keyword
https://read.qxmd.com/read/34876472/disruption-of-vglut1-in-cholinergic-medial-habenula-projections-increases-nicotine-self-administration
#21
JOURNAL ARTICLE
Elizabeth A Souter, Yen-Chu Chen, Vivien Zell, Valeria Lallai, Thomas Steinkellner, William S Conrad, William Wisden, Kenneth D Harris, Christie D Fowler, Thomas S Hnasko
Cholinergic projections from the medial habenula (MHb) to the interpeduncular nucleus (IPN) have been studied for their complex contributions to nicotine addiction and have been implicated in nicotine reinforcement, aversion, and withdrawal. While it has been established that MHb cholinergic projections co-release glutamate, no direct evidence has demonstrated a role for this glutamate projection in nicotine consumption. In the present study, a novel floxed Slc17a7 (VGLUT1) mouse was generated and used to create conditional knockout (cKO) mice that lack VGLUT1 in MHb cholinergic neurons...
December 3, 2021: ENeuro
https://read.qxmd.com/read/34681077/expression-of-urocortin-3-mrna-in-the-central-nervous-system-of-the-sea-lamprey-petromyzon-marinus
#22
JOURNAL ARTICLE
Daniel Sobrido-Cameán, Ramón Anadón, Antón Barreiro-Iglesias
In this study, we analyzed the organization of urocortin 3 (Ucn3)-expressing neuronal populations in the brain of the adult sea lamprey by means of in situ hybridization. We also studied the brain of larval sea lampreys to establish whether this prosocial neuropeptide is expressed differentially in two widely different phases of the sea lamprey life cycle. In adult sea lampreys, Ucn3 transcript expression was observed in neurons of the striatum, prethalamus, nucleus of the medial longitudinal fascicle, torus semicircularis, isthmic reticular formation, interpeduncular nucleus, posterior rhombencephalic reticular formation and nucleus of the solitary tract...
September 28, 2021: Biology
https://read.qxmd.com/read/34633611/nectin-2-in-general-and-in-the-brain
#23
REVIEW
Kiyohito Mizutani, Muneaki Miyata, Hajime Shiotani, Takeshi Kameyama, Yoshimi Takai
Nectins are immunoglobulin-like cell adhesion molecules constituting a family with four members, nectin-1, nectin-2, nectin-3, and nectin-4. In the brain, nectin-2 as well as nectin-1 and nectin-3 are expressed whereas nectin-4 is hardly expressed. In the nervous system, physiological functions of nectin-1 and nectin-3, such as synapse formation, mossy fiber trajectory regulation, interneurite affinity, contextual fear memory formation, and stress-related mental disorders, have been revealed. Nectin-2 is ubiquitously expressed in non-neuronal tissues and various nectin-2 functions in non-nervous systems have been extensively investigated, but nectin-2 functions in the brain have not been revealed until recently...
October 11, 2021: Molecular and Cellular Biochemistry
https://read.qxmd.com/read/34529937/trans-inhibition-of-axon-terminals-underlies-competition-in-the-habenulo-interpeduncular-pathway
#24
JOURNAL ARTICLE
Margherita Zaupa, Seyedeh Maryam Alavi Naini, Maroun Abi Younes, Erika Bullier, Erik R Duboué, Hervé Le Corronc, Hédi Soula, Sebastien Wolf, Raphaël Candelier, Pascal Legendre, Marnie E Halpern, Jean-Marie Mangin, Elim Hong
Survival of animals is dependent on the correct selection of an appropriate behavioral response to competing external stimuli. Theoretical models have been proposed and underlying mechanisms are emerging to explain how one circuit is selected among competing neural circuits. The evolutionarily conserved forebrain to midbrain habenulo-interpeduncular nucleus (Hb-IPN) pathway consists of cholinergic and non-cholinergic neurons, which mediate different aversive behaviors. Simultaneous calcium imaging of neuronal cell bodies and of the population dynamics of their axon terminals reveals that signals in the cell bodies are not reflective of terminal activity...
September 8, 2021: Current Biology: CB
https://read.qxmd.com/read/34326477/dynamic-activity-of-interpeduncular-nucleus-gabaergic-neurons-controls-expression-of-nicotine-withdrawal-in-male-mice
#25
JOURNAL ARTICLE
Paul M Klenowski, Rubing Zhao-Shea, Timothy G Freels, Susanna Molas, Andrew R Tapper
A critical brain area implicated in nicotine dependence is the interpeduncular nucleus (IPN) located in the ventral midbrain and consisting primarily of GABAergic neurons. Previous studies indicate that IPN GABAergic neurons contribute to expression of somatic symptoms of nicotine withdrawal; however, whether IPN neurons are dynamically regulated during withdrawal in vivo and how this may contribute to both somatic and affective withdrawal behavior is unknown. To bridge this gap in knowledge, we expressed GCaMP in IPN GABAergic neurons and used in vivo fiber photometry to record changes in fluorescence, as a proxy for neuronal activity, in male mice during nicotine withdrawal...
July 29, 2021: Neuropsychopharmacology
https://read.qxmd.com/read/34088738/genetically-targeted-connectivity-tracing-excludes-dopaminergic-inputs-to-the-interpeduncular-nucleus-from-the-ventral-tegmentum-and-substantia-nigra
#26
JOURNAL ARTICLE
Nailyam Nasirova, Lely A Quina, Shoshana Novik, Eric E Turner
The "habenulopeduncular system" consists of the medial habenula (MHb) and its principal target of innervation, the interpeduncular nucleus (IP). Neurons in the ventral MHb express acetylcholine along with glutamate, and both the MHb and IP are rich in nicotinic acetylcholine receptors. Much of the work on this system has focused on nicotinic mechanisms and their clinical implications for nicotine use, particularly because the IP expresses the α5 nicotinic receptor subunit, encoded by the CHRNA5 gene, which is genetically linked to smoking risk...
June 2, 2021: ENeuro
https://read.qxmd.com/read/33913808/gaba-b-receptor-auxiliary-subunits-modulate-cav2-3-mediated-release-from-medial-habenula-terminals
#27
JOURNAL ARTICLE
Pradeep Bhandari, David Vandael, Diego Fernández-Fernández, Thorsten Fritzius, David Kleindienst, Cihan Önal, Jacqueline Montanaro, Martin Gassmann, Peter Jonas, Akos Kulik, Bernhard Bettler, Ryuichi Shigemoto, Peter Koppensteiner
The synaptic connection from medial habenula (MHb) to interpeduncular nucleus (IPN) is critical for emotion-related behaviors, and uniquely expresses R-type Ca2+ channels (Cav2.3) and auxiliary GABAB receptor (GBR) subunits, the K+ -channel tetramerization domain-containing proteins (KCTDs). Activation of GBRs facilitates or inhibits transmitter release from MHb terminals depending on the IPN subnucleus, but the role of KCTDs is unknown. We therefore examined the localization and function of Cav2.3, GBRs, and KCTDs in this pathway in mice...
April 29, 2021: ELife
https://read.qxmd.com/read/33751631/amino-acid-systems-in-the-interpeduncular-nucleus-are-altered-in-a-sex-dependent-manner-during-nicotine-withdrawal
#28
JOURNAL ARTICLE
Luis M Carcoba, Kevin P Uribe, Sebastian Ortegon, Ian A Mendez, Mariella DeBiasi, Laura E O'Dell
Prior work in male rodents established that the medial habenula-interpeduncular nucleus (MHb-IPN) pathway modulates nicotine withdrawal. Specifically, withdrawal severity has been closely associated with inhibitory tone in the IPN via interneurons that release γ-aminobutyric acid (GABA). Inhibitory tone in the IPN is regulated by projections from the MHb that co-release glutamate and acetylcholine. Within the IPN, inhibitory tone is also regulated via corticotropin-releasing factor type 1 (CRF1) receptors that control GABA release from local interneurons...
March 22, 2021: Journal of Neuroscience Research
https://read.qxmd.com/read/33742685/addiction-related-neuroadaptations-following-chronic-nicotine-exposure
#29
REVIEW
Lauren Wills, Paul J Kenny
The addiction-relevant molecular, cellular and behavioral actions of nicotine are derived from its stimulatory effects on neuronal nicotinic acetylcholine receptors (nAChRs) in the central nervous system. nAChRs expressed by dopamine-containing neurons in the ventral midbrain, most notably in the ventral tegmental area (VTA), contribute to the reward-enhancing properties of nicotine that motivate the use of tobacco products. nAChRs are also expressed by neurons in the brain circuits that regulate aversion. In particular, nAChRs expressed by neurons in the medial habenula (mHb) and the interpeduncular nucleus (IPn) to which the mHb almost exclusively projects regulate the "set-point" for nicotine aversion and control nicotine intake...
March 20, 2021: Journal of Neurochemistry
https://read.qxmd.com/read/33664652/multiple-regionalized-genes-and-their-putative-networks-in-the-interpeduncular-nucleus-suggest-complex-mechanisms-of-neuron-development-and-axon-guidance
#30
JOURNAL ARTICLE
Isabel M García-Guillén, Antonia Alonso, Luis Puelles, Faustino Marín, Pilar Aroca
The interpeduncular nucleus (IPN) is a highly conserved limbic structure in the vertebrate brain, located in the isthmus and rhombomere 1. It is formed by various populations that migrate from different sites to the distinct domains within the IPN: the prodromal, rostral interpeduncular, and caudal interpeduncular nuclei. The aim here was to identify genes that are differentially expressed across these domains, characterizing their putative functional roles and interactions. To this end, we screened the 2,038 genes in the Allen Developing Mouse Brain Atlas database expressed at E18...
2021: Frontiers in Neuroanatomy
https://read.qxmd.com/read/33640680/female-rats-display-greater-nicotine-withdrawal-induced-cellular-activation-of-a-central-portion-of-the-interpeduncular-nucleus-versus-males-a-study-of-fos-immunoreactivity-within-provisionally-assigned-interpeduncular-subnuclei
#31
JOURNAL ARTICLE
Felix Matos-Ocasio, Veronika E Espinoza, Paola Correa-Alfonzo, Arshad M Khan, Laura E O'Dell
BACKGROUND: The interpeduncular nucleus (>1840) (IPN) has been shown to modulate the behavioral effects of nicotine withdrawal in male rodents. To date, the contribution of this brain structure to sex differences in withdrawal is largely unexplored. METHODS: This study compared neuronal activation, as reported by observable Fos expression in the IPN of nicotine-dependent female and male rats experiencing withdrawal. We provisionally localized the Fos-expressing cells to certain IPN subnuclei within Swanson's standardized brain atlas (2018)...
February 16, 2021: Drug and Alcohol Dependence
https://read.qxmd.com/read/33580180/down-regulation-of-habenular-calcium-dependent-secretion-activator-2-induces-despair-like-behavior
#32
JOURNAL ARTICLE
Hyeijung Yoo, Soo Hyun Yang, Jin Yong Kim, Esther Yang, Hyung Sun Park, Se Jeong Lee, Im Joo Rhyu, Gustavo Turecki, Hyun Woo Lee, Hyun Kim
Calcium-dependent secretion activator 2 (CAPS2) regulates the trafficking and exocytosis of neuropeptide-containing dense-core vesicles (DCVs). CAPS2 is prominently expressed in the medial habenula (MHb), which is related to depressive behavior; however, how MHb neurons cause depressive symptoms and the role of CAPS2 remains unclear. We hypothesized that dysfunction of MHb CAPS neurons might cause defects in neuropeptide secretion and the activity of monoaminergic centers, resulting in depressive-like behaviors...
February 12, 2021: Scientific Reports
https://read.qxmd.com/read/33511641/anatomical-projections-to-the-dorsal-tegmental-nucleus-and-abducens-nucleus-arise-from-separate-cell-populations-in-the-nucleus-prepositus-hypoglossi-but-overlapping-cell-populations-in-the-medial-vestibular-nucleus
#33
JOURNAL ARTICLE
Max L Mehlman, Jennifer L Marcroft, Jeffrey S Taube
Specialized circuitry in the brain processes spatial information to provide a sense of direction used for navigation. The dorsal tegmental nucleus (DTN) is a core component of this circuitry and utilizes vestibular inputs to generate neural activity encoding the animal's directional heading. Projections arising from the nucleus prepositus hypoglossi (NPH) and the medial vestibular nucleus (MVe) are thought to transmit critical vestibular signals to the DTN and other brain areas, including the abducens nucleus (ABN), a component of eye movement circuitry...
July 1, 2021: Journal of Comparative Neurology
https://read.qxmd.com/read/33421772/habenula-as-the-experience-dependent-controlling-switchboard-of-behavior-and-attention-in-social-conflict-and-learning
#34
REVIEW
Hitoshi Okamoto, Bor-Wei Cherng, Haruna Nakajo, Ming-Yi Chou, Masae Kinoshita
The habenula is among the evolutionarily most conserved parts of the brain and has been known for its role in the control of behavior to cope with aversive stimuli. Recent studies in zebrafish have revealed the novel roles of the two parallel neural pathways from the dorsal habenula to its target, the interpeduncular nucleus, in the control of behavioral choice whether to behave dominantly or submissively in the social conflict. They are modifiable depending on the internal state of the fish such as hunger and play another important role in orientation of attention whether to direct it internally to oneself or externally to others...
January 6, 2021: Current Opinion in Neurobiology
https://read.qxmd.com/read/33380469/%C3%AE-3-nicotinic-acetylcholine-receptors-in-the-habenula-interpeduncular-nucleus-circuit-regulate-nicotine-intake
#35
JOURNAL ARTICLE
Karim S Elayouby, Masago Ishikawa, Angeline Joan Dukes, Alexander C W Smith, Qun Lu, Christie D Fowler, Paul J Kenny
Allelic variation in CHRNA3 , the gene encoding the α3 nicotinic acetylcholine receptor (nAChR) subunit, increases vulnerability to tobacco dependence and smoking-related diseases, but little is known about the role for α3-containing (α3*) nAChRs in regulating the addiction-related behavioral or physiological actions of nicotine. α3* nAChRs are densely expressed by medial habenula (mHb) neurons, which project almost exclusively to the interpeduncular nucleus (IPn) and are known to regulate nicotine avoidance behaviors...
December 23, 2020: Journal of Neuroscience
https://read.qxmd.com/read/33253222/component-of-nicotine-induced-intracellular-calcium-elevation-mediated-through-%C3%AE-3-and-%C3%AE-5-containing-nicotinic-acetylcholine-receptors-are-regulated-by-cyclic-amp-in-sh-sy-5y-cells
#36
JOURNAL ARTICLE
Tamayo Takahashi, Takayuki Yoshida, Kana Harada, Tatsuhiko Miyagi, Kouichi Hashimoto, Izumi Hide, Shigeru Tanaka, Masahiro Irifune, Norio Sakai
The pathway from the medial habenular nucleus to the interpeduncular nucleus, in which nicotinic acetylcholine receptor (nAChR) including the α3 and α5 subunits (α3 * and α5 * nAChRs) are expressed, is implicated in nicotine dependence. We investigated whether α3 * and α5 * nAChRs are regulated by cAMP using SH-SY5Y cells to clarify the significance of these receptors in nicotine dependence. We analyzed the nicotine-induced elevation of intracellular Ca2+ ([Ca2+]i). Nicotine induces a concentration-dependent increase in [Ca2+]i...
2020: PloS One
https://read.qxmd.com/read/33195252/netrin-1-dcc-signaling-differentially-regulates-the-migration-of-pax7-nkx6-1-irx2-otp-and-otx2-cell-populations-in-the-developing-interpeduncular-nucleus
#37
JOURNAL ARTICLE
Isabel M García-Guillén, Antonia Alonso, Nicanor Morales-Delgado, Belén Andrés, Luis Puelles, Guillermina López-Bendito, Faustino Marín, Pilar Aroca
The interpeduncular nucleus (IPN) is a hindbrain structure formed by three main subdivisions, the prodromal (Pro) domain located at the isthmus (Ist), and the rostral and caudal interpeduncular domains (IPR, IPC) within rhombomere 1 (r1). Various cell populations can be detected in the IPN through the expression of the Nkx6.1 , Otp , Otx2 , Pax7 , and/or Irx2 transcription factors. These cell populations follow independent dorsoventral tangential and radial migratory routes targeting the ventral paramedian region of Ist and r1...
2020: Frontiers in Cell and Developmental Biology
https://read.qxmd.com/read/33139320/the-interpeduncular-ventral-hippocampus-pathway-mediates-active-stress-coping-and-natural-reward
#38
JOURNAL ARTICLE
Yasmine Sherafat, Malia Bautista, J P Fowler, Edison Chen, Amina Ahmed, Christie D Fowler
Maladaptive stress-related behaviors are integral to multiple complex psychiatric disorders, and it has been well established that serotonergic signaling mediates various aspects of these maladaptive states. In these studies, we sought to uncover the function of a previously undefined serotonergic pathway, which projects from the interpeduncular nucleus (IPN) to the ventral hippocampus (vHipp). Intersectional retrograde and chemogenetic viral manipulation strategies were employed to manipulate the function of the IPN-vHipp pathway during a variety of behavioral measures in male mice...
October 30, 2020: ENeuro
https://read.qxmd.com/read/32989244/regulation-of-habenular-g-protein-gamma-8-on-learning-and-memory-via-modulation-of-the-central-acetylcholine-system
#39
JOURNAL ARTICLE
Hyun-Ju Lee, Tae-Ik Choi, Yong-Min Kim, Soonje Lee, Bing Han, In Seon Bak, Sun Ae Moon, Dae-Yeul Yu, Ki Soon Shin, Yunhee Kim Kwon, Cheil Moon, Jae Hwan Ryu, Hyang-Sook Hoe, Cheol-Hee Kim, Insop Shim
Guanine nucleotide binding protein (G protein) gamma 8 (Gng8) is a subunit of G proteins and expressed in the medial habenula (MHb) and interpeduncular nucleus (IPN). Recent studies have demonstrated that Gng8 is involved in brain development; however, the roles of Gng8 on cognitive function have not yet been addressed. In the present study, we investigated the expression of Gng8 in the brain and found that Gng8 was predominantly expressed in the MHb-IPN circuit of the mouse brain. We generated Gng8 knockout (KO) mice by CRISPR/Cas9 system in order to assess the role of Gng8 on cognitive function...
September 28, 2020: Molecular Psychiatry
https://read.qxmd.com/read/32950561/chronic-exposure-to-cigarette-smoke-extract-upregulates-nicotinic-receptor-binding-in-adult-and-adolescent-rats
#40
JOURNAL ARTICLE
Michelle Cano, Daisy D Reynaga, James D Belluzzi, Sandra E Loughlin, Frances Leslie
Heavy smokers display increased radioligand binding of nicotinic acetylcholine receptors (nAChRs). This "upregulation" is thought to be a contributing factor to tobacco dependence. Although cigarette smoke contains thousands of constituents that can contribute to nicotine dependence, it is not well understood whether non-nicotine constituents contribute to nAChR upregulation. In this study, we used an aqueous cigarette smoke extract (CSE), which contains nicotine and soluble constituents of cigarette smoke, to induce nAChR upregulation in adult and adolescent rats...
December 15, 2020: Neuropharmacology
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