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Gastric volume

Elisa Franquet, George Watts, Gerald M Kolodny, Allison B Goldfine, Mary-Elizabeth Patti
BACKGROUND: Mechanisms of metabolic improvement after bariatric surgery remain incompletely understood. Intestinal glucose uptake is increased after gastric bypass in rodents, potentially contributing to reduced blood glucose and type 2 diabetes remission. OBJECTIVE: We assessed whether intestinal glucose uptake is increased in humans after gastric surgery. SETTING: University Hospital, United States. METHODS: In a retrospective, case-control cohort study, positron emission tomography-computerized tomography scans performed for clinical indications were analyzed to quantify intestinal glucose uptake in patients with or without history of gastric surgery...
January 25, 2019: Surgery for Obesity and related Diseases: Official Journal of the American Society for Bariatric Surgery
Mahboob Ahmad, Bilal Aslam, Faqir Muhammad, Mashkoor Mohsin, Ahmad Raza
Present study was planned to estimate the gastroprotective activity of Euphorbia prostrata plant against aspirin induced gastric ulcers in male adult albino rabbits. The ulcer was induced by oral administration of aspirin in all groups except normal control group. Gastric contents were used to estimate total acid output, gastric volume and gastric pH. Results showed that there was a significant decrease in gastric volume, total acid output, ulcer score and ulcer index in groups treated with extract of E. prostrata and it enhanced the pH of gastric mucosa...
January 2019: Pakistan Journal of Pharmaceutical Sciences
Gabriela Aguiluz Cornejo, Natalia Jelen, Antonio Gangemi
Laparoscopic gastric greater curvature plication (LGGCP) has been presented as an alternative to laparoscopic sleeve gastrectomy (LSG) for reversible reduction of stomach capacity without gastric reduction or stapling. We present a case of a 51-year-old Hispanic female with a BMI of 41.91 kg/m2 , who underwent (LGGCP) 5 years previously at another institution. Despite multiple interventions, the patient was unable to successfully lose weight, and the decision was made to reverse the procedure with a robot-assisted Roux-en-Y gastric bypass...
February 15, 2019: Obesity Surgery
Mark Schieren, Frank Wappler
Consumption of clear liquids (including coffee and orange juice without pulp) up to 2 hours before the start of anaesthesia is unproblematic. Contrary to the recommendations of the professional societies, the intake of beverages containing milk (up to 50% of the total volume) in small quantities seems to be harmless. Drinks containing alcohol can considerably delay emptying of the stomach. Immediate preoperative nicotine consumption has no influence on the risk of aspiration, but short-term nicotine abstinence in patients with CHD can reduce the risk of intraoperative myocardial ischaemia...
February 2019: Anästhesiologie, Intensivmedizin, Notfallmedizin, Schmerztherapie: AINS
Bing Han, Yang Yang, Jiang Chen, Xingxing He, Nonghua Lv, Runwei Yan
PRSS23 is a newly discovered serine protease that has been associated with tumor progression in various types of cancers. Our previous study showed PRSS23 is down-regulated obviously in Hedgehog pathway blocked gastric cancer cells. However, the correlation between PRSS23 and tumor progression of gastric cancer remains unclear. Here, the role and mechanism of PRSS23 in tumor progression of gastric cancer were determined. PRSS23 protein levels were significantly increased in gastric cancer tissues compared with the paired adjacent normal gastric mucosa tissues...
February 12, 2019: Pharmacological Research: the Official Journal of the Italian Pharmacological Society
Matthew C Hernandez, John R Bergquist, Jennifer L Leiting, Tommy Ivanics, Lin Yang, Rory L Smoot, David M Nagorney, Mark J Truty
BACKGROUND: Patient-derived xenografts (PDX) are clinically relevant human cancer models that can be used to guide individualized medicine. We aimed to generate PDX models from clinically obtained biopsy specimens (surgical or image-guided) hypothesizing that low volume biopsy specimens could provide sufficient viable tissue to successfully engraft PDX models from patients with unresectable or metastatic disease. MATERIALS AND METHODS: We maintain a prospective high volume gastrointestinal malignancy PDX program...
February 12, 2019: Journal of Gastrointestinal Surgery: Official Journal of the Society for Surgery of the Alimentary Tract
Talal Khewater, Nathalie Yercovich, Edouard Grymonprez, Isabelle Debergh, Bruno Dillemans
BACKGROUND: Conversional bariatric surgery has relatively high rates of complications. We aimed to analyze our single-center experience with patients requiring conversional laparoscopic Roux-en-Y gastric bypass (LRYGB) following a failed primary open or laparoscopic vertical banded gastroplasty (OVBG or LVBG, respectively). METHODS: The records of patients who underwent LRYGB as a conversional procedure after VBG between November 2004 and December 2017 were reviewed...
February 12, 2019: Obesity Surgery
Marc A Ward, Tareq Hassan, James S Burdick, Steven G Leeds
BACKGROUND: Endoluminal vacuum therapy (EVAC) is an emerging procedure used to treat anastomotic leaks and/or perforations that would otherwise require surgery. The aim of this study was to determine time to proficiency in EVAC and the cost effectiveness of the procedure. METHODS: We retrospectively reviewed a prospectively maintained IRB approved database for all patients undergoing EVAC after esophageal and gastric complications between October 2013 and December 2017...
February 11, 2019: Surgical Endoscopy
Lei Huang, Jian-Qiang Wu, Bing Han, Zhi Wen, Pei-Rui Chen, Xiao-Kang Sun, Xiang-Dong Guo, Chang-Ming Zhao
BACKGROUND: The main clinical treatment for esophageal cancer is surgery. Since traditional open esophageal cancer resection has the disadvantages of large trauma, long recovery period, and high postoperative complication rate, its clinical application is gradually reduced. The current report of minimally invasive Ivor-Lewis esophagectomy (MIILE) is increasing. However, researchers found that patients with MIILE had a higher incidence of early delayed gastric emptying (DGE). AIM: To investigate the influencing factors of postoperative early DGE after MIILE...
February 6, 2019: World Journal of Clinical Cases
Tessa Heinonen, Suzie Ferrie, Clare Ferguson
BACKGROUND: Management of gut function in the intensive care unit (ICU) is often protocol-driven. Protocols for enteral feeding or bowel management are based on assumptions about what is 'normal' gastrointestinal motility during critical illness or in the early postoperative period, although 'normal' has not been well described in this group. OBJECTIVES: This study aimed to describe aspects of gut function based on an audit of current ICU patients. METHODS: A retrospective medical audit of 100 recent consecutive ICU patients was conducted to obtain data on gut function parameters in the critically ill or postoperative population...
February 7, 2019: Australian Critical Care: Official Journal of the Confederation of Australian Critical Care Nurses
L A D Busweiler, M Jeremiasen, B P L Wijnhoven, M Lindblad, L Lundell, C J H van de Velde, R A E M Tollenaar, M W J M Wouters, J W van Sandick, J Johansson, J L Dikken
Background: Benchmarking on an international level might lead to improved outcomes at a national level. The aim of this study was to compare treatment and surgical outcome data from the Swedish National Register for Oesophageal and Gastric Cancer (NREV) and the Dutch Upper Gastrointestinal Cancer Audit (DUCA). Methods: All patients with primary oesophageal or gastric cancer who underwent a resection and were registered in NREV or DUCA between 2012 and 2014 were included...
February 2019: BJS open
Ji-Hyun Lee, Haesun Jung, Young-Eun Jang, Eun-Hee Kim, In-Kyung Song, Hee-Soo Kim, Jin-Tae Kim
BACKGROUND: Gastric insufflation frequently occurs during facemask ventilation in children. In the present study, we compared the incidence of gastric insufflation between pressure-controlled facemask ventilation and manual facemask ventilation during general anaesthesia induction in children. METHODS: Children in the pressure-controlled ventilation group (n = 76) received pressure-controlled facemask ventilation at an inspiratory pressure of 13 cmH2 O. In the manual ventilation group (n = 75), facemask ventilation was manually performed by anaesthesiologists, who tried to maintain an inspiratory pressure of 13 cmH2 O...
February 3, 2019: Paediatric Anaesthesia
Karen Van den Houte, Florencia Carbone, Ans Pauwels, Rita Vos, Tim Vanuytsel, Jan Tack
OBJECTIVE: Itopride, a prokinetic with dopamine D2-antagonistic and cholinesterase inhibitor properties, is used for treating functional dyspepsia (FD) patients. However, the effects of itopride on sensitivity to gastric distention and impaired gastric accommodation, major pathophysiological mechanisms of FD, are unknown. Our aim was to evaluate the effect of itopride on gastric distention and on gastric accommodation in healthy volunteers, compared to placebo and domperidone. METHODS: Fifteen healthy volunteers (6 male, mean age 28...
January 31, 2019: Neurogastroenterology and Motility: the Official Journal of the European Gastrointestinal Motility Society
Qi-Yue Chen, Zhi-Liang Hong, Qing Zhong, Zhi-Yu Liu, Chao-Hui Zheng, Ping Li, Jian-Wei Xie, Jia-Bin Wang, Jian-Xian Lin, Jun Lu, Long-Long Cao, Mi Lin, Ru-Hong Tu, Chang-Ming Huang
To identify the risk factors for intraoperative laparoscopic hemostasis during laparoscopic spleen-preserving splenic hilar lymph node dissection (LSPSD) for proximal gastric cancer (GC) and to develop and validate a model to estimate the risk of intraoperative laparoscopic hemostasis. Between January 2011 and December 2014, we prospectively collected and retrospectively analyzed the medical records of 398 patients with proximal GC who underwent LSPSD. The data were split 75/25, with one group used for model development and the other for validation testing...
January 28, 2019: Asian Journal of Surgery
Carmil Azran, Daniel Porat, Noa Fine-Shamir, Nirvana Hanhan, Arik Dahan
BACKGROUND: Bariatric surgery can lead to changes in the oral absorption of many drugs. Levothyroxine is a narrow therapeutic drug for hypothyroidism, a common condition among patients with obesity. OBJECTIVE: The purpose of this work was to provide a mechanistic overview of levothyroxine absorption, and to thoroughly analyze the expected effects of bariatric surgery on oral levothyroxine therapy. METHODS: We performed a systematic review of the relevant literature reporting the effects of bariatric surgery on oral levothyroxine absorption and postoperative thyroid function...
January 10, 2019: Surgery for Obesity and related Diseases: Official Journal of the American Society for Bariatric Surgery
Uberto Fumagalli, Gian Luca Baiocchi, Andrea Celotti, Paolo Parise, Andrea Cossu, Luigi Bonavina, Daniele Bernardi, Giovanni de Manzoni, Jacopo Weindelmayer, Giuseppe Verlato, Stefano Santi, Giovanni Pallabazzer, Nazario Portolani, Maurizio Degiuli, Rossella Reddavid, Stefano de Pascale
BACKGROUND: Mediastinal leakage (ML) is one of the most feared complications of esophagectomy. A standard strategy for its diagnosis and treatment has been difficult to establish because of the great variability in their incidence and mortality rates reported in the existing series. AIM: To assess the incidence, predictive factors, treatment, and associated mortality rate of mediastinal leakage using the standardized definition of mediastinal leaks recently proposed by the Esophagectomy Complications Consensus Group (ECCG)...
January 21, 2019: World Journal of Gastroenterology: WJG
Hang-Cheng Xu, Ying-Chang Pang, Jing-Wen Chen, Jia-Yu Cao, Zhi Sheng, Jun-Hua Yuan, Rui Wang, Cai-Shun Zhang, Liu-Xin Wang, Jing Dong
BACKGROUND: Roux-en-Y gastric bypass (RYGB) is considered effective for weight loss and for treatment of many obesity-related metabolic diseases. Ghrelin is an essential orexigenic peptide that plays an indispensable role in controlling body weight and energy homeostasis of post-operative patients. This systematic review and meta-analysis aimed to investigate changes in the level of fasting total ghrelin following RYGB. METHODS: A systematic literature search of PubMed, EMBASE, and the Cochrane Library until April 2018 with keywords "ghrelin" and "gastric bypass" was performed in accordance with the MOOSE guidelines and PRISMA statement...
January 25, 2019: Obesity Surgery
Anita P Courcoulas, Margaret A Stefater, Eleanor Shirley, William F Gourash, Nicholas Stylopoulos
BACKGROUND: Bariatric surgery, especially Roux-en-Y gastric bypass (RYGB), is the best treatment for severe obesity and its complications including type 2 diabetes mellitus (T2DM). Understanding the mechanisms responsible for the beneficial metabolic effects will help to engineer ways to improve the procedure or produce these effects without surgery. OBJECTIVE: The aim is to present data on recruitment and feasibility of a translational study designed to collect intestinal samples before and after bariatric surgery...
January 24, 2019: JMIR Research Protocols
Zhuo Wang, Wei Ding, Qi Fang, Lulu Zhang, Xueyun Liu, Zaixiang Tang
BACKGROUND: Monitoring gastric residual volume has been a common practice in intensive care patients receiving enteral feeding worldwide. Recent studies though, have challenged the reliability and necessity of this routine monitoring process. Several studies even reported improvements in the delivery of enteral feeding without monitoring gastric residual volume, while incurring no additional adverse events. However, the benefit of monitoring gastric residual volume remains controversial in intensive care patients...
January 3, 2019: International Journal of Nursing Studies
Wladyslaw Januszewicz, Paulina Wieszczy, Andrzej Bialek, Katarzyna Karpinska, Jakub Szlak, Jakub Szymonik, Maciej Rupinski, Andrzej Mroz, Jaroslaw Regula, Michal F Kaminski
BACKGROUND AND AIMS: The gastric premalignant conditions (GPCs) diagnosis rely on endoscopy with mucosal sampling. We hypothesized that the endoscopists' biopsy rate (EBR) might constitute a quality indicator for esophagogastroduodenoscopy (EGD) and we have analyzed its association with GPC detection and the rate of missed gastric cancers (GCs). METHODS: We analyzed EGD databases from 2 high-volume outpatient units. EBR values, defined as proportion of EGDs with ≥1 biopsy to all examinations, were calculated for each endoscopist in Unit A (derivation cohort) and divided by the quartile values into 4 groups...
January 16, 2019: Gastrointestinal Endoscopy
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