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Keywords Medical and biological complex...

Medical and biological complex systems

https://read.qxmd.com/read/38465431/the-multiple-roles-of-heat-shock-proteins-in-the-development-of-inflammatory-bowel-disease
#21
JOURNAL ARTICLE
Jinfeng Su, Haiyan Wang, Zun Wang
Inflammatory bowel disease (IBD), a chronic inflammatory condition of the human intestine, comprises Crohn's Disease (CD) and Ulcerative Colitis (UC). IBD causes severe gastrointestinal symptoms and increases the risk of developing colorectal carcinoma. Although the etiology of IBD remains ambiguous, complex interactions between genetic predisposition, microbiota, epithelial barrier, and immune factors have been implicated. The disruption of intestinal homeostasis is a cardinal characteristic of IBD. Patients with IBD exhibit intestinal microbiota dysbiosis, impaired epithelial tight junctions, and immune dysregulation; however, the relationship between them is not completely understood...
March 7, 2024: Current Molecular Medicine
https://read.qxmd.com/read/38463626/clinically-relevant-stratification-of-lung-squamous-carcinoma-patients-based-on-ubiquitinated-proteasome-genes-for-3p-medical-approach
#22
JOURNAL ARTICLE
Jingru Yang, Serge Yannick Ouedraogo, Jingjing Wang, Zhijun Li, Xiaoxia Feng, Zhen Ye, Shu Zheng, Na Li, Xianquan Zhan
RELEVANCE: The proteasome is a crucial mechanism that regulates protein fate and eliminates misfolded proteins, playing a significant role in cellular processes. In the context of lung cancer, the proteasome's regulatory function is closely associated with the disease's pathophysiology, revealing multiple connections within the cell. Therefore, studying proteasome inhibitors as a means to identify potential pathways in carcinogenesis and metastatic progression is crucial in in-depth insight into its molecular mechanism and discovery of new therapeutic target to improve its therapy, and establishing effective biomarkers for patient stratification, predictive diagnosis, prognostic assessment, and personalized treatment for lung squamous carcinoma in the framework of predictive, preventive, and personalized medicine (PPPM; 3P medicine)...
March 2024: EPMA Journal
https://read.qxmd.com/read/38462489/how-are-we-handling-protein-drugs-in-hospitals-a-human-factors-and-systems-engineering-approach-to-compare-two-hospitals-and-suggest-a-best-practice
#23
JOURNAL ARTICLE
Clàudia Sabaté-Martínez, Mattias Paulsson, Silvia González-Suárez, Ulla Elofsson, Anna Millqvist Fureby, Marie Wahlgren, Carmen López-Cabezas
BACKGROUND: Biopharmaceuticals are complex biological molecules that require careful storage and handling to ensure medication integrity. In this study, a work system analysis of real-world protein drug (PD) handling was performed with the following goals: identify main barriers and facilitators for successful adherence to accepted recommendations in PD handling, analyse differences in two organisations, and define a Best Current Practice in the real-life handling of PDs based on the results of the work system analysis...
March 11, 2024: International Journal for Quality in Health Care
https://read.qxmd.com/read/38457871/experimental-and-theoretical-investigation-of-low-frequency-vibrational-modes-of-4-amino-3-5-dinitro-pyrazole-in-terahertz-frequency-domain
#24
JOURNAL ARTICLE
Rajesh Koalla, Supratik Mukherjee, Shivanand Mangali, G Vaitheeswaran, Anil Kumar Chaudhary
Pyrazoles have recently received significant attention due to their unique and potential applications in the medical field, agriculture and are also known to be highly stable explosives. The present work describes the terahertz time-domain spectroscopy (THz-TDS) based study of 4-Amino 3,5 Dinitro Pyrazole(ADNP) in between the 0.1 and 3.0 THz ranges. A Toptica-Teraflash fibre-coupled handheld terahertz system has been employed in reflection mode configuration. We ascertained complex refractive index, absorption coefficients, and complex dielectric constants from 0...
February 28, 2024: Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy
https://read.qxmd.com/read/38457066/resdac-net-a-novel-pancreas-segmentation-model-utilizing-residual-double-asymmetric-spatial-kernels
#25
JOURNAL ARTICLE
Zhanlin Ji, Jianuo Liu, Juncheng Mu, Haiyang Zhang, Chenxu Dai, Na Yuan, Ivan Ganchev
The pancreas not only is situated in a complex abdominal background but is also surrounded by other abdominal organs and adipose tissue, resulting in blurred organ boundaries. Accurate segmentation of pancreatic tissue is crucial for computer-aided diagnosis systems, as it can be used for surgical planning, navigation, and assessment of organs. In the light of this, the current paper proposes a novel Residual Double Asymmetric Convolution Network (ResDAC-Net) model. Firstly, newly designed ResDAC blocks are used to highlight pancreatic features...
March 8, 2024: Medical & Biological Engineering & Computing
https://read.qxmd.com/read/38457065/direct-lingam-and-visibility-graphs-for-analyzing-brain-connectivity-in-bci
#26
JOURNAL ARTICLE
Hoda Majdi, Mahdi Azarnoosh, Majid Ghoshuni, Vahid Reza Sabzevari
The brain-computer interface (BCI) is a direct pathway of communication between the electrical activity of the brain and an external device. The present paper was aimed to investigate directed connectivity between different areas of the brain during motor imagery (MI)-based BCI. For this purpose, two methods were implemented including, Limited Penetrable Horizontal Visibility Graph (LPHVG) and Direct Lingam. The visibility graph (VG) is a robust algorithm for analyzing complex systems such as the brain. Direct Lingam uses a non-Gaussian model to extract causal links which is appropriate for analyzing large-scale connectivity...
March 8, 2024: Medical & Biological Engineering & Computing
https://read.qxmd.com/read/38456205/recent-advances-in-multifunctional-dendrimer-based-complexes-for-cancer-treatment
#27
REVIEW
Dzmitry Shcharbin, Viktoria Zhogla, Viktar Abashkin, Yue Gao, Jean-Pierre Majoral, Serge Mignani, Mingwu Shen, Maria Bryszewska, Xiangyang Shi
The application of nanotechnology in biological and medical fields have resulted in the creation of new devices, supramolecular systems, structures, complexes, and composites. Dendrimers are relatively new nanotechnological polymers with unique features; they are globular in shape, with a topological structure formed by monomeric subunit branches diverging to the sides from the central nucleus. This review analyzes the main features of dendrimers and their applications in biology and medicine regarding cancer treatment...
2024: Wiley Interdisciplinary Reviews. Nanomedicine and Nanobiotechnology
https://read.qxmd.com/read/38453634/defense-and-anti-defense-mechanisms-of-bacteria-and-bacteriophages
#28
JOURNAL ARTICLE
Xiaoqing Wang, Sebastian Leptihn
In the post-antibiotic era, the overuse of antimicrobials has led to a massive increase in antimicrobial resistance, leaving medical doctors few or no treatment options to fight infections caused by superbugs. The use of bacteriophages is a promising alternative to treat infections, supplementing or possibly even replacing antibiotics. Using phages for therapy is possible, since these bacterial viruses can kill bacteria specifically, causing no harm to the normal flora. However, bacteria have developed a multitude of sophisticated and complex ways to resist infection by phages, including abortive infection and the clustered regularly interspersed short palindromic repeats (CRISPR)/CRISPR-associated (Cas) system...
February 14, 2024: Journal of Zhejiang University. Science. B
https://read.qxmd.com/read/38452831/multifunctionality-of-cyclodextrin-based-polymeric-nanoparticulate-delivery-systems-for-chemotherapeutics-combination-therapy-and-theranostics
#29
REVIEW
Lakshmi Sathi Devi, Cristina Casadidio, Maria Rosa Gigliobianco, Piera Di Martino, Roberta Censi
As cancer being the most difficult disease to treat, different kinds of medications and therapeutic approaches have been prominently developed by scientists. For certain families of drugs, such as immuno-therapeutics or antibody-drug conjugates, efficient delivery systems are required during administration to protect the drugs from chemical degradation or biological inactivation. Delivery systems with the ability to carry different therapeutics or diagnostic agents or both, hold promising potential to tackle the abnormalities behind cancer...
March 5, 2024: International Journal of Pharmaceutics
https://read.qxmd.com/read/38447915/association-between-depression-and-diabetes-mellitus-and-the-impact-of-their-comorbidity-on-mortality-evidence-from-a-nationally-representative-study
#30
JOURNAL ARTICLE
Jingda Cai, Songyan Zhang, Renrong Wu, Jing Huang
BACKGROUND: Depression and diabetes mellitus (DM) are major chronic noncommunicable diseases that impair one's mental and physical well-being and impose substantial burdens on the health system. Depressed individuals have an increased risk of impaired blood glucose, weight gain and dyslipidemia which could induce poorer long-term survival. METHODS: 37,040 individuals from the National Health and Nutrition Examination Survey (NHANES) were included. Depressive symptoms were assessed by the Patient Health Questionnaire (PHQ-9) and classified by the total scores as no (0-4), mild (5-9), moderate (10-14), and severe (15-27)...
March 4, 2024: Journal of Affective Disorders
https://read.qxmd.com/read/38447587/sociotechnical-feasibility-of-natural-language-processing-driven-tools-in-clinical-trial-eligibility-prescreening-for-alzheimer-s-disease-and-related-dementias
#31
JOURNAL ARTICLE
Betina Idnay, Jianfang Liu, Yilu Fang, Alex Hernandez, Shivani Kaw, Alicia Etwaru, Janeth Juarez Padilla, Sergio Ozoria Ramírez, Karen Marder, Chunhua Weng, Rebecca Schnall
BACKGROUND: Alzheimer's disease and related dementias (ADRD) affect over 55 million globally. Current clinical trials suffer from low recruitment rates, a challenge potentially addressable via natural language processing (NLP) technologies for researchers to effectively identify eligible clinical trial participants. OBJECTIVE: This study investigates the sociotechnical feasibility of NLP-driven tools for ADRD research prescreening and analyzes the tools' cognitive complexity's effect on usability to identify cognitive support strategies...
March 6, 2024: Journal of the American Medical Informatics Association: JAMIA
https://read.qxmd.com/read/38446742/new-classifications-for-quantum-bioinformatics-q-bioinformatics-qct-bioinformatics-qcg-bioinformatics-and-qcr-bioinformatics
#32
JOURNAL ARTICLE
Majid Mokhtari, Samane Khoshbakht, Kobra Ziyaei, Mohammad Esmaeil Akbari, Sayyed Sajjad Moravveji
Bioinformatics has revolutionized biology and medicine by using computational methods to analyze and interpret biological data. Quantum mechanics has recently emerged as a promising tool for the analysis of biological systems, leading to the development of quantum bioinformatics. This new field employs the principles of quantum mechanics, quantum algorithms, and quantum computing to solve complex problems in molecular biology, drug design, and protein folding. However, the intersection of bioinformatics, biology, and quantum mechanics presents unique challenges...
January 22, 2024: Briefings in Bioinformatics
https://read.qxmd.com/read/38440935/molecular-modelling-approaches-can-reveal-the-molecular-interactions-established-between-antimalarial-targets-of-hemozoin-pathway-and-the-organic-phytochemicals-of-artocarpus-species
#33
JOURNAL ARTICLE
Surabhi Chaurasia, Anima Pandey
Ayurveda, the traditional Indian medical system, has potential applications in early malaria treatment. In an in silico docking study, 50 phytochemicals from two plants Artocarpus lakoocha Roxb. (AL) And Artocarpus heterophyllus Lam. (AH), were examined for their interactions with anti-malarial proteins (PDB IDs: 3BWK, 3BPF, 1LF3). The nucleotide analogue Artemisinin, a current malaria treatment, served as a positive control. Result showed that phytochemicals from AL and AH exhibited binding affinities as high as -9...
March 5, 2024: Natural Product Research
https://read.qxmd.com/read/38436563/scdot-enhancing-single-cell-rna-seq-data-annotation-and-uncovering-novel-cell-types-through-multi-reference-integration
#34
JOURNAL ARTICLE
Yi-Xuan Xiong, Xiao-Fei Zhang
The proliferation of single-cell RNA-seq data has greatly enhanced our ability to comprehend the intricate nature of diverse tissues. However, accurately annotating cell types in such data, especially when handling multiple reference datasets and identifying novel cell types, remains a significant challenge. To address these issues, we introduce Single Cell annotation based on Distance metric learning and Optimal Transport (scDOT), an innovative cell-type annotation method adept at integrating multiple reference datasets and uncovering previously unseen cell types...
January 22, 2024: Briefings in Bioinformatics
https://read.qxmd.com/read/38436561/benchmarking-enrichment-analysis-methods-with-the-disease-pathway-network
#35
JOURNAL ARTICLE
Davide Buzzao, Miguel Castresana-Aguirre, Dimitri Guala, Erik L L Sonnhammer
Enrichment analysis (EA) is a common approach to gain functional insights from genome-scale experiments. As a consequence, a large number of EA methods have been developed, yet it is unclear from previous studies which method is the best for a given dataset. The main issues with previous benchmarks include the complexity of correctly assigning true pathways to a test dataset, and lack of generality of the evaluation metrics, for which the rank of a single target pathway is commonly used. We here provide a generalized EA benchmark and apply it to the most widely used EA methods, representing all four categories of current approaches...
January 22, 2024: Briefings in Bioinformatics
https://read.qxmd.com/read/38435719/investigating-the-overlap-of-machine-learning-algorithms-in-the-final-results-of-rna-seq-analysis-on-gene-expression-estimation
#36
JOURNAL ARTICLE
Kalliopi-Maria Stathopoulou, Spiros Georgakopoulos, Sotiris Tasoulis, Vassilis P Plagianakos
Advances in computer science in combination with the next-generation sequencing have introduced a new era in biology, enabling advanced state-of-the-art analysis of complex biological data. Bioinformatics is evolving as a union field between computer Science and biology, enabling the representation, storage, management, analysis and exploration of many types of data with a plethora of machine learning algorithms and computing tools. In this study, we used machine learning algorithms to detect differentially expressed genes between different types of cancer and showing the existence overlap to final results from RNA-sequencing analysis...
December 2024: Health Information Science and Systems
https://read.qxmd.com/read/38434281/on-the-generality-of-the-finite-element-modeling-physical-fields-in-biological-systems-by-the-multiscale-smeared-concept-kojic-transport-model
#37
JOURNAL ARTICLE
Milos Kojic, Miljan Milosevic, Vladimir Simic, Bogdan Milicevic, Rossana Terracciano, Carly S Filgueira
The biomechanical and biochemical processes in the biological systems of living organisms are extremely complex. Advances in understanding these processes are mainly achieved by laboratory and clinical investigations, but in recent decades they are supported by computational modeling. Besides enormous efforts and achievements in this modeling, there still is a need for new methods that can be used in everyday research and medical practice. In this report, we give a view of the generality of the finite element methodology introduced by the first author and supported by his collaborators...
March 15, 2024: Heliyon
https://read.qxmd.com/read/38421835/nanomaterials-in-medicine-understanding-cellular-uptake-localization-and-retention-for-enhanced-disease-diagnosis-and-therapy
#38
REVIEW
Yue Peng, Zhengshuang Yang, Hui Sun, Jinling Li, Xiuwan Lan, Sijia Liu
Nanomaterials (NMs) have emerged as promising tools for disease diagnosis and therapy due to their unique physicochemical properties. To maximize the effectiveness and design of NMs-based medical applications, it is essential to comprehend the complex mechanisms of cellular uptake, subcellular localization, and cellular retention. This review illuminates the various pathways that NMs take to get from the extracellular environment to certain intracellular compartments by investigating the various mechanisms that underlie their interaction with cells...
February 22, 2024: Aging and Disease
https://read.qxmd.com/read/38418620/the-therapeutic-effect-of-mesenchymal-stem-cells-in-diabetic-kidney-disease
#39
JOURNAL ARTICLE
Umm E Habiba, Nasar Khan, David Lawrence Greene, Sabiha Shamim, Amna Umer
Diabetes mellitus (DM) often causes chronic kidney damage despite best medical practices. Diabetic kidney disease (DKD) arises from a complex interaction of factors within the kidney and the whole body. Targeting specific disease-causing agents using drugs has not been effective in treating DKD. However, stem cell therapies offer a promising alternative by addressing multiple disease pathways and promoting kidney regeneration. Mesenchymal stem cells (MSCs) offer great promise due to their superior accessibility ratio from adult tissues and remarkable modes of action, such as the production of paracrine anti-inflammatory and cytoprotective substances...
February 29, 2024: Journal of Molecular Medicine: Official Organ of the "Gesellschaft Deutscher Naturforscher und Ärzte"
https://read.qxmd.com/read/38414408/pancreatic-cancer-environment-from-patient-derived-models-to-single-cell-omics
#40
REVIEW
Ao Gu, Jiatong Li, Shimei Qiu, Shenglin Hao, Zhu-Ying Yue, Shuyang Zhai, Meng-Yao Li, Yingbin Liu
Pancreatic cancer (PC) is a highly malignant cancer characterized by poor prognosis, high heterogeneity, and intricate heterocellular systems. Selecting an appropriate experimental model for studying its progression and treatment is crucial. Patient-derived models provide a more accurate representation of tumor heterogeneity and complexity compared to cell line-derived models. This review initially presents relevant patient-derived models, including patient-derived xenografts (PDXs), patient-derived organoids (PDOs), and patient-derived explants (PDEs), which are essential for studying cell communication and pancreatic cancer progression...
February 28, 2024: Molecular Omics
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