keyword
https://read.qxmd.com/read/38519344/a-randomized-blind-parallel-controlled-phase-i-clinical-trial-to-evaluate-the-safety-and-preliminary-immunogenicity-of-23-valent-pneumococcal-polysaccharide-vaccine-in-healthy-people-aged-2%C3%A2-years-and-older
#21
JOURNAL ARTICLE
Yuhui Zhang, Yanxia Wang, Guangfu Li, Xue Zhao, Kai Wang, Chunyu Jia, Yongli Yang, Lili Huang, Jiebing Tan, Xiaofen Chen, Wenna Leng, Zhiqiang Xie, Wei Zhang, Juan Zong, Kang Chen, Qin Li, Xiaocan Jia, Dongyang Zhao, Youcai An, Yaodong Zhang
BACKGROUND: Despite some progress in pneumococcal immunization, the global burden of pneumococcal infection remains high, and pneumococcal disease remains a public health concern. Studies in China and abroad have found that 23-valent pneumococcal polysaccharide vaccine (PPV23) vaccination can effectively prevent invasive pneumococcal disease. This phase Ⅰ clinical study assessed the safety and immunogenicity of a PPV23 vaccine candidate. METHODS: All subjects were randomly assigned to receive one dose intramuscular injection of experimental vaccine or control vaccine at a ratio of 1:1...
March 21, 2024: Vaccine
https://read.qxmd.com/read/38517265/strategies-for-pneumococcal-vaccination-in-older-adults-in-the-coming-era
#22
JOURNAL ARTICLE
Kei Nakashima, Wakaba Fukushima
Pneumonia, predominantly caused by Streptococcus pneumoniae , remains a leading cause of global mortality. The 23-valent Pneumococcal polysaccharide vaccine (PPSV23) and conjugate vaccines (PCVs) are vital measures to fight against it. This paper discussed the changes in pneumococcal vaccination strategies, particularly for older adults, as vaccine effectiveness and epidemiological patterns shift. While PPSV23 maintains effectiveness against invasive pneumococcal disease (IPD), its effectiveness against pneumococcal pneumonia is declining...
December 31, 2024: Human Vaccines & Immunotherapeutics
https://read.qxmd.com/read/38517206/rapid-in-vivo-evaluation-system-for-cholestasis-related-genes-in-mice-with-humanized-bile-acid-profiles
#23
JOURNAL ARTICLE
Kihiro Wakasa, Ryutaro Tamura, Shuhei Osaka, Hajime Takei, Akihiro Asai, Hiroshi Nittono, Hiroyuki Kusuhara, Hisamitsu Hayashi
BACKGROUND: Pediatric cholestatic liver diseases (Ped-CLD) comprise many ultrarare disorders with a genetic basis. Pharmacologic therapy for severe cases of Ped-CLD has not been established. Species differences in bile acid (BA) metabolism between humans and rodents contribute to the lack of phenocopy of patients with Ped-CLD in rodents and hinder the development of therapeutic strategies. We aimed to establish an efficient in vivo system to understand BA-related pathogenesis, such as Ped-CLD...
April 1, 2024: Hepatology Communications
https://read.qxmd.com/read/38516018/nanopore-sequencing-for-identification-and-characterization-of-antimicrobial-resistant-escherichia-coli-and-salmonella-spp-from-tilapia-and-shrimp-sold-at-wet-markets-in-dhaka-bangladesh
#24
JOURNAL ARTICLE
Shafiq Rheman, Sabrina Hossain, Md Samun Sarker, Farhana Akter, Laura Khor, Han Ming Gan, Andy Powell, Roderick M Card, Yaovi Mahuton Gildas Hounmanou, Anders Dalsgaard, Chadag Vishnumurthy Mohan, Zamila Bueaza Bupasha, Mohammed A Samad, David W Verner-Jeffreys, Jérôme Delamare-Deboutteville
Wet markets in low-and middle-income countries are often reported to have inadequate sanitation resulting in fecal contamination of sold produce. Consumption of contaminated wet market-sourced foods has been linked to individual illness and disease outbreaks. This pilot study, conducted in two major wet markets in Dhaka city, Bangladesh during a 4-month period in 2021 aimed to assess the occurrence and characteristics of Escherichia coli and non-typhoidal Salmonella spp. (NTS) from tilapia ( Oreochromis niloticus ) and shrimp ( Penaeus monodon )...
2024: Frontiers in Microbiology
https://read.qxmd.com/read/38515161/htra1-driven-detachment-of-type-i-collagen-from-endoplasmic-reticulum-contributes-to-myocardial-fibrosis-in-dilated-cardiomyopathy
#25
JOURNAL ARTICLE
Hongjie Shi, Ming Yuan, Jie Cai, Lan Lan, Yumou Wang, Wei Wang, Jianliang Zhou, Bin Wang, Wenjun Yu, Zhe Dong, Dawei Deng, Qiaofeng Qian, Yang Li, Xianwu Zhou, Jinping Liu
BACKGROUND: The aberrant secretion and excessive deposition of type I collagen (Col1) are important factors in the pathogenesis of myocardial fibrosis in dilated cardiomyopathy (DCM). However, the precise molecular mechanisms underlying the synthesis and secretion of Col1 remain unclear. METHODS AND RESULTS: RNA-sequencing analysis revealed an increased HtrA serine peptidase 1 (HTRA1) expression in patients with DCM, which is strongly correlated with myocardial fibrosis...
March 22, 2024: Journal of Translational Medicine
https://read.qxmd.com/read/38514466/specific-interaction-between-group-b-streptococcus-cc17-hypervirulent-clone-and-phagocytes
#26
JOURNAL ARTICLE
Anne-Sophie Bourrel, Amandine Picart, Jose-Carlos Fernandez, Constantin Hays, Virginie Mignon, Bruno Saubaméa, Claire Poyart, Agnès Fouet, Asmaa Tazi, Julie Guignot
Streptococcus agalactiae also named Group B Streptococcus (GBS) is the most significant pathogen causing invasive infections, such as bacteremia and meningitis, in neonates. Worldwide epidemiological studies have shown that a particular clonal complex (CC) of capsular serotype III, the CC17, is strongly associated with meningitis in neonates and is therefore, designated as the hypervirulent clone. Macrophages are a permissive niche for intracellular bacteria of all GBS clones. In this study, we deciphered the specific interaction of GBS CC17 strains with macrophages...
March 22, 2024: Infection and Immunity
https://read.qxmd.com/read/38514188/genetic-structure-and-diversity-of-the-rfb-locus-of-pathogenic-species-of-the-genus-leptospira
#27
JOURNAL ARTICLE
Leonardo Ca Ferreira, Luiz de Fa Ferreira Filho, Maria Raquel V Cosate, Tetsu Sakamoto
Leptospirosis is caused by pathogenic strains of the genus Leptospira and is considered the most widespread zoonotic bacterial disease. The genus is characterized by the large number of serology variants, which challenges developing effective serotyping methods and vaccines with a broad spectrum. Because knowledge on the genetic basis of the serological diversity among leptospires is still limited, we aimed to explore the genetic structure and patterns of the rfb locus, which is involved in the biosynthesis of lipopolysaccharides, the major surface antigen that defines the serovar in leptospires...
June 2024: Life Science Alliance
https://read.qxmd.com/read/38512525/epidemiology-and-molecular-characterization-of-carbapenem-resistant-klebsiella-pneumoniae-isolated-from-neonatal-intensive-care-units-in-general-hospital-of-ningxia-medical-university-china-2017-2021
#28
JOURNAL ARTICLE
Zhuoran Qiu, Yuting Kang, Chao Xu, Wanting Ma, Gang Li, Wei Jia, Pengtao Wang
OBJECTIVES: This study aimed to retrospectively investigate the epidemiology and molecular characteristics of carbapenem-resistant Klebsiella pneumoniae (CRKP) isolates from neonatal intensive care units (NICU) between 2017 and 2021. METHODS: The antibacterial susceptibility of all strains was assessed using the VITEK 2 compact system. The presence of antibiotic resistance, virulence genes, sequence types (STs), capsular (K) types, and the wzi genes was determined through polymerase chain reaction (PCR)...
March 21, 2024: International Microbiology: the Official Journal of the Spanish Society for Microbiology
https://read.qxmd.com/read/38512514/salmonella-infections-in-denmark-from-2013-2022-with-focus-on-serotype-distribution-invasiveness-age-sex-and-travel-exposition
#29
JOURNAL ARTICLE
Nicholas Slinning Aarø, Mia Torpdahl, Torben Rasmussen, Martin Jensen, Hans Linde Nielsen
PURPOSE: To analyze the nationwide incidence of Salmonella infections in Denmark from 2013 to 2022. METHODS: Confirmed cases of Salmonella enterica subsp. enterica were examined using the National Register of Enteric Pathogens during 2013-2022. Proportions, incidence rates (IR), relative risk (RR), and 95% confidence intervals (CI) were calculated to assess differences in serotypes, invasiveness, age, sex, and travel exposure. RESULTS: We identified 9,944 Danish Salmonella enterica subsp...
March 21, 2024: European Journal of Clinical Microbiology & Infectious Diseases
https://read.qxmd.com/read/38512319/e-protein-protonation-titration-induced-single-particle-chemical-force-spectroscopy-for-microscopic-understanding-and-pi-estimation-of-infectious-denv
#30
JOURNAL ARTICLE
Manorama Ghosal, Tatini Rakshit, Shreya Bhattacharya, Sankar Bhattacharyya, Priyadarshi Satpati, Dulal Senapati
The ionization state of amino acids on the outer surface of a virus regulates its physicochemical properties toward the sorbent surface. Serologically different strains of the dengue virus (DENV) show different extents of infectivity depending upon their interactions with a receptor on the host cell. To understand the structural dependence of E-protein protonation over its sequence dependence, we have followed E-protein titration kinetics both experimentally and theoretically for two differentially infected dengue serotypes, namely, DENV-2 and DENV-4...
March 21, 2024: Journal of Physical Chemistry. B
https://read.qxmd.com/read/38510999/antimicrobial-resistance-and-genomic-investigation-of-salmonella-isolated-from-retail-foods-in-guizhou-china
#31
JOURNAL ARTICLE
Li Zhou, Qian Ye, Qian Zhou, Jian Wang, Guanqiao Li, Jingshu Xiang, Jingyu Huang, Yuanyuan Zhao, Tianli Zheng, Haojiang Zuo, Shijun Li
INTRODUCTION: Salmonella is a major foodborne pathogen worldwide that causes severe morbidity and mortality. It is mainly caused by consuming contaminated food, with retail food considered the primary source. METHODS: In Guizhou, China, 102 Salmonella strains isolated from 2016 to 2021 underwent phenotypic antimicrobial resistance testing and whole-genome sequencing (WGS) to understand Salmonella diversity, including serotypes, sequencing types (STs), antimicrobial genes, virulence genes, plasmid types, multi-locus sequence types (MLST), and core genome MLST (cgMLST)...
2024: Frontiers in Microbiology
https://read.qxmd.com/read/38509699/a-phase-3-randomized-open-label-study-evaluating-the-immunogenicity-and-safety-of-concomitant-and-staggered-administration-of-a-live-pentavalent-rotavirus-vaccine-and-an-inactivated-poliomyelitis-vaccine-in-healthy-infants-in-china
#32
JOURNAL ARTICLE
Shaomin Chen, Zhifang Ying, Yan Liu, Yuan Li, Yebin Yu, Meilian Huang, Zhuhang Huang, Zhiqiang Ou, Yuyi Liao, Yong Zhang, Guixiu Liu, Weiwei Zhao, Rong Fu, Qiong Shou, Minghuan Zheng, Xueyan Liao, Yingmei Tu, Jon Stek, Jonathan Hartzel, Changgui Li, Jikai Zhang
This open-label, randomized, phase 3 study in China (V260-074; NCT04481191) evaluated the immunogenicity and safety of concomitant and staggered administration of three doses of an oral, live, pentavalent rotavirus vaccine (RV5) and three doses of an intramuscular, inactivated poliomyelitis vaccine (IPV) in 400 healthy infants. The primary objective was the non-inferiority of neutralizing antibody (nAb) responses in the concomitant- versus the staggered-use groups. Antibody responses were measured at baseline and 1-month post-dose 3 (PD3)...
December 31, 2024: Human Vaccines & Immunotherapeutics
https://read.qxmd.com/read/38504299/lipoteichoic-acids-influence-cell-shape-and-bacterial-division-of-streptococcus-suis-serotype-2-but-play-a-limited-role-in-the-pathogenesis-of-the-infection
#33
JOURNAL ARTICLE
Servane Payen, Marie-Christine Giroux, Nicolas Gisch, Ursula Schombel, Nahuel Fittipaldi, Mariela Segura, Marcelo Gottschalk
Streptococcus suis serotype 2 is a major swine pathogen and a zoonotic agent, causing meningitis in both swine and humans, responsible for substantial economic losses to the swine industry worldwide. The pathogenesis of infection and the role of bacterial cell wall components in virulence have not been fully elucidated. Lipoproteins, peptidoglycan, as well as lipoteichoic acids (LTA) have all been proposed to contribute to virulence. In the present study, the role of the LTA in the pathogenesis of the infection was evaluated through the characterisation of a mutant of the S...
March 19, 2024: Veterinary Research
https://read.qxmd.com/read/38502979/novel-variant-infectious-bursal-disease-virus-diminishes-fadv-4-vaccination-and-enhances-pathogenicity-of-fadv-4
#34
JOURNAL ARTICLE
Zhishan Liang, Mei Leng, Jiamin Lian, Yazheng Chen, Qi Wu, Feng Chen, Zhanxin Wang, Wencheng Lin
Infectious bursal disease virus (IBDV) caused an acute and highly contagious infectious disease characterized by severe immunosuppression, causing considerable economic losses to the poultry industry globally. Although this disease was well-controlled under the widely use of commercial vaccines in the past decades, the novel variant IBDV strains emerged recently because of the highly immunized-selection pressure in the field, posting new threats to poultry industry. Here, we reported novel variant IBDV is responsible for a disease outbreak, and assessed the epidemic and pathogenicity of IBDV in this study...
March 11, 2024: Veterinary Microbiology
https://read.qxmd.com/read/38502894/a-phase-3-single-arm-trial-to-evaluate-the-safety-and-immunogenicity-of-a-20-valent-pneumococcal-conjugate-vaccine-in-healthy-children-15-months-through-18-years-of-age
#35
JOURNAL ARTICLE
Jay Meyer, Peter Silas, G Laïssa Ouedraogo, Kathleen McElwee, Georgina Keep, James Trammel, Yahong Peng, Ingrid L Scully, William C Gruber, Daniel A Scott, Wendy Watson
BACKGROUND: A 20-valent pneumococcal conjugate vaccine (PCV20), containing 13-valent PCV (PCV13) components and 7 additional polysaccharide conjugates, was developed to extend protection for pneumococcal disease. This phase 3 study assessed the safety and immunogenicity of PCV20 in children. METHODS: In this single-arm study, children (≥15 months-<18 years of age) received 1 dose of PCV20. Children <5 years of age had ≥3 prior doses of PCV13; children ≥5 years were recruited regardless of previous PCV receipt...
March 15, 2024: Pediatric Infectious Disease Journal
https://read.qxmd.com/read/38502796/prevalence-and-genomic-investigation-of-salmonella-isolates-associated-with-watermelons-and-their-environmental-reservoirs-in-bejaia-algeria
#36
JOURNAL ARTICLE
Zahra Bellil, Sylvain Meyer, Valentin Tilloy, Assia Mairi, Christophe De Champs, Olivier Barraud, Abdelaziz Touati
This study was conducted in Bejaia, Algeria, to determine the presence of Salmonella in fresh watermelon ( n  = 105), soil ( n  = 23), and irrigation water samples ( n  = 17) collected from two different farms. After isolation, antimicrobial susceptibility testing, serotype determination, multilocus sequence typing, antimicrobial resistance genes detection, and whole genome sequencing were performed. Twenty watermelon samples (19%) were contaminated with Salmonella , but none were found in the soil or irrigation water...
March 18, 2024: Foodborne Pathogens and Disease
https://read.qxmd.com/read/38502711/estimated-population-level-impact-of-pneumococcal-conjugate-vaccines-against-all-cause-pneumonia-mortality-among-unvaccinated-age-groups-in-five-latin-american-countries
#37
JOURNAL ARTICLE
Ottavia Prunas, Kayoko Shioda, Cristiana M Toscano, Magdalena Bastias, Maria Teresa Valenzuela-Bravo, Janepsy Diaz Tito, Joshua L Warren, Daniel M Weinberger, Lucia H de Oliveira
BACKGROUND: Pneumococcal conjugate vaccines (PCVs) provide strong direct protection in children, while limited data are available on their indirect effect on mortality among older age groups. This multi-country study aimed to assess the population-level impact of pediatric PCVs on all-cause pneumonia mortality among ≥5 years of age, and invasive pneumococcal disease (IPD) cases in Chile. METHODS: Demographic and mortality data from Argentina, Brazil, Chile, Colombia, and Mexico were collected considering the ≥ 5-year-old population, from 2000-2019, with 1,795,789 deaths due to all-cause pneumonia...
March 19, 2024: Journal of Infectious Diseases
https://read.qxmd.com/read/38502392/interferon-%C3%AE-il-2-elispot-and-mrna-responses-to-the-sars-cov2-feline-coronavirus-serotypes-1-fcov1-and-fcov2-receptor-binding-domains-by-the-t-cells-from-covid-19-vaccinated-humans-and-fcov1-infected-cats
#38
JOURNAL ARTICLE
Sabarinath Nair, Bikash Sahay, Ananta P Arukha, Lekshmi K Edison, Chiquitha D Crews, John G Morris, Subhashinie Kariyawasam, Janet K Yamamoto
The receptor binding domain (RBD) of SARS-CoV-2 (SCoV2) has been used recently to identify the RBD sequences of feline coronavirus serotypes 1 (FCoV1) and 2 (FCoV2). Cats naturally infected with FCoV1 have been shown to possess serum reactivities with FCoV1 and SCoV2 RBDs but not with FCoV2 RBD. In the current study, COVID-19-vaccinated humans and FCoV1-infected laboratory cats were evaluated for interferon-gamma (IFNγ) and interleukin-2 (IL-2 ELISpot responses by their peripheral blood mononuclear cells (PBMC) to SCoV2, FCoV1, and FCoV2 RBDs...
2024: Methods in Molecular Biology
https://read.qxmd.com/read/38501831/structural-implications-of-bk-polyomavirus-sequence-variations-in-the-major-viral-capsid-protein-vp1-and-large-t-antigen-a-computational-study
#39
JOURNAL ARTICLE
Janani Durairaj, Océane M Follonier, Karoline Leuzinger, Leila T Alexander, Maud Wilhelm, Joana Pereira, Caroline A Hillenbrand, Fabian H Weissbach, Torsten Schwede, Hans H Hirsch
UNLABELLED: BK polyomavirus (BKPyV) is a double-stranded DNA virus causing nephropathy, hemorrhagic cystitis, and urothelial cancer in transplant patients. The BKPyV-encoded capsid protein Vp1 and large T-antigen (LTag) are key targets of neutralizing antibodies and cytotoxic T-cells, respectively. Our single-center data suggested that variability in Vp1 and LTag may contribute to failing BKPyV-specific immune control and impact vaccine design. We, therefore, analyzed all available entries in GenBank (1516 VP1 ; 742 LTAG ) and explored potential structural effects using computational approaches...
March 19, 2024: MSphere
https://read.qxmd.com/read/38500580/a-bacteriophage-cocktail-can-efficiently-reduce-five-important-salmonella-serotypes-both-on-chicken-skin-and-stainless-steel
#40
JOURNAL ARTICLE
Tamar Gvaladze, Hansjörg Lehnherr, Stefan Hertwig
Salmonella is one of the most important zoonotic pathogens and is mostly transmitted through food of animal origin. Application of bacteriophages is a promising tool to biocontrol Salmonella on both food and food contact surfaces. In this study, we evaluated the effectiveness of a six-phage cocktail for the reduction of Salmonella Enteritidis and a mixture of five major Salmonella serotypes ( S . Enteritidis, Salmonella Typhimurium, Salmonella Infantis, Salmonella Paratyphi B, and Salmonella Indiana) on chicken skin and stainless steel...
2024: Frontiers in Microbiology
keyword
keyword
161352
2
3
Fetch more papers »
Fetching more papers... Fetching...
Remove bar
Read by QxMD icon Read
×

Save your favorite articles in one place with a free QxMD account.

×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"

We want to hear from doctors like you!

Take a second to answer a survey question.