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Telomere AND aging

Thomas Brand
No abstract text is available yet for this article.
February 15, 2019: EMBO Journal
Dan T A Eisenberg
No abstract text is available yet for this article.
February 2019: PLoS Genetics
Christina Bauch, Jelle J Boonekamp, Peter Korsten, Ellis Mulder, Simon Verhulst
Telomere length (TL) predicts health and survival across taxa. Variation in TL between individuals is thought to be largely of genetic origin, but telomere inheritance is unusual, because zygotes already express a TL phenotype, the TL of the parental gametes. Offspring TL changes with paternal age in many species including humans, presumably through age-related TL changes in sperm, suggesting an epigenetic inheritance mechanism. However, present evidence is based on cross-sectional analyses, and age at reproduction is confounded with between-father variation in TL...
February 2019: PLoS Genetics
Jianhao Xiao, Qian Yuan, Simiao Zhang, Xiaodong Li, Hongying Bai, Yunliang Wang, Shiwei Duan
BACKGROUND: Telomere length is closely related to the onset and prognosis of ischemic stroke. This study was to investigate the relationship between telomere length and the incidence of ischemic stroke in Han population of northern China. METHODS: In the present study, 152 patients with ischemic stroke were selected as the case group, and 152 healthy persons were used as the control group. Detection of telomere length was done by real-time polymerase chain reaction after extraction of genomic DNA from peripheral venous blood...
February 2019: Medicine (Baltimore)
Qi Wu, Dongyang Han, Jiangkuan Zhang, Xin Li
OBJECTIVE: The objective of this study was to investigate the expression of serum telomere repeat binding factor 1 (TRF1) and TRF2 in patients with Alzheimer's disease (AD) and their correlation with clinicopathological features. METHODS: Fifty AD subjects and 50 healthy controls were enrolled in this study. Enzyme-linked immunosorbent assay (ELISA) was used to determine the expression of TRF1 and TRF2 in the peripheral blood plasma. Correlation analysis was used to evaluate the correlation between the protein expression and AD clinical parameters...
February 14, 2019: Neurological Research
Jerry W Shay, Woodring E Wright
Many recent advances have emerged in the telomere and telomerase fields. This Timeline article highlights the key advances that have expanded our views on the mechanistic underpinnings of telomeres and telomerase and their roles in ageing and disease. Three decades ago, the classic view was that telomeres protected the natural ends of linear chromosomes and that telomerase was a specific telomere-terminal transferase necessary for the replication of chromosome ends in single-celled organisms. While this concept is still correct, many diverse fields associated with telomeres and telomerase have substantially matured...
February 13, 2019: Nature Reviews. Genetics
James M Antonini, Vamsi Kodali, Terence G Meighan, Katherine A Roach, Jenny R Roberts, Rebecca Salmen, Greg R Boyce, Patti C Zeidler-Erdely, Michael Kashon, Aaron Erdely, Mohammad Shoeb
The objective of the current study was to determine if age, diet, and genetic disposition (animal strain) in an animal model had early effects on specific molecular markers in circulating peripheral blood mononuclear cells (PBMCs). Three strains [Sprague-Dawley (SD), Fischer 344 (F344), and Brown-Norway (BN)] of male rats were maintained on a high-fat (HF) or regular diet. Blood was collected at 4, 12, and 24 wk to assess chemistry and to recover PBMCs. Triglycerides and body weight gain increased at all time points in the HF diet group for each strain...
February 13, 2019: Scientific Reports
Nana Akino, Osamu Wada-Hiraike, Wataru Isono, Hiromi Terao, Harunori Honjo, Yuichiro Miyamoto, Michihiro Tanikawa, Kenbun Sone, Mana Hirano, Miyuki Harada, Tetsuya Hirata, Yasushi Hirota, Kaori Koga, Katsutoshi Oda, Tomoyuki Fujii, Yutaka Osuga
BACKGROUND: Age-associated infertility is a problem worldwide, and management of oxidative stress is known to be essential. Nuclear factor-E2-related factor 2 (Nrf2)/Kelch-like ECH-associated protein 1 (Keap1)-antioxidant response element (ARE) signaling pathway works as an essential defense mechanism against oxidative stress, and an oral drug Dimethylfumarate (DMF) is known to activate the pathway. METHODS: We tested the hypothesis that oral DMF could alleviate oxidative stress in the ovary, resulting in salvation of age-associated infertility in a mouse model of reproductive age, and we examined the effects of DMF administration...
February 13, 2019: Reproductive Biology and Endocrinology: RB&E
Yiqiang Zhan, Sara Hägg
PURPOSE OF REVIEW: Telomere length has been hypothesized as a putative biomarker for cardiovascular disease. However, the findings are mixed and shared confounding factors may explain these associations. The current review aims to summarize the recent literature on the role of telomere length in cardiovascular disease and give directions for future potential as a predictive biomarker. RECENT FINDINGS: In this review, we outline the biology of telomeres as a biomarker of aging through its shortening capacity across the life course...
February 11, 2019: Current Opinion in Cardiology
Francesco De Rango, Paolina Crocco, Francesca Iannone, Adolfo Saiardi, Giuseppe Passarino, Serena Dato, Giuseppina Rose
Biogerontological research highlighted a complex and dynamic connection between aging, health and longevity, partially determined by genetic factors. Multifunctional proteins with moonlighting features, by integrating different cellular activities in the space and time, may explain part of this complexity. Inositol Polyphosphate Multikinase (IPMK) is a potential moonlighting protein performing multiple unrelated functions. Initially identified as a key enzyme for inositol phosphates synthesis, small messengers regulating many aspects of cell physiology, IPMK is now implicated in a number of metabolic pathways affecting the aging process...
February 8, 2019: Genes
Rebecca F Slykerman, Mugdha V Joglekar, Anandwardhan A Hardikar, Sarang N Satoor, John M D Thompson, Alicia Jenkins, Edwin A Mitchell, Rinki Murphy
BACKGROUND: Previous studies indicate that low birth weight and exposure to maternal stress during pregnancy may result in shortened telomeres in infants. Shorter telomere length has in turn been linked with accelerated ageing and with age-related diseases. This study aimed to investigate the association between pregnancy and birth factors and relative telomere length in offspring at 11 years of age. METHODS: Participants were aged 11 years enrolled in the Auckland Birthweight Collaborative Study at birth (n = 380)...
February 7, 2019: Gene
Tinhinane Fali, Laura Papagno, Charles Bayard, Yanis Mouloud, Jacques Boddaert, Delphine Sauce, Victor Appay
αβ CD8+ , γδ, and NK lymphocytes are fundamental effector cells against viruses and tumors. These cells can be divided into multiple subsets according to their phenotype. Based on progressive telomere attrition from naive to late effector memory cells, human CD8+ T cell subsets have been positioned along a pathway of differentiation, which is also considered as a process of lymphocyte aging or senescence. A similar categorization has not been clearly established for γδ and NK cell populations. Moreover, the distinction between the aging of these populations due to cellular differentiation or due to the chronological age of the donor has not been formally considered...
February 8, 2019: Journal of Immunology: Official Journal of the American Association of Immunologists
Rhys Anderson, Anthony Lagnado, Damien Maggiorani, Anna Walaszczyk, Emily Dookun, James Chapman, Jodie Birch, Hanna Salmonowicz, Mikolaj Ogrodnik, Diana Jurk, Carole Proctor, Clara Correia-Melo, Stella Victorelli, Edward Fielder, Rolando Berlinguer-Palmini, Andrew Owens, Laura C Greaves, Kathy L Kolsky, Angelo Parini, Victorine Douin-Echinard, Nathan K LeBrasseur, Helen M Arthur, Simon Tual-Chalot, Marissa J Schafer, Carolyn M Roos, Jordan D Miller, Neil Robertson, Jelena Mann, Peter D Adams, Tamara Tchkonia, James L Kirkland, Jeanne Mialet-Perez, Gavin D Richardson, João F Passos
Ageing is the biggest risk factor for cardiovascular disease. Cellular senescence, a process driven in part by telomere shortening, has been implicated in age-related tissue dysfunction. Here, we address the question of how senescence is induced in rarely dividing/post-mitotic cardiomyocytes and investigate whether clearance of senescent cells attenuates age-related cardiac dysfunction. During ageing, human and murine cardiomyocytes acquire a senescent-like phenotype characterised by persistent DNA damage at telomere regions that can be driven by mitochondrial dysfunction and crucially can occur independently of cell division and telomere length...
February 8, 2019: EMBO Journal
Young Soon Yoon, Minhee Jin, Don D Sin
Introduction The prevalence of chronic obstructive pulmonary disease (COPD) increases exponentially with aging. Its pathogenesis, however, is not well known and aside from smoking cessation, there are no disease-modifying treatments for this disease. Areas covered COPD is associated with accelerating aging and aging-related diseases. In this review, we will discuss the hallmarks of aging including genomic instability, telomere attrition, epigenetic alteration, loss of proteostasis, mitochondrial dysfunction, deregulated nutrient sensing, cellular senescence, stem cell exhaustion, and altered intercellular communication, which may be involved in COPD pathogenesis...
February 8, 2019: Expert Review of Respiratory Medicine
Shalini Dixit, Mary A Whooley, Eric Vittinghoff, Jason D Roberts, Susan R Heckbert, Annette L Fitzpatrick, Jue Lin, Cindy Leung, Kenneth J Mukamal, Gregory M Marcus
The relationship between alcohol consumption and mortality generally exhibits a U-shaped curve. The longevity observed with moderate alcohol consumption may be explained by other confounding factors, and, if such a relationship is present, the mechanism is not well understood. Indeed, the optimal amount of alcohol consumption for health has yet to be determined. Leukocyte telomere length is an emerging quantifiable marker of biological age and health, and a shorter telomere length is a predictor of increased mortality...
February 5, 2019: Scientific Reports
Lina Zhang, Lulu Song, Bingqing Liu, Mingyang Wu, Lulin Wang, Bin Zhang, Chao Xiong, Wei Xia, Yuanyuan Li, Zhongqiang Cao, Youjie Wang, Shunqing Xu
BACKGROUND: Newborn telomere length (TL) is considered a potential marker for future disease and lifelong health, but few epidemiological studies have examined the determinants of TL in early life. The study aim was to investigate whether there is an association between prenatal cadmium exposure and relative cord blood TL in Chinese newborns. METHODS: Participants were 410 mother-newborn pairs drawn from a prospective birth cohort study conducted in Wuhan, China, between November 2013 and March 2015...
February 6, 2019: BMC Medicine
Shotaro Suzuki, Toshifumi Nomura, Toshinari Miyauchi, Masae Takeda, Yasuyuki Fujita, Wataru Nishie, Masashi Akiyama, Akemi Ishida-Yamamoto, Hiroshi Shimizu
Revertant mosaicism is a phenomenon in which pathogenic mutations are rescued by somatic events, representing a form of natural gene therapy. Here, we report on the first evidence for revertant mosaicism in loricrin keratoderma (LK), an autosomal dominant form of ichthyosis caused by mutations in LOR on 1q21.3. We identified two unrelated LK families exhibiting dozens of previously unreported white spots, which increased in both number and size with age. Biopsies of these spots revealed that they had normal histology and that causal LOR mutations were lost...
February 2019: Life science alliance
Miles J McKenna, Erin Robinson, Lynn Taylor, Christopher Tompkins, Michael N Cornforth, Steven L Simon, Susan M Bailey
It is now approaching six decades since U.S. nuclear testing was conducted in the Pacific islands, exposing military personnel to varying levels of ionizing radiation. Actual doses are not well-established, as film badges in the 1950s had many limitations. We sought a means of independently assessing dose for comparison with historical film badge records and dose reconstruction conducted in parallel. For the purpose of quantitative retrospective biodosimetry, peripheral blood samples from 12 exposed veterans and 12 age-matched (>80 years) veteran controls were collected and evaluated for radiation-induced chromosome damage utilizing directional genomic hybridization (dGH), a cytogenomics-based methodology that facilitates simultaneous detection of translocations and inversions...
February 4, 2019: Radiation Research
Xingxing Chen, Chenchen Zeng, Chun Gong, Lei Zhang, Yuhui Wan, Fangbiao Tao, Ying Sun
BACKGROUND: Given the ethical limitations of exposing children to experimentally manipulated adverse experiences, evidence of the effects of parent-child separation on subsequent psychopathology are based mostly on animal studies. Left-behind children phenomenon resulting from rural-urban mobility in China offers unique "natural experiments" to explore the long-term physical and mental health consequences of parent-child separation in childhood. OBJECTIVE: To test the associations between parent-child separation with telomere length (TL) and psychopathology during adolescence...
January 21, 2019: Psychoneuroendocrinology
Peter H Rej, Robert L Tennyson, Nanette R Lee, Dan T A Eisenberg
BACKGROUND: Caring for chronically disabled family members is a stressful experience. In turn, psychosocial stress is linked to premature aging. Telomere length (TL) is a plastic genetic trait that is a biomarker of aging, and a possible mechanism linking psychosocial stress and accelerated aging. METHODS: TL was measured using qPCR method from blood samples in 1233 Filipino adults from Cebu, Philippines. Caregiving was measured as chronicity of care, or the sum total number of years an individual was the primary caregiver for any household member with a chronic illness or disability...
January 25, 2019: Psychoneuroendocrinology
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