keyword
Keywords Kidney, hemodialysis, clinical...

Kidney, hemodialysis, clinical pathology

https://read.qxmd.com/read/37077588/progression-to-end-stage-renal-disease-due-to-igg4-related-nephritis-refractory-to-rituximab
#21
Tien Nguyen, Sergey Brodsky, Natallia Maroz
An 81-year-old woman was referred to nephrology for a follow-up on progressive chronic kidney disease. She has a past medical history of hypertension, T2DM, breast cancer, and secondary hyperparathyroidism related to renal disease. A renal biopsy showed patchy interstitial fibrosis and tubular atrophy with an increased number of IgG4-positive plasma cells. A diagnosis of IgG4-related kidney disease was made based on clinical presentation and pathology. The patient ultimately required the initiation of hemodialysis, despite the administration of steroids and rituximab...
March 2023: Curēus
https://read.qxmd.com/read/37070916/screening-of-fabry-disease-of-patients-in-renal-replacement-therapy-in-a-population-from-lazio-italy
#22
JOURNAL ARTICLE
G Marrone, R Angelico, M Di Lauro, E Sargentini, T M Manzia, G Tisone, A P Mitterhofer, D Della Morte Canosci, M Tesauro, N Di Daniele, A Noce
OBJECTIVE: Fabry's disease (FD) is a genetic disorder of lysosomal storage characterized by the intralysosomal accumulation of globotriaosylceramide (Gb3). This genetic mutation causes a total or partial deficit of the α-galactosidase (GAL) enzyme activity. FD has an incidence of 1:40000-60000 born alive. Its prevalence is higher in specific pathological conditions like chronic kidney disease (CKD). The aim of this study was to evaluate the FD prevalence in Italian renal replacement therapy (RRT) patients from Lazio region...
April 2023: European Review for Medical and Pharmacological Sciences
https://read.qxmd.com/read/37033238/cancer-related-hypercalcemia-and-potential-treatments
#23
REVIEW
Elvina Almuradova, Irfan Cicin
Cancer-related hypercalcemia is a common finding typically seen in patients with advanced cancer and occurs in about 20 to 30 percent of cases. The most common cause of hypercalcemia in hospitalized patients is hypercalcemia due to malignancy.This clinical problem is seen in patients with both solid tumors and patients with hematologic malignancies. Hypercalcemia is associated with a poor prognosis in oncology patients. This pathologic condition can occur due to many different mechanisms but is usually caused by abnormal calcium use resulting from bone resorption, intestinal absorption, or renal excretion...
2023: Frontiers in Endocrinology
https://read.qxmd.com/read/37007048/investigating-the-effect-of-dehydromiltirone-on-septic-aki-using-a-network-pharmacology-method-molecular-docking-and-experimental-validation
#24
JOURNAL ARTICLE
Sijia Chen, Yanzhe Wang, Yuyuan Liu, Linnan Bai, Fengqin Li, Yue Wu, Xinmiao Xie, Nan Zhang, Chuchu Zeng, Ling Zhang, Xiaoxia Wang
Acute kidney injury (AKI) is a severe and frequent complication of sepsis that occurs in intensive care units with inflammation and rapid decline in renal function as the main pathological features. Systemic inflammation, microvascular dysfunction, and tubule injury are the main causes of sepsis-induced AKI (SI-AKI). The high prevalence and death rate from SI-AKI is a great challenge for clinical treatment worldwide. However, in addition to hemodialysis, there is no effective drug to improve renal tissue damage and alleviate the decline in kidney function...
2023: Frontiers in Pharmacology
https://read.qxmd.com/read/36928585/validating-a-simplified-lung-ultrasound-protocol-for-detection-and-quantification-of-pulmonary-edema-in-patients-with-chronic-kidney-disease-receiving-maintenance-hemodialysis
#25
JOURNAL ARTICLE
Carl Hallgren, Carl Johan Svensson, Tobias Ullerstam, Max Olin, Hamid Dezfoolian, Pavlos Kashioulis, Jonatan Oras
OBJECTIVES: Pulmonary edema is a common clinical problem and lung ultrasound (LUS) presents an efficient method for evaluating this pathology. This study aims to investigate if a clinically efficient LUS protocol can quantify the level of extravascular lung fluid in patients receiving hemodialysis, and to develop a simplified B-line scoring system based on this protocol. METHODS: A simple 8-area LUS approach was used for the assessment of the extravascular fluid status in patients before, during, and after receiving hemodialysis...
September 2023: Journal of Ultrasound in Medicine: Official Journal of the American Institute of Ultrasound in Medicine
https://read.qxmd.com/read/36923829/extrapyramidal-syndromes-of-chronic-kidney-disease-and-dialysis-diabetic-uremic-syndrome-with-reversible-parkinsonism-and-lentiform-fork-sign-a-case-report-and-literature-review-including-metformin-induced-encephalopathy
#26
Takeo Sakurai, Hiroshi Nishida
Diabetic uremic syndrome has been rarely reported in patients on maintenance dialysis for diabetic nephropathy who present subacutely with neurological symptoms and bilateral basal ganglia lesions. There are also a few reports on metformin-induced encephalopathy, which is clinically similar to diabetic uremic syndrome. Because some patients with each of these diseases also have metabolic acidosis, it is speculated that these two diseases may have the same pathology. Recently, the term "extrapyramidal syndromes of chronic kidney disease and dialysis" (EPS-CKDD), with associated diagnostic criteria, has been proposed to describe these conditions, and metformin use is considered a risk factor for developing these syndromes...
March 2023: Heliyon
https://read.qxmd.com/read/36864620/the-association-of-cognition-with-protein-energy-wasting-and-synaptic-transmission-in-chronic-kidney%C3%A2-disease
#27
JOURNAL ARTICLE
Xia Yang, Yujun Quan, Erzhong Wu, Yuecheng Jiang, Qian Song, Yue Li, Qian Li, Zhaolin Sun, Jing Yuan, Yan Zha, Xiaoli Cui
INTRODUCTION:  In recent years, consciousness impairment in patients with end-stage renal disease (ESRD) has been paid more and more attention, but the cause and mechanism of consciousness state change is not clear. METHODS:  As the hippocampus played a crucial role in consciousness, we explored the pathological and electrophysiological changes in chronic kidney disease (CKD) mouse hippocampus. RESULTS:  Whole-cell recordings in hippocampal neurons showed that miniature excitatory postsynaptic current (mEPSC) frequency decreased, but the amplitude was unaltered in CKD_8w mice...
March 2, 2023: Seminars in Dialysis
https://read.qxmd.com/read/36668916/prevalence-of-jc-and-bk-polyomavirus-infection-in-patients-with-chronic-kidney-disease-in-the-state-of-par%C3%A3-brazil
#28
JOURNAL ARTICLE
Scheila do Socorro Vasconcelos Ávila da Costa, Jacqueline Cortinhas Monteiro, Ana Paula do Vale Viegas, Keyla Santos Guedes de Sá, Silvia Regina da Cruz, Sandra Souza Lima, Izaura Maria Vieira Cayres Vallinoto, Igor Brasil Costa, Antonio Carlos Rosário Vallinoto
The polyomaviruses that infect humans, JC virus (JCV) and BK virus (BKV), can establish persistent infections in the cells that make up the renal system, causing nephritis and BKV-associated nephropathy in up to 10% of renal transplant patients, and of these, 90% lose the graft and return for hemodialysis. This study aimed to determine the prevalence of polyomaviruses (PyV) in the population with chronic kidney disease (CKD), classified into three groups (conservative, dialysis, and transplanted) and a control group...
December 23, 2022: Tropical Medicine and Infectious Disease
https://read.qxmd.com/read/36654590/use-of-sodium-glucose-transport-protein-2-sglt2-inhibitor-remogliflozin-and-possibility-of-acute-kidney-injury-in-type-2-diabetes
#29
Rajesh Jain, Natrajan Bhavatharini, Thangavel Saravanan, Veeraswamy Seshiah, Nishchal Jain
The major trials, e.g., EMPA-REG OUTCOME, CANVAS, and CREDENCE, showed the renal and cardiovascular benefit of sodium-glucose transport protein 2 (SGLT2) inhibitors. The SGLT2 inhibitors, Empagliflozin, Dapagliflozin, and Canagliflozin, have shown no significant adverse renal effects. Still, our patients with type 2 diabetes on Remogliflozin, a type of SGLT2 inhibitor approved in India for the treatment of diabetes, seems to cause acute tubular necrosis as confirmed by clinical and pathological evidence in our study...
December 2022: Curēus
https://read.qxmd.com/read/36450526/oxidized-albumin-evaluation-of-oxidative-stress-as-a-marker-for-the-progression-of-kidney-disease
#30
JOURNAL ARTICLE
Hiroshi Watanabe
Oxidative stress has been reported to be associated with the progression of renal pathology as well as with the onset of complications associated with this condition. Bardoxolone methyl, a nuclear factor-erythroid 2-related factor 2 (Nrf2) activator with anti-oxidative and inflammatory modulation effects, has been reported to improve renal function in clinical trials. As of this writing, there have been no systems for the quantitative evaluation of oxidative stress that could be applied as a clinical test. We recently reported on post-translational modifications of albumin using electrospray-ionization time-of-flight mass spectrometry (ESI-TOF MS) and the results indicated that oxidized albumin (cysteinylated albumin: a molecule that was oxidatively cysteinylated at Cys34) was found to increase with the progression of renal pathology...
2022: Biological & Pharmaceutical Bulletin
https://read.qxmd.com/read/36422760/association-between-covid-19-vaccination-and-relapse-of-glomerulonephritis
#31
JOURNAL ARTICLE
Yuki Ota, Ryoma Kuroki, Mayu Iwata, Hiroshi Taira, Sayumi Matsuo, Masafumi Kamijo, Kumiko Muta, Tomoya Nishino
BACKGROUND: Vaccines for coronavirus disease 2019 (COVID-19) have been developed and are recommended for patients with chronic kidney disease; however, it has been reported that glomerulonephritis worsens after vaccination. We aimed to elucidate the incidence and association between COVID-19 vaccination and glomerulonephritis relapse. METHODS: We investigated the onset of renal events and adverse reactions after COVID-19 vaccination in 111 patients diagnosed with glomerulonephritis...
November 23, 2022: Clinical and Experimental Nephrology
https://read.qxmd.com/read/36387107/high-cutoff-hemodialysis-in-multiple-myeloma-patients-with-acute-kidney-injury
#32
REVIEW
Yan Xing, Jipeng Yan, Zixian Yu, Jin Zhao, Yuwei Wang, Xiayin Li, Yunlong Qin, Shiren Sun
Multiple myeloma (MM), an incurable hematological malignancy with clonal proliferation of plasma cells, is mainly characterized by excessive production of monoclonal immunoglobulins and free light chains (FLCs). Kidney injury is one of the main clinical manifestations and is also a significant predictor of the prognosis of symptomatic MM patients, especially those who require dialysis-supported treatment. Overproduction of FLCs is the trigger for kidney injury, as they can induce the transcription of inflammatory and profibrotic cytokines in the proximal tubule and bind to Tamm-Horsfall protein in the distal tubules to form casts that obstruct the tubules, leading to kidney injury and even renal fibrosis...
2022: Frontiers in Oncology
https://read.qxmd.com/read/36291403/intrinsic-kidney-pathology-in-children-and-adolescents-following-covid-19-vaccination-a-systematic-review
#33
REVIEW
Henry H L Wu, Mohan Shenoy, Philip A Kalra, Rajkumar Chinnadurai
Global COVID-19 vaccination programs for children and adolescents have been developed with international clinical trial data confirming COVID-19 mRNA vaccine safety and efficacy for the pediatric population. The impact of COVID-19 vaccination in the kidneys is thought to be explained by a complex immune-mediated relationship between the two, although the pathophysiological mechanisms of how COVID-19 vaccination potentially induces kidney pathology are not presently well known. Whilst intrinsic kidney pathologies following COVID-19 vaccination have been reported in adults, such cases are only being recently reported with greater frequency in children and adolescents...
September 26, 2022: Children
https://read.qxmd.com/read/36275986/primary-non-function-in-a-deceased-donor-kidney-transplant-even-with-a-kidney-donor-risk-index-less-than-1-0-a-case-report
#34
Sang Oh Yun, Min Jung Kim, Kyo Won Lee, Jae Berm Park
Donations from deceased donors have been increasing since the introduction of expanded criteria for donor kidney selection. Several studies have shown that patients receiving deceased donor kidneys using these expanded criteria have improved survival compared to those remaining on the waiting list during hemodialysis. It is important, however, to consider that some of the kidneys classed as usable under the expanded criteria may in fact be unacceptable. To address this concern, preoperative biopsy and imaging of deceased donor kidneys are increasingly being used to assess candidate kidneys...
September 30, 2022: Korean journal of transplantation
https://read.qxmd.com/read/36242751/the-role-of-copeptin-in-kidney-disease
#35
REVIEW
Pedro Iglesias, Ramona A Silvestre, María José Fernández-Reyes, Juan J Díez
Copeptin is a 39-amino acid glycopeptide that is secreted equimolecularly with arginine-vasopressin (AVP) from the prepro-hormone AVP in the posterior pituitary. While AVP is a very unstable molecule and is accompanied by significant technical troubles in its quantification, copeptin is a stable and easily quantifiable molecule. For this reason, circulating copeptin is currently used as a surrogate for AVP in different pathological conditions, including renal diseases. In recent years it has been shown that copeptin is associated with an increased risk of developing chronic kidney disease in the general population...
October 15, 2022: Endocrine
https://read.qxmd.com/read/36221874/relation-between-soluble-cd14-levels-inflammation-subclinical-atherosclerosis-and-mortality-in-hemodialysis-patients
#36
JOURNAL ARTICLE
Amany M Abdalla, Heba Elhakeem, Mohamed Basiouny Yahia, Eman M I Youssef, Nashwa El-Khouly, Ghada F Elmohaseb, Eman Abu-Elnasr Awad, Marwa M Hassan, Esam M Ghamry, Mohamed R Abdelhamed, E Kotb, Tamer M Mahmoud
BACKGROUND AND AIM: Chronic kidney disease (CKD) is characterized by persistent low-grade inflammation. Soluble CD14 (sCD14) is involved in many pathological conditions including inflammation and atherosclerosis. The present study aimed to assess the relation between sCD14 levels, subclinical atherosclerosis (SCA), inflammation and mortality in Egyptian hemodialysis (HD) patients. PATIENTS AND METHODS: The present longitudinal study included 62 HD patients. All patients were submitted to careful history taking, thorough clinical examination and laboratory assessment for high-sensitivity C-reactive protein (hsCRP) and sCD14...
October 11, 2022: Endocrine, Metabolic & Immune Disorders Drug Targets
https://read.qxmd.com/read/36172352/clinicopathological-features-and-individualized-treatment-of-kidney-involvement-in-b-cell-lymphoproliferative-disorder
#37
JOURNAL ARTICLE
Guangyan Nie, Lianqin Sun, Chengning Zhang, Yanggang Yuan, Huijuan Mao, Zhen Wang, Jianyong Li, Suyan Duan, Changying Xing, Bo Zhang
BACKGROUND: Due to the various clinical and pathological manifestations of kidney involvement in lymphoproliferative disorder (LPD), the whole spectrum of kidney disease in LPD is still unclear, and data on kidney prognosis is scarce. METHODS: We retrospectively reviewed the renal pathology profiles from January 2010 to December 2021, and 28 patients with B-cell LPD combined with intact renal biopsy data were included. RESULTS: There were 20 men and eight women aging 41 to 79 years at the time of renal biopsy (median age 62 years)...
2022: Frontiers in Immunology
https://read.qxmd.com/read/36123635/the-systemic-immune-response-due-to-cholesterol-crystal-embolization-syndrome-a-case-report
#38
JOURNAL ARTICLE
Tetsu Sakamoto, Takafumi Yamakawa, Keita Hirano, Arisa Kobayashi, Mio Kasai, Kiyoshi Koizumi, Takashi Yokoo, Satoru Komatsumoto, Toshimitsu Murohisa, Taro Shimizu
BACKGROUND: Cholesterol crystal embolization syndrome (CES) occurs when an atherosclerotic plaque causes small-vessel embolization, resulting in multi-organ damage. Although CES is pathologically characterized by an infiltration of eosinophils, the implication of the systemic inflammatory response represented by hypereosinophilia is unclear in clinical practice. Herein we present the case of a patient diagnosed with CES who developed multiple allergic organ injuries, including daptomycin-related dermatitis and later vancomycin-induced acute tubulointerstitial nephritis, which was successfully treated by the withdrawal of each medicine with or without corticosteroid therapy, one by one...
September 19, 2022: BMC Nephrology
https://read.qxmd.com/read/36082243/the-sustained-and-marked-elevation-of-serum-procalcitonin-in-a-hemodialysis-patient-with-tuberculous-lymphadenitis-but-without-the-evidence-of-sepsis-a-case-report
#39
Peiyi Luo, Yanqiong Long, Liang Ma, Ye Tao, Shenju Gou
Background: The elevation of serum procalcitonin (PCT) has been considered as a marker of systemic bacterial infection and sepsis. However, the marked elevation of PCT in non-sepsis conditions was rare. Here, we report a rare case of sustained markedly elevation of serum PCT in a dialysis patient with tuberculosis, but without the evidence of sepsis. Case Presentation: A 25-year-old man on maintenance hemodialysis was admitted to the hospital for kidney transplantation...
2022: Infection and Drug Resistance
https://read.qxmd.com/read/35980440/romosozumab-successfully-regulated-progressive-osteoporosis-in-a-patient-with-autosomal-dominant-polycystic-kidney-disease-undergoing-hemodialysis
#40
JOURNAL ARTICLE
Taihei Suzuki, Masahide Mizobuchi, Shunsuke Yoshida, Narumi Terado, Shugo Aoki, Nozomi Sato, Hirokazu Honda
Osteoporosis is a crucial complication in patients with chronic kidney disease (CKD), similar to that in the general population. Although romosozumab, a monoclonal antibody targeting sclerostin, has been administered for patients with CKD, its clinical effectiveness in these patients, especially in patients on hemodialysis (HD), remains to be studied. Herein, we report the case of a 42-year-old man on HD who developed severe osteoporosis. Serum calcium levels were extremely high, bone metabolic markers were abnormal, and the patient had pathological fractures...
August 18, 2022: Osteoporosis International
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