Amit A Upadhyay, Timothy N Hoang, Maria Pino, Arun K Boddapati, Elise G Viox, Michelle Y H Lee, Jacqueline Corry, Zachary Strongin, David A Cowan, Elizabeth N Beagle, Tristan R Horton, Sydney Hamilton, Hadj Aoued, Justin L Harper, Kevin Nguyen, Kathryn L Pellegrini, Gregory K Tharp, Anne Piantadosi, Rebecca D Levit, Rama R Amara, Simon M Barratt-Boyes, Susan P Ribeiro, Rafick P Sekaly, Thomas H Vanderford, Raymond F Schinazi, Mirko Paiardini, Steven E Bosinger
The COVID-19 pandemic remains a global health crisis, yet, the immunopathological mechanisms driving the development of severe disease remain poorly defined. Here, we utilize a rhesus macaque (RM) model of SARS-CoV-2 infection to delineate perturbations in the innate immune system during acute infection using an integrated systems analysis. We found that SARS-CoV-2 initiated a rapid infiltration (two days post infection) of plasmacytoid dendritic cells into the lower airway, commensurate with IFNA production, natural killer cell activation, and induction of interferon-stimulated genes...
October 5, 2021: bioRxiv