Yang Qin, Feiyang Huang, Qi Tang, Jiangtian Li, Heao Zhang, Kuangdi Luo, Jiahui Zhou, Hongxun Wang, Limei Wang, Longjie Li, Xianjin Xiao
DNA nanomaterials have a wide application prospect in biomedical field, among which DNA computers and biosensors based on Seesaw-based DNA circuit is considered to have the most development potential. However, the serious leakage of Seesaw-based DNA circuit prevented its further development and application. Moreover, the existing methods to suppress leakage can't achieve the ideal effect. Interestingly, we found a new source of leakage in Seesaw-based DNA circuit, which we think is the main reason why the previous methods to suppress leakage are not satisfactory...
March 22, 2024: Biosensors & Bioelectronics