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JOURNAL ARTICLE
Maya Ronse, Thuan Thi Nguyen, Xa Xuan Nguyen, Brecht Ingelbeen, Mira Leonie Schneiders, Duong Thanh Tran, Joan Muela Ribera, Charlotte Gryseels, Koen Peeters Grietens
Despite the global threat of antimicrobial resistance (AMR), evidence on the use and quality of medicines at community level is limited, particularly in impoverished, rural areas where prevalence of (bacterial) infections is high. To better understand the processes that drive vulnerability to AMR' effects, this study aimed to assess social factors underpinning access to-and use of-medical products and healthcare, among people from the Raglai ethnic minority in Ninh Thuan Province, Vietnam. We conducted ethnographic research in eight villages in 2018-2019, using interviewing and participant observation methods for data collection...
2024: PLOS Glob Public Health
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JOURNAL ARTICLE
Zosia Goossens, Thomas Bilterys, Eveline Van Looveren, Anneleen Malfliet, Mira Meeus, Lieven Danneels, Kelly Ickmans, Barbara Cagnie, Aurore Roland, Maarten Moens, Jo Nijs, Liesbet De Baets, Olivier Mairesse
(1) Background : This exploratory study aims to explore the relationship between nonspecific chronic spinal pain (nCSP) and insomnia symptoms, by examining the interconnections, strengths, and directional dependence of the symptoms. In addition, we aim to identify the key symptoms of the nCSP-insomnia relationship and shed light on the bidirectional nature of this relationship. (2) Methods : This study is a secondary analysis of the baseline data (cross-sectional) from a randomized controlled trial, which examined the added value of Cognitive Behavioral Therapy for Insomnia (CBT-I) combined with cognition-targeted exercise therapy, conducted in collaboration with the Universiteit Gent and Vrije Universiteit Brussel (Belgium)...
March 2, 2024: Journal of Clinical Medicine
#23
JOURNAL ARTICLE
Mira T Tanenbaum, Andres V Figueroa, K Benjamin Lee, Jose Eduardo Costa Filho, Marilisa Soto Gonzalez, Mirza S Baig, Carlos H Timaran
OBJECTIVE: Endovascular repair of chronic dissecting aortoiliac aneurysms is challenging given the rigid septum, compressed true lumen (TL), and target vessels frequently originating in the false lumen. We have used transcatheter electrosurgical aortic septotomy (TEAS) before stent graft implantation under intravascular ultrasound (IVUS) and fusion guidance. The purpose of this study is to assess the outcomes of TEAS during complex endovascular repair of dissecting aneurysms. METHODS: From 2021 to 2023, 17 patients underwent TEAS...
June 2024: Journal of Vascular Surgery Cases and Innovative Techniques
#24
JOURNAL ARTICLE
José Joaquín Mira, Valerie Matarredona, Susanna Tella, Paulo Sousa, Vanessa Ribeiro Neves, Reinhard Strametz, Adriana López-Pineda
BACKGROUND: When healthcare students witness, engage in, or are involved in an adverse event, it often leads to a second victim experience, impacting their mental well-being and influencing their future professional practice. This study aimed to describe the efforts, methods, and outcomes of interventions to help students in healthcare disciplines cope with the emotional experience of being involved in or witnessing a mistake causing harm to a patient during their clerkships or training...
April 8, 2024: BMC Medical Education
#25
JOURNAL ARTICLE
Matthew Holderfield, Bianca J Lee, Jingjing Jiang, Aidan Tomlinson, Kyle J Seamon, Alessia Mira, Enrico Patrucco, Grace Goodhart, Julien Dilly, Yevgeniy Gindin, Nuntana Dinglasan, Yingyun Wang, Lick Pui Lai, Shurui Cai, Lingyan Jiang, Nicole Nasholm, Nataliya Shifrin, Cristina Blaj, Harshit Shah, James W Evans, Nilufar Montazer, Oliver Lai, Jade Shi, Ethan Ahler, Elsa Quintana, Stephanie Chang, Anthony Salvador, Abby Marquez, Jim Cregg, Yang Liu, Anthony Milin, Anqi Chen, Tamar Bar Ziv, Dylan Parsons, John E Knox, Jennifer E Klomp, Jennifer Roth, Matthew Rees, Melissa Ronan, Antonio Cuevas-Navarro, Feng Hu, Piro Lito, David Santamaria, Andrew J Aguirre, Andrew M Waters, Channing J Der, Chiara Ambrogio, Zhengping Wang, Adrian L Gill, Elena S Koltun, Jacqueline A M Smith, David Wildes, Mallika Singh
RAS oncogenes (collectively NRAS, HRAS and especially KRAS) are among the most frequently mutated genes in cancer, with common driver mutations occurring at codons 12, 13 and 611 . Small molecule inhibitors of the KRAS(G12C) oncoprotein have demonstrated clinical efficacy in patients with multiple cancer types and have led to regulatory approvals for the treatment of non-small cell lung cancer2,3 . Nevertheless, KRASG12C mutations account for only around 15% of KRAS-mutated cancers4,5 , and there are no approved KRAS inhibitors for the majority of patients with tumours containing other common KRAS mutations...
April 8, 2024: Nature
#26
JOURNAL ARTICLE
Viviana Ostrovsky, Mira Ulman, Rina Hemi, Samuel Lurie, Inon Hazan, Alon Ben Ari, Oleg Sukmanov, Tal Schiller, Alena Kirzhner, Taiba Zornitzki
SUMMARY: Total testosterone, which is peripherally converted to its biologically active form dihydrotestosterone (DHT), is the first-line hormone investigation in hyperandrogenic states and infertility in premenopausal women. Polycystic ovary syndrome (PCOS), the most common cause of hyperandrogenism and infertility in young women, is often associated with mild elevations of total testosterone. Whereas very high levels of total testosterone (>2-3 SD of normal reference), are most often associated with hyperandrogenic signs, menstrual irregularity, rapid onset of virilization, and demand a prompt investigation...
April 1, 2024: Endocrinology, Diabetes & Metabolism Case Reports
#27
JOURNAL ARTICLE
Salome Rudin, Lilian Kriemler, Tolga D Dittrich, Annaelle Zietz, Juliane Schweizer, Markus Arnold, Nils Peters, Filip Barinka, Simon Jung, Marcel Arnold, Urs Fischer, Katharina Rentsch, Mirjam Christ-Crain, Mira Katan, Gian Marco De Marchis
BACKGROUND: Lipoprotein (a) [Lp(a)] serum levels are highly genetically determined and promote atherogenesis. High Lp(a) levels are associated with increased cardiovascular morbidity. Serum Lp(a) levels have recently been associated with large artery atherosclerosis (LAA) stroke. We aimed to externally validate this association in an independent cohort. METHODS: This study stems from the prospective multicentre CoRisk study (CoPeptin for Risk Stratification in Acute Stroke patients [NCT00878813]), conducted at the University Hospital Bern, Switzerland, between 2009 and 2011, in which Lp(a) plasma levels were measured within the first 24 hours after stroke onset...
April 2, 2024: Swiss Medical Weekly
#28
JOURNAL ARTICLE
Maria A Fiol-deRoque, Maria J Serrano-Ripoll, Sofia Mira-Martínez, Guadalupe Pastor-Moreno, Carolina Sitges, M Esther García-Buades, Elena Gervilla, Mauro Garcia-Toro, Rocío Zamanillo-Campos, Ignacio Ricci-Cabello
INTRODUCTION: PsyCovidApp, a digital intervention aimed at safeguarding the mental health of healthcare workers during the COVID-19 pandemic, demonstrated in a randomized clinical trial to yield significant improvements solely among healthcare workers undergoing psychotherapy or receiving psychotropic medication. OBJECTIVES: (1) To identify contextual factors and mechanisms of action that influenced the impact of PsyCovidApp during the aforementioned trial; (2) To pinpoint enhancements for optimizing its efficacy...
2024: Frontiers in Psychology
#29
JOURNAL ARTICLE
Sin Hye Park, Mira Han, Hong Man Yoon, Keun Won Ryu, Young-Woo Kim, Bang Wool Eom
PURPOSE: The study aimed to investigate real-world surgical outcomes of minimally invasive surgery (MIS) for advanced gastric cancer using Korean Gastric Cancer Association (KGCA)-led nationwide data. MATERIALS AND METHODS: A nationwide survey of patients who underwent surgical treatment for gastric cancer in 2019 was conducted by the KGCA. A total of 14,076 patients from 68 institutions underwent surgery, and 4,953 patients diagnosed with pathological stages IB-III gastric cancer were included...
April 2024: Journal of Gastric Cancer
#30
REVIEW
Suhaniya N S Samarasinghe, Eduard Ostarijas, Matthew J Long, Simon Erridge, Sanjay Purkayastha, Georgios K Dimitriadis, Alexander D Miras
Polycystic ovary syndrome (PCOS) is the most common endocrine disorder in reproductive-age women. This systematic review, meta-analysis, and meta-regression aims to compare the effect of insulin sensitizer pharmacotherapy on metabolic and reproductive outcomes in women with PCOS and overweight or obesity. We searched online databases MEDLINE via OVID, EMBASE, Clinicaltrials.gov, and EudraCT for trials published from inception to November 13, 2023. Inclusion criteria were double-blind, randomized controlled trials in women diagnosed with PCOS, body mass index (BMI) ≥ 25 kg/m2 , which reported metabolic or reproductive outcomes...
April 4, 2024: Obesity Reviews
#31
JOURNAL ARTICLE
Yilin Kang, Jussi Hepojoki, Rocio Sartori Maldonado, Takayuki Mito, Mügen Terzioglu, Tuula Manninen, Ravi Kant, Sachin Singh, Alaa Othman, Rohit Verma, Johanna Uusimaa, Kirmo Wartiovaara, Lauri Kareinen, Nicola Zamboni, Tuula Anneli Nyman, Anders Paetau, Anja Kipar, Olli Vapalahti, Anu Suomalainen
Mitochondria are critical modulators of antiviral tolerance through the release of mitochondrial RNA and DNA (mtDNA and mtRNA) fragments into the cytoplasm after infection, activating virus sensors and type-I interferon (IFN-I) response1-4 . The relevance of these mechanisms for mitochondrial diseases remains understudied. Here we investigated mitochondrial recessive ataxia syndrome (MIRAS), which is caused by a common European founder mutation in DNA polymerase gamma (POLG1)5 . Patients homozygous for the MIRAS variant p...
April 3, 2024: Nature
#32
JOURNAL ARTICLE
Miras Issakhov, Maral Khanjani, Adiya Muratkhozhina, Peyman Pourafshary, Saule Aidarova, Altynay Sharipova
Application of surfactant-based foam flooding is an effective approach to reduce mobility and control early breakthrough. Despite the proper performance of surfactant-based foams in decreasing the channeling of the flooded gas and water, high pressure, high temperature, and high salinity of the reservoirs put some limitations on the foam flooding efficiency. Nanoparticles are used to improve the quality of the foams, enhance stability, and transcend the limitations. Although there are many benefits of using nanoparticles in foam flooding, their performance at surfactant critical micelle concentration (CMC) is not fully investigated and the optimum nanoparticle concentration is not specified...
April 3, 2024: Scientific Reports
#33
JOURNAL ARTICLE
K Benjamin Lee, Mira T Tanenbaum, Angela Wang, Shirling Tsai, J Gregory Modrall, Carlos H Timaran, Melissa L Kirkwood, Bala Ramanan
INTRODUCTION: Radiation-induced carotid artery stenosis (RICS) is a well-described phenomenon seen after head and neck cancer radiation. Previously published literature suggests that compared to atherosclerotic disease, RICS may result in worse long-term outcomes and early restenosis. This study aims to evaluate the effect of radiation on long-term outcomes after various carotid revascularization techniques using a multi-center registry database. METHODS: Patients in the Society for Vascular Surgery (SVS) Vascular Quality Initiative (VQI) registry for carotid artery intervention (carotid endarterectomy, CEA; transfemoral carotid artery stenting, CAS; transcarotid artery revascularization, TCAR), who are 65 years or older were included in the study...
April 1, 2024: Journal of Vascular Surgery
#34
REVIEW
Rebeca Mira Sánchez, Juan Felipe Bermeo Losada, Juan Antonio Marín Martínez
In recent years, environmental epidemiology and toxicology have seen a growing interest in the environmental factors that contribute to the increased prevalence of neurodevelopmental disorders, with the purpose of establishing appropriate prevention strategies. A literature review was performed, and 192 articles covering the topic of endocrine disruptors and neurodevelopmental disorders were found, focusing on polychlorinated biphenyls, polybrominated diphenyl ethers, bisphenol A, and pesticides. This study contributes to analyzing their effect on the molecular mechanism in maternal and infant thyroid function, essential for infant neurodevelopment, and whose alteration has been associated with various neurodevelopmental disorders...
March 30, 2024: Frontiers in Neuroendocrinology
#35
JOURNAL ARTICLE
Mauricio López, Andrea Mira, Daniela Mauricia, Paulina Acevedo, Ruth Lopez, Pamela Molina, Lina Gutiérrez, Eloisa de Billerbeck, Cecilia Breinbauer
No abstract text is available yet for this article.
2024: Frontiers in Public Health
#36
JOURNAL ARTICLE
Markus Zadrazil, Peter Marhofer, Philipp Opfermann, Werner Schmid, Daniela Marhofer, Mira Zeilberger, Lena Pracher, Markus Zeitlinger
BACKGROUND: Little is known about the pharmacodynamic characteristics of liposomal bupivacaine. Hypothesizing that we would not identify pharmacodynamic differences from plain bupivacaine during the initial period after administration, but would find better long-term pharmacodynamic characteristics, we designed a randomized, controlled, triple-blinded, single-center study in volunteers. METHODS: Volunteers aged 18 to 55 years (body mass index: 18 to 35 kg/m²) received two ulnar nerve blocks under ultrasound guidance...
April 1, 2024: Anesthesiology
#37
JOURNAL ARTICLE
Harshdeep Acharya, Kevin J Sykes, Ton Mirás Neira, Angela Scott, Christina M Pacheco, Matthew Sanner, Elizabeth Ablah, Kevin Oyowe, Edward F Ellerbeck, K Allen Greiner, Erin A Corriveau, Sarah Finocchario-Kessler
BACKGROUND: The COVID-19 pandemic added to the decades of evidence that public health institutions are routinely stretched beyond their capacity. Community health workers (CHWs) can be a crucial extension of public health resources to address health inequities, but systems to document CHW efforts are often fragmented and prone to unneeded redundancy, errors, and inefficiency. OBJECTIVE: We sought to develop a more efficient data collection system for recording the wide range of community-based efforts performed by CHWs...
April 1, 2024: JMIR Formative Research
#38
REVIEW
Thomas Matoska, Mira Patel, Hefei Liu, Sushil Beriwal
PURPOSE: Manual contour work for radiation treatment planning takes significant time to ensure volumes are accurately delineated. The use of artificial intelligence with deep learning based autosegmentation (DLAS) models has made itself known in recent years to alleviate this workload. It is used for organs at risk contouring with significant consistency in performance and time saving. The purpose of this study was to evaluate the performance of present published data for DLAS of clinical target volume (CTV) contours, identify areas of improvement, and discuss future directions...
May 2024: Advances in Radiation Oncology
#39
JOURNAL ARTICLE
Georgios Eleftheriadis, Marcel G Naik, Bilgin Osmanodja, Fabian Halleck, Eva Schrezenmeier, Lutz Liefeldt, Mira Choi, Friederike Bachmann, Despina Parthenopi Avaniadi, Ellen von Hoerschelmann, Christian Lücht, Marina Zaks, Wiebke Duettmann, Klemens Budde
BACKGROUND AND HYPOTHESIS: The aim of this study was to quantify hypertension control and evaluate concordance between all commonly available blood pressure modalities in kidney transplant recipients (KTR). METHODS: For this prospective cross-sectional study 89 stable KTR were recruited at the Charité Transplant Outpatient Clinic. For each study participant office (manual office blood pressure 'MOBP' and automated office blood pressure 'AOBP'), 7-day home (HBPM) and 24-hour ambulatory blood pressure measurement (24h-ABPM) were performed...
March 28, 2024: Nephrology, Dialysis, Transplantation
#40
REVIEW
Nils Kriedemann, Wiebke Triebert, Jana Teske, Mira Mertens, Annika Franke, Kevin Ullmann, Felix Manstein, Lika Drakhlis, Alexandra Haase, Caroline Halloin, Ulrich Martin, Robert Zweigerdt
A promising cell-therapy approach for heart failure aims at differentiating human pluripotent stem cells (hPSCs) into functional cardiomyocytes (CMs) in vitro to replace the disease-induced loss of patients' heart muscle cells in vivo. But many challenges remain for the routine clinical application of hPSC-derived CMs (hPSC-CMs), including good manufacturing practice (GMP)-compliant production strategies. This protocol describes the efficient generation of hPSC-CM aggregates in suspension culture, emphasizing process simplicity, robustness and GMP compliance...
March 28, 2024: Nature Protocols
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