Matthew Griffin, Veena S Rao, Juan Ivey-Miranda, James Fleming, Devin Mahoney, Christopher Maulion, Nisha Suda, Krishmita Siwakoti, Tariq Ahmad, Daniel Jacoby, Ralph Riello, Lavanya Bellumkonda, Zachary Cox, Sean Collins, Sangchoon Jeon, Jeffrey M Turner, F Perry Wilson, Javed Butler, Silvio E Inzucchi, Jeffrey M Testani
BACKGROUND: Sodium-glucose cotransporter-2 inhibitors improve heart failure-related outcomes. The mechanisms underlying these benefits are not well understood, but diuretic properties may contribute. Traditional diuretics such as furosemide induce substantial neurohormonal activation, contributing to the limited improvement in intravascular volume often seen with these agents. However, the proximal tubular site of action of the sodium-glucose cotransporter-2 inhibitors may help circumvent these limitations...
September 15, 2020: Circulation