keyword
https://read.qxmd.com/read/38530276/new-neuroprotective-derivatives-of-cinnamic-acid-by-biotransformation
#1
JOURNAL ARTICLE
Hadeer Elkharsawy, Ramadan A Eldomany, Amira Mira, Amal F Soliman, Mohamed Amir, Saleh El-Sharkawy
Microbial transformation is extensively utilized to generate new metabolites in bulk amounts with more specificity and improved activity. As cinnamic acid was reported to exhibit several important pharmacological properties, microbial transformation was used to obtain its new derivatives with enhanced biological activities. By manipulating the 2-stage fermentation protocol of biotransformation, five metabolites were produced from cinnamic acid. Two of them were new derivatives; N -propyl cinnamamide 2̲ and 2-methyl heptyl benzoate 3̲ produced by Alternaria alternata ...
March 26, 2024: Food & Function
https://read.qxmd.com/read/38528599/local-alternating-heat-and-cold-stimulation-affects-hemodynamics-and-oxygenation-in-fatigued-muscle-tissue-and-autonomic-nervous-activity-a-single-arm-interventional-study
#2
JOURNAL ARTICLE
Tomonori Sawada, Hiroki Okawara, Daisuke Nakashima, Kentaro Aoki, Mira Namba, Shuhei Iwabuchi, Yoshinori Katsumata, Masaya Nakamura, Takeo Nagura
BACKGROUND: Local alternating heat and cold stimulation as an alternative to contrast bath may cause intermittent vasoconstriction and vasodilation, inducing a vascular pumping effect and consequently promoting increased tissue blood flow and oxygenation. This study aimed to examine the effects of local alternating heat and cold stimulation, using a wearable thermal device, on the hemodynamics of fatigued muscle tissue and autonomic nervous activity. METHODS: Twenty healthy individuals experienced fatigue in the periarticular muscles of the shoulder joint due to a typing task...
March 25, 2024: Journal of Physiological Anthropology
https://read.qxmd.com/read/38528578/matrix-free-human-pluripotent-stem-cell-manufacturing-by-seed-train-approach-and-intermediate-cryopreservation
#3
JOURNAL ARTICLE
Kevin Ullmann, Felix Manstein, Wiebke Triebert, Nils Kriedemann, Annika Franke, Jana Teske, Mira Mertens, Victoria Lupanow, Gudrun Göhring, Alexandra Haase, Ulrich Martin, Robert Zweigerdt
BACKGROUND: Human pluripotent stem cells (hPSCs) have an enormous therapeutic potential, but large quantities of cells will need to be supplied by reliable, economically viable production processes. The suspension culture (three-dimensional; 3D) of hPSCs in stirred tank bioreactors (STBRs) has enormous potential for fuelling these cell demands. In this study, the efficient long-term matrix-free suspension culture of hPSC aggregates is shown. METHODS AND RESULTS: STBR-controlled, chemical aggregate dissociation and optimized passage duration of 3 or 4 days promotes exponential hPSC proliferation, process efficiency and upscaling by a seed train approach...
March 25, 2024: Stem Cell Research & Therapy
https://read.qxmd.com/read/38528457/full-length-16s-rrna-gene-sequencing-by-pacbio-improves-taxonomic-resolution-in-human-microbiome-samples
#4
JOURNAL ARTICLE
Elena Buetas, Marta Jordán-López, Andrés López-Roldán, Giuseppe D'Auria, Llucia Martínez-Priego, Griselda De Marco, Miguel Carda-Diéguez, Alex Mira
BACKGROUND: Sequencing variable regions of the 16S rRNA gene (≃300 bp) with Illumina technology is commonly used to study the composition of human microbiota. Unfortunately, short reads are unable to differentiate between highly similar species. Considering that species from the same genus can be associated with health or disease it is important to identify them at the lowest possible taxonomic rank. Third-generation sequencing platforms such as PacBio SMRT, increase read lengths allowing to sequence the whole gene with the maximum taxonomic resolution...
March 25, 2024: BMC Genomics
https://read.qxmd.com/read/38527626/infrared-microspectroscopy-to-elucidate-the-underlying-biomolecular-mechanisms-of-flash-radiotherapy
#5
JOURNAL ARTICLE
Immaculada Martínez-Rovira, Pierre Montay-Gruel, Benoît Petit, Ron Leavitt, Roberto González-Vegas, Pascal Froidevaux, Marjorie Juchaux, Yolanda Prezado, Ibraheem Yousef, Marie-Catherine Vozenin
BACKGROUND: FLASH-radiotherapy (FLASH-RT) is an emerging modality that uses ultra-high dose rates of radiation to enable curative doses to the tumor while preserving normal tissue. The biological studies showed the potential of FLASH-RT to revolutionize radiotherapy cancer treatments. However, the complex biological basis of FLASH-RT is not fully known yet. AIM: Within this context, our aim is to get deeper insights into the biomolecular mechanisms underlying FLASH-RT through Fourier Transform Infrared Microspectroscopy (FTIRM)...
March 23, 2024: Radiotherapy and Oncology
https://read.qxmd.com/read/38521127/hypervirulent-klebsiella-pneumoniae-related-bacteremia-in-intensive-care-unit-a-retrospective-cohort-study
#6
JOURNAL ARTICLE
Marin Moutel, Edwidge Peju, Martin Belan, Ariane Gavaud, Jean-Paul Mira, Caroline Charlier, Etienne Canouï, Nabil Gastli
INTRODUCTION: Hypervirulent Klebsiella pneumoniae (hvKP) bloodstream infections (BSI) have rarely been reported in critically ill patients. METHODS: We conducted a retrospective study of KP-BSI between January 2016 and December 2020 in an adult medical intensive care unit (ICU) of our tertiary care hospital. Hypervirulent phenotype was defined by the detection of both rmpA and iutA. RESULTS: Seventy patients diagnosed with K. pneumonia BSI were included, of whom 9 (13 %) had hvKP infection...
March 21, 2024: Infectious diseases now
https://read.qxmd.com/read/38519899/development-of-an-interdisciplinary-training-program-about-chronic-pain-management-with-a-cognitive-behavioural-approach-for-healthcare-professionals-part-of-a-hybrid-effectiveness-implementation-study
#7
JOURNAL ARTICLE
Wouter Munneke, Christophe Demoulin, Jo Nijs, Carine Morin, Emy Kool, Anne Berquin, Mira Meeus, Margot De Kooning
BACKGROUND: Many applied postgraduate pain training programs are monodisciplinary, whereas interdisciplinary training programs potentially improve interdisciplinary collaboration, which is favourable for managing patients with chronic pain. However, limited research exists on the development and impact of interdisciplinary training programs, particularly in the context of chronic pain. METHODS: This study aimed to describe the development and implementation of an interdisciplinary training program regarding the management of patients with chronic pain, which is part of a type 1 hybrid effectiveness-implementation study...
March 22, 2024: BMC Medical Education
https://read.qxmd.com/read/38519334/silk-hyaluronic-acid-for-vocal-fold-augmentation-safety-profile-and-long-term-voice-outcomes
#8
JOURNAL ARTICLE
Christopher D Dwyer, Samantha Kridgen, Simon Chiang, Mira Fein, Carly Forrester, Lindsey Gordon, Douglas F Roth, Jennifer J Shin, Jennifer Winston, Thomas L Carroll
OBJECTIVES: Silk-hyaluronic acid (silk-HA) is a novel vocal fold augmentation material used in humans since July 2020. We aim to describe indications, voice outcomes, and longevity data for silk-HA injectable when used for vocal fold injection (VFI) augmentation in a large cohort of patients with longer-term follow-up than preliminary clinical studies. METHODS: Retrospective chart review of Silk-HA injections for glottic insufficiency (GI) and follow-up between July 2020 and November 2023...
March 21, 2024: Journal of Voice
https://read.qxmd.com/read/38518694/determination-of-asbestos-cement-rooftop-surface-composition-using-regression-analysis-and-hyper-spectral-reflectance-data-in-the-visible-and-near-infrared-ranges
#9
JOURNAL ARTICLE
Mira Sabat, Noura Fares, George Mitri, Adib Kfoury
The effects of asbestos on human health have spurred numerous studies examining its risks in urban environments. Recent works have shifted towards less-invasive techniques for remote detection and classification of asbestos-cement. In this context, this study combines visible (VIS) and near-infrared (NIR) reflectance data collected in-situ with reference signals from the USGS spectral library, utilizing optimized regression analysis to determine the surface composition of corrugated asbestos-cement rooftops...
March 12, 2024: Journal of Hazardous Materials
https://read.qxmd.com/read/38517657/a-comparative-study-assessing-the-efficacy-and-safety-of-radiofrequency-ablation-versus-surgical-treatment-for-osteoid-osteoma-retrospective-analysis-in-a-single-institution
#10
JOURNAL ARTICLE
Jasminka Igrec, Maria Anna Smolle, Michael Meszarics, Theresa Marie Godschachner, Jakob Steiner, Mira Feichtinger, Emina Talakic, Rupert Horst Portugaller, Andreas Leithner, Michael Fuchsjäger, Iva Brcic
OBJECTIVE: We aim to evaluate the efficacy of CT-guided percutaneous radiofrequency ablation (RFA) and surgical treatment in osteoid osteoma (OO) treated at the Medical University of Graz. MATERIALS AND METHODS: In a single-institution study, we analysed data from January 2005 to January 2021 of patients with histological/radiological diagnosis of OO. CT and MRI scans were reviewed for typical findings. Means (with SD) and medians (with IQR) were reported for normally and non-normally distributed variables...
March 22, 2024: Insights Into Imaging
https://read.qxmd.com/read/38516443/congenital-extrahepatic-portosystemic-shunt-complicated-by-the-development-of-hepatoblastoma-a-case-report-and-review-of-literature
#11
Mira AlMheiri, Hala B Mrayyan, Balaji Krishnamurthy, Ajay P Dsouza
Congenital portosystemic shunts (CPSS) or congenital extrahepatic portosystemic shunts (CEPS) is a rare malformation. This congenital anomaly presents with a diverse array of clinical manifestations, ranging from asymptomatic to severe complications such as cardiac failure, pronounced pulmonary hypertension, and widespread pulmonary arteriovenous malformations. CPSS increases the risk of developing benign or malignant liver tumors, including nodular regenerative hyperplasia, focal nodular hyperplasia, hepatic adenoma, hepatocellular carcinoma, and hepatoblastoma...
February 2024: Curēus
https://read.qxmd.com/read/38511016/prognostic-implications-of-various-surgical-procedures-and-postoperative-margin-status-in-gastroesophageal-junction-tumors
#12
JOURNAL ARTICLE
Mira Sudam Wagh, Chandramohan K, Abdulla Kp, Arun Peter Mathew, Madhu Muralee, Jagathnath Krishna K M
Esophagogastric junction (EGJ) carcinomas often require access to two compartments of the body for good margin and lymphadenectomy. Whether it is required to do so in all patients is debatable. We analyzed outcomes of patients who underwent surgeries for EGJ carcinomas in terms of margin status and survival. This is a retrospective analysis of a prospectively maintained database of patients with EGJ adenocarcinomas operated between January 2014 and December 2016. Type of surgery performed and its impact on margin status and survival were assessed...
March 2024: Indian Journal of Surgical Oncology
https://read.qxmd.com/read/38510089/up-and-over-staged-endoconduit-technique-for-endovascular-aortic-aneurysm-repair
#13
JOURNAL ARTICLE
Andres V Figueroa, Mira T Tanenbaum, Jose Eduardo Costa-Filho, Marilisa S Gonzalez, Mirza S Baig, Carlos H Timaran
Adverse iliofemoral anatomy can preclude complex endovascular aortic aneurysm repair. This study aims to describe the "up-and-over" staged endoconduit technique to improve access and avoid vascular injury before complex endovascular aneurysm repair. A staged procedure for complex endovascular aortic aneurysm repair is performed using an endoconduit (W.L. Gore & Associates). After obtaining contralateral femoral access, the extension of iliofemoral disease is assessed using angiography. The endoconduit is advanced "up and over" the aortic bifurcation and delivered percutaneously into the common femoral artery to treat a diseased access site and maintain intact the ipsilateral femoral access for future stent graft deployment...
June 2024: Journal of Vascular Surgery Cases and Innovative Techniques
https://read.qxmd.com/read/38509212/author-correction-chemical-disinfection-as-a-simple-and-reliable-method-to-control-the-amphibian-chytrid-fungus-at-breeding-points-of-endangered-amphibians
#14
Barbora Thumsová, Emilio González-Miras, Ángel Rubio, Ignacio Granados, Kieran A Bates, Jaime Bosch
No abstract text is available yet for this article.
March 20, 2024: Scientific Reports
https://read.qxmd.com/read/38508182/synchronized-assembly-of-the-oxidative-phosphorylation-system-controls-mitochondrial-respiration-in-yeast
#15
JOURNAL ARTICLE
Daiana N Moretti-Horten, Carlotta Peselj, Asli Aras Taskin, Lisa Myketin, Uwe Schulte, Oliver Einsle, Friedel Drepper, Marcin Luzarowski, F-Nora Vögtle
Control of protein stoichiometry is essential for cell function. Mitochondrial oxidative phosphorylation (OXPHOS) presents a complex stoichiometric challenge as the ratio of the electron transport chain (ETC) and ATP synthase must be tightly controlled, and assembly requires coordinated integration of proteins encoded in the nuclear and mitochondrial genome. How correct OXPHOS stoichiometry is achieved is unknown. We identify the MitochondrialRegulatory hub for respiratoryAssembly (MiRA) platform, which synchronizes ETC and ATP synthase biogenesis in yeast...
March 18, 2024: Developmental Cell
https://read.qxmd.com/read/38506939/-you-matter-patients-perceptions-and-disparities-about%C3%A2-cancer-care-and-telehealth-during-and-after-covid-19-pandemic
#16
JOURNAL ARTICLE
Mohamed Mohanna, María Herrán, Barbara Dominguez, Saad Sabbagh, Ali Msheik, Mira Itani, Ludovic Saba, Sindu Iska, Hong Liang, Caroline Metzel Diaz, Zeina Nahleh
PURPOSE: Disparities in cancer care have been exacerbated by the COVID-19 pandemic. The aim of this study is to establish how telehealth mitigated the effect of COVID-19 on the healthcare sector and to identify potential disparities in perception and experience with telehealth in cancer care during and after the pandemic. METHODS: We identified individuals with an established cancer diagnosis who received treatment at a comprehensive academic cancer center with a diverse patient population between 2019 and 2021, during the COVID-19 pandemic...
March 20, 2024: Supportive Care in Cancer
https://read.qxmd.com/read/38506566/evidence-for-trans-oligoene-chain-formation-in-graphene-induced-by-iodine
#17
JOURNAL ARTICLE
Fabian Grote, Benjamin I Weintrub, Mira Kreßler, Qing Cao, Christian E Halbig, Patryk Kusch, Kirill I Bolotin, Siegfried Eigler
Functionalization of pristine graphene by hydrogen and fluorine is well studied, resulting in graphane and fluorographene structures. In contrast, functionalization of pristine graphene with iodine has not been reported. Here, the functionalization of graphene with iodine using photochemical activation is presented, which is thermally reversible at 400 °C. Additional dispersive dominant Raman modes that are probed by resonance Raman spectroscopy are observed. Additionally, iodinated graphene is probed by Kelvin probe force microscopy and by transport measurements showing p-doping surpassing non-covalent iodine doping by charge transfer-complex formation...
March 20, 2024: Small
https://read.qxmd.com/read/38506332/using-a-translanguaging-framework-to-examine-language-production-in-a-trilingual-person-with-aphasia
#18
JOURNAL ARTICLE
Mira Goral, Katarina Antolovic, Zahra Hejazi, Franziska M Schulz
When language abilities in aphasia are assessed in clinical and research settings, the standard practice is to examine each language of a multilingual person separately. But many multilingual individuals, with and without aphasia, mix their languages regularly when they communicate with other speakers who share their languages. We applied a novel approach to scoring language production of a multilingual person with aphasia. Our aim was to discover whether the assessment outcome would differ meaningfully when we count accurate responses in only the target language of the assessment session versus when we apply a translanguaging framework, that is, count all accurate responses, regardless of the language in which they were produced...
March 20, 2024: Clinical Linguistics & Phonetics
https://read.qxmd.com/read/38498596/concurrent-validity-of-dynamic-bedside-quantitative-sensory-testing-paradigms-in-breast-cancer-survivors-with-persistent-pain
#19
JOURNAL ARTICLE
Vincent Haenen, Mira Meeus, Nele Devoogdt, Bart Morlion, Lore Dams, Amber De Groote, Anthe Foubert, An De Groef
BACKGROUND: Studies on the concurrent validity of clinically applicable testing protocols for conditioned pain modulation (CPM) and temporal summation of pain (TSP) in breast cancer survivors (BCS) with persistent pain are lacking. OBJECTIVES: This study investigated the concurrent validity of two bedside protocols for CPM and TSP in comparison to a respective reference protocol. The participants' preferences for bedside CPM and TSP protocols were assessed. METHODS: Thirty BCS experiencing persistent pain were included in this study...
January 1, 2024: Scandinavian Journal of Pain
https://read.qxmd.com/read/38498459/oncolytic-vaccinia-virus-immunotherapy-antagonizes-image-guided-radiotherapy-in-mouse-mammary-tumor-models
#20
JOURNAL ARTICLE
Brittany A Umer, Ryan S Noyce, Quinten Kieser, Nicole A Favis, Mira M Shenouda, Kim J Rans, Jackie Middleton, Mary M Hitt, David H Evans
Ionizing radiation (IR) and oncolytic viruses are both used to treat cancer, and the effectiveness of both agents depends upon stimulating an immune response against the tumor. In this study we tested whether combining image guided ionizing radiation (IG-IR) with an oncolytic vaccinia virus (VACV) could yield a better therapeutic response than either treatment alone. ΔF4LΔJ2R VACV grew well on irradiated human and mouse breast cancer cells, and the virus can be combined with 4 or 8 Gy of IR to kill cells in an additive or weakly synergistic manner...
2024: PloS One
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