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https://read.qxmd.com/read/30901712/reduced-left-lateralized-pattern-of-event-related-eeg-oscillations-in-infants-at-familial-risk-for-language-and-learning-impairment
#1
Chiara Cantiani, Silvia Ortiz-Mantilla, Valentina Riva, Caterina Piazza, Roberta Bettoni, Gabriella Musacchia, Massimo Molteni, Cecilia Marino, April A Benasich
The ability to rapidly discriminate successive auditory stimuli within tens-of-milliseconds is crucial for speech and language development, particularly in the first year of life. This skill, called Rapid Auditory Processing (RAP), is altered in infants at familial risk for language and learning impairment (LLI) and is a robust predictor of later language outcomes. In the present study, we investigate the neural substrates of RAP, i.e., the underlying neural oscillatory patterns, in a group of Italian 6-month-old infants at risk for LLI (FH+, n = 24), compared to control infants with no known family history of LLI (FH-, n = 32)...
March 12, 2019: NeuroImage: Clinical
https://read.qxmd.com/read/30901617/effect-of-whole-body-vibration-and-sitting-configurations-on-lumbar-spinal-loads-of-vehicle-occupants
#2
Sorosh Amiri, Sadegh Naserkhaki, Mohamad Parnianpour
Whole-body vibration (WBV) has been identified as one of the serious risk factors leading to spinal disorders, particularly in professional drivers. Although the influential factors in this area have been investigated epidemiologically, finite element (FE) modeling can efficiently help us better understand the problem. In this study, a modified HYBRID III dummy FE model which was enhanced by detailed viscoelastic discs in the lumbar region was utilized to simulate the effect of WBV on lumbar spine loads. Spinal responses to the vertical sinusoidal vibrations of a generic seat were obtained and spinal injury risk factors were calculated...
February 25, 2019: Computers in Biology and Medicine
https://read.qxmd.com/read/30901602/association-of-frailty-and-cognitive-impairment-with-benefits-of-oral-anticoagulation-in-patients-with-atrial-fibrillation
#3
Malini Madhavan, DaJuanicia N Holmes, Jonathan P Piccini, Jack E Ansell, Gregg C Fonarow, Elaine M Hylek, Peter R Kowey, Kenneth W Mahaffey, Laine Thomas, Eric D Peterson, Paul Chan, Larry A Allen, Bernard J Gersh
BACKGROUND: The incidence of cognitive impairment and frailty increase with age and may impact both therapy and outcomes in atrial fibrillation (AF). METHODS: We examined the prevalence of clinically recognized cognitive impairment and frailty (as defined by the American Geriatric Society Criteria) in the Outcomes Registry for Better Informed Care in AF (ORBIT AF) and associated adjusted outcomes via multivariable Cox regression. The interaction between cognitive impairment and frailty and oral anticoagulation (OAC) in determining outcomes was examined...
January 30, 2019: American Heart Journal
https://read.qxmd.com/read/30901543/the-missing-diversity-in-human-genetic-studies
#4
Giorgio Sirugo, Scott M Williams, Sarah A Tishkoff
The majority of studies of genetic association with disease have been performed in Europeans. This European bias has important implications for risk prediction of diseases across global populations. In this commentary, we justify the need to study more diverse populations using both empirical examples and theoretical reasoning.
March 21, 2019: Cell
https://read.qxmd.com/read/30901441/combat-related-extremity-wounds-injury-factors-predicting-early-onset-infections
#5
Laveta Stewart, Faraz Shaikh, William Bradley, Dan Lu, Dana M Blyth, Joseph L Petfield, Timothy J Whitman, Margot Krauss, Lauren Greenberg, David R Tribble
We examined risk factors for combat-related extremity wound infections (CEWI) among U.S. military patients injured in Iraq and Afghanistan (2009-2012). Patients with ≥1 combat-related, open extremity wound admitted to a participating U.S. hospital (≤7 days postinjury) were retrospectively assessed. The population was classified based upon most severe injury (amputation, open fracture without amputation, or open soft-tissue injury defined as non-fracture/non-amputation wounds). Among 1271 eligible patients, 395 (31%) patients had ≥1 amputation, 457 (36%) had open fractures, and 419 (33%) had open soft-tissue wounds as their most severe injury, respectively...
March 1, 2019: Military Medicine
https://read.qxmd.com/read/30901433/computational-modeling-of-primary-blast-lung-injury-implications-for-ventilator-management
#6
Jacob Herrmann, Merryn H Tawhai, David W Kaczka
Primary blast lung injury (PBLI) caused by exposure to high-intensity pressure waves is associated with parenchymal tissue injury and severe ventilation-perfusion mismatch. Although supportive ventilation is often required in patients with PBLI, maldistribution of gas flow in mechanically heterogeneous lungs may lead to further injury due to increased parenchymal strain and strain rate, which are difficult to predict in vivo. In this study, we developed a computational lung model with mechanical properties consistent with healthy and PBLI conditions...
March 1, 2019: Military Medicine
https://read.qxmd.com/read/30901387/association-of-gene-polymorphisms-with-primary-open-angle-glaucoma-a-systematic-review-and-meta-analysis
#7
Min Chen, Xiaoning Yu, Jia Xu, Jian Ma, Xinyi Chen, Binbin Chen, Yuxiang Gu, Kaijun Wang
Purpose: To confirm the association of all reported common polymorphisms with POAG. Methods: We searched in PubMed and Web of Science (up to January 10, 2018) for genetic studies of POAG. All case control studies investigating the association between single-nucleotide polymorphisms (SNPs) and POAG risk were included. Odds ratios (ORs) with 95% confidence intervals (CIs) were calculated by fixed- or random-effect model. Results: This meta-analysis included 108 case control studies involving 35,389 POAG patients and 51,742 controls...
March 1, 2019: Investigative Ophthalmology & Visual Science
https://read.qxmd.com/read/30901330/landscape-correlates-of-space-use-in-the-critically-endangered-african-wild-dog-lycaon-pictus
#8
Mariëtte E Pretorius, Nimmi Seoraj-Pillai, Neville Pillay
Human-carnivore conflict can threaten human life and livelihoods, leading to retaliation that negatively affects carnivore conservation. The endangered African wild dog Lycaon pictus is prone to human-carnivore conflict. Therefore, it is imperative to understand which landscape features are associated with African wild dog occurrence since selection or avoidance of these features could predict the levels of conflict. We investigated resource selection in the African wild dog in relation to four anthropogenic landscape features (livestock density, agriculture, roads and human land use) within the landscape that may pose a mortality risk, as well as one natural feature (nature reserves)...
2019: PloS One
https://read.qxmd.com/read/30901138/association-of-lung-lesions-measured-by-thoracic-ultrasonography-at-first-diagnosis-of-bronchopneumonia-with-relapse-rate-and-growth-performance-in-feedlot-cattle
#9
Edouard Timsit, Nicolas Tison, Calvin W Booker, Sébastien Buczinski
BACKGROUND: Severity of lung lesions quantified by thoracic ultrasonography (TUS) at time of bronchopneumonia (BP) diagnosis predicted death among steers not treated for this condition. Further research is needed to confirm that lung lesions detected by TUS can be associated with negative outcomes in cattle with BP that subsequently were treated. OBJECTIVE: To quantify the effects on relapse rate and average daily gain (ADG) of lung lesions detected by TUS at first BP diagnosis in feedlot cattle...
March 22, 2019: Journal of Veterinary Internal Medicine
https://read.qxmd.com/read/30901048/evaluation-of-machine-learning-algorithms-for-predicting-opioid-overdose-risk-among-medicare-beneficiaries-with-opioid-prescriptions
#10
Wei-Hsuan Lo-Ciganic, James L Huang, Hao H Zhang, Jeremy C Weiss, Yonghui Wu, C Kent Kwoh, Julie M Donohue, Gerald Cochran, Adam J Gordon, Daniel C Malone, Courtney C Kuza, Walid F Gellad
Importance: Current approaches to identifying individuals at high risk for opioid overdose target many patients who are not truly at high risk. Objective: To develop and validate a machine-learning algorithm to predict opioid overdose risk among Medicare beneficiaries with at least 1 opioid prescription. Design, Setting, and Participants: A prognostic study was conducted between September 1, 2017, and December 31, 2018. Participants (n = 560 057) included fee-for-service Medicare beneficiaries without cancer who filled 1 or more opioid prescriptions from January 1, 2011, to December 31, 2015...
March 1, 2019: JAMA Network Open
https://read.qxmd.com/read/30900957/interaction-of-antioxidant-gene-variants-and-susceptibility-to-type-2-diabetes-mellitus
#11
M Banerjee, P Vats, A S Kushwah, N Srivastava
BACKGROUND: Diabetes is the seventh most common disease leading to death with a global estimate of 425 million diabetics, which is expected to be 629 million in 2045. The role of reactive metabolites and antioxidants, such as glutathione, glutathione peroxidase, superoxide dismutase and catalase in type 2 diabetes mellitus (T2DM) provides an opportunity for identifying gene variants and risk genotypes. We hypothesised that certain antioxidant gene-gene interactions are linked to susceptibility to T2DM and so can model disease risk prediction...
March 22, 2019: British Journal of Biomedical Science
https://read.qxmd.com/read/30900792/the-independent-association-of-non-alcoholic-fatty-liver-disease-with-lower-urinary-tract-symptoms-benign-prostatic-hyperplasia-and-erectile-function-scores
#12
Huseyin Eren, Mustafa Ozan Horsanali
OBJECTIVES: To evaluate the association between non-alcoholic fatty liver disease and Lower urinary tract symptoms/ Benign prostate hyperplasia and erectile function scores. MATERIAL AND METHODS: Totally 356 men diagnosed with LUTS/ BPH were evaluated retrospectively between January 2016 and March 2018. Anthropometric and laboratory characteristics were collected. According to the liver echogenicity degree, patients were divided into four groups: grade 0 was normal; NAFLD grades 1 to 3 had increasing fat...
March 22, 2019: BJU International
https://read.qxmd.com/read/30900790/spatial-resilience-of-the-great-barrier-reef-under-cumulative-disturbance-impacts
#13
C Mellin, S Matthews, K R N Anthony, S C Brown, M J Caley, K Johns, K Osborne, M Puotinen, A Thompson, N H Wolff, D A Fordham, M A MacNeil
In the face of increasing cumulative effects from human and natural disturbances, sustaining coral reefs will require a deeper understanding of the drivers of coral resilience in space and time. Here we develop a high-resolution, spatially explicit model of coral dynamics on Australia's Great Barrier Reef (GBR). Our model accounts for biological, ecological and environmental processes, as well as spatial variation in water quality and the cumulative effects of coral diseases, bleaching, outbreaks of crown-of-thorns starfish (Acanthaster cf...
March 22, 2019: Global Change Biology
https://read.qxmd.com/read/30900756/identifying-patients-who-will-not-reachieve-remission-after-breakthrough-seizures
#14
David M Hughes, Laura J Bonnett, Anthony G Marson, Marta García-Fiñana
OBJECTIVE: We aim to identify people with epilepsy who are unlikely to reachieve a 12-month remission within 2 years after experiencing a breakthrough seizure following an initial 12-month remission. METHODS: We apply a novel longitudinal discriminant approach to data from the Standard and New Antiepileptic Drugs study to dynamically predict the risk of a patient not achieving a second remission after a breakthrough seizure by combining both baseline covariates (collected at the time of breakthrough seizure) and follow-up data...
March 22, 2019: Epilepsia
https://read.qxmd.com/read/30900708/a-self-assembly-and-higher-order-structure-forming-triple-helical-protein-as-a-novel-biomaterial-for-cell-proliferation
#15
Meganathan Ilamaran, Asuma Janeena, Sisila Valappil, Kamini Numbi Ramudu, Ganesh Shanmugam, Ayyadurai Niraikulam
Collagen plays a critical role in the structural design of the extracellular matrix (ECM) and cell signaling in mammals, which makes it one of the most promising biomaterials with versatile applications. However, there is considerable concern regarding the purity and predictability of the product performance. At present, it is mainly derived as a mixture of collagen (different types) from animal tissues, where the selective enrichment of a particular type of collagen is generally difficult and expensive. Collagen derived from bovine sources poses the risk of transmitting diseases and can cause adverse immunologic and inflammatory responses...
March 22, 2019: Biomaterials Science
https://read.qxmd.com/read/30900695/-the-role-of-endogenous-mirnas-in-the-development-of-cerebral-aneurysms
#16
I F Gareev, Sh M Safin
Cerebral aneurysms are characterized by pathological expansion and thinning of the wall of vessels on the brain base, which may lead to rupture and subarachnoid hemorrhage (SAH) that is a life-threatening condition. This dictates the need for identification of new biological markers that predict the presence of aneurysms and the risk of their rupture. In the last decade, the role of microRNAs (miRNAs), which are considered to be key regulators of biological processes, has been investigated. miRNAs have been shown to play a role in the development of aneurysms, but today there is little similar data...
2019: Zhurnal Voprosy Neĭrokhirurgii Imeni N. N. Burdenko
https://read.qxmd.com/read/30900618/role-of-serum-prostate-specific-antigen-as-predictor-for-bone-metastases-in-newly-diagnosed-prostate-cancer
#17
O P Singh, Veenita Yogi, Pallavi Redhu, H U Ghori, Ananya Pareek, Nancy Lal
Introduction: Prostate cancer is most frequently diagnosed cancer of men and bone is the most common site of metastasis. There is a lack of consensus for the selection criteria for bone scan in low-risk patients. Western guidelines do not recommend use of bone scan in asymptomatic patients and in low prostate-specific antigen (PSA) values. We try to correlate the PSA value with bone metastases through bone scan in the Indian population. Materials and Methods: A total of 68 histologically newly diagnosed prostate cancer subjected to bone scan were retrospectively analyzed...
March 2019: Journal of Cancer Research and Therapeutics
https://read.qxmd.com/read/30900614/magnetic-resonance-imaging-radiomic-feature-analysis-of-radiation-induced-femoral-head-changes-in-prostate-cancer-radiotherapy
#18
Hamid Abdollahi, Seied Rabi Mahdavi, Isaac Shiri, Bahram Mofid, Mohsen Bakhshandeh, Kazem Rahmani
Background and Purpose: As a feasible approach, radiotherapy has a great role in prostate cancer (Pca) management. However, Pca patients have an increased risk of femoral head damages including fractures after radiotherapy. The mechanisms of these complications are unknown and time of manifestations is too long; however, they may be predicted by early imaging. The main purpose of this study was to assess the early changes in femoral heads in Pca patients treated with intensity-modulated radiation therapy (IMRT) using multiparametric magnetic resonance imaging (mpMRI) radiomic feature analysis...
March 2019: Journal of Cancer Research and Therapeutics
https://read.qxmd.com/read/30900551/genomic-assays-to-assess-local-recurrence-risk-and-predict-radiation-therapy-benefit-in-patients-with-ductal-carcinoma-in-situ
#19
Mylin A Torres
No abstract text is available yet for this article.
April 1, 2019: International Journal of Radiation Oncology, Biology, Physics
https://read.qxmd.com/read/30900483/low-phase-angle-in-body-composition-measurements-correlates-with-prolonged-hospital-stay-in-head-and-neck-cancer-patients
#20
Marie Lundberg, Amy Dickinson, Pia Nikander, Helena Orell, Antti Mäkitie
BACKGROUND: Bioelectrical impedance analysis (BIA) is a method for estimating body composition. Clinically the most important parameter is the phase angle (PA), which decreases with progressing malnutrition and is highly predictive for impaired survival and mortality. AIM: To evaluate the association of low PA with the complication rate and length of hospital stay. MATERIAL AND METHODS: A cohort of 61 head and neck cancer (HNC) patients underwent BIA prior to surgical treatment...
March 22, 2019: Acta Oto-laryngologica
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