keyword
https://read.qxmd.com/read/38547453/fibrinogen-levels-and-clot-properties-identify-patients-that-benefit-from-catheter-directed-thrombolysis-after-dvt
#1
JOURNAL ARTICLE
Aaron F J Iding, Ghadir Alkarithi, Hugo Ten Cate, Robert A S Ariëns, Arina J Ten Cate-Hoek
Ultrasound-accelerated catheter-directed thrombolysis (UA-CDT) to improve patency after deep vein thrombosis (DVT) has not conclusively been shown to prevent post-thrombotic syndrome (PTS) but might benefit patients who are unlikely to obtain patency with standard treatment. We hypothesized that these patients could be selected based on their fibrin clot properties. To study this, patients with acute iliofemoral DVT from the CAVA trial had blood samples taken at inclusion. Fibrin clot properties in plasma were determined by turbidimetric clotting (lag time and maximal turbidity) and lysis assays (time to 50% lysis and lysis rate), permeation assay (Ks), and confocal microscopy (fiber density), as well as levels of fibrin clot modifiers fibrinogen and C-reactive protein (CRP)...
March 28, 2024: Blood Advances
https://read.qxmd.com/read/38547396/predicting-oncology-drug-induced-cardiotoxicity-with-donor-specific-ipsc-cms-a-proof-of-concept-study-with-doxorubicin
#2
JOURNAL ARTICLE
Li Pang, Chengzhong Cai, Praful Aggarwal, Dong Wang, Vikrant Vijay, Prathyusha Bagam, Jacob Blamer, Andrea Matter, Amy Turner, Lijun Ren, Katy Papineau, Vinodh Srinivasasainagendra, Hemant K Tiwari, Xi Yang, Laura Schnackenberg, William Mattes, Ulrich Broeckel
Many oncology drugs have been found to induce cardiotoxicity in a subset of patients, which significantly limits their clinical use and impedes the benefit of lifesaving anti-cancer treatments. Human induced pluripotent stem cell-derived cardiomyocytes (iPSC-CMs) carry donor-specific genetic information and have been proposed for exploring the inter-individual difference in oncology drug-induced cardiotoxicity. Herein, we evaluated the inter- and intra- individual variability of iPSC-CM-related assays and presented a proof of concept to prospectively predict doxorubicin (DOX)-induced cardiotoxicity (DIC) using donor-specific iPSC-CMs...
March 28, 2024: Toxicological Sciences: An Official Journal of the Society of Toxicology
https://read.qxmd.com/read/38547299/early-prediction-of-the-impact-of-public-health-policies-on-obesity-and-lifetime-risk-of-type-2-diabetes-a-modelling-approach
#3
JOURNAL ARTICLE
Pierre Bauvin, Claire Delacôte, Line Carolle Ntandja Wandji, Guillaume Lassailly, Violeta Raverdy, François Pattou, Sylvie Deuffic-Burban, Philippe Mathurin
OBJECTIVE: Help public health decision-making requires a better understanding of the dynamics of obesity and type 2 diabetes and an assessement of different strategies to decrease their burdens. METHODS: Based on 97,848 individual data, collected in the French Health, Health Care and Insurance Survey over 1998-2014, a Markov model was developed to describe the progression of being overweight to obesity, and the onset of type 2 diabetes. This model traces and predicts 2022-2027 burdens of obesity and type 2 diabetes, and lifetime risk of diabetes, according to different scenarios aiming at minimum to stabilize obesity at 5 years...
2024: PloS One
https://read.qxmd.com/read/38547239/the-causal-effect-of-iron-status-on-risk-of-anxiety-disorders-a-two-sample-mendelian-randomization-study
#4
JOURNAL ARTICLE
Ruiying Yin, Qi Gao, Guangzhen Fu, Qiang Zhao
OBJECTIVES: Observational studies had investigated the association of iron metabolism with anxiety disorders. The conclusions were inconsistent and not available to reveal the causal or reverse-causal association due to the confounding. In this study we estimated the potential causal effect of iron homeostasis markers on anxiety disorders using two-sample Mendelian randomization (MR) analysis. METHODS: Summary data of single nucleotide polymorphisms (SNPs) associated with four iron-related biomarkers were extracted from a recent report about analysis of three genome-wide association study (GWAS), the sample size of which ranged from 131471 to 246139 individuals...
2024: PloS One
https://read.qxmd.com/read/38547199/prognostic-accuracy-of-early-warning-scores-for-predicting-serious-illness-and-in-hospital-mortality-in-patients-with-covid-19
#5
JOURNAL ARTICLE
Mehnaz Kamal, S M Tafsir Hasan, Monira Sarmin, Subhasish Das, Lubaba Shahrin, A S G Faruque, Mohammod Jobayer Chisti, Tahmeed Ahmed
A simple bedside triage tool is essential to stratify COVID-19 patients in the emergency department (ED). This study aimed to identify an early warning score (EWS) that could best predict the clinical outcomes in COVID-19 patients. Data were obtained from medical records of 219 laboratory-confirmed COVID-19 positive patients. We calculated 13 EWSs based on the admission characteristics of the patients. Receiver operating characteristic (ROC) curve analysis was used to assess the performance of the scores in predicting serious illness and in-hospital mortality...
2024: PLOS Glob Public Health
https://read.qxmd.com/read/38547186/reflected-generalized-concentration-addition-and-bayesian-hierarchical-models-to-improve-chemical-mixture-prediction
#6
JOURNAL ARTICLE
Daniel Zilber, Kyle Messier
Environmental toxicants overwhelmingly occur together as mixtures. The variety of possible chemical interactions makes it difficult to predict the danger of the mixture. In this work, we propose the novel Reflected Generalized Concentration Addition (RGCA), a piece-wise, geometric technique for sigmoidal dose-responsed inverse functions that extends the use of generalized concentration addition (GCA) for 3+ parameter models. Since experimental tests of all relevant mixtures is costly and intractable, we rely only on the individual chemical dose responses...
2024: PloS One
https://read.qxmd.com/read/38547100/early-warning-on-safety-risk-of-highly-aggregated-tourist-crowds-based-on-vggt-count-network-model
#7
JOURNAL ARTICLE
Jingjing Liu, Gengan Wu, Yao Liu
In the era of mass tourism, more and more people are attracted by internet-famous site. With people's demand for travel surged, tourists are getting together in one scenic spot with doubling numbers, which easily leads to high concentration of tourists with uncontrollable security risks. It needs to be highly valued by the tourism department. Monitoring and issuing warnings for crowd density in scenic areas with Highly Aggregated Tourist Crowds (HATCs) is an urgent challenge that needs to be addressed. In this paper, Highly Aggregated Tourist Crowds is taken as the research objective, and a VGGT-Count network model is proposed to forecast the density of HATCs...
2024: PloS One
https://read.qxmd.com/read/38547082/morality-self-control-age-type-of-offence-and-sentence-length-as-predictors-of-psychopathy-amongst-female-incarcerated-offenders-in-south-africa
#8
JOURNAL ARTICLE
Judite Danielle de Oliveira, Jacques Jordaan, Matthew Cronjé
There has been an increase in female incarcerated offenders nationally and internationally. Despite this trend, literature and research on female offenders remain limited compared to their male counterparts. Evidence of the relationship between certain personality disorders and offending behaviour has led numerous countries to prioritise identifying and assessing personality disorders among the offender population. Psychopathic personality traits may contribute to women's risk factors for expressing antisocial behaviours, resulting in their potential future incarceration...
2024: PloS One
https://read.qxmd.com/read/38546971/risk-factors-for-thyroid-dysfunction-in-pregnancy-an-individual-participant-data-meta-analysis
#9
JOURNAL ARTICLE
Joris A J Osinga, Yindi Liu, Tuija Männistö, Marina Vafeiadi, Fang-Biao Tao, Bijay Vaidya, Tanja G M Vrijkotte, Lorena Mosso, Judit Bassols, Abel López-Bermejo, Laura Boucai, Ashraf Aminorroaya, Ulla Feldt-Rasmussen, Aya Hisada, Jun Yoshinaga, Maarten A C Broeren, Sachiko Itoh, Reiko Kishi, Ghalia Ashoor, Liangmiao Chen, Flora Veltri, Xuemian Lu, Peter N Taylor, Suzanne J Brown, Leda Chatzi, Polina V Popova, Elena N Grineva, Farkhanda Ghafoor, Amna Pirzada, Maryam Kianpour, Emily Oken, Eila Suvanto, Andrew Hattersley, Marisa Rebagliato, Isolina Riaño-Galán, Amaia Irizar, Martine Vrijheid, Juana Maria Delgado-Saborit, Ana Fernández-Somoano, Loreto Santa-Marina, Kristien Boelaert, Gabriela Brenta, Rima Dhillon-Smith, Chrysoula Dosiou, Jennifer L Eaton, Haixia Guan, Sun Y Lee, Spyridoula Maraka, Lilah F Morris-Wiseman, Caroline T Nguyen, Zhongyan Shan, Mònica Guxens, Victor J M Pop, John P Walsh, Kypros H Nicolaides, Mary E D'Alton, W Edward Visser, David M Carty, Christian Delles, Scott M Nelson, Erik K Alexander, Layal Chaker, Glenn E Palomaki, Robin P Peeters, Sofie Bliddal, Kun Huang, Kris G Poppe, Elizabeth N Pearce, Arash Derakhshan, Tim I M Korevaar
Background: International guidelines recommend targeted screening to identify gestational thyroid dysfunction. However, currently used risk factors have questionable discriminative ability. We quantified the risk for thyroid function test abnormalities for a subset of risk factors currently used in international guidelines. Methods: We included prospective cohort studies with data on gestational maternal thyroid function and potential risk factors (maternal age, body mass index [BMI], parity, smoking status, pregnancy through in vitro fertilization, twin pregnancy, gestational age, maternal education, and thyroid peroxidase antibody [TPOAb] or thyroglobulin antibody [TgAb] positivity)...
March 28, 2024: Thyroid: Official Journal of the American Thyroid Association
https://read.qxmd.com/read/38546945/structural-racism-related-state-laws-and-healthcare-access-among-black-latine-and-white-u-s-adults
#10
JOURNAL ARTICLE
Dougie Zubizarreta, Ariel L Beccia, Jarvis T Chen, Jaquelyn L Jahn, S Bryn Austin, Madina Agénor
Racialized healthcare inequities in the USA remain glaring, yet root causes are understudied. To address this gap, we created a state-level structural racism legal index (SRLI) using the Structural Racism-Related State Law Database and analyzed its association with racialized inequities in four outcomes (lacking health insurance coverage, lacking a personal doctor, avoiding care due to cost, lacking a routine check-up) from the 2013 Behavioral Risk Factor Surveillance System (N = 454,834). To obtain predicted probabilities by SRLI quartiles (Q1 = less structural racism, Q4 = more structural racism) and racialized group, we fit survey-weighted multilevel logistic models adjusted for individual- and state-level covariates...
March 28, 2024: Journal of Racial and Ethnic Health Disparities
https://read.qxmd.com/read/38546916/extracellular-matrix-protein-1-ecm1-is-a-potential-biomarker-in-b-cell-acute-lymphoblastic-leukemia
#11
JOURNAL ARTICLE
Li-Xin Wu, Ming-Yue Zhao, Nan Yan, Ya-Lan Zhou, Lei-Ming Cao, Ya-Zhen Qin, Qian Jiang, Lan-Ping Xu, Xiao-Hui Zhang, Xiao-Jun Huang, Hao Jiang, Guo-Rui Ruan
B cell acute lymphoblastic leukemia (ALL) is characterized by the highly heterogeneity of pathogenic genetic background, and there are still approximately 30-40% of patients without clear molecular markers. To identify the dysregulated genes in B cell ALL, we screened 30 newly diagnosed B cell ALL patients and 10 donors by gene expression profiling chip. We found that ECM1 transcription level was abnormally elevated in newly diagnosed B cell ALL and further verified in another 267 cases compared with donors (median, 124...
March 28, 2024: Clinical and Experimental Medicine
https://read.qxmd.com/read/38546913/genetic-variations-related-to-angiotensin-ii-production-and-risk-for-basal-cell-carcinoma
#12
REVIEW
Iphigenia Gintoni, Michael Mastrogeorgiou, Veronica Papakosta, Stavros Vassiliou, Christos Yapijakis
Basal cell carcinoma (BCC) is the most prevalent human neoplasm, with constantly increasing annual incidence. Despite its slow growth, BCC is locally invasive and, if left untreated, can cause severe complications, including metastasis and death. The renin-angiotensin system (RAS) plays a key role in electrolyte balance, atrial pressure, tissue development, homeostasis, and inflammation, but also in cancer development. After binding to its type 1 receptor (AT1R), angiotensin II (ANGII), the system's principal hormonal effector, regulates cancer pathways spanning from the formation of the initial cancer cell to the construction and nutrition of the tumor microenvironment, angiogenesis, proliferation, and metastasis...
March 28, 2024: Biochemical Genetics
https://read.qxmd.com/read/38546902/the-value-of-neutrophil-to-lymphocyte-ratio-in-predicting-severity-of-coronary-involvement-and-long-term-outcome-of-percutaneous-coronary-intervention-in-patients-with-acute-coronary-syndrome-a-systematic-review-and-meta-analysis
#13
REVIEW
Farzad Shahsanaei, Shahin Abbaszadeh, Soudabeh Behrooj, Nima Rahimi Petrudi, Bahareh Ramezani
BACKGROUND: The value of counting inflammatory cells and especially their counting ratio in predicting adverse clinical outcomes in patients with acute coronary syndrome (ACS) undergoing revascularization has been shown, but the results of studies have been very diverse and paradoxical. The aim of the current study was to systematically review the studies that investigated the role of increased neutrophil-to-lymphocyte ratio (NLR) in predicting long-term clinical outcomes in patients with acute coronary syndrome (ACS) undergoing percutaneous coronary intervention (PCI)...
March 28, 2024: Egyptian Heart Journal: EHJ
https://read.qxmd.com/read/38546896/development-of-a-nomogram-to-predict-the-prognosis-of-patients-with-secondary-bone-tumors-in-the-intensive-care-unit-a-retrospective-analysis-based-on-the-mimic-iv-database
#14
JOURNAL ARTICLE
Weikang Li, Jinliang Li, Jinkui Cai
PURPOSE: The present study aimed to develop a nomogram to predict the prognosis of patients with secondary bone tumors in the intensive care unit to facilitate risk stratification and treatment planning. METHODS: We used the MIMIC IV 2.0 (the Medical Information Mart for Intensive Care IV) to retrieve patients with secondary bone tumors as a study cohort. To evaluate the predictive ability of each characteristic on patient mortality, stepwise Cox regression was used to screen variables, and the selected variables were included in the final Cox proportional hazard model...
March 28, 2024: Journal of Cancer Research and Clinical Oncology
https://read.qxmd.com/read/38546885/revisiting-the-issue-of-beach-balls-in-holmium-laser-enucleation-of-prostate-clinical-and-histological-characterization
#15
JOURNAL ARTICLE
Haim Herzberg, Ziv Savin, Ibrahim Fahoum, Karin Lifshitz, Omri Schwarztuch Gildor, Yotam Veredgorn, Ron Marom, Ofer Yossepowitch, Mario Sofer
PURPOSE: To clinically and histologically characterize prostatic nodules resistant to morcellation ("beach balls," BBs). PATIENTS AND METHODS: We reviewed a consecutive cohort of 559 holmium laser enucleation of the prostate (HoLEP) procedures performed between January 2020 and November 2023. The BBs group comprised 55 men (10%) and the control group comprised 504 men (90%). The clinical, intraoperative, outcome, and histologic data were statistically processed for the prediction of the presence of BBs and their influence on the perioperative course and outcome...
March 28, 2024: World Journal of Urology
https://read.qxmd.com/read/38546837/predicting-deamidation-and-isomerization-sites-in-therapeutic-antibodies-using-structure-based-in-silico-approaches
#16
JOURNAL ARTICLE
David Hoffmann, Joschka Bauer, Markus Kossner, Andrew Henry, Anne R Karow-Zwick, Giuseppe Licari
Asparagine (Asn) deamidation and aspartic acid (Asp) isomerization are common degradation pathways that affect the stability of therapeutic antibodies. These modifications can pose a significant challenge in the development of biopharmaceuticals. As such, the early engineering and selection of chemically stable monoclonal antibodies (mAbs) can substantially mitigate the risk of subsequent failure. In this study, we introduce a novel in silico approach for predicting deamidation and isomerization sites in therapeutic antibodies by analyzing the structural environment surrounding asparagine and aspartate residues...
2024: MAbs
https://read.qxmd.com/read/38546813/cysteine-and-glycine-rich-protein-1-predicts-prognosis-and-therapy-response-in-patients-with-acute-myeloid-leukemia
#17
JOURNAL ARTICLE
Qianqian Hao, Yu Liu, Yajun Liu, Luyao Shi, Yufei Chen, Lu Yang, Zhongxing Jiang, Yanfang Liu, Chong Wang, Shujuan Wang, Ling Sun
Acute myeloid leukemia (AML) is a heterogeneous disease with a poor prognosis. The current risk stratification system is essential but remains insufficient to select the best schedules. Cysteine-rich protein 1 (CSRP1) is a member of the CSRP family and associated with poor clinicopathological features in many tumors. This study aimed to explore the clinical significance and molecular mechanisms of cysteine- and glycine-rich protein 1 (CSRP1) in AML. RT-qPCR was used to detect the relative expression of CSRP1 in our clinical cohort...
March 28, 2024: Clinical and Experimental Medicine
https://read.qxmd.com/read/38546700/patient-specific-factors-for-deformity-after-upper-blepharoplasty-in-an-asian-population
#18
JOURNAL ARTICLE
Jiaxi Liu, Junzheng Wu, Xianhui Zeng, Zhen Liang, Xiao Fan, Baoqiang Song
BACKGROUND: The success of upper blepharoplasty depends on both surgeon experience and skill as well as patient factors. Therefore, we aimed to identify patient-specific characteristics that may contribute to poor prognoses by analyzing data derived from patients with various deformities after undergoing upper blepharoplasty. METHODS: This study included 202 patients who underwent revision surgery for upper blepharoplasty. We explored relationships between types of deformities before revisions and relevant patient factors before initial surgery using statistical analyses...
March 25, 2024: Plastic and Reconstructive Surgery
https://read.qxmd.com/read/38546697/machine-learning-based-prediction-of-hospitalization-during-chemoradiotherapy-with-daily-step-counts
#19
JOURNAL ARTICLE
Isabel D Friesner, Jean Feng, Shalom Kalnicki, Madhur Garg, Nitin Ohri, Julian C Hong
IMPORTANCE: Toxic effects of concurrent chemoradiotherapy (CRT) can cause treatment interruptions and hospitalizations, reducing treatment efficacy and increasing health care costs. Physical activity monitoring may enable early identification of patients at high risk for hospitalization who may benefit from proactive intervention. OBJECTIVE: To develop and validate machine learning (ML) approaches based on daily step counts collected by wearable devices on prospective trials to predict hospitalizations during CRT...
March 28, 2024: JAMA Oncology
https://read.qxmd.com/read/38546669/college-student-mental-health-psychiatric-risk-and-psychological-wellbeing
#20
JOURNAL ARTICLE
Paul G Nestor, Sara B Boodai, Keira O'Donovan, Victoria Choate Hasler, Richard Hunter
OBJECTIVE: To examine both psychiatric risk and psychological wellbeing in a college student sample drawn from a majority-minority university. PARTICIPANTS: 100 participants (42% White; 70 females), mean age, 21.22 years. METHODS: Univariate and multivariate analyses examined the relationship of psychiatric risk (Brief Symptom Inventory; BSI) and psychological wellbeing (Mental Health Continuum-Short Form; MHC-SF) with student stress, cognition, Adverse Childhood Experiences (ACEs) and a new Positive Childhood Experiences (PCEs) scale...
March 28, 2024: Journal of American College Health: J of ACH
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