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"Magnesium Deficiency" OR "Magnesium Depletion" AND treatment

Xinying Hou, Qiming Zhou, Zeshuang Wang, Qingdan Kong, Yunfei Sun, Lu Zhang, Xuexia Zhu, Yuan Huang, Zhou Yang
In aquatic ecosystems, many phytoplankton species have evolved various inducible defense mechanisms against the predation. The expression of these defenses is affected by environmental conditions such as nutrient availability. Here, we investigated the anti-grazer colony formation in Scenedesmus obliquus at different magnesium concentrations (0-7.3 mg L-1  Mg2+ ) in the presence of zooplankton (Daphnia)-derived infochemicals. Results showed that at adequate Mg2+ , S. obliquus formed high proportions of multi-celled (e...
December 2018: Environmental Science and Pollution Research International
Malcolm G Keeping
Soils of the tropics and sub-tropics are typically acid and depleted of soluble sources of silicon (Si) due to weathering and leaching associated with high rainfall and temperatures. Together with intensive cropping, this leads to marginal or deficient plant Si levels in Si-accumulating crops such as rice and sugarcane. Although such deficiencies can be corrected with exogenous application of Si sources, there is controversy over the effectiveness of sources in relation to their total Si content, and their capacity to raise soil and plant Si concentrations...
2017: Frontiers in Plant Science
P Fatuzzo, G Portale, V Scollo, L Zanoli, Antonio Granata
Hypomagnesemia is a common but often overlooked problem in hospitalized patients. Unrecognized hypomagnesemia can cause serious complications. The association of hypokalemia and hypocalcemia is strongly evocative of a magnesium deficiency. Research into the causes of hypomagnesemia is imperative, as it will definitely change the approach, treatment and prognosis. We report the case of a 65-year-old man with chronic hypocalcemia and hypokalemia associated with cerebellar syndrome, a solitary seizure and cerebellar hyperintensities on magnetic resonance imaging...
April 2017: Journal of Nephrology
Loris Pironi
The European Society for Clinical Nutrition and Metabolism defined intestinal failure (IF) as "the reduction of gut function below the minimum necessary for the absorption of macronutrients and/or water and electrolytes, such that intravenous supplementation is required to maintain health and/or growth". IF is classified as type 1-acute, type 2-prolonged acute and type 3-chronic IF. A short bowel syndrome (SBS) due to the intestinal malabsorption associated with a functional small intestine length of less than 200 cm is the most frequent mechanism of IF...
April 2016: Best Practice & Research. Clinical Gastroenterology
Toru Shimaoka, Yan Wang, Masaki Morishima, Shinji Miyamoto, Katsushige Ono
The present study was designed to investigate the effect of magnesium (Mg) depletion on the expression of voltage-gated calcium (Ca(2+)) channels and Ca(2+) currents in the heart and thereby on hypomagnesemic arrhythmogenesis in adult male rats. Male Wistar rats were fed an Mg-free diet or a normal diet for up to 16 weeks. Serum Mg concentrations were significantly reduced at week 4 or later with an Mg-free diet, which experimentally represents hypomagnesemia. Myocardial Mg contents were also reduced at week 16 accompanied by myocardial hypertrophy...
June 2015: Pathophysiology: the Official Journal of the International Society for Pathophysiology
Mehmet Emin Demir, Zafer Ercan, Emel Yigit Karakas, Turgay Ulas, Hakan Buyukhatipoglu
CONTEXT: Short bowel syndrome is a rare and devastating complication in chronic inflammatory bowel disease following functional or anatomic loss of extensive segments of the intestine. CASE REPORT: A 60-year-old male patient with Crohn's disease had undergone multiple resections of the intestine and developed short bowel syndrome. Despite up to 4-5 liters of orally fluid, sufficient calcium and magnesium intake, he suffered from recurrent acute kidney injury due to profound volume depletion and those electrolyte deficiencies...
December 2014: North American Journal of Medical Sciences
George Liamis, Evangelos Liberopoulos, Fotios Barkas, Moses Elisaf
Diabetic patients frequently develop a constellation of electrolyte disorders. These disturbances are particularly common in decompensated diabetics, especially in the context of diabetic ketoacidosis or nonketotic hyperglycemic hyperosmolar syndrome. These patients are markedly potassium-, magnesium- and phosphate-depleted. Diabetes mellitus (DM) is linked to both hypo- and hyper-natremia reflecting the coexistence of hyperglycemia-related mechanisms, which tend to change serum sodium to opposite directions...
October 16, 2014: World Journal of Clinical Cases
Hana Inoue, Takashi Murayama, Michiko Tashiro, Takashi Sakurai, Masato Konishi
Transient receptor potential melastatin 7 (TRPM7) is a Ca(2+)- and Mg(2+)-permeable nonselective cation channel that contains a unique carboxyl-terminal serine/threonine protein kinase domain. It has been reported that reactive oxygen species associated with hypoxia or ischemia activate TRPM7 current and then induce Ca(2+) overload resulting in neuronal cell death in the brain. In this study, we aimed to investigate the molecular mechanisms of TRPM7 regulation by hydrogen peroxide (H2O2) using murine TRPM7 expressed in HEK293 cells...
July 2014: Free Radical Biology & Medicine
Verena Schick, Jonas A Scheiber, Frank C Mooren, Stefan Turi, Güralp O Ceyhan, Jürgen Schnekenburger, Matthias Sendler, Theresa Schwaiger, Armin Omercevic, Cindy van den Brandt, Gabriele Fluhr, Wolfram Domschke, Burkhard Krüger, Julia Mayerle, Markus M Lerch
BACKGROUND AND OBJECTIVE: High calcium concentrations are an established risk factor for pancreatitis. We have investigated whether increasing magnesium concentrations affect pathological calcium signals and premature protease activation in pancreatic acini, and whether dietary or intraperitoneal magnesium administration affects the onset and course of experimental pancreatitis. METHODS: Pancreatic acini were incubated with up to 10 mM magnesium; [Ca(2+)](i) (fura-2AM) and intracellular protease activation (fluorogenic substrates) were determined over 60 min...
September 2014: Gut
M C Bermúdez-Peña, C López-Chaves, J Llopis, F Guerrero-Romero, M Montes-Bayón, A Sanz-Medel, C Sánchez-González
This study examined changes in the metabolism of magnesium (Mg), and related serum parameters, following treatment with vanadium (V) in streptozotocin-diabetic rats. Over a period of five weeks, four groups were examined: control, diabetic, diabetic-treated with 1 mg V/day or 3 mg V/day. The V was supplied in drinking water as bis(maltolato)oxovanadium(IV). The Mg levels were measured in food, faeces, urine, serum, muscle, kidney, liver, spleen, heart and femur. Albumin, uric acid, urea, total-cholesterol, LDL-cholesterol, triglycerides, aspartate-aminotransferase and alkaline-phosphatase were determined in serum...
April 2013: Magnesium Research: Official Organ of the International Society for the Development of Research on Magnesium
Harald Murck
UNLABELLED: The glutamatergic mechanism of antidepressant treatments is now in the center of research to overcome the limitations of monoamine-based approaches. There are several unresolved issues. For the action of the model compound, ketamine, NMDA-receptor block, AMPA-receptor activation and BDNF release appear to be involved in a mechanism, which leads to synaptic sprouting and strengthened synaptic connections. The link to the pathophysiology of depression is not clear. An overlooked connection is the role of magnesium, which acts as physiological NMDA-receptor antagonist: 1...
July 2013: Journal of Psychiatric Research
Sylvia Lymburner, Sarah McLeod, Markus Purtzki, Calvin Roskelley, Zhaoming Xu
Metastasis is the major cause of breast cancer mortality. The strength of cell adhesion to extracellular matrix is critical to cancer cell migration. Integrins, the primary mediators of cell to extra-cellular matrix adhesion, contain distinct divalent cation-binding sites. Binding of manganese and magnesium is vital to integrin-mediated cancer cell adhesion and migration. We hypothesized that zinc, a divalent cation, can modulate breast cancer metastasis through interfering with these divalent cation-dependent integrin-mediated cancer cell adhesion and migration...
June 2013: Journal of Nutritional Biochemistry
Sahabeh Etebary, Sara Nikseresht, Hamid Reza Sadeghipour, Mohammad Reza Zarrindast
Postpartum depression (PPD) is a major depressive disorder that most often emerges within 6 to 12 weeks of delivery, but can happen any time up to 1 year after birth. In developed countries, the incidence of postnatal depression is about 10-15% in adult women depending upon the diagnostic criteria, timing of screening and screening instruments used. Mothers with depressive symptoms have been found to have more complex behavioral contacts with their children; this situation can damage family relationships, and even leads to infanticide...
2010: Iranian Journal of Psychiatry
Giovanni Camardese, Luisa De Risio, Giusy Pizi, Bruna Mattioli, Francesco Buccelletti, Riccardo Serrani, Beniamino Leone, Alessandro Sgambato, Pietro Bria, Luigi Janiri
OBJECTIVES: High, normal, or low plasma magnesium (Mg) levels have been observed in depressed patients. The aim of our study was to investigate the relationship of Mg levels with depression severity, specific psychopathological dimensions, and treatment outcome. METHODS: A total of 123 outpatients during a major depressive episode were recruited. All patients showed at least two major depressive episodes and did not achieve remission in the former treatment trial...
March 2012: Nutritional Neuroscience
Cristina Sánchez, Miguel Torres, María C Bermúdez-Peña, Pilar Aranda, María Montes-Bayón, Alfredo Sanz-Medel, Juan Llopis
Vanadium is an element whose role as a micronutrient and hypoglycaemic drug has yet to be fully clarified. The present study was undertaken to investigate the bioavailability and tissue distribution of vanadium and its interactions with magnesium in healthy and in magnesium-deficient rats, in order to determine its role as a micronutrient and antidiabetic agent. Four groups were used: control (456.4 mg magnesium and 0.06 mg vanadium/kg food); control treated with 1mg vanadium/day; magnesium-deficient (164.4 mg magnesium/kg food and 0...
December 2011: Magnesium Research: Official Organ of the International Society for the Development of Research on Magnesium
John Ayuk, Neil J L Gittoes
Hypomagnesaemia is relatively common, with an estimated prevalence in the general population ranging from 2·5% to 15%. It may result from inadequate magnesium intake, increased gastrointestinal or renal loss or redistribution from extracellular to intracellular space. Drug-induced hypomagnesaemia, particularly related to proton pump inhibitor (PPI) therapy, is being increasingly recognized. Most patients with hypomagnesaemia are asymptomatic; symptomatic magnesium depletion is often associated with multiple other biochemical abnormalities, including hypokalaemia, hypocalcaemia and metabolic acidosis...
December 2011: Clinical Endocrinology
D Almoznino-Sarafian, G Sarafian, S Berman, M Shteinshnaider, I Tzur, N Cohen, O Gorelik
BACKGROUND AND AIM: Intracellular magnesium (icMg) depletion may coexist with normomagnesemia. Mg deficiency (serum and/or intracellular) and decreased heart rate variability (HRV) are common in heart failure (HF). Since both are predictors of poor prognosis, it was of interest to evaluate the effect of Mg supplementation on HRV in patients with HF. METHODS AND RESULTS: We investigated the effect of Mg administration on HRV in normomagnesemic patients with systolic HF...
November 2009: Nutrition, Metabolism, and Cardiovascular Diseases: NMCD
A A Spasov, I N Iezhitsa, M V Kharitonova, M S Kravchenko
The aims of this study were to estimate of psychomotor activity, emotional status and magnesium (Mg) content in blood of rats fed with Mg-deficient diet for 49 days; and to find out whether the combination of vitamin B6 with Mg will reveal antidepressant- and anxiolytic-like activity and reduce the length of the treatment needed to recover rats from Mg-deficient condition. To induce hypomagnesemia, seventy-nine rats were placed on a Mg-deficient diet (Mg content < or = 15 mg/kg) and demineralized water for 7 weeks...
July 2008: Zhurnal Vyssheĭ Nervnoĭ Deiatelnosti Imeni I P Pavlova
Maria Dalamaga, Konstantinos Karmaniolas, Athina Nikolaidou, Evangelia Papadavid
Dermal exposure to hydrofluoric acid could potentially result in severe serum calcium and magnesium depletion induced by binding with fluoride anion. This report describes the case of a 48-year-old man who developed hypocalcemia and hypomagnesemia accompanied by hypokalemia-an interesting finding-following a chemical injury with exposure to 70% hydrofluoric acid. Successful treatment included administration of calcium gluconate and magnesium both intravenously and topically.
May 2008: Journal of Burn Care & Research: Official Publication of the American Burn Association
I N Iezhitsa, A A Spasov
The metabolism of K and Mg is closely linked. Mg deficiency may arise together with and contribute to the persistence of K deficiency. Isolated disturbances of K balance do not produce secondary abnormalities in Mg homeostasis. In contrast, primary disturbances in Mg balance, particularly Mg depletion, produce secondary K depletion. This appears to result from an inability of the cell to maintain the normally high intracellular concentration of K, perhaps as a result of an increase in membrane permeability to K and / or inhibition of Na+-K+-ATPase...
January 2008: Uspekhi Fiziologicheskikh Nauk
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