacology, or genetics. Regarding medical imaging, dynamic contrast enhanced MRI (DCE-MRI) and diffusion weighted imaging (DWI) are now both universally recognized and widely used modalities in multiparametric MRI (mp-MRI) to diagnose and stage BC, to assess post-chemotherapy response, and to differentiate between scar tissue and recurrent tumor. Meanwhile, pathologists have provided evidence of BC being heterogeneous and having several subtypes, which in turn might affect its prognostic and therapeutic outcomes...
January 2019: Discovery Medicine
Masayuki Nagasawa, Susumu Kageyama, Tetsuya Yoshida, Yuki Okinaka, Shigehisa Kubota, Akinori Wada, Kenichi Kobayashi, Keiji Tomita, Ryosuke Murai, Teruhiko Tsuru, Kazuyoshi Johnin, Mitsuhiro Narita, Akihiro Kawauchi
The present study evaluated the impact of nedaplatin-containing chemotherapy on renal function in 35 patients with urothelial carcinoma (UC) between 2001 and 2014 who were unfit for cisplatin treatment. As comparative controls, the present study also examined 35 patients with the same disease who underwent cisplatin-containing chemotherapy during the same period. The changes in the estimated glomerular filtration rate (eGFR) prior to and following the administration of nedaplatin during each cycle of chemotherapy was investigated...
February 2019: Oncology Letters
George E Duran, Branimir I Sikic
In a previously published study, higher levels of spleen tyrosine kinase (Syk) were observed in recurrent post-chemotherapy ovarian cancers compared to primary tumors. Syk inhibition was found to stabilize microtubules and potentiate paclitaxel activity in cellular models of taxane-resistant ovarian cancers. We further studied the effects of Syk inhibition on paclitaxel activity in Syk(+) ovarian cancer cell models and in variants selected for taxane resistance. Syk inhibition was accomplished using RNAi and by exposure to the small molecule competitive inhibitor R406, the active metabolite of fostamatinib...
2019: PloS One
Costantine Albany, Kenneth Kesler, Clint Cary
PURPOSE OF REVIEW: The purpose of this review is to educate medical oncologists on the management of patients with residual germ cell tumors and the role of surgical resection after platinum-based chemotherapy. RECENT FINDINGS: Patients with non-seminomatous testicular cancer and residual enlarged retroperitoneal lymph nodes > 1 cm following induction chemotherapy with normal tumor markers should undergo a post-chemotherapy retroperitoneal lymph node dissection...
January 21, 2019: Current Oncology Reports
Ashwin Sunil Tamhankar, Saurabh Ramesh Patil, Surya Prakash Ojha, Puneet Ahluwalia, Gagan Gautam
Retroperitoneal lymph node dissection (RPLND) is a therapeutic standard of care for post-chemotherapy residual masses in testicular cancer. While a robotic approach to this procedure has the potential of decreasing the morbidity associated with this major endeavour, it is often criticised for its inability to provide a bilateral complete template resection without redocking and repositioning the patient. Herein, we present the technique and initial outcomes of a supine approach to Robotic RPLND (R-RPLND) using the da Vinci Xi® system, which obviates the need for repositioning or redocking for a bilateral full template resection...
January 17, 2019: Journal of Robotic Surgery
Meng Zhao, Fang Tao, Aparna Venkatraman, Zhenrui Li, Sarah E Smith, Jay Unruh, Shiyuan Chen, Christina Ward, Pengxu Qian, John M Perry, Heather Marshall, Jinxi Wang, Xi C He, Linheng Li
Regulation of hematopoietic stem cells (HSCs) by bone marrow (BM) niches has been extensively studied; however, whether and how HSC subpopulations are distinctively regulated by BM niches remain unclear. Here, we functionally distinguished reserve HSCs (rHSCs) from primed HSCs (pHSCs) based on their response to chemotherapy and examined how they are dichotomously regulated by BM niches. Both pHSCs and rHSCs supported long-term hematopoiesis in homeostasis; however, pHSCs were sensitive but rHSCs were resistant to chemotherapy...
January 15, 2019: Cell Reports
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