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Keywords Treatment Complication In Pedi...

Treatment Complication In Pediatric Leukemia

https://read.qxmd.com/read/38112148/-blinatumomab-as-bridging-therapy-in-two-children-with-b-cell-acute-lymphoblastic-leukemia-complicated-by-invasive-fungal-disease
#21
JOURNAL ARTICLE
Xiao-Fei Liu, Xue Tang, Lu-Lu Wang, Ying Wang, Shi-Lin Liu, Gui-Chi Zhou, Tong-Hui Li, Hui-Rong Mai
This article reports two cases of children with B-cell acute lymphoblastic leukemia (B-ALL) complicated by invasive fungal disease (IFD) who received bridging treatment using blinatumomab. Case 1 was a 4-month-old female infant who experienced recurrent high fever and limb weakness during chemotherapy. Blood culture was negative, and next-generation sequencing (NGS) of peripheral blood, bronchoalveolar lavage fluid, and cerebrospinal fluid were all negative. Chest CT and cranial MRI revealed obvious infection foci...
December 15, 2023: Zhongguo Dang Dai Er Ke za Zhi, Chinese Journal of Contemporary Pediatrics
https://read.qxmd.com/read/38092476/asparaginase-dosing-for-obese-patients-with-acute-lymphoblastic-leukemia-and-factors-that-contribute-to-outcomes
#22
REVIEW
Ryan D Cassaday
Asparaginase in various forms is a standard part of the treatment of acute lymphoblastic leukemia (ALL) in children and adolescents. However, its use is more selective in adults. One of the key reasons is the toxicity observed from this class of agents. In a series of recent post hoc analyses of large prospective studies, obesity has emerged as a key factor that contributes to the challenges with administering regimens that include asparaginase. In this review, the most salient findings are highlighted from these latest publications, both from the pediatric and adult literature...
December 2023: Best Practice & Research. Clinical Haematology
https://read.qxmd.com/read/38078321/short-mid-and-long-term-complications-after-multisystem-inflammatory-syndrome-in-children-over-a-24-month-follow-up-period-in-a-hospital-in-lima-peru-2020-2022
#23
JOURNAL ARTICLE
Giancarlo Alvarado-Gamarra, Matilde Estupiñan-Vigil, Raquel Garcés-Ghilardi, Jesús Domínguez-Rojas, Olguita Del Águila, Katherine Alcalá-Marcos, Rafael Márquez Llanos, Lucie Ecker, Carlos R Celis, Carlos Alva-Diaz, Claudio F Lanata
OBJECTIVE: To determine the short-, mid-, and long-term complications after multisystem inflammatory syndrome in children (MIS-C) over a 24-month follow-up period in a hospital in Lima, Peru, 2020-2022, and to explore differences according to the immunomodulatory treatment received and type of SARS-CoV-2 virus circulating. METHODS: Ambispective 24-month follow-up study in children <14 years of age diagnosed with MIS-C at the Hospital Nacional Edgardo Rebagliati Martins (HNERM)...
2023: Frontiers in Pediatrics
https://read.qxmd.com/read/38071039/-safety-and-the-short-term-efficacy-of-venetoclax-combined-with-azacitidine-followed-by-cladribine-in-children-with-refractory-relapsed-acute-myeloid-leukemia
#24
JOURNAL ARTICLE
Wei-Wei DU, Su-Xiang Liu, Yi Wang, Hai-Long He, Ai-Lian Guo, Shao-Yan Hu, Jun Lu
OBJECTIVE: To investigate the safety and the short-term efficacy of venetoclax combined with azacitidine followed by cladribine (VAC regimen) in children with refractory/ relapsed acute myeloid leukemia (AML). METHODS: The clinical data, treatment outcomes, complications, and blood product consumption of 6 children with refractory/relapsed AML treated with VAC regimen in the Children's Hospital of Soochow University from August 2021 to December 2021 were retrospectively analyzed...
December 2023: Zhongguo Shi Yan Xue Ye Xue za Zhi
https://read.qxmd.com/read/38066851/too-many-white-cells-tam-jmml-or-something-else
#25
JOURNAL ARTICLE
Alexandra Satty, Elliot Stieglitz, Nicole Kucine
Leukocytosis is a common finding in pediatric patients, and the differential diagnosis can be broad, including benign reactive leukocytosis and malignant myeloproliferative disorders. Transient abnormal myelopoiesis is a myeloproliferative disorder that occurs in young infants with constitutional trisomy 21 and somatic GATA1 mutations. Most patients are observed, but outcomes span the spectrum from spontaneous resolution to life-threatening complications. Juvenile myelomonocytic leukemia is a highly aggressive myeloproliferative disorder associated with altered RAS-pathway signaling that occurs in infants and young children...
December 8, 2023: Hematology—the Education Program of the American Society of Hematology
https://read.qxmd.com/read/38030834/extramedullary-relapsed-acute-lymphoblastic-leukemia-presenting-as-asymptomatic-acute-kidney-injury-after-hematopoietic-stem-cell-transplantation
#26
JOURNAL ARTICLE
Bingjie Cheng, Hongying Zhang, Chang Qi, Gaohong Zhu, Lin Huang, Xiaowen Wang
Acute kidney injury (AKI) is a common complication in children with hematological malignancies. Although AKI due to infiltration of tumor cells in children is rare, it negatively impacts treatment outcomes and increases the risk of mortality. We introduce a case of a child with acute lymphoblastic leukemia (ALL) who experienced kidney relapse resulting in asymptomatic AKI after remission from treatment, to remind clinicians not to overlook the primary disease in clinical judgment. In cases of unexplained AKI, kidney biopsy should be performed when feasible to get an accurate diagnosis and scientific treatment...
November 29, 2023: Pediatric Nephrology
https://read.qxmd.com/read/38023223/long-term-experience-in-treatment-of-acute-promyelocytic-leukemia-in-mexican-children-in-a-tertiary-care-hospital
#27
JOURNAL ARTICLE
Marco Antonio Murillo-Maldonado, Paulina González Galván, Israel Parra Ortega, Félix Gaytán Morales, Luis Juárez Villegas, Elisa Dorantes Acosta
INTRODUCTION: Acute promyelocytic leukemia (APL) is a rare myeloid leukemia subtype affecting adult and pediatric populations. APL constitutes 15-20% of all childhood AML in Latin America, compared to 7% in the non-Latino population. This leukemia has unique characteristics, such as its association with chromosomal translocations involving the retinoid acid receptor α (RARA) gene on chromosome 17. In addition, APL is also distinct from other AML subtypes due to its response to all-trans-retinoic acid (ATRA), which induces terminal granulocytic differentiation of blasts...
2023: Frontiers in Oncology
https://read.qxmd.com/read/38023197/case-report-blinatumomab-as-upfront-consolidation-and-maintenance-therapy-in-a-pediatric-patient-with-high-risk-b-cell-acute-lymphoblastic-leukemia
#28
Sumit Gupta, Jessica Casey, Joseph Lasky
INTRODUCTION: B-cell acute lymphoblastic leukemia (B-ALL) is the most common malignancy in children. The current conventional chemotherapy regimens have high overall survival but with significant short- and long-term toxicities, sometimes requiring delay and termination of chemotherapy. Bispecific T-cell engager antibody blinatumomab has been successful in achieving bone marrow remission and acting as bridging therapy in minimal residual disease (MRD)-positive relapsed adult and pediatric B-ALL patients...
2023: Frontiers in Oncology
https://read.qxmd.com/read/37918224/a-comprehensive-comparison-between-tbi-vs-non-tbi-based-conditioning-regimen-in-pediatric-patients-with-acute-lymphoblastic-leukemia-a-systematic-review-and-meta-analysis
#29
REVIEW
Faezeh Ansari, Maryam Behfar, Leila Jafari, Rashin Mohseni, Parisa Naji, Yalda Karamlou, Mohammad Hossein Amirzade-Iranaq, Amir Ali Hamidieh
INTRODUCTION: We aimed to evaluate the efficacy, safety, and latent toxicity of total body irradiation (TBI)-based conditioning regimens compared to non-TBI regimens for pediatric patients (under 18 years old) with acute lymphoblastic leukemia (ALL) undergoing allogeneic hematopoietic stem cell transplantation (HSCT). METHODS: A systematic search was performed on MEDLINE, Scopus, WOS, and PMC. Also, a search for grey literature was performed on Google Scholar and relevant articles' references were included...
December 2023: Leukemia Research
https://read.qxmd.com/read/37909942/necrotizing-gastritis-as-a-rare-complication-in-a-pediatric-patient-with-acute-lymphoid-leukemia
#30
JOURNAL ARTICLE
Carolina Rivero Bustos, Carlos Augusto Cuadros, Kelly Paz Amado, Alexandra Perez Sotelo, Edwin Abraham Medina, Irina Suley Tirado Perez
UNLABELLED: Necrotizing gastritis is an infrequent entity with unknown prevalence, the diagnosis is often incidental during exploratory laparotomy or autopsies of patients with acute abdomen. OBJECTIVE: To present a clinical case of necrotizing gastritis, a rare entity that should be taken into account in the context of immunocompromised patients with associated risk factors. CLINICAL CASE: 7-year-old male schoolboy diagnosed with T-precursor acute lymphoid leukemia, finishing induction chemotherapy cycle with PETHEMA 2013 protocol...
June 2023: Andes pediatrica: revista Chilena de pediatría
https://read.qxmd.com/read/37899194/-hematopoietic-stem-cell-transplantation-for-adults-with-philadelphia-chromosome-negative-acute-lymphoblastic-leukemia-in-the-first-complete-remission
#31
JOURNAL ARTICLE
Koji Nagafuji
The treatment outcomes for adult Philadelphia chromosome-negative acute lymphoblastic leukemia (ALL) have improved with the introduction of pediatric protocols. On assessing long-term survivors of chemotherapy who underwent allogeneic hematopoietic stem cell transplantation (allo-HSCT), it was found that these patients had good performance status and few complications. Therefore, in the first complete remission (1CR) of ALL, allo-HSCT is indicated for patients in whom the results of chemotherapy are predicted to be poor...
2023: [Rinshō Ketsueki] the Japanese Journal of Clinical Hematology
https://read.qxmd.com/read/37885398/-autochthonous-case-of-malaria-prediagnosed-as-leukemia
#32
JOURNAL ARTICLE
Hüseyin Gülen, Ayşe Türedi Yıldırım, İbrahim Çavuş, Hülya Türkmen, Ahmet Özbilgin
Malaria is a parasitic disease transmitted by infected female Anopheles mosquitoes. There are five species of Plasmodium species that can infect humans. Of these species, especially P.falciparum and P.vivax pose the greatest threat to human health. In the 2014 report of the World Health Organization, it was reported that there were no locally acquired cases of malaria in 16 countries including Türkiye. Malaria cases originating from outside the country and imported due to migration, travel and working abroad are reported as import cases...
October 2023: Mikrobiyoloji Bülteni
https://read.qxmd.com/read/37870252/association-of-prophylactic-antibiotics-with-early-infectious-complications-in-children-with-cancer-undergoing-central-venous-access-device-placement
#33
JOURNAL ARTICLE
Steven T Papastefan, Suhail Zeineddin, Martin L Blakely, Harold N Lovvorn, Lynn Wei Huang, Mehul V Raval, Timothy B Lautz
OBJECTIVE: To evaluate the impact of prophylactic antibiotics on early infectious complications after central venous access device (VAD) placement in children with cancer. SUMMARY OF BACKGROUND DATA: Despite the frequency of VAD procedures in children, the effectiveness of prophylactic antibiotics for reducing infectious complications is unknown. METHODS: This was a retrospective cohort study of children with cancer undergoing central VAD placement identified in the Pediatric Health Information System database between 2017-2021...
October 23, 2023: Annals of Surgery
https://read.qxmd.com/read/37868174/invasive-fungal-infections-in-children-treated-for-hematologic-malignancies-a-five-year-single-center-experience
#34
JOURNAL ARTICLE
Domagoj Buljan, Izabela Kranjčec, Ivan Pavić, Paola Krnjaić, Sanela Šalig, Gordana Jakovljević, Jasminka Stepan Giljević
Invasive fungal infections (IFI) are life-threatening complications of intensive chemotherapy treatment, with the incidence in pediatric patients ranging from 2% to 21%. In this article, we describe our 5-year experience of IFI in pediatric oncology patients and its clinical manifestations with radiological findings, treatment and outcome. A retrospective and descriptive survey of IFI in children with hematologic neoplasms was conducted at the Department of Oncology and Hematology, Zagreb Children's Hospital...
December 2022: Acta Clinica Croatica
https://read.qxmd.com/read/37856184/lack-of-benefit-from-premedication-for-pegylated-asparaginase-during-pediatric-acute-lymphoblastic-leukemia-lymphoma-therapy-a-side-by-side-comparison
#35
JOURNAL ARTICLE
Sarah Menig, Andrew Dinh, Jonathan Angus, Sarah Tucker, Kasey J Leger, Teresa Rushing, Etan Orgel
BACKGROUND: Pegylated l-asparaginase (PEG) is integral to treatment regimens for acute lymphoblastic leukemia (ALL) and lymphoma. Hypersensitivity reactions (HSRs) to PEG are common and can preclude continued administration. Data supporting recommendations for universal premedication (UPM) prior to PEG infusion to reduce incidence of HSRs are limited; UPM has become common practice. PROCEDURES: Two free-standing children's hospitals independently implemented UPM prior to PEG infusions in 2016 and 2019, respectively...
October 19, 2023: Pediatric Blood & Cancer
https://read.qxmd.com/read/37842028/endovascular-treatment-of-a-mycotic-aneurysm-in-an-immunocompromised-child-with-acute-leukemia-case-report-and-review-of-the-literature
#36
Sabine Daphne Diepenbruck, Andre Jakob, Nikolaus Alexander Haas, Guido Mandilaras
Mycotic aneurysms are dilatations of an artery, a rare but severe complication arising from infectious obliteration of the vessel wall. Thoracic aneurysms often present with unspecific symptoms and multiple diagnostic and therapeutic challenges. In an advanced state, they have an increased risk of perforation and a high mortality rate. The surgical therapeutic approach has a high perioperative complication rate. In this study, we report a case of a thoracic mycotic aortic aneurysm in an immunocompromised pediatric patient caused by Klebsiella pneumoniae bacteremia...
2023: Frontiers in Pediatrics
https://read.qxmd.com/read/37803853/-interim-results-of-a-multicenter-cohort-study-for-chinese-children-leukemia-group-acute-lymphoblastic-leukemia-2018-regimen
#37
JOURNAL ARTICLE
(no author information available yet)
Objective: To summarize the therapeutic effects of Chinese Children Leukemia Group-acute lymphoblastic leukemia (CCLG-ALL) 2018 regimen in children with T cell acute lymphoblastic leukemia (T-ALL) and to find out risk indicators for prognosis. Methods: This study was a prospective multicenter cohort study involving 299 newly diagnosed T-ALL children in 21 Grade A tertiary hospitals nationwide. All patients received CCLG-ALL 2018 regimen and clinical data for treatment efficacy evaluating was collected. Variables associated with event free survival (EFS) rate, overall survival (OS) rate and cumulative recurrence rate were evaluated by Lasso regression analysis (including variables selection, model construction and hazard ratio calculating)...
October 2, 2023: Zhonghua Er Ke za Zhi. Chinese Journal of Pediatrics
https://read.qxmd.com/read/37786830/incidence-and-management-of-thromboembolism-in-patients-with-acute-leukemia
#38
JOURNAL ARTICLE
Salih Güler, Aytül Temuroğlu, Melike Sezgin Evim, Adalet Meral Günes
Thromboembolic events (TE) in childhood are relatively rare but, serious complications of acute leukemia. The aim was to define the incidence and risk factors of thrombosis in children with leukemias. The electronic files of pediatric denovo/relapsed acute leukemia patients aged below 18 years, treated between 2011 and 2021 were retrospectively evaluated for thrombotic attacks. Thirty out of 469 patients developed 35 thrombotic events. The median age at the time of the TE was 11.8 (2-17.6) years, and the median time from diagnosis to TE was 9 (0-58) months...
October 2023: Indian Journal of Hematology & Blood Transfusion
https://read.qxmd.com/read/37775598/the-gut-microbiome-an-important-factor-influencing-therapy-for-pediatric-acute-lymphoblastic-leukemia
#39
REVIEW
Yafang Xu, Hui Gao, Huajun Li
Acute lymphoblastic leukemia (ALL) is the most prevalent form of pediatric leukemia. The gut microbiome (GM) is crucial for proper nutrition, immunity, and biological conflict. Since the relationship between ALL and GM is bidirectional, ALL occurrence and treatment are closely related to GM destruction and the development of impaired immunity. Studies have discovered significant GM alterations in patients with ALL, including decreased diversity, that are likely directly caused by the development of ALL. Chemotherapy, antibiotic therapy, and hematopoietic stem cell transplantation (HSCT) are the mainstays of treatment for pediatric ALL...
September 29, 2023: Annals of Hematology
https://read.qxmd.com/read/37754666/oral-manifestations-a-warning-sign-in-children-with-hematological-disease-acute-lymphocytic-leukemia
#40
REVIEW
Sandra Clara Soares, Louis J D Roux, Ana Rita Castro, Cristina Cardoso Silva, Rita Rodrigues, Viviana M P Macho, Fátima Silva, Céu Costa
Acute lymphocytic leukemia (ALL) is the most frequent form of all childhood leukemias, mostly affecting children between 2 and 4 years old. Oral symptoms, such as mouth ulcers, mucositis, xerostomia, Herpes or Candidiasis, gingival enlargement and bleeding, petechiae, erythema, mucosal pallor and atrophic glossitis, are very common symptoms of ALL and can be early signs of the disease. Secondary and tertiary complications, a direct effect of chemo and radiotherapy, are associated with more severe bleeding, higher susceptibility to infections, ulcerations, inflammation of the mucous membranes, osteoradionecrosis, xerostomia, taste alterations, trismus, carious lesions and dental abnormalities...
August 24, 2023: Hematology Reports
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