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https://read.qxmd.com/read/30865922/management-of-immunotherapy-related-toxicities-version-1-2019
#1
John A Thompson, Bryan J Schneider, Julie Brahmer, Stephanie Andrews, Philippe Armand, Shailender Bhatia, Lihua E Budde, Luciano Costa, Marianne Davies, David Dunnington, Marc S Ernstoff, Matthew Frigault, Brianna Hoffner, Christopher J Hoimes, Mario Lacouture, Frederick Locke, Matthew Lunning, Nisha A Mohindra, Jarushka Naidoo, Anthony J Olszanski, Olalekan Oluwole, Sandip P Patel, Sunil Reddy, Mabel Ryder, Bianca Santomasso, Scott Shofer, Jeffrey A Sosman, Momen Wahidi, Yinghong Wang, Alyse Johnson-Chilla, Jillian L Scavone
The aim of the NCCN Guidelines for Management of Immunotherapy-Related Toxicities is to provide guidance on the management of immune-related adverse events resulting from cancer immunotherapy. The NCCN Management of Immunotherapy-Related Toxicities Panel is an interdisciplinary group of representatives from NCCN Member Institutions and ASCO, consisting of medical and hematologic oncologists with expertise in a wide array of disease sites, and experts from the fields of dermatology, gastroenterology, neuro-oncology, nephrology, emergency medicine, cardiology, oncology nursing, and patient advocacy...
March 1, 2019: Journal of the National Comprehensive Cancer Network: JNCCN
https://read.qxmd.com/read/30826891/cardiac-complications-in-the-adult-bone-marrow-transplant-patient
#2
REVIEW
Mirela Tuzovic, Monica Mead, Patricia A Young, Gary Schiller, Eric H Yang
PURPOSE OF REVIEW: Due to advancements in oncologic treatment strategies and techniques, the number of survivors who have undergone hematopoetic stem cell transplant (HCT) continues to increase in the United States; this number is projected to reach 502,000 by the year 2030. There is significant interest within the field of cardio-oncology to identify cardiotoxicity and cardiovascular disease in the HCT population. Epidemiologic studies analyzing both short- and long-term cardiovascular effects, risk stratification modeling, cardioprotective strategies, and expert consensus documents for cardiotoxicity surveillance recommendations are reviewed...
March 2, 2019: Current Oncology Reports
https://read.qxmd.com/read/30793937/the-new-novel-oral-anticoagulants-and-their-impact-on-patients-being-considered-for-shock-wave-lithotripsy-the-findings-of-an-international-survey-of-the-endourological-society
#3
Abdulaziz H Alathel, Linda Nott, Jennifer Bjazevic, Ben H Chew, Kenneth T Pace, Hassan Razvi
INTRODUCTION: Although general guidelines exist directing the management of new/novel oral anticoagulants (NOACs) in the perioperative period for open/endoscopic procedures, no consensus exists for those patients being considered for shock wave lithotripsy (SWL). In order to gauge current practice, we administered a survey to the international endourological community. METHODS: A web-based survey was sent to current Endourological Society members. Respondents were asked whether they would consider SWL in patients receiving NOACs; and if they used SWL how these agents were managed perioperatively...
February 22, 2019: Journal of Endourology
https://read.qxmd.com/read/30598674/incidence-and-etiology-of-stroke-among-hospitalized-children-a-case-series-study
#4
Zarin Taj Keihani Doust, Fatemeh Noori Sari, Parvin Akbari Asbagh, Zahra Farahani, Fatemeh Tehrani, Mamak Shariat
Objectives: Stroke is a sudden blockage or rupture of brain vessels resulting neural defect or impairment. We aimed to investigate the incidence and causes of stroke in hospitalized children (Tehran-Iran, 2008-2013). Materials & Methods: This case series study was carried out in pediatric ward of tertiary care Vali-Asr Hospital, Imam Khomeini Hospitals Complex (Tehran- Iran) from 2008 to 2013. One month to 15 yr old admitted children due to stroke were enrolled into this case series study...
2019: Iranian Journal of Child Neurology
https://read.qxmd.com/read/30293798/-evaluation-of-the-quality-of-long-term-anticoagulation-therapy-with-antivitamin-k-in-atrial-fibrillation
#5
O Ben Rejeb, W Brahim, H Ghali, S Ernez, A Mahdhaoui, G Jeridi
AIM: To assess the quality of long-term anticoagulation therapy with antivitamin-K in patients with atrial fibrillation by measuring the TTR and to determine the factors associated with a good TTR. PATIENTS AND METHODS: This is an observational study conducted over a period of three years (from January 2013 until December 2015) in the outpatient clinic of cardiology of Farhat Hached hospital of Sousse, Tunisia. Pre-established individual plugs were used for data collection...
October 4, 2018: Annales de Cardiologie et D'angéiologie
https://read.qxmd.com/read/30248706/development-of-an-open-metadata-schema-for-clinical-pathway-opencp-in-china
#6
Wei Xu, Yanxin Zhu, Yibing Geng
BACKGROUND: By the end of the first quarter of 2017, 1212 standard Clinical Pathways (CPs) had been developed and implemented in China since 2009, however, Chinese standard CPs are still paper-based CPs. OBJECTIVES: To optimize the data structure and content of Chinese standard CPs based on Chinese health standards by two-level modeling approach and archetype method, and develop an Open Metadata Schema for Clinical Pathway (openCP) in China. METHODS: We chose 43 diseases covering 7 departments of internal medicine as samples and source materials including Respiratory, Gastroenterology, Neurology, Cardiology, Nephrology, Endocrinology, and Hematology, and we followed 4 steps to develop openCP: identify reference model of openCP; develop archetype models; standardize archetype terms and metadata; and evaluate its functionality...
September 2018: Methods of Information in Medicine
https://read.qxmd.com/read/30177139/pericarditis-in-patients-with-chronic-graft-vs-host-disease
#7
E Karakulska-Prystupiuk, G Basak, J Dwilewicz-Trojaczek, M Paluszewska, P Boguradzki, W Jędrzejczak
BACKGROUND: There are only a few cases of pericarditis complications following allogeneic bone marrow transplantation described in the literature and there are no data available on the risk and frequency of this condition. The aim of this study was to assess the frequency of exudative pericarditis complicating chronic graft-vs-host disease in allogeneic hematopoietic cell transplant recipients. METHODS: Retrospective analysis involved a group of 105 patients of the Outpatient Transplantation Service of the Department of Hematology, Medical University of Warsaw, who received transplants in the years 2010-2016 and were evaluated for the years 2014-2016...
September 2018: Transplantation Proceedings
https://read.qxmd.com/read/30153372/antithrombotic-therapy-management-of-adult-and-pediatric-cardiac-surgery-patients
#8
REVIEW
L Baumann Kreuziger, K Karkouti, J Tweddell, M P Massicotte
Despite the development of catheter-based interventions for ischemic and valvular heart disease, hundreds of thousands of people undergo open heart surgery annually for coronary artery bypass graft (CABG), valve replacement or cardiac assist device implantation. Cardiac surgery patients are unique because therapeutic anticoagulation is required during cardiopulmonary bypass. Developmental hemostasis and altered drug metabolism affect management in children. This narrative review summarizes the current evidence-based and consensus guidelines regarding perioperative, intraoperative and postoperative antithrombotic therapy in patients undergoing cardiac surgery...
November 2018: Journal of Thrombosis and Haemostasis: JTH
https://read.qxmd.com/read/30128557/molecular-basis-and-clinical-overview-of-mcleod-syndrome-compared-with-other-neuroacanthocytosis-syndromes-a-review
#9
Eileen Roulis, Catherine Hyland, Robert Flower, Christoph Gassner, Hans H Jung, Beat M Frey
Importance: McLeod syndrome, encoded by the gene XK, is a rare and progressive disease that shares important similarities with Huntington disease but has widely varied neurologic, neuromuscular, and cardiologic manifestations. Patients with McLeod syndrome have a distinct hematologic presentation with specific transfusion requirements. Because of its X-linked location, loss of the XK gene or pathogenic variants in this gene are principally associated with the McLeod blood group phenotype in male patients...
December 1, 2018: JAMA Neurology
https://read.qxmd.com/read/30039233/management-of-venous-thromboembolism-in-pregnancy
#10
REVIEW
Annemarie E Fogerty
PURPOSE OF REVIEW: This manuscript addresses the risks for venous thromboembolism (VTE) during pregnancy and the associated challenges of both diagnosis and treatment. RECENT FINDINGS: The obstacles to diagnosis given lack of specificity of typical biomarkers to predict VTE in pregnancy, as well as the unique fetal and bleeding risks introduced by managing massive pulmonary embolism (PE) with thrombolytics or thrombectomy are highlighted. VTE during pregnancy and the postpartum window occurs at a 6-10-fold higher rate compared with age-matched peers and is a major cause of morbidity and mortality...
July 23, 2018: Current Treatment Options in Cardiovascular Medicine
https://read.qxmd.com/read/30035733/-morphological-changes-of-the-urogenital-system-internal-structure-at-modeling-of-portal-hypertension-in-rats
#11
I Pylypko, O Halytska-Kharkhalis, T Henyk, N Flekey, N Panchyshyn
Portal hypertension is a constant companion of numerous diseases in gastroenterology, vascular surgery, cardiology, and hematology with grave consequences for the health and life of patients. The development of portal hypertension leads to significant violations of hemodynamics in the liver vessels and the development of arterial and venous hypertrophy, stasis of blood in the vessels of the portal tract. In the experiment on rats, portal hypertension was simulated in an original way with the following study of the peculiarities of morphological changes in the internal structure of the kidneys and gonads in males as a manifestation of a violation of systemic hemodynamics...
June 2018: Georgian Medical News
https://read.qxmd.com/read/29927711/a-systematic-review-of-asynchronous-provider-to-provider-electronic-consultation-services-to-improve-access-to-specialty-care-available-worldwide
#12
Clare Liddy, Isabella Moroz, Ariana Mihan, Nikhat Nawar, Erin Keely
BACKGROUND: Electronic consultation (eConsult) is an asynchronous electronic communication tool allowing primary care providers to obtain a specialist consultant's expert opinion in a timely manner, thereby offering a potential solution to excessive wait times for specialist care, which remain a serious concern in many countries. INTRODUCTION: Our 2014 review of eConsult services demonstrated feasibility and high acceptability among patients and providers. However, gaps remain in knowledge regarding eConsult's impact on system costs and patient outcomes...
June 21, 2018: Telemedicine Journal and E-health: the Official Journal of the American Telemedicine Association
https://read.qxmd.com/read/29873678/do-recent-reports-about-the-adverse-effects-of-proton-pump-inhibitors-change-providers-prescription-practice
#13
M T Al-Qaisi, A Kahn, M D Crowell, G E Burdick, M F Vela, F C Ramirez
Proton pump inhibitors (PPI) are utilized for a variety of indications, including treatment of gastroesophageal reflux disease, peptic ulcer disease, and prevention of gastrointestinal (GI) bleeding. Several studies have documented an increasing prevalence of inappropriate PPI use. Furthermore, recent media reports have highlighted new research data suggesting a possible association between chronic PPI use and several adverse medical outcomes, leading to frequent patient inquiries about these associations. Thus, providers face the challenge of counseling patients about the balance of risks and benefits related to PPI use...
December 1, 2018: Diseases of the Esophagus: Official Journal of the International Society for Diseases of the Esophagus
https://read.qxmd.com/read/29078707/continuous-care-provided-through-comprehensive-medication-management-in-an-acute-care-practice-model
#14
T David Marr, Nicole R Pinelli, Jamie A Jarmul, Kayla M Waldron, Stephen F Eckel, Jonathan D Cicci, Jill S Bates, Lindsey B Amerine
BACKGROUND: Pharmacy practice models that foster pharmacists' accountability for medication-related outcomes are imperative for the profession. Comprehensive medication management (CMM) is an opportunity to advance patient care. OBJECTIVE: The objective of this study was to evaluate the impact of a CMM practice model in the acute care setting on organizational, patient, and financial outcomes. METHODS: Three adult service lines focused on at-risk patients identified using internal risk stratification methodology were implemented...
April 2018: Annals of Pharmacotherapy
https://read.qxmd.com/read/29077292/-scientific-publication-output-of-spanish-emergency-physicians-from-2005-to-2014-a-comparative-study
#15
COMPARATIVE STUDY
Inés María Fernández-Guerrero, Francisco Javier Martín-Sánchez, Guillermo Burillo-Putze, Òscar Miró
OBJECTIVES: To analyze the research output of Spanish emergency physicians between 2005 and 2014 and to compare it to their output in the previous 10-year period (1995-2004) as well as to that of emergency physicians in other countries and Spanish physicians in other specialties. MATERIAL AND METHODS: Original articles indexed in the Science Citation Index Expanded of the Web of Science were included. Documents from Spanish emergency physicians were identified by combining the word Spain and any other search term identifying an emergency service or unit in Spain...
October 2017: Emergencias: Revista de la Sociedad Española de Medicina de Emergencias
https://read.qxmd.com/read/29075564/gender-differences-in-safety-issues-during-fingolimod-therapy-evidence-from-a-real-life-relapsing-multiple-sclerosis-cohort
#16
Alessia Manni, Vita Direnzo, Antonio Iaffaldano, Valentina Di Lecce, Carla Tortorella, Stefano Zoccolella, Pietro Iaffaldano, Maria Trojano, Damiano Paolicelli
OBJECTIVE: Benefits and risks of new therapies in Multiple Sclerosis (MS) must be balanced carefully and tailored to patients. We aimed to describe our experience with Fingolimod (FTY), correlating demographics, clinical and hematological features of the Relapsing MS (RMS) cohort with the occurring Adverse Events (AEs). MATERIAL AND METHODS: Pretreatment screening tests, cardiological observation, and safety follow-up data were analyzed in 225 RMS patients. Changes in continuous data were analyzed post hoc with Wilcoxon ranks test; categorical variables were examined using McNemar test...
October 2017: Brain and Behavior
https://read.qxmd.com/read/28982637/pediatric-chronic-patients-at-outpatient-clinics-a-study-in-a-latin-american-university-hospital
#17
Renata A Alveno, Caroline V Miranda, Caroline G Passone, Aurora R Waetge, Elza S Hojo, Sylvia C L Farhat, Vicente Odone-Filho, Uenis Tannuri, Werther B Carvalho, Magda Carneiro-Sampaio, Clovis A Silva
OBJECTIVE: To describe the characteristics of children and adolescentes with chronic diseases of outpatient clinics at a tertiary university hospital. METHODS: A cross-sectional study was performed with 16,237 patients with chronic diseases followed-up in one year. The data were collected through the electronic system, according to the number of physician appointments in 23 pediatric specialties. Patients were divided in two groups: children (0-9 years) and adolescents (10-19 years)...
October 2, 2017: Jornal de Pediatria
https://read.qxmd.com/read/28842438/plastics-and-cardiovascular-health-phthalates-may-disrupt-heart-rate-variability-and-cardiovascular-reactivity
#18
Rafael Jaimes, Adam Swiercz, Meredith Sherman, Narine Muselimyan, Paul J Marvar, Nikki Gillum Posnack
Plastics have revolutionized medical device technology, transformed hematological care, and facilitated modern cardiology procedures. Despite these advances, studies have shown that phthalate chemicals migrate out of plastic products and that these chemicals are bioactive. Recent epidemiological and research studies have suggested that phthalate exposure adversely affects cardiovascular function. Our objective was to assess the safety and biocompatibility of phthalate chemicals and resolve the impact on cardiovascular and autonomic physiology...
November 1, 2017: American Journal of Physiology. Heart and Circulatory Physiology
https://read.qxmd.com/read/28807405/initiation-of-a-multidisciplinary-rapid-response-team-to-massive-and-submassive-pulmonary-embolism
#19
Brett J Carroll, Heather Pemberton, Kenneth A Bauer, Louis M Chu, Jeffrey L Weinstein, Barbara L Levarge, Duane S Pinto
Pulmonary embolism (PE) can result in rapid clinical decompensation in many patients. With increasing patient complexity and advanced treatment options for PE, multidisciplinary, rapid response teams can optimize risk stratification and expedite management strategies. The Massive And Submassive Clot On-call Team (MASCOT) was created at our institution, which comprised specialists from cardiology, pulmonology, hematology, interventional radiology, and cardiac surgery. MASCOT offers rapid consultation 24 hours a day with a web-based conference call to review patient data and discuss management of patients with high-risk PE...
October 15, 2017: American Journal of Cardiology
https://read.qxmd.com/read/28587606/quality-of-anticoagulation-management-with-warfarin-among-outpatients-in-a-tertiary-hospital-in-addis-ababa-ethiopia-a-retrospective-cross-sectional-study
#20
Teferi Gedif Fenta, Tamrat Assefa, Bekele Alemayehu
BACKGROUND: Warfarin is the most widely used anticoagulant in the world. The difficulty of managing warfarin contributes to great potential for patient harm, both from excessive anticoagulation and insufficient anticoagulation. This study assessed the International Normalized Ratio (INR) control outcome measures and warfarin dose adjustment practices at cardiology and hematology outpatient clinics at a teaching hospital in Addis Ababa, Ethiopia. METHODS: The study was based on a cross - sectional study design involving 360 retrospective patients' chart review among outpatients who received warfarin for its various indications...
June 6, 2017: BMC Health Services Research
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