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Viola Kretschmer, Sarita Rani Patnaik, Friedrich Kretschmer, Mira Manilal Chawda, Victor Hernandez-Hernandez, Helen Louise May-Simera
Purpose: Bardet-Biedl syndrome (BBS) is an archetypical ciliopathy caused by defective ciliary trafficking and consequent function. Insights gained from BBS mouse models are applicable to other syndromic and nonsyndromic retinal diseases. This progressive characterization of the visual phenotype in three BBS mouse models sets a baseline for testing therapeutic interventions. Methods: Longitudinal acquisition of electroretinograms, optical coherence tomography scans, and visual acuity using the optomotor reflex in Bbs6/Mkks, Bbs8/Ttc8, and Bbs5 knockout mice...
March 1, 2019: Investigative Ophthalmology & Visual Science
Mira Mahendra Shah, Derek Isrow, Muhammad M Fareed, Ning Wen, Samuel Ryu, Munther Ajlouni, Farzan Siddiqui
Objective: The objective of the study is to present our experience of treating adrenal metastases using stereotactic body radiation therapy (SBRT). Materials and Methods: We retrospectively reviewed patients with adrenal metastases treated using SBRT from 2001 to 2014. Response Evaluation Criteria in Solid Tumors v1.1 was used. Maximum tumor response was defined as the greatest percentage tumor reduction noted on two or more post-SBRT CT scans. Results: We identified 44 patients (median age 61...
March 2019: Journal of Cancer Research and Therapeutics
Nika Shakiba, Ahmed Fahmy, Gowtham Jayakumaran, Sophie McGibbon, Laurent David, Daniel Trcka, Judith Elbaz, Mira C Puri, Andras Nagy, Derek van der Kooy, Sidhartha Goyal, Jeffrey L Wrana, Peter W Zandstra
The ability to generate induced pluripotent stem cells from differentiated cell types has enabled researchers to engineer cell states. Although studies have identifed molecular networks that reprogram cells to pluripotency, the cellular dynamics of these processes remain poorly understood. Here, by combining cellular barcoding, mathematical modelling, and lineage tracing approaches, we demonstrate that reprogramming dynamics in heterogeneous populations are driven by dominant "elite" clones. Clones arise a priori from a population of poised mouse embryonic fibroblasts (MEFs) derived from Wnt1-expressing cells that may represent a neural crest population...
March 21, 2019: Science
Jean-Pierre Frat, Jean-Damien Ricard, Jean-Pierre Quenot, Nicolas Pichon, Alexandre Demoule, Jean-Marie Forel, Jean-Paul Mira, Rémi Coudroy, Guillaume Berquier, Benoit Voisin, Gwenhaël Colin, Bertrand Pons, Pierre Eric Danin, Jérome Devaquet, Gwenael Prat, Raphaël Clere-Jehl, Franck Petitpas, Emmanuel Vivier, Keyvan Razazi, Mai-Anh Nay, Vincent Souday, Jean Dellamonica, Laurent Argaud, Stephan Ehrmann, Aude Gibelin, Christophe Girault, Pascal Andreu, Philippe Vignon, Laurence Dangers, Stéphanie Ragot, Arnaud W Thille
BACKGROUND: Non-invasive ventilation has never been compared with high-flow oxygen to determine whether it reduces the risk of severe hypoxaemia during intubation. We aimed to determine if preoxygenation with non-invasive ventilation was more efficient than high-flow oxygen in reducing the risk of severe hypoxaemia during intubation. METHODS: The FLORALI-2 multicentre, open-label trial was done in 28 intensive care units in France. Adult patients undergoing tracheal intubation for acute hypoxaemic respiratory failure (a partial pressure of arterial oxygen [PaO2 ] to fraction of inspired oxygen [FiO2 ] ratio of ≤300 mm Hg) were randomly assigned (1:1; block size, four participants) to non-invasive ventilation or high-flow oxygen during preoxygenation, with stratification by PaO2 /FiO2 ratio (≤200 mm Hg vs >200 mm Hg)...
March 14, 2019: Lancet Respiratory Medicine
Andreas Seeber, Georges Chahine, Fadi Nasr, Andrew Dean, Mira Miranova, Gayle Jameson, Nicholas Robert, Guenther Gastl, Heinz Zwierzina
PURPOSE: Improvements in systemic treatment have led to a prolongation of survival and quality of life in patients with metastatic tumors in recent years. However, despite this improved standard of care, it is expected that the progression-free survival (PFS) for patients with refractory cancers will continue to decline over subsequent therapy lines. In those patients, studies and meta-analyses showed that treatment based on multiplatform molecular profiling (MMP) of tumor tissue may derive a clinical benefit...
March 2019: Cancer Journal
Sung-Min Jun, Mira Park, Ji Yoon Lee, Sookyung Jung, Jeoung Eun Lee, Sung Han Shim, Haengseok Song, Dong Ryul Lee
OBJECTIVES: Because primary mesenchymal progenitor cells (adult-MPCs) have various functions that depend on the tissue origin and donor, de novo MPCs from human pluripotent stem cells (hPSCs) would be required in regenerative medicine. However, the characteristics and function of MPCs derived from reprogrammed hPSCs have not been well studied. Thus, we show that functional MPCs can be successfully established from a single cell-derived clonal expansion following MPC derivation from somatic cell nuclear transfer-derived (SCNT)-hPSCs, and these cells can serve as therapeutic contributors in an animal model of Asherman's syndrome (AS)...
March 21, 2019: Cell Proliferation
Nayera E Hassan, Abeer A El Ashmawi, Sahar A El-Masry, Waheba A Zarouk, Marwa F Mira, Gamila Sm El-Saeed, Omar H Dwidar
AIM: Obesity and its metabolic complications are increasing in childhood and extend to adulthood. The aims of this study were to assess the prevalence of metabolic syndrome (MS) in a sample of Egyptian adolescent girls and investigate its association with apolipoprotein E. METHODS: A cross-sectional study design was used, including 200 Egyptian adolescent girls aged between 12 and 18 years. They were subjected to blood pressure (BP) measurement, anthropometric measurements (weight, height and waist circumference (WC)), laboratory investigations (fasting glucose and lipid profile) and molecular analysis (Apo E)...
March 20, 2019: Journal of Paediatrics and Child Health
Kumju Youn, Mira Jun
Alzheimer's disease (AD) is an irreversible neurodegenerative disorder characterized by progressive impairment of cognitive functions. Beta-site amyloid precursor protein cleaving enzyme1 (BACE1) is essential for the formation of β-amyloid peptide (Aβ), a major constituent of amyloid plaques that represent a neuropathological hallmark of this disorder. To find alternative therapies for AD sourced from natural products, the present study focused on three flavonoids from Boesenbergia rotunda , namely, cardamonin, pinocembrin, and pinostrobin...
March 19, 2019: Nutrients
Jake McGuire, Bradley Wilson, James McAllister, Haralampos N Miras, Claire Wilson, Stephen Sproules, Joy H Farnaby
Heterometallic rare earth transition metal compounds of dithioxalate (dto)2-, [NiII{(dto)LnIIITp2}2] (Ln = Y (1), Gd (2); Tp = hydrotris(pyrazol-1-yl)borate) were synthesised. The Lewis acidic rare earth ions are bound to the dioxolene and chemical reduction of 1 and 2 with cobaltocene yielded [CoCp2]+[NiII{(dto)LnIIITp2}2]˙- Ln = Y (3), Gd (4). The reduction is ligand-based and 3 and 4 are the first examples of both molecular and electronic structural characterisation of the dithiooxalato radical (dto)3˙-...
March 20, 2019: Dalton Transactions: An International Journal of Inorganic Chemistry
Zeinab Awada, Hassan Al Moussawi, Mira Alsheikh
Visceral artery aneurysms (VAAs) and visceral artery pseudoaneurysms (VAPAs) are defined as more than a 1.5 fold increase in the normal diameter of the celiac, superior, or inferior mesenteric arteries and their branches. They represent a rare finding with an incidence ranging between 0.1% to 0.2%. Depending on the mechanism of formation, aneurysms can be divided into true aneurysms or pseudoaneurysms. True aneurysms involve all layers of the wall, which are usually thinned but remain intact and commonly result from vessel wall abnormalities...
January 7, 2019: Curēus
Sarah R Barger, Nicholas S Reilly, Maria S Shutova, Qingsen Li, Paolo Maiuri, John M Heddleston, Mark S Mooseker, Richard A Flavell, Tatyana Svitkina, Patrick W Oakes, Mira Krendel, Nils C Gauthier
Phagocytosis of invading pathogens or cellular debris requires a dramatic change in cell shape driven by actin polymerization. For antibody-covered targets, phagocytosis is thought to proceed through the sequential engagement of Fc-receptors on the phagocyte with antibodies on the target surface, leading to the extension and closure of the phagocytic cup around the target. We find that two actin-dependent molecular motors, class 1 myosins myosin 1e and myosin 1f, are specifically localized to Fc-receptor adhesions and required for efficient phagocytosis of antibody-opsonized targets...
March 19, 2019: Nature Communications
Anabel Lifszyc-Friedlander, Mira Honovich, Ilana Stolerman, Batya Madjar, Sivia Barnoy
PURPOSE: To examine the extent to which Family Health Clinics (FHCs) contribute to the formation of social capital among mothers, and determine whether it is influenced by socioeconomic factors. In FHCs, social capital can be gained by relationships between mothers (bonding social capital), by relationships between mothers and FHCs team, or between mothers of different origins/culture (bridging social capital) and health services institutional bodies (linking social capital). DESIGN: This is a mixed method study...
March 13, 2019: Journal of Pediatric Nursing
Jean-François Llitjos, Aïcha Gassama, Julien Charpentier, Jérôme Lambert, Charles de Roquetaillade, Alain Cariou, Jean-Daniel Chiche, Jean-Paul Mira, Matthieu Jamme, Frédéric Pène
PURPOSE: To investigate the determinants and the prognosis of intensive care unit (ICU)-acquired pneumonia in patients with septic shock. METHODS: This single-center retrospective study was conducted in a medical ICU in a tertiary care center from January 2008 to December 2016. All consecutive patients diagnosed for septic shock within the first 48 h of ICU admission were included. Patients were classified in three groups: no ICU-acquired infections (no ICU-AI), ICU-acquired pneumonia and non-pulmonary ICU-AI...
March 15, 2019: Annals of Intensive Care
Aurora Holgado, Harald Braun, Elien Van Nuffel, Sammy Detry, Martijn J Schuijs, Kim Deswarte, Karl Vergote, Mira Haegman, Griet Baudelet, Jurgen Haustraete, Hamida Hammad, Bart N Lambrecht, Savvas N Savvides, Inna S Afonina, Rudi Beyaert
BACKGROUND: The emergence of IL-33 as a key molecular player in the development and propagation of widespread inflammatory diseases including asthma and atopic dermatitis has established the need for effective IL-33 neutralizing biologics. OBJECTIVE: Here we describe the development and validation of a new antagonist of IL-33, termed IL-33trap, which combines the extracellular domains of the IL-33 receptor (ST2) and its co-receptor IL-1 receptor accessory protein, into a single fusion protein...
March 12, 2019: Journal of Allergy and Clinical Immunology
Andrew H Chon, Yen Chan, Lisa M Korst, Arlyn Llanes, Mira Abdel-Sattar, Ramen H Chmait
Our goal was to assess whether quantitative fetal fibronectin (qfFN) is associated with spontaneous preterm birth (sPTB) after laser surgery for twin-twin transfusion syndrome (TTTS). qfFN was collected within 24 hours before and after laser surgery. Aims were: (1) To determine if qfFN changed with operative fetoscopy; and (2) To estimate the number of patients needed to study the predictive value of qfFN for sPTB <28 and <32 weeks. Results are reported as median (range). Among 49 patients, there was no net difference in qfFN levels after laser surgery [0...
March 14, 2019: Scientific Reports
Mirae Park, Giovanni Satta, Onn Min Kon
Of the 10 million incident cases of tuberculosis (TB) globally in 2017, around 558,000 cases were rifampicin-resistant of which 82% were multidrug-resistant (MDR) TB. In England, 5,102 cases were recorded of which 55 cases (1.8%) were MDR-TB. MDR-TB cases have worse outcomes and are a serious public health issue.Polymerase chain reaction (PCR) tests allow a faster approach to diagnose TB and predict drug susceptibility. The emerging use of whole genome sequencing may improve the diagnostic workflow compared with standard drug susceptibility testing, with more rapid molecular sensitivity results and more precise contact investigation of linked cases...
March 2019: Clinical Medicine: Journal of the Royal College of Physicians of London
Peter Sparber, Alexandra Filatova, Mira Khantemirova, Mikhail Skoblov
BACKGROUND: Thousands of long non-coding RNA (lncRNA) genes are annotated in the human genome. Recent studies showed the key role of lncRNAs in a variety of fundamental cellular processes. Dysregulation of lncRNAs can drive tumorigenesis and they are now considered to be a promising therapeutic target in cancer. However, how lncRNAs contribute to the development of hereditary diseases in human is still mostly unknown. RESULTS: This review is focused on hereditary diseases in the pathogenesis of which long non-coding RNAs play an important role...
March 13, 2019: BMC Medical Genomics
Sergio Martín, Yohei Takashima, Chang-Gen Lin, Yu-Fei Song, Haralampos N Miras, Leroy Cronin
Polyoxometalates (POMs) have been found to be good end-capping ligands for gold nanoparticles (AuNPs). Herein, we introduce a new synthetic method to synthesize gold nanoparticle-POM hybrids by heating a solution of AuNO3 (PMe3 ) in acetonitrile in the presence of appropriate POM species with tetrabutylammonium (TBA) as a countercation at 120 °C in a microwave. This method allowed us to produce POM-capped AuNPs without over-reduction of the solution causing decomposition or reorganization of the POMs. Analysis of the resulting material by transmission electron microscopy showed that the POM's size, charge, and functionality are key factors controlling the resulting POM-AuNP hybrid structure...
March 14, 2019: Inorganic Chemistry
Christina M Burden, Mira O Morgan, Kristen R Hladun, Gro V Amdam, John J Trumble, Brian H Smith
Heavy metal toxicity is an ecological concern in regions affected by processes like mining, industry, and agriculture. At sufficiently high concentrations, heavy metals are lethal to honey bees, but little is known about how sublethal doses affect honey bees or whether they will consume contaminated food. We investigated whether honey bees reject sucrose solutions contaminated with three heavy metals - cadmium, copper, and lead - as a measure of their ability to detect the metals, and whether ingesting these metals altered the bees' sucrose sensitivity...
March 12, 2019: Scientific Reports
Javier Aguilera-Lizarraga, Morgane V Florens, Thomas Van Brussel, Egbert Clevers, Lukas Van Oudenhove, Diether Lambrechts, Mira M Wouters, Guy E Boeckxstaens
BACKGROUND: Mucosal immune activation has been postulated to play an important role in the pathogenesis of irritable bowel syndrome (IBS). However, data are conflicting and often based on small patient cohorts. Here, we aimed to evaluate the gene expression of a large set of immune-related genes in mucosal biopsies from IBS patients and healthy volunteers (HV). METHODS: A total of 171 IBS patients and 127 HV were included in the study. Rectum biopsies were collected from a cohort of 70 HV and 77 IBS patients (Rome III) and colon descendens biopsies from another cohort of 57 HV and 94 IBS patients (Rome II)...
March 10, 2019: Neurogastroenterology and Motility: the Official Journal of the European Gastrointestinal Motility Society
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