Antoine Rimbert, Ming W Yeung, Nawar Dalila, Chris H L Thio, Haojie Yu, Natalia Loaiza, Federico Oldoni, Adriaan van der Graaf, Siqi Wang, M Abdullah Said, Lisanne L Blauw, Aurore Girardeau, Lise Bray, Amandine Caillaud, Vincent W Bloks, Marie Marrec, Philippe Moulin, Patrick C N Rensen, Bart van de Sluis, Harold Snieder, Mathilde Di Filippo, Pim van der Harst, Anne Tybjaerg-Hansen, Philip Zimmerman, Bertrand Cariou, Jan Albert Kuivenhoven
BACKGROUND: In mice, GPR146 (G-protein-coupled receptor 146) deficiency reduces plasma lipids and protects against atherosclerosis. Whether these findings translate to humans is unknown. METHODS: Common and rare genetic variants in the GPR146 gene locus were used as research instruments in the UK Biobank. The Lifelines, The Copenhagen-City Heart Study, and a cohort of individuals with familial hypobetalipoproteinemia were used to find and study rare GPR146 variants...
October 2022: Arteriosclerosis, Thrombosis, and Vascular Biology